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314 Results Found

  • Article
  • Open Access
1 Citations
5,036 Views
14 Pages

10 November 2024

Objectives: This study aimed to investigate factors that influence the 12-month outcomes after the treatment of multiple gingival recessions (GRs) with a modified coronally advanced tunnel (MCAT) and a subepithelial connective tissue graft (SCTG), wi...

  • Article
  • Open Access
8 Citations
4,563 Views
13 Pages

4 January 2022

To improve treatment efficacy of gingival recessions (GR), chemical preparation of the exposed root surface was advocated. The aim of this study was to compare the additional influence of root biomodifications with 24% ethylenediaminetetraacetic acid...

  • Article
  • Open Access
4 Citations
6,569 Views
13 Pages

Clinical Outcomes of the Double Lateral Sliding Bridge Flap Technique with Simultaneous Connective Tissue Graft in Sextant V Recessions: Three-Year Follow-Up Study

  • Norberto Quispe-López,
  • Antonio Castaño-Séiquer,
  • Beatriz Pardal-Peláez,
  • Pablo Garrido-Martínez,
  • Cristina Gómez-Polo,
  • Jesús Mena-Álvarez and
  • Javier Montero-Martín

20 January 2022

The presence of isolated or multiple gingival recessions in the mandibular anterior region is a challenge for the clinician, as they may be associated with a shallow vestibule, high frenum insertion and/or little or no attached gingiva. Only limited...

  • Systematic Review
  • Open Access
709 Views
19 Pages

Comparative Effectiveness of Autogenous Connective Tissue Grafts and Xenogeneic Soft Tissue Substitutes for Multiple Gingival Recessions: A Systematic Review and Meta-Analysis

  • Pradeep Koppolu,
  • Sally Abd-ElMeniem ElHaddad,
  • Azza A. Abushama,
  • Omar Soliman,
  • Abdelrahman Afsa,
  • Abrar Hamed Almutairi,
  • Mariem S. A. Youssef,
  • Ferdous Bukhary,
  • Maei Hesham Saleh Almoallim and
  • Salah A. Yousief
  • + 1 author

12 February 2026

Background and Objectives: Gingival recession (GR) is a recognized periodontal condition that can expose the tooth root, imposing aesthetic, functional, and hypersensitivity concerns. We conducted this study to investigate xenogenic soft tissue subst...

  • Article
  • Open Access
6 Citations
3,988 Views
12 Pages

Limited long-term data are available when analyzing gingival recession coverage between the maxillary and mandibular sites. Therefore, the aim of this study was to evaluate the influence of location (maxilla versus mandible) of multiple gingival rece...

  • Article
  • Open Access
1 Citations
5,483 Views
16 Pages

There is continuing interest in using biologics in root coverage procedures. The aim of the present study was to explore the 2-year outcomes following multiple gingival recessions (GRs) coverage using the application of cross-linked hyaluronic acid (...

  • Article
  • Open Access
4 Citations
7,125 Views
17 Pages

25 January 2021

Achieving the coverage of multiple adjacent gingival recessions (MAGRs) in a single surgical procedure poses a major clinical challenge. The gold standard procedure involves the collection of autogenous connective tissue from the palatal mucosa. In c...

  • Systematic Review
  • Open Access
1 Citations
2,538 Views
16 Pages

4 September 2025

Background and Objectives: This systematic review and meta-analysis aimed to evaluate the efficacy of xenogeneic collagen matrix (XCM) in combination with a coronally advanced flap (CAF) in the management of multiple gingival recessions and to c...

  • Review
  • Open Access
49 Citations
6,216 Views
20 Pages

Platelet-Rich Fibrin in Single and Multiple Coronally Advanced Flap for Type 1 Recession: An Updated Systematic Review and Meta-Analysis

  • Leonardo Mancini,
  • Francesco Tarallo,
  • Vincenzo Quinzi,
  • Adriano Fratini,
  • Stefano Mummolo and
  • Enrico Marchetti

5 February 2021

Background and Objectives: The aim of the present systematic review and meta-analysis was to investigate the efficacy of leukocyte–platelet-rich fibrin (L-PRF) in addition to coronally advanced flap (CAF) for the treatment of both single and multiple...

