Skip to Content
You are currently on the new version of our website. Access the old version .

51,818 Results Found

  • Article
  • Open Access
3 Citations
13,574 Views
9 Pages

Transient Elevation of Liver Function Tests and Bilirubin Levels After Laparoscopic Cholecystectomy

  • Alexandros Giakoustidis,
  • Menelaos Papakonstantinou,
  • Christos Gkoutzios,
  • Paraskevi Chatzikomnitsa and ,
  • Areti Danai Gkaitatzi,
  • Athanasia Myriskou,
  • Petros Bangeas,
  • Panagiotis Dimitrios Loufopoulos,
  • Vasileios N. Papadopoulos and
  • Dimitrios Giakoustidis
  • + 5 authors+ 0 author

17 November 2024

Background and Objectives: Laparoscopic cholecystectomy constitutes the current “gold standard” treatment of symptomatic gallstone disease. In order to avoid intraoperative vasculobiliary injuries, it is mandatory to establish the “...

(This article belongs to the Special Issue Gallbladder, Bile Duct and Pancreas Disorders: Current Challenges, New Perspectives and Innovative Techniques)
  • Article
  • Open Access
25 Citations
10,992 Views
17 Pages

Cross-Sectional Analysis of the Utility of Pulmonary Function Tests in Predicting Emphysema in Ever-Smokers

  • Sean E. Hesselbacher,
  • Robert Ross,
  • Matthew B. Schabath,
  • E. O’Brian Smith and ,
  • Sarah Perusich,
  • Nadia Barrow,
  • Pamela Smithwick,
  • Manoj J. Mammen,
  • Harvey Coxson and
  • Farrah Kheradmand
  • + 7 authors+ 2 authors

Emphysema is largely an under-diagnosed medical condition that can exist in smokers in the absence of airway obstruction. We aimed to determine the sensitivity and specificity of pulmonary function tests (PFTs) in assessing emphysema using quantitati...

(This article belongs to the Special Issue Tobacco Smoking and Public Health)
  • Article
  • Open Access
96 Views
25 Pages

Functional Testing and Numerical Analysis of Initial Freezing in Overboard Discharge Valve at Small Lift

  • Peiyue Li,
  • Shihao Zhou,
  • Xinqi Zhang,
  • Cheng Li and ,
  • Xingyu Liu,
  • Zhenhao Xiao and
  • Yuwei Sun
  • + 2 authors+ 0 author

1 November 2026

Local freezing may affect subsequent discharge when a cold fluid enters a water-containing passage in an overboard discharge valve. Compressed-air functional tests assessed prototype opening and discharge performance. A volume-of-fluid (VOF) model co...

(This article belongs to the Section Ocean Engineering)
  • Article
  • Open Access
236 Views
16 Pages

Machine Learning-Based Prediction of Pulmonary Function Test Outcomes Using Oscillometry in Patients with COPD

  • Seyedfakhreddin Nabavi,
  • Lennart K. A. Lundblad,
  • Ronald J. Dandurand and
  • Bryan A. Ross

20 October 2026

Oscillometry has been recognized as a non-invasive method for assessing respiratory conditions and is increasingly being implemented in routine clinical practice. Currently, a full pulmonary function test (PFT), which requires extensive infrastructur...

(This article belongs to the Special Issue Advanced Non-Invasive Sensors: Methods and Applications—2nd Edition)
  • Article
  • Open Access
1,033 Views
14 Pages

Association of MASLD with Baseline and New-Onset Liver Function Test Elevation in Medical ICU Patients

  • Ali Karataş,
  • Kamil İnci,
  • Nazlıhan Boyacı Dündar,
  • Gülbin Aygencel and ,
  • Melda Türkoğlu,
  • Ali Osman Taş,
  • Beril Avcı,
  • Cansu Gedik and
  • Mehmet Cindoruk
  • + 4 authors+ 0 author

24 November 2025

Background and Objectives: Metabolic dysfunction-associated steatotic liver disease (MASLD) is highly prevalent and may influence the outcome of critical illness. Although abnormal liver function tests (LFTs) are frequent in the intensive care unit (...

