Dry powder inhalers (DPIs) are drug–device combination products where the complexity of the formulation, its interaction with the device, and input from users play important roles in the drug delivery. As the landscape of DPI products advances...
Iron deficiency anemia is a common clinical consequence for people who suffer from chronic kidney disease, especially those requiring dialysis. Intravenous (IV) iron therapy is a widely accepted safe and efficacious treatment for iron deficiency anem...
14 August 2020
The factors influencing General Practitioners’ (GPs) prescribing behavior are diverse in terms of health care policies and regulations, GPs’ education and experience, demographic trends and disease profiles. Thus, it can be useful to anal...
Due to its links to computer science (CS), teaching computational thinking (CT) often involves the handling of algorithms in activities, such as their implementation or analysis. Although there already exists a wide variety of different tasks for var...
Thermomass theory was developed to deal with the non-Fourier heat conduction phenomena involving the influence of heat inertia. However, its structure, derived from an analogy to fluid mechanics, requires further mathematical verification. In this pa...
In the era of data-driven technologies, the need for diverse and high-quality datasets for training and testing machine learning models has become increasingly critical. In this article, we present a versatile methodology, the Generic Methodology for...
The objective of this study was to evaluate physicochemical equivalence between brand (i.e., Ferrlecit) and generic sodium ferric gluconate (SFG) in sucrose injection by conducting a series of comparative in vitro characterizations using advanced ana...
26 April 2021
Generic drugs were instituted in 1984 in the United States. Since that time, many studies have been conducted in several countries into consumer attitude and behavior when purchasing generic drugs. Understanding the factors that can influence attitud...
Large language model (LLM) and Crowd Intelligent Innovation (CII) are reshaping the field of engineering design and becoming a new design context. Generative generic-field design can solve more general design problems innovatively by integrating mult...
Artificial intelligence-driven molecular generation has become an increasingly used computational approach for proposing candidate chemical structures in early-stage drug discovery, yet the practical value of the molecules produced is often difficult...
Aim: The majority of medicines used in Poland are generic drugs and substitutions of the originals. The objective of this study was to obtain information on the current knowledge about generic medicines among Polish patients with epilepsy. Material a...
In order to generalise semi-invariant Riemannian maps, Sahin first introduced the idea of “Generic Riemannian maps”. We extend the idea of generic Riemannian maps to the case in which the total manifold is a nearly Kaehler manifold. We st...
Virtual private network (VPN) gateways are widely applied to provide secure end-to-end remote access and to relay reliable interconnected communication in cloud computing. As network convergence nodes, the performance of VPN gateways is limited by tr...
Biphasic soft materials are challenging to model by nature. Ongoing efforts are targeting their effective modeling and simulation. This work uses experimental atomic force nanoindentation of thick hydrogels to identify the indentation forces are a fu...
In our 2014 work with M. Gabour, we introduced a metric space of generalized nonexpansive self-mappings of bounded and closed subsets of a Banach space and studied, using the Baire category approach, the asymptotic behavior of iterates of a generic o...
We show that if a
When an innovative product (innovator) is not covered anymore by intellectual property rights, cheaper equivalent medicinal products (generic products) may be marketed and used in clinical practice. The regulation of generic products is well-establis...
The advent of cooperative systems entails a dynamic composition of their components. As this contrasts current, statically composed systems, new approaches for maintaining their safety are required. In that endeavor, we propose an integration step th...
A main barrier for autonomous and general learning systems is their inability to understand and adapt to new environments—that is, to apply previously learned abstract solutions to new problems. Supervised learning system functions such as clas...
This paper extends the theory of Riemannian maps to the setting of generic submanifolds of Kähler manifolds. We introduce the notion of holomorphic Riemannian maps from generic submanifolds and establish fundamental relations between the geometr...
State-dependent resistors, capacitors, and inductors are a common part of many smart engineering solutions, e.g., in MEMS (Micro-Electro-Mechanical Systems) sensors and actuators, Micro/NanoMachines, or biomimetic systems. These memory elements are t...
Background: Economic evaluations are an integral component of many clinical trials. Costs used in those analyses are based on the prices of branded drugs when they first enter the market. The effect of genericization on the cost-effectiveness (CE) or...
This paper assesses the influence of a number of factors taken into account when a brand name drug is replaced by a generic one. It also evaluates responses of health professionals – physicians and pharmacist—and patients regarding the issue of switc...
Generic medicine pricing is an area of national responsibility of European Union countries. This article aims to present the current status and impact of generic medicine pricing policies in ambulatory care in Europe. The study conducts a literature...
A novel approach to generic (or generalized) robot programming and a novel simplified, block-based programming environment, called “Assembly”, are introduced. The approach leverages the newest graphical user interface automation tools and...