  • Article
  • Open Access
2 Citations
7,055 Views
17 Pages

Laterally Positioned Flap Procedure with Augmented or Nonaugmented Palatal Connective Tissue Grafts in the Treatment of Multiple Adjacent Gingival Recessions: A Two-Year Follow-Up Study

  • Wojciech Bednarz,
  • Jennifer Majer,
  • Justyna Pakuszyńska-Błaszczyk,
  • Marzena Dominiak,
  • Tomasz Gedrange and
  • Agata Zielińska-Pałasz

The most commonly used technique for covering gingival recessions is the coronally advanced flap (CAF) technique due to its high success rate. In clinical situations where there is less keratinized tissue apical to the defect due to unfavorable anato...

  • Case Report
  • Open Access
1 Citations
3,929 Views
10 Pages

A Novel Homozygous Variant in the COMP Gene Causing a Multiple Epiphyseal Dysplasia 1 with Autosomal Recessive Inheritance

  • Tatiana Markova,
  • Aysylu Murtazina,
  • Vladimir Kenis,
  • Evgenii Melchenko,
  • Maria Ampleeva,
  • Tatiana Nagornova,
  • Aynur Alieva,
  • Elena Dadali and
  • Sergey Kutsev

Multiple epiphyseal dysplasia type 1 is one of the most common autosomal dominant types of the genetically heterogeneous group of skeletal dysplasias characterized by impaired ossification of the epiphyses of long bones. To date, it is known that the...

  • Article
  • Open Access
4 Citations
6,997 Views
20 Pages

Treatment of Multiple RT1 Gingival Recessions Using a Coronally Advanced Flap Associated with L-PRF or Subgingival Connective Tissue Graft from Maxillary Tuberosity: A Randomized, Controlled Clinical Trial

  • Giuseppe Balice,
  • Michele Paolantonio,
  • Matteo Serroni,
  • Paolo De Ninis,
  • Imena Rexhepi,
  • Alessio Frisone,
  • Stefania Di Gregorio,
  • Luigi Romano,
  • Bruna Sinjari and
  • Beatrice Femminella
  • + 1 author

28 March 2024

The goal of plastic periodontal surgery is to obtain complete root coverage, increasing gingival thickness (GT), a positive prognostic factor for gingival margin stability over time. The aim of this study was to compare the effectiveness of the Coron...

  • Article
  • Open Access
3 Citations
2,893 Views
14 Pages

6 February 2021

Understanding the recharge and runoff processes of the vadose zone is significant for water resource management and utilization in karst mountain areas. Hydrological modeling of the vadose zone in karst caves has provided new methods of evaluating wa...

  • Article
  • Open Access
1 Citations
2,789 Views
26 Pages

Background/Objectives: This study introduces the Multi Group Cost Malmquist Index (CMgm), a novel tool for comparing and ranking the cost efficiency of multiple groups of similar decision-making units operating in different contexts. It was appl...

  • Article
  • Open Access
2 Citations
4,277 Views
11 Pages

The Use of Collagen Matrix in the Treatment of Gingival Recession—A Pilot Study

  • Marlena Pedowska,
  • Marta Prokop,
  • Renata Chałas and
  • Maja Ptasiewicz

15 November 2022

Background. Gingival recessions are common mucogingival deformities and conditions around teeth, which are described as the apical migration of tissues in the relation to the cementoenamel junction. One of the types of graft materials used to treat t...

  • Article
  • Open Access
3 Citations
3,072 Views
15 Pages

We conducted recession analyses on cave drip hydrographs from a 10-year record (2008–2018) of three drip monitoring stations within James Cave (Pulaski County, VA, USA) to examine differences in hydrologic characteristics of the epikarst and qu...

