8 December 2023
In pharmaceutical research and development, pursuing novel therapeutics and optimizing existing drugs have been revolutionized by the fusion of cutting-edge technologies and computational methodologies. Over the past few decades, the field of drug de...
This article presents evidence of the convenience of implementing the geometric places of the plane into commercial computer-aided design (CAD) software as auxiliary tools in the computer-aided sketching process. Additionally, the research considers...
Traditional dental implant surgery has been challenged by the phenomenal progression in computer-assisted surgery (CAS) that we have been witnessing in recent years. Among the computer-aided technologies, computer-aided design and computer-aided manu...
Computer-Aided Biomimetics (CAB) tools aim to support the integration of relevant biological knowledge into biomimetic problem-solving processes. Specific steps of biomimetic processes that require support include the identification, selection and ab...
Computer-aided design (CAD) systems have advanced to become a critical tool in product design. Nevertheless, they still primarily rely on the traditional mouse and keyboard interface. This limits the naturalness and intuitiveness of the 3D modeling p...
The CAD/CAM technology has been increasingly popular in manufacturing spinal braces for patients with adolescent idiopathic scoliosis (AIS) in clinics. However, whether the CAD/CAM-manufactured braces or the CAD/CAM-manufactured braces integrating wi...
The Rat Sarcoma (RAS) family (NRAS, HRAS, and KRAS) is endowed with GTPase activity to regulate various signaling pathways in ubiquitous animal cells. As proto-oncogenes, RAS mutations can maintain activation, leading to the growth and proliferation...
Collaborative production is growing in its importance to the global economy, and along with it, so are other collaborative activities along the production chain, such as collaborative design. Nowadays, collaborative detail design can be implemented u...
Lipase, a green biocatalyst, finds extensive application in the food sector. Enhancing the thermal stability of lipase presents both challenges and opportunities within the food industry. This research employed multiple rounds of cross-screening usin...
This study investigated the integration of computer-aided design (CAD) and additive manufacturing (AM) in prototype production, particularly in the automotive industry. It explores how these technologies redefine prototyping practices, with a focus o...
In the dynamic landscape of drug discovery, Computer-Aided Drug Design (CADD) emerges as a transformative force, bridging the realms of biology and technology. This paper overviews CADDs historical evolution, categorization into structure-based and l...
Central nervous system (CNS) disorders are a therapeutic area in drug discovery where demand for new treatments greatly exceeds approved treatment options. This is complicated by the high failure rate in late-stage clinical trials, resulting in exorb...
30 January 2012
Complex 3-D defects of the facial skeleton are difficult to reconstruct with freehand carving of autogenous bone grafts. Onlay bone grafts are hard to carve and are associated with imprecise graft-bone interface contact and bony resorption. Autologou...
How can cellular interactions in solid tumors guide molecular interventions against immune suppression? This critical review examines how computer-aided drug design (CADD) connects immunosuppressive tumor microenvironment (TME) states to testable mol...
Since the outbreak of SARS-CoV-2, numerous compounds against COVID-19 have been derived by computer-aided drug design (CADD) studies. They are valuable resources for the development of COVID-19 therapeutics. In this work, we reviewed these studies an...
The demand for new novel flavour and fragrance (F&F) molecules has boosted the need for a systematic approach to designing fragrance molecules. However, the F&F-related industry still relies heavily on experimental approaches or on existing d...
Multiple laser beams and single-mode optical fibers output can be approximated by assuming that the emitted light has a symmetrical Gaussian intensity profile, which corresponds to the transverse electromagnetic mode (TEM00), which is designated as a...
Addressing the insufficient identification of key consumer requirements in refrigerator design and the current limitations in understanding the impacts and underlying mechanisms of product design on sustainability, this study develops an interdiscipl...
Oxidative stress is linked to a series of diseases; therefore, the development of efficient antioxidants might be beneficial in preventing or ameliorating these conditions. Based on the structure of a previously reported compound with good antioxidan...
Aging-associated neurodegenerative diseases, which are characterized by progressive neuronal death and synapses loss in human brain, are rapidly growing affecting millions of people globally. Alzheimer’s is the most common neurodegenerative dis...
The Nuss procedure is one of the most widely used operation techniques for pectus excavatum (PE) patients. It attains the normal shape of the chest wall by lifting the patient’s chest wall with the Nuss bar. However, the Nuss bar is for the mos...
Influenza A is an acute respiratory infectious disease caused by the influenza A virus, which seriously threatens global human health and causes substantial economic losses every year. With the emergence of new viral strains, anti-influenza drugs rem...
The low productivity in long fermentation duration and high-salt working conditions limit the application of L-glutaminase in soy sauce brewing. In this study, a novel L-glutaminase (LreuglsA) with eminent salt tolerance was mined and achieved more t...
Breast cancer is a heterogeneous malignancy with distinct molecular subtypes that complicate the development of effective therapies. Traditional drug discovery methods are often constrained by high cost and long development timelines, underscoring th...