(This article belongs to the Section Gastroenterology & Hepatology)
  • Article
  • Open Access
11 Citations
8,990 Views
13 Pages

Predicting Maximal Oxygen Uptake Using the 3-Minute All-Out Test in High-Intensity Functional Training Athletes

  • Joshua D. Dexheimer,
  • Shane J. Brinson,
  • Robert W. Pettitt,
  • E. Todd Schroeder and ,
  • Brandon J. Sawyer and
  • Edward Jo
  • + 1 author+ 0 author

30 November 2020

Maximal oxygen uptake (VO2max) and critical speed (CS) are key fatigue-related measurements that demonstrate a relationship to one another and are indicative of athletic endurance performance. This is especially true for those that participate in com...

(This article belongs to the Special Issue Exercise Physiology: New Frontiers for Exercise Testing and Prescription)
  • Review
  • Open Access
33 Citations
9,785 Views
34 Pages

Mitochondria Matter: Systemic Aspects of Nonalcoholic Fatty Liver Disease (NAFLD) and Diagnostic Assessment of Liver Function by Stable Isotope Dynamic Breath Tests

  • Agostino Di Ciaula,
  • Giuseppe Calamita,
  • Harshitha Shanmugam,
  • Mohamad Khalil and ,
  • Leonilde Bonfrate,
  • David Q.-H. Wang,
  • Gyorgy Baffy and
  • Piero Portincasa
  • + 3 authors+ 0 author

The liver plays a key role in systemic metabolic processes, which include detoxification, synthesis, storage, and export of carbohydrates, lipids, and proteins. The raising trends of obesity and metabolic disorders worldwide is often associated with...

(This article belongs to the Special Issue Targeting Mitochondria in Metabolic Diseases)
  • Article
  • Open Access
3 Citations
5,022 Views
12 Pages

Objectives: To identify typical patterns of abdominal wall muscle activation in patients with diastasis recti and inguinal hernias compared to controls during the Valsalva maneuver, voluntary coughing, and physical activity. Methods: The study includ...

(This article belongs to the Special Issue Basis of Applied Kinesiology, Innovations and Clinical Applications in Musculoskeletal Health)
  • Article
  • Open Access
804 Views
14 Pages

Evaluation of the 3 Min Walk Test as a Distinct Measure of Functional Capacity in Healthy Singaporean Adults: A Cross-Sectional Analysis

  • Meredith T. Yeung,
  • Christian Villanueva,
  • Sen Q. Neo,
  • Muhammad Hidir Bin Salim and ,
  • Xian Cong Goh,
  • Ray Han Lian,
  • Anne C. Ting and
  • Mingxing Yang
  • + 3 authors+ 0 author

Background: The 6 min walk test (6MWT) is the gold standard for field-based functional assessment, yet the 3 min walk test (3MWT) offers a time-efficient alternative. However, a lack of localised normative reference values (NRV) and an over-reliance...

  • Article
  • Open Access
6 Citations
3,407 Views
9 Pages

24 March 2023

Background and Objectives: One of the most challenging tasks in a clinical setting is to differentiate between complex regional pain syndrome (CRPS) type II and traumatic neuropathic pain (NeP). CRPS is characterized by several dysautonomic manifesta...

(This article belongs to the Special Issue Chronic Neuropathic Pain Therapy and Anaesthesia)
  • Article
  • Open Access
666 Views
16 Pages

Functional Thresholds Derived from Dynamometry and 6-Minute Walk Test with Morphofunctional Assessment to Guide Individualized Exercise Prescription in Cardiac Rehabilitation

  • María del Mar Amaya-Campos,
  • Ramón Zafra Jiménez,
  • Rocío Fernández-Jiménez,
  • Isabel M. Vegas-Aguilar and ,
  • María García-Olivares,
  • Mónica Diaz-Cordovés Rego,
  • Yolanda Ruiz Molina,
  • Adela María Gómez González,
  • Angel Montiel Trujillo and
  • Lucía Jiménez Laguna
  • + 7 authors+ 2 authors

3 June 2026

Background/Objectives: To evaluate the associations and concurrent validity between baseline functional and morphofunctional assessments in patients with cardiovascular disease participating in a Phase II cardiac rehabilitation program, as a basis fo...