  • Review
  • Open Access
18 Citations
4,191 Views
15 Pages

Additive Effect of Platelet Rich Fibrin with Coronally Advanced Flap Procedure in Root Coverage of Miller’s Class I and II Recession Defects—A PRISMA Compliant Systematic Review and Meta-Analysis

  • Saurav Panda,
  • Anurag Satpathy,
  • Abhaya Chandra Das,
  • Manoj Kumar,
  • Lora Mishra,
  • Swati Gupta,
  • Gunjan Srivastava,
  • Monika Lukomska-Szymanska,
  • Silvio Taschieri and
  • Massimo Del Fabbro

27 September 2020

Aim: This systematic review and meta-analysis aims to assess the additive effect of leukocyte and platelet-rich fibrin (L-PRF) on coronally advanced flap (CAF) procedures in root coverage of Miller’s class I and II gingival recession defects. R...

  • Article
  • Open Access
6 Citations
2,378 Views
10 Pages

Quantification of the Number of Steps in a School Recess by Means of Smart Bands: Proposal of Referential Values for Children and Adolescents

  • Jose Sulla-Torres,
  • Rubén Vidal-Espinoza,
  • Christopher Avendaño Llanque,
  • Alexander Calla Gamboa,
  • Manuel Zúñiga Carnero,
  • Marco Cossio-Bolaños and
  • Rossana Gomez-Campos

(1) Background: Regular physical activity has multiple benefits. Therefore, school recess is a key tool to provide opportunities for schoolchildren to engage in extracurricular physical activity, have fun, play and interact with their peers. The aim...

  • Article
  • Open Access
20 Citations
5,041 Views
17 Pages

This pilot study used accelerometers to investigate the effectiveness of a multiple recess school intervention on physical activity patterns in younger elementary children using a post-test only with nonequivalent groups design. First and second grad...

  • Article
  • Open Access
2 Citations
3,455 Views
9 Pages

Examination of the Responsiveness of the Great Recess Framework—Observational Tool

  • William V. Massey,
  • Megan B. Stellino,
  • Laura Hayden and
  • Janelle Thalken

The purpose of this study was to test the responsiveness of the great recess framework-observational tool (GRF-OT) to detect changes in recess quality. GRF-OT data were collected at two time points (fall 2017 and spring 2018) in four geographically d...

  • Article
  • Open Access
2,224 Views
16 Pages

Awareness of Gingival Recession and Its Causes and Consequences Among Adults in Saudi Arabia

  • Marwa Madi,
  • Eman Aljoghaiman,
  • Shahad T. Alameer,
  • Mohammed Albander,
  • Muntathir Alahmed,
  • Mujtaba Almuallim,
  • Ahmed Elakel and
  • Maha Abdelsalam

28 October 2025

Background/Objectives: Gingival recession (GR), characterized by the apical displacement of the gingival margin leading to root exposure, risk of root caries, dentine hypersensitivity (DH), and plaque accumulation. This study aimed to evaluate the aw...

  • Article
  • Open Access
65 Citations
57 Views

Gastrocnemius Soleus Recession. A Simpler, More Limited Approach

  • Bradley M. Lamm,
  • Dror Paley and
  • John E. Herzenberg

Multiple surgical procedures have been described for the correction of equinus deformity. We present a review of the anatomy, biomechanics, and clinical assessment of equinus. In addition, we provide a detailed surgical technique for gastrocnemius so...

  • Case Report
  • Open Access
10 Citations
9,375 Views
7 Pages

20 November 2017

In this case of extensive gingival recession (Miller’s Class II) and mild physiologic pigmentation, an alternative method for the placement of Amaris Gingiva-Colored Composite was used to produce a non-invasive, aesthetic result acceptable to the pat...

  • Article
  • Open Access
6 Citations
3,237 Views
11 Pages

Compound Phenotype Due to Recessive Variants in LARP7 and OTOG Genes Disclosed by an Integrated Approach of SNP-Array and Whole Exome Sequencing

  • Pietro Palumbo,
  • Orazio Palumbo,
  • Maria Pia Leone,
  • Ester di Muro,
  • Stefano Castellana,
  • Luigi Bisceglia,
  • Tommaso Mazza,
  • Massimo Carella and
  • Marco Castori

31 March 2020

Neurodevelopmental disorders are a challenge in medical genetics due to genetic heterogeneity and complex genotype-phenotype correlations. For this reason, the resolution of single cases not belonging to well-defined syndromes often requires an integ...