In this paper, a generic fractional derivative is defined as a set of the linear operators left-inverse to the Riemann–Liouville fractional integral. Then, the theory of the left-invertible operators developed by Przeworska-Rolewicz is applied...
A conformally flat hypersurface
23 October 2020
Background: Generic health literacy measurement (GHLM) is an important tool to identify individuals with limited health literacy and can assist the design of tailored interventions for improving public health literacy. However, there is no consensus...
In this paper, we prove that for a generically
Background and Objective. In external preparations, types and ratios of additives are not necessarily the same for brand-name drugs and generic drugs. Thus, the physicochemical properties of preparations may differ despite the fact that they contain...
Toxicokinetic modelling provides a powerful tool in relating internal human exposure (i.e., assessed through urinary biomarker levels) to external exposure. Chemical specific toxicokinetic models are available; however, this specificity prevents thei...
Internet of Things (IoT) platforms are the key for the development of scalable IoT applications and services that connect real and virtual worlds between objects, systems, and people. However, as the IoT platform market represents a truly new market...
Generic polymer models capturing the chain connectivity and the non-bonded excluded-volume interactions between polymer segments can be classified into hard- and soft-core models depending on their non-bonded pair potential. Here we compared the corr...
Low generic drug prices in the US and Europe have benefited from offshoring production to low-cost overseas plants in countries with a strong manufacturing base, such as China and India. However, the ongoing quality control and reliability issues wit...
In a previous work we devised a framework to derive generalised gradient systems for an evolution equation from the large deviations of an underlying microscopic system, in the spirit of the Onsager–Machlup relations. Of particular interest is...
The search for generation approaches to robust chaos has received considerable attention due to potential applications in cryptography or secure communications. This paper is of interest regarding a 1-D sigmoidal chaotic map, which has never been dis...
In this paper, we obtain an existence theorem of general strong noncooperative equilibrium point of vector-valued games, in which every player maximizes all goals. We also obtain an existence theorem of strong equilibrium point of vector-valued games...
Background: Candesartan cilexetil, a Biopharmaceutics Classification System (BCS) II prodrug, demonstrates compromised bioavailability attributable to its limited aqueous solubility coupled with P-glycoprotein (P-gp)-mediated efflux and hepatic first...
Sophisticated mechanisms for attacking computer networks are emerging, making it crucial to have equally advanced mechanisms in place to defend against these malicious attacks. Autonomous cyber operations (ACOs) are considered a potential solution to...
Background: Phosphodiesterase type 5 inhibitors (PDE5i), particularly tadalafil and sildenafil, are the first-line therapies for erectile dysfunction (ED). After the patent expiration of branded tadalafil in 2017, generic formulations became availabl...
Chemometric models for on-line process monitoring have become well established in pharmaceutical bioprocesses. The main drawback is the required calibration effort and the inflexibility regarding system or process changes. So, a recalibration is nece...
Symmetric cryptography methods have an important role in security solutions design in data protection. In that context, symmetric cryptography algorithms and pseudo-random generators connected with them have strong influence on designed security solu...
This paper introduces a high-conversion ratio multiphase nonisolated converter built from generic LC cells. The unique architecture that hinges on a generic capacitor inductor switching module enables the high modularity of the topology, providing a...
One of the potential essential factors that restricts generic industry from applying the Biopharmaceutics Classification System (BCS) Class III biowaiver is adherence to the stringent formulation criteria for formulation qualitative (Q1) sameness and...
Teriparatide is an anabolic peptide drug indicated for the treatment of osteoporosis. Recombinant teriparatide was first approved in 2002 and has since been followed by patent-free alternatives under biosimilar or hybrid regulatory application. The a...
Introduction: Oncological diseases are one of the leading causes of mortality worldwide, with the high cost of therapies representing a critical barrier for health systems. Generic drugs have emerged as an alternative to reduce costs and improve acce...
Optimising an existing production plant is a challenging task for companies. Necessary physical test runs disturb running production processes. Simulation models are one opportunity to limit these physical test runs. This is particularly important si...
21 July 2021
The purpose of this study is to investigate physicians’ knowledge, attitudes and practice of generic medicine substitutions in China. We conducted a cross-sectional online questionnaire survey on physicians from secondary or tertiary hospitals in Chi...
Regulatory authorities authorize the clinical use of generic drugs (GD) based on bioequivalence studies, which consist of the evaluation of pharmacokinetics after a single dose in vitro or in healthy individuals. There are few data on clinical equiva...
Recently, person-following robots have been increasingly used in many real-world applications, and they require robust and accurate person identification for tracking. Recent works proposed to use re-identification metrics for identification of the t...
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