Fifty 2-[(arylidene)amino]-4,5-cycloalkyl[b]thiophene-3-carbonitrile derivatives were screened for their in vitro antifungal activities against Candida krusei and Cryptococcus neoformans. Based on experimentally determined minimum inhibitory concentr...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a positive-sense RNA virus with an unusually large genome of approximately 30 kb. It is highly transmissible and exhibits broad tissue tropism. The third most pathogenic of all known cor...
Recent studies have shown that the use of membranes based on artificial nanoporous materials can be effective for desalination and decontamination of water, separation of ions and gases as well as for solutions to other related problems. Before the e...
Background/Objectives: Mandibular gingival squamous cell carcinoma (SCC) is the second most common oral cancer after tongue cancer. As these carcinomas often invade the mandible early, accurately defining the resection extent is important. This repor...
Lysine-specific demethylase 1 (LSD1/KDM1A) has emerged as a promising therapeutic target for treating various cancers (such as breast cancer, liver cancer, etc.) and other diseases (blood diseases, cardiovascular diseases, etc.), owing to its observe...
This review presents an survey to the biological importance of sesquiterpene lactones (SLs) in the fight against four infectious neglected tropical diseases (NTDs)—leishmaniasis, schistosomiasis, Chagas disease, and sleeping sickness—as alternatives...
Fluid effects are important in films and advertisements, where their realism and aesthetic quality directly impact the visual experience. With the rapid advancement of digital technology and computer-aided design (CAD), modern visual effects are used...
The use of Topology Optimization techniques has seen a great development since the last decade. The principal contributor to this trend is the widespread use of Additive Manufacturing technologies to effectively build complex and performant structure...
Computer-aided drug discovery/design (CADD) techniques allow the identification of natural products that are capable of modulating protein functions in pathogenesis-related pathways, constituting one of the most promising lines followed in drug disco...
Biofouling is the undesirable growth of micro- and macro-organisms on artificial water-immersed surfaces, which results in high costs for the prevention and maintenance of this process (billion €/year) for aquaculture, shipping and other industr...
Making smart and informed decisions often requires the integration and analysis of large amounts of data. However, integrating these data is rarely straightforward, mainly because of heterogeneities in data structure and format. In this study, we foc...
Computer-aided drug design (CADD) techniques allow the identification of compounds capable of modulating protein functions in pathogenesis-related pathways, which is a promising line on drug discovery. Marine natural products (MNPs) are considered a...
Genioplasty is performed for the orthognathic surgical correction of dentofacial deformities. This article reports a safe and accurate method for genioplasty combining a novel three-dimensional (3D) device with mixed reality (MR)-assisted surgery usi...
The development of supersonic aircraft presents significant challenges in ensuring safety during early design stages, particularly for fuel tank systems exposed to extreme thermal and structural loads. Conventional document-based zonal safety analysi...
The growing importance of the membrane-based air separation processes results in an increasing demand for suitable polymeric membrane structures. This has spurred the interest in designing polymer structures for O2/N2 separation by employing a system...
Three-dimensional (3D) computer-aided design (CAD) is a vital tool for visualizing design ideas. While conventional parametric CAD modeling is commonly used, emerging virtual reality (VR) applications in 3D CAD modeling require further exploration. T...
This study offers a comprehensive overview of the scientific landscape surrounding computer-aided drug design (CADD) for triplex-forming oligonucleotides (TFOs) within antisense and antigene therapeutic strategies. A dual-method approach was used, co...
The band structure characteristics of a copper indium gallium sulfur selenide (Cu(In1–xGax)SeS, CIGS) solar cell incorporating a cadmium-free zinc sulfide (ZnS) buffer layer were investigated using technology computer-aided design simulations....
In this work, we developed a software tool for the simplified, automated definition and viewing of loci in the plane, an essential task in the design, engineering and architectural fields. The process was started by identifying the most salient geome...
Background: This paper presents a novel approach for a hand prosthesis consisting of a flexible, anthropomorphic, 3D-printed replacement hand combined with a commercially available motorized orthosis that allows gripping. Methods: A 3D light scanner...
Knight Götz von Berlichingen (1480–1562) lost his right hand distal to the wrist due to a cannon ball splinter injury in 1504 in the Landshut War of Succession at the age of 24. Early on, Götz commissioned a gunsmith to build the first “Iron Hand,” i...
Background/Objectives: The subject of this work is the reconstruction of the inner mechanics of Götz von Berlichingen’s second iron hand. The complex inner mechanics were unknown until Christian von Mechel published a detailed description...
Distinct PAEs are implicated in breast cancer progression through multiple molecular pathways. This study aims to elucidate the potential mechanisms in common by which PAEs promote breast cancer progression. Dibutyl phthalate (DBP), benzyl butyl phth...
This article presents both the three-dimensional modelling of the isochronous pendulum clock and the simulation of its movement, as designed by the Dutch physicist, mathematician, and astronomer Christiaan Huygens, and published in 1673. This inventi...
Background: Mechanical reliability and size-dependent strength behavior remain critical concerns for CAD/CAM restorative materials. This study evaluated resin-based CAD/CAM materials, including resin composite blocks (RCBs) and nanoceramics. The infl...
The problem of the parametric design of ship hull structures is considered here. The parametric design of ship hull structures is intended to determine the dimensions of structural elements that meet the requirements of regulatory documents (Rules of...
of 63