  • Article
  • Open Access
8 Citations
3,215 Views
20 Pages

28 October 2022

Corner modifications can reduce wind loads acting on supertall buildings and modify the corresponding flow structures. The present study investigated the aerodynamic shape optimization of the corner recession square cylinders with multiple geometric...

  • Article
  • Open Access
2 Citations
3,964 Views
18 Pages

Clinical Efficacy of Er,Cr:YSGG Laser for Deepithelialization of Free Gingival Grafts in Gingival Recession Treatment: A Randomized, Split-Mouth Clinical Trial

  • Artur Banyś,
  • Jakub Fiegler-Rudol,
  • Zuzanna Grzech-Leśniak,
  • Rafał Wiench,
  • Jacek Matys,
  • Jamil A. Shibli and
  • Kinga Grzech-Leśniak

29 July 2025

Bcakground: The deepithelialized free gingival graft (DGG) technique provides high-quality connective tissue grafts (CTGs) with predictable outcomes for recession coverage. This study evaluates a novel method of free gingival graft (FGG) deepithelial...

  • Article
  • Open Access
5 Citations
2,561 Views
11 Pages

Increased Carotid Intima-Media Thickness in Asymptomatic Individuals Is Associated with the PCSK9 (rs2149041) Gene Polymorphism in the Mexican Mestizo Population: Results of the GEA Cohort

  • Rosalinda Posadas-Sánchez,
  • Gilberto Vargas-Alarcón,
  • Óscar Pérez-Méndez,
  • Nonanzit Pérez-Hernández and
  • José Manuel Rodríguez-Pérez

30 September 2022

The increase in carotid intima-media thickness (CIMT) and coronary artery calcification (CAC) are features of subclinical atherosclerosis that might be determined by the genetic background of patients. Among the multiple risk factors, the proprotein...

  • Article
  • Open Access
7 Citations
3,311 Views
30 Pages

Predictive Resilience Modeling Using Statistical Regression Methods

  • Priscila Silva,
  • Mariana Hidalgo,
  • Mindy Hotchkiss,
  • Lasitha Dharmasena,
  • Igor Linkov and
  • Lance Fiondella

31 July 2024

Resilience describes the capacity of systems to react to, withstand, adjust to, and recover from disruptive events. Despite numerous metrics proposed to quantify resilience, few studies predict these metrics or the restoration time to nominal perform...

  • Article
  • Open Access
1 Citations
869 Views
16 Pages

Recessive Effect of GC-NPFFR2 rs137147462 on Somatic Cell Score (Mastitis Susceptibility) in Japanese Holsteins

  • Yoshiyuki Akiyama,
  • Takaaki Ando,
  • Nobuhiro Nozaki,
  • Mohammad Arif,
  • Yutaro Ide,
  • Shaohsu Wang and
  • Naoki Miura

8 November 2025

We evaluated four candidate SNPs (GC-NPFFR2 rs137147462, GC-NPFFR2 rs109452259, BRCA1 rs134817801, and DGAT1 p.K232A) previously reported in relation to mastitis or milk production traits, using 10,729 test-day phenotypic records collected over 10 ye...

  • Article
  • Open Access
4 Citations
2,947 Views
8 Pages

A Missense Mutation (c.1037 G > C, p. R346P) in PAPSS2 Gene Results in Autosomal Recessive form of Brachyolmia Type 1 (Hobaek Form) in A Consanguineous Family

  • Saima Mustafa,
  • Malik Fiaz Hussain,
  • Muhammad Latif,
  • Maryam Ijaz,
  • Muhammad Asif,
  • Mubashir Hassan,
  • Muhammad Faisal and
  • Furhan Iqbal

11 November 2022

Background: Brachyolmia is a skeletal disorder with an autosomal mode of inheritance (both dominant and recessive) in which the patients have a short height, scoliosis and a reduced trunk size. Methods: From the Muzaffargarh District in Pakistan, a c...