(This article belongs to the Special Issue Clinical Cardiac Rehabilitation: Integrating Multidimensional Approaches for Enhanced Cardiovascular Health)
  • Article
  • Open Access
3 Citations
2,451 Views
9 Pages

The Ultrasound Renal Stress Test for the Assessment of Functional Renal Reserve in Kidney Transplantation: A Pilot Study in Living Donors

  • Federico Nalesso,
  • Francesca K. Martino,
  • Marco Bogo,
  • Elisabetta Bettin and ,
  • Marianna Alessi,
  • Lucia F. Stefanelli,
  • Cristina Silvestre,
  • Lucrezia Furian and
  • Lorenzo A. Calò
  • + 4 authors+ 0 author

17 January 2024

In the evolving landscape of nephrology and kidney transplants, assessing renal functional reserve (RFR) in living kidney donors is essential for ensuring donor safety and successful transplantation. This study explores the use of the Intra-Parenchym...

(This article belongs to the Section Nephrology & Urology)
  • Article
  • Open Access
498 Views
16 Pages

Cardiopulmonary Exercise Testing and Exercise Stress Echocardiography in Degenerative Mitral Regurgitation: An Exploratory Analysis of Functional and Left Ventricular Outcomes After Surgery

  • Laura Besola,
  • Giulia Bacci,
  • Cinzia Anna Maria Papappicco,
  • Dario Gregori and ,
  • Giosuè Salvatore Falcetta,
  • Federico Giorgi,
  • Nicola Riccardo Pugliese and
  • Andrea Colli
  • + 3 authors+ 0 author

Background: Surgical correction of severe degenerative Mitral Regurgitation (DMR) is indicated in the presence of symptoms and signs of left ventricular (LV) dysfunction. However, conventional clinical and resting echocardiographic parameters may und...

(This article belongs to the Special Issue State of the Art in Mitral Valve Disease, 2nd Edition)
  • Article
  • Open Access
1 Citations
1,182 Views
14 Pages

Can Artificial Intelligence Interpret Pulmonary Function Tests and Predict Prolonged Air Leaks After Lung Resection

  • Omar Zahra,
  • Alexander Pohlman,
  • Ayham Odeh,
  • Mohammad Alhusseini and ,
  • James Lubawski,
  • Julia M. Coughlin,
  • Wissam Raad,
  • Amit Goyal and
  • Zaid M. Abdelsattar
  • + 4 authors+ 0 author

5 May 2026

Background/Objectives: Preoperative pulmonary function tests (PFTs) contain numerous physiologic parameters, yet surgeons typically rely on forced expiratory volume in one second (FEV1) and diffusing capacity of the lung for carbon monoxide (DLCO) to...

(This article belongs to the Special Issue Artificial Intelligence (AI), Robotics, and Cancer Surgery)
  • Article
  • Open Access
7 Citations
3,992 Views
12 Pages

Abnormal Liver Function Tests and Long-Term Outcomes in Patients Discharged after Acute Heart Failure

  • Hiroshi Miyama,
  • Yasuyuki Shiraishi,
  • Shun Kohsaka,
  • Ayumi Goda and ,
  • Yosuke Nishihata,
  • Yuji Nagatomo,
  • Makoto Takei,
  • Keiichi Fukuda,
  • Takashi Kohno and
  • Tsutomu Yoshikawa
  • + 5 authors+ 0 author

16 April 2021

Abnormal liver function tests (LFTs) are known to be associated with impaired clinical outcomes in heart failure (HF) patients. However, this implication varies with each single LFT panel. We aim to evaluate the long-term outcomes of acute HF (AHF) p...

(This article belongs to the Section Cardiology)
  • Article
  • Open Access
3,371 Views
16 Pages

29 November 2024

Currently, writing aids for upper extremity rehabilitation in stroke patients are not developed with consideration of biomechanical characteristics, making it difficult to achieve proper support effects. Therefore, in this study, we conducted a compa...

  • Article
  • Open Access
3,645 Views
7 Pages

The Modified Functional Reach Test (mFRT) was developed to assess sitting balance in individuals with spinal cord injury (SCI). No studies have explored which mFRT reach directions correlate with the center of pressure (CoP) variables in patients wit...

(This article belongs to the Section Biomechanics and Sports Medicine)
  • Article
  • Open Access
369 Views
18 Pages

21 August 2026

Background: The ability of preseason screening to identify athletes at risk for non-contact lower-limb injury remains uncertain. Purpose: To determine whether knee and ankle joint tests, body mass index (BMI), prior lower-limb injury, and Functional...

