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Review

Platelet-Rich Fibrin in Single and Multiple Coronally Advanced Flap for Type 1 Recession: An Updated Systematic Review and Meta-Analysis

Department of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, Italy
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Author to whom correspondence should be addressed.
Academic Editor: Gaia Pellegrini
Medicina 2021, 57(2), 144; https://doi.org/10.3390/medicina57020144
Received: 20 January 2021 / Revised: 25 January 2021 / Accepted: 2 February 2021 / Published: 5 February 2021
(This article belongs to the Special Issue Personalized Periodontics: From Basic Research to Clinical Activity)
Background and Objectives: The aim of the present systematic review and meta-analysis was to investigate the efficacy of leukocyte–platelet-rich fibrin (L-PRF) in addition to coronally advanced flap (CAF) for the treatment of both single and multiple gingival recessions (GRs) compared to the CAF alone and to the adjunct of connective tissue graft (CTG). Root coverage outcomes using platelet concentrates have gained increased interest. In particular, it has been suggested that adding L-PRF to CAF may provide further benefits in the treatment of GRs. Materials and Methods: An electronic and manual literature search was conducted to identify randomized controlled trials (RTCs) investigating root coverage outcomes with CAF + L-PRF. The outcomes of interest included mean root coverage (mRC), recession reduction, keratinized tissue width (KTW) gain, gingival thickness (GT) gain, and patient-reported outcome measures (PROms) such as pain perception and discomfort. Results: A total of 275 patients and 611 surgical sites were analyzed. L-PRF in adjunct to single CAF seems to show statistically significant results regarding clinical attachment level (CAL) with a weighted means (WM) 0.43 95% CI (−0.04, 0.91), p < 0.0001, GT (WM 0.17 95% CI (−0.02, 0.36), p < 0.0001, and mRC (WM 13.95 95% CI (−1.99, 29.88) p < 0.0001, compared to single CAF alone. Interesting results were obtained from the adjunct of PRF to multiple CAF with respect to multiple CAF alone with an increase in the mRC WM 0.07 95% CI (−30.22, 30.35), p = 0.0001, and PPD change WM 0.26 95% CI (−0.06, 0.58), p < 00001. On the other hand, no statistically significant data were obtained when L-PRF was added to single or multiple CAF combined with CTG according to the included outcomes such as mRC (p = 0.03 overall). Conclusions: L-PRF is a valid alternative to CAF alone. L-PRF compared to CTG in single and multiple CAF showed statistically significant results regarding pain perception and discomfort PROms (p < 0.0001). However, CTG remains the gold standard for treating gingival recession. View Full-Text
Keywords: root coverage; gingival recession; PRF; platelet-rich fibrin; coronally advanced flap; connective tissue graft root coverage; gingival recession; PRF; platelet-rich fibrin; coronally advanced flap; connective tissue graft
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MDPI and ACS Style

Mancini, L.; Tarallo, F.; Quinzi, V.; Fratini, A.; Mummolo, S.; Marchetti, E. Platelet-Rich Fibrin in Single and Multiple Coronally Advanced Flap for Type 1 Recession: An Updated Systematic Review and Meta-Analysis. Medicina 2021, 57, 144. https://doi.org/10.3390/medicina57020144

AMA Style

Mancini L, Tarallo F, Quinzi V, Fratini A, Mummolo S, Marchetti E. Platelet-Rich Fibrin in Single and Multiple Coronally Advanced Flap for Type 1 Recession: An Updated Systematic Review and Meta-Analysis. Medicina. 2021; 57(2):144. https://doi.org/10.3390/medicina57020144

Chicago/Turabian Style

Mancini, Leonardo, Francesco Tarallo, Vincenzo Quinzi, Adriano Fratini, Stefano Mummolo, and Enrico Marchetti. 2021. "Platelet-Rich Fibrin in Single and Multiple Coronally Advanced Flap for Type 1 Recession: An Updated Systematic Review and Meta-Analysis" Medicina 57, no. 2: 144. https://doi.org/10.3390/medicina57020144

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