  • Article
  • Open Access
25 Citations
4,986 Views
19 Pages

Long-Term Electricity Load Forecasting Considering Volatility Using Multiplicative Error Model

  • Swasti R. Khuntia,
  • Jose L. Rueda and
  • Mart A.M.M. Van der Meijden

27 November 2018

Long-term electricity load forecasting plays a vital role for utilities and planners in terms of grid development and expansion planning. An overestimate of long-term electricity load will result in substantial wasted investment on the construction o...

  • Case Report
  • Open Access
851 Views
14 Pages

Fatal Infantile Cardiomyopathy Associated with a Homozygous MYL2 c.413T>A (p.Met138Lys) Variant: A Case Expanding the Recessive MYL2 Phenotypic Spectrum

  • Mohammed Shahab Uddin,
  • Yasmeen Alnamshan,
  • Khaled Shafeen,
  • Syeda Nilofer Jahan,
  • Nora AlMadhi,
  • Karthiga Gurumurthy,
  • Abdullah Bin Hassan,
  • Amr Esmail and
  • Maryam AlQannas

12 April 2026

Background/Objectives: Infantile cardiomyopathy is a rare but often life-threatening condition in which monogenic causes are particularly relevant, especially when cardiac disease is preceded by hypotonia or multisystem involvement. Among sarcomeric...

  • Feature Paper
  • Article
  • Open Access
4 Citations
1,754 Views
25 Pages

24 March 2025

Against the backdrop of global economic changes and rapid technological innovation, the sharing economy model is gradually transforming the operational mechanisms of traditional industries. However, some industries have experienced stagnation and rec...

  • Article
  • Open Access
22 Citations
5,905 Views
20 Pages

From Rural Spaces to Peri-Urban Districts: Metropolitan Growth, Sparse Settlements and Demographic Dynamics in a Mediterranean Region

  • Rosanna Salvia,
  • Rares Halbac-Cotoara-Zamfir,
  • Sirio Cividino,
  • Luca Salvati and
  • Giovanni Quaranta

17 June 2020

Considering settlement characteristics and population dynamics together over multiple spatio-temporal scales, the present study analyzes the spatial distribution of sparse settlements and population surrounding a large city in Southern Europe (Athens...

  • Article
  • Open Access
9 Citations
4,845 Views
11 Pages

Genetics of Height and Branching in Faba Bean (Vicia faba)

  • Jessa Hughes,
  • Hamid Khazaei and
  • Albert Vandenberg

13 August 2020

A better understanding of the genetics of plant architecture, including height and branching, could improve faba bean breeding for varieties with better fit into specific cropping systems. This study aimed to determine the inheritance and genetic int...

  • Article
  • Open Access
19 Citations
3,406 Views
18 Pages

Recession, Local Fertility, and Urban Sustainability: Results of a Quasi-Experiment in Greece, 1991–2018

  • Rares Halbac-Cotoara-Zamfir,
  • Gianluca Egidi,
  • Rosanna Salvia,
  • Luca Salvati,
  • Adele Sateriano and
  • Antonio Gimenez-Morera

20 January 2021

Fertility is a spatially non-stationary property of regional demographic systems. Despite the wealth of quantitative (micro–macro) information delineating short-term population dynamics in advanced economies, the contribution of economic downtu...

  • Article
  • Open Access
1,417 Views
17 Pages

Pyramiding Recessive Resistance Genes Enhances Bacterial Leaf Spot Resistance in Peppers by Suppressing In Planta Bacterial Growth

  • Mousami Poudel,
  • Sophia McDuffee,
  • Gerald V. Minsavage,
  • Samuel F. Hutton,
  • Anuj Sharma and
  • Jeffrey B. Jones

17 August 2025

Bacterial spot of the pepper (BSP) and the tomato (BST) caused by multiple Xanthomonas spp. remains a major constraint to production of both crops worldwide. The widespread breakdown of dominant resistance genes, such as Bs2, due to the emergence of...