(This article belongs to the Special Issue Sports Injuries: Emerging Trends in Risk Mitigation, Management and Recovery)
  • Article
  • Open Access
6 Citations
4,798 Views
8 Pages

No Correlation between Positive Fructose Hydrogen Breath Test and Clinical Symptoms in Children with Functional Gastrointestinal Disorders: A Retrospective Single-Centre Study

  • Jarosław Kwiecień,
  • Weronika Hajzler,
  • Klaudia Kosek,
  • Sylwia Balcerowicz and ,
  • Dominika Grzanka,
  • Weronika Gościniak and
  • Katarzyna Górowska-Kowolik
  • + 2 authors+ 0 author

23 August 2021

Fructose malabsorption is regarded as one of the most common types of sugar intolerance. However, the correlation between gastrointestinal symptoms and positive results in fructose hydrogen breath tests (HBTs) remains unclear. The aim of this study w...

(This article belongs to the Special Issue Food Sensitivity: Causes and Management)
  • Article
  • Open Access
28 Citations
6,166 Views
12 Pages

Tele-Assessment of Functional Capacity through the Six-Minute Walk Test in Patients with Diabetes Mellitus Type 2: Validity and Reliability of Repeated Measurements

  • Garyfallia Pepera,
  • Evmorfia Karanasiou,
  • Christina Blioumpa,
  • Varsamo Antoniou and ,
  • Konstantinos Kalatzis,
  • Leonidas Lanaras and
  • Ladislav Batalik
  • + 2 authors+ 0 author

25 January 2023

A tele-assessed 6MWT (TL 6MWT) could be an alternative method of evaluating functional capacity in patients with diabetes mellitus type 2 (DM2). This study aimed to assess the validity and reliability of a TL 6MWT. The functional capacity of 28 patie...

(This article belongs to the Section Wearables)
  • Review
  • Open Access
21 Citations
15,379 Views
32 Pages

8 February 2025

Musculoskeletal injury (MSI) risk screening has gained significant attention in rehabilitation, sports, and fitness due to its ability to predict injuries and guide preventive interventions. This review analyzes the Functional Movement Screen (FMS) a...

  • Article
  • Open Access
6 Citations
3,090 Views
15 Pages

Differential Impact of Cytochrome 2C19 Allelic Variants on Three Different Platelet Function Tests in Clopidogrel-Treated Patients

  • Renske H. Olie,
  • Rachelle R. K. Hensgens,
  • Petal A. H. M. Wijnen,
  • Leo F. Veenstra and ,
  • Bianca T. A. de Greef,
  • Minka J. A. Vries,
  • Paola E. J. van der Meijden,
  • Jurriën M. ten Berg,
  • Hugo ten Cate and
  • Yvonne M. C. Henskens
  • + 6 authors+ 1 author

3 September 2021

On-treatment platelet reactivity in clopidogrel-treated patients can be measured with several platelet function tests (PFTs). However, the agreement between different PFTs is only slight to moderate. Polymorphisms of the CYP2C19 gene have an impact o...

(This article belongs to the Section Pharmacology)
  • Article
  • Open Access
10 Citations
9,227 Views
15 Pages

21 November 2013

Spirometry is regarded as the only effective method for detecting pulmonary function test (PFT) indices. In this study, a novel impedance pulmonary function measurement system (IPFS) is developed for directly assessing PFT indices. IPFS can obtain hi...

(This article belongs to the Special Issue Biomedical Sensors and Systems)
  • Article
  • Open Access
723 Views
15 Pages

7 April 2026

Background: Regular aerobic exercise during childhood promotes critical physiological adaptations in the cardiovascular and respiratory system. Finswimming, a unique aquatic sport, requires high-intensity demands and specific breathing patterns. The...

