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Article

Quantitative Evaluation of Fibrosis in IPF Patients: Meaning of Diffuse Pulmonary Ossification

1
Radiology Unit 1, Department of Medical Surgical Sciences and Advanced Technologies “GF Ingrassia”, University—Hospital Policlinico “G. Rodolico—S. Marco”, University of Catania, 95123 Catania, Italy
2
Regional Referral Centre for Rare Lung Diseases, Department of Clinical and Experimental Medicine, University—Hospital Policlinico “G. Rodolico—S. Marco”, University of Catania, 95123 Catania, Italy
3
Department of Medical, Surgical and Health Sciences, University of Trieste, 34151 Trieste, Italy
*
Author to whom correspondence should be addressed.
Diagnostics 2021, 11(1), 113; https://doi.org/10.3390/diagnostics11010113
Received: 12 November 2020 / Revised: 28 December 2020 / Accepted: 8 January 2021 / Published: 12 January 2021
(This article belongs to the Special Issue Clinical and Radiological Features of Interstitial Lung Diseases 2.0)
To investigate the role of diffuse pulmonary ossification (DPO) in disease severity in a population of Idiopathic Pulmonary Fibrosis (IPF) patients. This retrospective study was carried out on 95 IPF patients—44 with DPO on high resolution computed tomography (HRCT) and 51 with no calcifications detected on HRCT. Pulmonary Function Tests (PFTs) acquired nearest to the HRCT were collected. Images were analyzed by two radiologists using a qualitative method, based on HRCT fibrosis visual score, and using a quantitative method, based on histogram-based analysis. The Spearman’s rank correlation coefficient was used to measure the strength and direction of the linear relationship between HRCT fibrosis score and PFTs; in addition, Spearman’s rank correlation coefficient was used to explore the relationships between HRCT fibrosis score and quantitative index and between quantitative indexes and PFTs. A weak correlation between HRCT fibrosis score and PFTs was proven (r =–0.014 and p = 0.9347 for FVC (Forced Vital Capacity), r = −0.379 and p = 0.0174 for DLCO (Carbon monoxide diffusing capacity)). We found a moderate negative correlation between HRCT fibrosis score and kurtosis (r = −0.448, p = 0.004272) and skewness (r = −0.463, p = 0.003019) and a weak positive correlation with High Attenuation Area (HAA)% (r = 0.362, p = 0.0235). Moreover, a moderate linear correlation between Quantitative Indexes and FVC (r = 0.577, p = 0.000051 for kurtosis and FVC, r = 0.598, p = 0.000023 for skewness and FVC, r = −0.519, p = 0.0000364 for HAA% and FVC) and between quantitative indexes and DLCO (r = 0.469, p = 0.001508 for kurtosis, and DLCO, r = 0.474, p = 0.001309 for skewness and DLCO, r = −0.412, p = 0.005996 for HAA% and DLCO) was revealed. To better investigate the influence of DPO in disease progression, a longitudinal evaluation should be performed. View Full-Text
Keywords: lung diseases; interstitial lung diseases; IPF; fibrosis; HRCT; pulmonary ossification; visual score; quantification; histogram-based analysis; kurtosis lung diseases; interstitial lung diseases; IPF; fibrosis; HRCT; pulmonary ossification; visual score; quantification; histogram-based analysis; kurtosis
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MDPI and ACS Style

Palermo, M.; Tiralongo, F.; Distefano, G.; Vancheri, A.; Giuffrè, M.; Pino, F.; Foti, P.V.; Sambataro, G.; Vancheri, C.; Palmucci, S.; Basile, A. Quantitative Evaluation of Fibrosis in IPF Patients: Meaning of Diffuse Pulmonary Ossification. Diagnostics 2021, 11, 113. https://doi.org/10.3390/diagnostics11010113

AMA Style

Palermo M, Tiralongo F, Distefano G, Vancheri A, Giuffrè M, Pino F, Foti PV, Sambataro G, Vancheri C, Palmucci S, Basile A. Quantitative Evaluation of Fibrosis in IPF Patients: Meaning of Diffuse Pulmonary Ossification. Diagnostics. 2021; 11(1):113. https://doi.org/10.3390/diagnostics11010113

Chicago/Turabian Style

Palermo, Monica, Francesco Tiralongo, Giulio Distefano, Ada Vancheri, Mauro Giuffrè, Fabio Pino, Pietro V. Foti, Gianluca Sambataro, Carlo Vancheri, Stefano Palmucci, and Antonio Basile. 2021. "Quantitative Evaluation of Fibrosis in IPF Patients: Meaning of Diffuse Pulmonary Ossification" Diagnostics 11, no. 1: 113. https://doi.org/10.3390/diagnostics11010113

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