  • Review
  • Open Access
2 Citations
4,170 Views
13 Pages

The Use of Multimodality Imaging for the Diagnosis of Myocardial Outpouchings and Invaginations: A Systematic Review

  • Rita Pavasini,
  • Nicola Bianchi,
  • Federica Frascaro,
  • Federico Marchini,
  • Sofia Meossi,
  • Luca Zanarelli,
  • Federico Sanguettoli,
  • Alberto Cossu,
  • Elisabetta Tonet and
  • Gianluca Campo
  • + 1 author

26 February 2023

Cardiac ventricular outpouchings and invaginations are rare structural abnormalities and usually incidental findings during cardiac imaging. A definitive diagnosis is possible through the use of multimodality imaging. A systematic review of the liter...

  • Article
  • Open Access
8 Citations
4,732 Views
19 Pages

The Great Recession and Children’s Mental Health in Australia

  • Melisa Bubonya,
  • Deborah A. Cobb-Clark,
  • Daniel Christensen,
  • Sarah E. Johnson and
  • Stephen R. Zubrick

This paper analyzes the effects of “shocks” to community-level unemployment expectations, induced by the onset of the Great Recession, on children’s mental well-being. The Australian experience of the Great Recession represents a un...

  • Article
  • Open Access
10 Citations
6,026 Views
10 Pages

Children with Physical Disabilities at School and Home: Physical Activity and Contextual Characteristics

  • Ru Li,
  • Cindy Hui-Ping Sit,
  • Jane Jie Yu,
  • Raymond Kim-Wai Sum,
  • Stephen Heung-Sang Wong,
  • Kenneth Chik-Chi Cheng and
  • Thomas L. McKenzie

The purpose of this study was to assess the physical activity (PA) of children with physical disabilities (PD) in school and home settings and to simultaneously examine selected contextual characteristics in relation to PA in those settings. Children...

  • Article
  • Open Access
11 Citations
4,786 Views
18 Pages

A Possible Link of Genetic Variations in ER/IGF1R Pathway and Risk of Melanoma

  • Tze-An Yuan,
  • Vandy Yourk,
  • Ali Farhat,
  • Katherine L. Guo,
  • Angela Garcia,
  • Frank L. Meyskens and
  • Feng Liu-Smith

The mechanism of gender disparity in cutaneous melanoma incidence remains unclear. Steroid hormones including estrogens have long been implicated in the course of melanoma, but the conclusion is controversial. Estrogen receptors (ERs) and insulin-lik...

  • Article
  • Open Access
230 Views
14 Pages

17 April 2026

Background/Objectives: Musculoskeletal soft-tissue injuries are common among physically active individuals and arise from complex interactions between environmental and biological factors. Genetic variation in genes involved in extracellular matrix (...

  • Article
  • Open Access
372 Views
20 Pages

Background: The integration of active breaks during the school day has been widely demonstrated to be effective in counteracting sedentary behaviors. The present study assessed the efficacy of a structured active breaks (ABs) intervention implemented...

  • Article
  • Open Access
17 Citations
6,461 Views
11 Pages

Association of the rs1346044 Polymorphism of the Werner Syndrome Gene RECQL2 with Increased Risk and Premature Onset of Breast Cancer

  • Karin Zins,
  • Barbara Frech,
  • Eva Taubenschuss,
  • Christian Schneeberger,
  • Dietmar Abraham and
  • Martin Schreiber

10 December 2015

Like other RECQ helicases, WRN/RECQL2 plays a crucial role in DNA replication and the maintenance of genome stability. Inactivating mutations in RECQL2 lead to Werner syndrome, a rare autosomal disease associated with premature aging and an increased...