(This article belongs to the Special Issue Insights and Innovations in Sports Cardiology)
  • Communication
  • Open Access
6 Citations
8,436 Views
9 Pages

Structural Changes in Stx1 Engineering Monoclonal Antibody Improves Its Functionality as Diagnostic Tool for a Rapid Latex Agglutination Test

  • Daniela Luz,
  • Emerson A. Shiga,
  • Gang Chen,
  • Wagner Quintilio and ,
  • Fernanda B. Andrade,
  • Andrea Q. Maranhão,
  • Bruna A. Caetano,
  • Thaís Mitsunari,
  • Míriam A. Silva and
  • Roxane M. F. Piazza
  • + 8 authors+ 3 authors

1 February 2018

Stx1 toxin is one of the AB5 toxins of Shiga toxin-producing Escherichia coli (STEC) responsible for foodborne intoxication during outbreaks. The single-chain variable fragment (scFv) is the most common recombinant antibody format; it consists of bot...

  • Article
  • Open Access
1 Citations
988 Views
13 Pages

Beta-Cell Function Assessment by In-Silico Modeling Using Three Samples from an Oral Glucose Tolerance Test During Pregnancy Possibly Complicated by Gestational Diabetes

  • Christian Göbl,
  • Agnese Piersanti,
  • Florian Heinzl,
  • Tina Linder and ,
  • Micaela Morettini and
  • Andrea Tura
  • + 1 author+ 0 author

Background/Objectives: In pregnancy, beta-cell function is of interest since not only insulin resistance but also beta-cell dysfunction is common, especially when gestational diabetes mellitus (GDM) occurs. Typically, model-based beta-cell function i...

(This article belongs to the Special Issue Beta-Cell Failure and Death: A Cornerstone in Diabetes Pathogenesis)
  • Article
  • Open Access
3 Citations
2,393 Views
14 Pages

Evaluating the Functionality of a Field-Based Test Battery for the Identification of Risk for Anterior Cruciate Ligament Injury: An Exploratory Factor Analysis

  • Charis Tsarbou,
  • Nikolaos I. Liveris,
  • Sofia A. Xergia,
  • George Papageorgiou and ,
  • Vasileios Sideris,
  • Giannis Giakas and
  • Elias Tsepis
  • + 2 authors+ 0 author

28 December 2024

(1) Background: A parsimonious test battery is deemed necessary to efficiently assess the functional performance of athletes avoiding redundant measurements. This study investigates the interrelationships between elements of an experimental field-bas...

(This article belongs to the Special Issue Recent Advances in the Prevention and Rehabilitation of ACL Injuries—2nd Edition)
  • Article
  • Open Access
1,182 Views
20 Pages

Establishing the Reliability of a Functional Performance Test Battery That Incorporates the QASLS Tool in Pre-Elite Female Field Hockey Players

  • Rosalyn Cooke,
  • Lee Herrington,
  • James Martin,
  • Alison Rushton and ,
  • Nicola Heneghan and
  • Andy Soundy
  • + 1 author+ 0 author

12 May 2026

Pre-elite female field hockey players have a high incidence of lower extremity injury, highlighting the need for practical and reliable screening approaches. A dual assessment combining Functional Performance Tests (FPTs) with movement quality scorin...

(This article belongs to the Special Issue Women's Special Issue Series: Sports)
  • Article
  • Open Access
1 Citations
1,586 Views
14 Pages

9 June 2025

This observational pilot study investigated neurocardiovascular responses to an active stand test using continuous physiological monitoring and functional data analysis (FDA) in older women. A sample of 25 community-dwelling female adults aged 59&nda...

(This article belongs to the Special Issue (Bio)sensors for Physiological Monitoring)
  • Article
  • Open Access
11 Citations
5,037 Views
11 Pages

Dose Volume and Liver Function Test Relationship following Radiotheraphy for Right Breast Cancer: A Multicenter Study

  • Zeliha Güzelöz,
  • Oğuzhan Ayrancıoğlu,
  • Nesrin Aktürk,
  • Merve Güneş and
  • Zümre Arıcan Alıcıkuş

26 September 2023

Objective: The liver is a critical organ at risk during right breast radiotherapy (RT). Liver function tests (LFTs) such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyl transferase (GGT) serve as biochemical ma...

(This article belongs to the Special Issue Breast Cancer: A Multi-Disciplinary Approach from Imaging to Therapy)
  • Article
  • Open Access
393 Views
20 Pages

20 August 2026

Background/Objectives: Pulmonary function tests (PFTs), especially spirometry, are important for chronic respiratory disease diagnosis and management, but Baidu-based online search interest in PFT-related information remains insufficiently characteri...

(This article belongs to the Topic Advances in Chronic Disease Management)
  • Article
  • Open Access
2 Citations
3,523 Views
13 Pages

Stair-Climbing Tests or Self-Reported Functional Capacity for Preoperative Pulmonary Risk Assessment in Patients with Known or Suspected COPD—A Prospective Observational Study

  • André Dankert,
  • Benedikt Neumann-Schirmbeck,
  • Thorsten Dohrmann,
  • Lili Plümer and ,
  • Viktor Alexander Wünsch,
  • Phillip Brenya Sasu,
  • Susanne Sehner,
  • Christian Zöllner and
  • Martin Petzoldt
  • + 4 authors+ 0 author

21 June 2023

Background: This prospective study aims to determine whether preoperative stair-climbing tests (SCT) predict postoperative pulmonary complications (PPC) better than self-reported poor functional capacity (SRPFC) in patients with known or suspected CO...

(This article belongs to the Section General Surgery)
  • Article
  • Open Access
3 Citations
3,596 Views
19 Pages

5 June 2023

Detecting and understanding DTF is very important under various DIF conditions. In this study, the performance of DTF, DRF, SIBTEST, and CSIBTEST approaches in detecting DIF effects was investigated using a simulation study and a real dataset. It was...

  • Article
  • Open Access
16 Citations
3,233 Views
13 Pages

25 August 2021

(1) Background: Visually induced vertigo (i.e., vertigo provoked by moving visual scenes) can be considered a noticeable feature of vestibular migraines (VM) and can be present in patients suffering from acute unilateral vestibulopathy (AUV). Hyperse...

(This article belongs to the Section Clinical Neurology)
  • Article
  • Open Access
2 Citations
1,242 Views
14 Pages

Putting DOAC Doubts to Bed(Side): Preliminary Evidence of Comparable Functional Outcomes in Anticoagulated and Non-Anticoagulated Stroke Patients Using Point-of-Care ClotPro® Testing

  • Jessica Seetge,
  • Balázs Cséke,
  • Zsófia Nozomi Karádi,
  • Edit Bosnyák and ,
  • Eszter Johanna Jozifek and
  • László Szapáry
  • + 1 author+ 0 author

4 August 2025

Background/Objectives: Direct oral anticoagulants (DOACs) are now the guideline-recommended alternative to vitamin K antagonists (VKAs) for long-term anticoagulation in patients with non-valvular atrial fibrillation. However, accurately assessing the...

(This article belongs to the Section Clinical Neurology)
  • Systematic Review
  • Open Access
5 Citations
1,207 Views
13 Pages

28 November 2025

Background/Objectives: A significant proportion of patients with angina undergoing invasive coronary angiography have no obstructive coronary artery disease (ANOCA), often due to coronary microvascular dysfunction (CMD). Coronary function testing (CF...

(This article belongs to the Section Cardiology)
  • Article
  • Open Access
1 Citations
1,539 Views
9 Pages

24 February 2026

Background and Objectives: Given that hormone levels vary with age, the application of age-specific reference intervals in older populations is clinically essential. In this study, we aimed to establish age- and sex-specific reference intervals (RIs)...

(This article belongs to the Section Epidemiology & Public Health)
  • Article
  • Open Access
8 Citations
8,960 Views
9 Pages

A Prototype of an Electronic Pegboard Test to Measure Hand-Time Dexterity with Impaired Hand Functionality

  • Bassam Al-Naami,
  • Feras Al-Naimat,
  • Abdul-Majeed Raja M. Almalty,
  • Paolo Visconti and
  • Abdel-Razzak Al-Hinnawi

This paper proposes an electronic prototype of the Grooved Pegboard Test (GPT), which is normally used to test the presence of hand dexterity. The prototype imitates the geometrical dimensions of an on-the-market GPT device, but it is electronic, not...