  • Article
  • Open Access
8 Citations
5,978 Views
10 Pages

Genetic Variant in GRM1 Underlies Congenital Cerebellar Ataxia with No Obvious Intellectual Disability

  • Maria S. Protasova,
  • Tatiana V. Andreeva,
  • Sergey A. Klyushnikov,
  • Sergey N. Illarioshkin and
  • Evgeny I. Rogaev

12 January 2023

Metabotropic glutamate receptor 1 (mGluR1) plays a crucial role in slow excitatory postsynaptic conductance, synapse formation, synaptic plasticity, and motor control. The GRM1 gene is expressed mainly in the brain, with the highest expression in the...

  • Communication
  • Open Access
1 Citations
4,147 Views
12 Pages

Clinical Evaluation of Bilateral Multiple Gingival Recession Treatment with Autogenous Connective Tissue Graft Associated with Low-Level Laser Therapy

  • Ricardo Roberto de Souza Fonseca,
  • Camila Pantoja Silva,
  • Beatriz Leal de Senna Sastre,
  • Erich Brito Tanaka,
  • Tábata Resque Beckmann Carvalho,
  • Paula Gabriela Faciola Pessôa de Oliveira,
  • Silvio Augusto Fernandes de Menezes,
  • Rogério Valois Laurentino,
  • Renata Pimentel de Oliveira and
  • Luiz Fernando Almeida Machado
  • + 2 authors

17 March 2023

Background: Gingival recession (GR) is described as an apical displacement of the gingival margin in relation to the cementoenamel junction, exposing the root surface to the oral cavity environment. This study aimed to evaluate the clinical results o...

  • Communication
  • Open Access
1,576 Views
13 Pages

Transfer of Downy Mildew Resistance Genes from Wild Cucumbers to Beit Alpha Types

  • Rivka S. Hammer,
  • Yariv Ben Naim,
  • Arnon Brand and
  • Yigal Cohen

16 August 2025

Downy mildew, caused by the oomycete Pseudoperonospora cubensis, is the most destructive foliar disease of cucumbers. While partially resistant slicer cultivars (with spined fruits) are commercially available, no resistant Beit Alpha cultivars (chara...

  • Feature Paper
  • Review
  • Open Access
44 Citations
10,582 Views
15 Pages

19 July 2023

Limb–girdle muscular dystrophies (LGMDs) are caused by mutations in multiple genes. This review article presents 39 genes associated with LGMDs. Some forms are inherited in a dominant fashion, while for others this occurs recessively. The class...

  • Article
  • Open Access
21 Citations
4,806 Views
15 Pages

Identification of Novel CDH23 Variants Causing Moderate to Profound Progressive Nonsyndromic Hearing Loss

  • Khushnooda Ramzan,
  • Nouf S. Al-Numair,
  • Sarah Al-Ageel,
  • Lina Elbaik,
  • Nadia Sakati,
  • Selwa A. F. Al-Hazzaa,
  • Mohammed Al-Owain and
  • Faiqa Imtiaz

9 December 2020

Mutant alleles of CDH23, a gene that encodes a putative calcium-dependent cell-adhesion glycoprotein with multiple cadherin-like domains, are responsible for both recessive DFNB12 nonsyndromic hearing loss (NSHL) and Usher syndrome 1D (USH1D). The en...

  • Article
  • Open Access
25 Citations
12,825 Views
15 Pages

L-Ferritin: One Gene, Five Diseases; from Hereditary Hyperferritinemia to Hypoferritinemia—Report of New Cases

  • Beatriz Cadenas,
  • Josep Fita-Torró,
  • Mar Bermúdez-Cortés,
  • Inés Hernandez-Rodriguez,
  • José Luis Fuster,
  • María Esther Llinares,
  • Ana María Galera,
  • Julia Lee Romero,
  • Santiago Pérez-Montero and
  • Mayka Sanchez
  • + 1 author

23 January 2019

Ferritin is a multimeric protein composed of light (L-ferritin) and heavy (H-ferritin) subunits that binds and stores iron inside the cell. A variety of mutations have been reported in the L-ferritin subunit gene (FTL gene) that cause the following f...

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