  • Article
  • Open Access
12 Citations
3,869 Views
14 Pages

Functional Ex Vivo Tissue-Based Chemotherapy Sensitivity Testing for Breast Cancer

  • Marjolijn M. Ladan,
  • Titia G. Meijer,
  • Nicole S. Verkaik,
  • Zofia M. Komar and ,
  • Carolien H. M. van Deurzen,
  • Michael A. den Bakker,
  • Roland Kanaar,
  • Dik C. van Gent and
  • Agnes Jager
  • + 4 authors+ 0 author

28 February 2022

Background chemotherapy is part of most breast cancer (BC) treatment schedules. However, a substantial fraction of BC tumors does not respond to the treatment. Unfortunately, no standard biomarkers exist for response prediction. Therefore, we aim to...

  • Article
  • Open Access
6 Citations
2,870 Views
16 Pages

9 March 2023

With the rapid development of intelligent vehicle safety verification, scenario-based testing methods have received increasing attention. As the space of driving scenarios is vast, the challenge in scenario-based testing is the generation and selecti...

(This article belongs to the Section Transportation and Future Mobility)
  • Review
  • Open Access
7 Citations
5,814 Views
25 Pages

Patient-Derived Ex Vivo Cultures and Endpoint Assays with Surrogate Biomarkers in Functional Testing for Prediction of Therapeutic Response

  • Yoshiyuki Tsukamoto,
  • Yuka Hirashita,
  • Tomotaka Shibata,
  • Shoichi Fumoto and ,
  • Shusaku Kurogi,
  • Chisato Nakada,
  • Keisuke Kinoshita,
  • Takafumi Fuchino,
  • Kazunari Murakami and
  • Naoki Hijiya
  • + 7 authors+ 2 authors

15 August 2023

Prediction of therapeutic outcomes is important for cancer patients in order to reduce side effects and improve the efficacy of anti-cancer drugs. Currently, the most widely accepted method for predicting the efficacy of anti-cancer drugs is gene pan...

(This article belongs to the Special Issue Towards Precision Medicine: From Biomarker Discovery to Novel Therapeutic Target Candidates for Human Cancers)
  • Article
  • Open Access
5 Citations
3,531 Views
34 Pages

13 November 2021

The breakage index equation (BIE), or t10 model from drop weight testing (DWT) data for rocks and ores is used in the design of crushers and mills. Such models are becoming increasingly difficult to visualize as the number of variables increases. The...

(This article belongs to the Section Mineral Processing and Extractive Metallurgy)
  • Feature Paper
  • Article
  • Open Access
9 Citations
8,862 Views
14 Pages

Movement Coordination during Functional Single-Leg Squat Tests in Healthy, Recreational Athletes

  • Korbinian Sebastian Hermann Ksoll,
  • Matthias Cotic,
  • Kathrin Schmalzl,
  • Knut Beitzel and ,
  • Andrea Achtnich,
  • Andreas Imhoff,
  • Ansgar Schwirtz,
  • Florian Kreuzpointner and
  • Wolfgang Seiberl
  • + 4 authors+ 0 author

15 February 2022

The single-leg squat (SLS) represents a functional movement task for determining leg function. Objective movement analysis is required to evaluate inter-limb symmetry and movement coordination. Therefore, this study aimed to investigate inter-limb sy...

(This article belongs to the Section E: Life Sciences)
  • Feature Paper
  • Article
  • Open Access
18 Citations
6,257 Views
8 Pages

The Utility of the Supine-to-Stand Test as a Measure of Functional Motor Competence in Children Aged 5–9 Years

  • Michael J. Duncan,
  • Chelsey Lawson,
  • Leanne Jaye Walker,
  • David Stodden and
  • Emma L. J. Eyre

12 September 2017

This study examined how supine-to-stand (STS) performance is related to process and product assessment of motor competence (MC) in children. Ninety-one children aged 5–9 years were assessed for process and product MC (10 m running speed and standing...

(This article belongs to the Special Issue Motor Competence for Health, Exercise and Sports Performance across the Lifespan)
  • Article
  • Open Access
3 Citations
2,541 Views
11 Pages

The Impact of COVID-19 on Functional Capacity and Pulmonary Outcomes in the Hail Region: A Cross-Sectional Study

  • Omar W. Althomali,
  • Daria Hussain Shaik,
  • Raheela Kanwal,
  • Junaid Amin and ,
  • Tolgahan Acar,
  • Ahmed Abdelmoniem Ibrahim,
  • Hisham M. Hussein,
  • Aisha Ansari,
  • Ayman A. Alhammad and
  • Wael Alghamdi
  • + 7 authors+ 2 authors

20 September 2024

Background/Objectives: COVID-19, caused by the novel coronavirus SARS-CoV-2, has had a significant impact on life worldwide since its emergence in late 2019. The virus has caused a global pandemic, leading to widespread health, social, economic, and...

(This article belongs to the Special Issue Long COVID: Current Approaches and Clinical Challenges in Treatment and Rehabilitation—2nd Edition)
  • Article
  • Open Access
2 Citations
2,627 Views
11 Pages

High-Frequency Vestibular Function Is Vulnerable to Presbyvestibulopathy

  • Seonghoon Bae,
  • Jimin Yun,
  • Seungmin Kwak,
  • Hyuntaek Jung and ,
  • Hancheol Lee,
  • Juyoung Kim,
  • Chanhee Kim,
  • Yujin Lee and
  • Sunghuhn Kim
  • + 4 authors+ 0 author

Introduction: In 2019, mild vestibular function deficiency in elder populations was defined as presbyvestibulopathy (PVP) by the Classification Committee of the Bárány Society. The diagnostic criteria include tests for low-, mid-, and h...

(This article belongs to the Special Issue Advances in Diagnosis and Treatment in Otolaryngology)
  • Article
  • Open Access
542 Views
16 Pages

Baseline Functional Performance Predicts Better Long-Term Self-Reported Physical Function After Auto-HSCT

  • Lindsey J. Anderson,
  • Lily Okamura,
  • Nina Dhunjishah,
  • Roshni Gowrisankar and ,
  • Jennifer Song,
  • Thomas R. Chauncey and
  • Jose M. Garcia
  • + 2 authors+ 0 author

3 June 2026

Background/Objectives: Determination of baseline predictors of longer-term quality of life (QOL) after autologous hematopoietic stem cell transplantation (Auto-HSCT) may identify patients with the greatest supportive care needs. We hypothesized that...

(This article belongs to the Special Issue Hematological Neoplasms: Diagnosis, Treatment, and Management in the Department of Veterans Affairs)
  • Article
  • Open Access
42 Citations
9,034 Views
13 Pages

Complexity of Frontal Cortex fNIRS Can Support Alzheimer Disease Diagnosis in Memory and Visuo-Spatial Tests

  • David Perpetuini,
  • Antonio M. Chiarelli,
  • Daniela Cardone,
  • Chiara Filippini and ,
  • Roberta Bucco,
  • Michele Zito and
  • Arcangelo Merla
  • + 2 authors+ 0 author

1 January 2019

Decline in visuo-spatial skills and memory failures are considered symptoms of Alzheimer’s Disease (AD) and they can be assessed at early stages employing clinical tests. However, performance in a single test is generally not indicative of AD....

(This article belongs to the Special Issue Multiscale Entropy Approaches and Their Applications)
  • Article
  • Open Access
4 Citations
4,207 Views
11 Pages

Method and Test Bench for Hydro-Mechanical Continuously Variable Transmission Based on Multi-Level Test and Verification

  • Hanzheng Dai,
  • Lirong Wan,
  • Qingliang Zeng,
  • Zhenguo Lu and ,
  • Zhiyuan Sun and
  • Wenting Liu
  • + 1 author+ 0 author

16 December 2021

According to the structural characteristics of Hydro-mechanical continuously variable transmission (HMCVT), a multi-functional test bench was developed, and the basic structure, working principle, and test functions of the test bench were introduced....

(This article belongs to the Special Issue Applied Nonlinear Dynamics, Vibration, and Control in Industrial Systems)
  • Review
  • Open Access
20 Citations
4,414 Views
14 Pages

Locomotive Syndrome and Lumbar Spine Disease: A Systematic Review

  • Takaomi Kobayashi,
  • Tadatsugu Morimoto,
  • Koji Otani and
  • Masaaki Mawatari

27 February 2022

Locomotive syndrome (LS) is defined based on the Loco-Check, 25-question Geriatric Locomotive Function Scale (GLFS-25), 5-question Geriatric Locomotive Function Scale (GLFS-5), Stand-Up Test, Two-Step Test, or a total assessment (i.e., positive for o...

(This article belongs to the Section Clinical Neurology)

of 1,037