14,182 Results Found

Circulating tumor cells (CTCs) have been implicated in tumor progression and prognosis. Techniques detecting CTCs in the peripheral blood of patients with non-small cell lung carcinoma (NSCLC) may help to identify individuals likely to benefit from e...

High content imaging (HCI) is a multiplexed cell staining assay developed for better understanding of complex biological functions and mechanisms of drug action, and it has become an important tool for toxicity and efficacy screening of drug candidat...

The toxic effects of individual and binary mixtures of five metal oxide nanoparticles (NPs) were evaluated based on changes in two endpoints of algal growth: the cell count and chlorophyll content. Various effects were observed according to the conce...

Viruses modulate a number of host biological responses including the cell cycle to favor their replication. In this study, we developed a high-content imaging (HCI) assay to measure DNA content and identify different phases of the cell cycle. We then...

The low molecular weight thiol (-SH) content of a human prostate carcinoma cell line (LNCap), important to the cellular resistance to drugs and irradiation, was investigated using three forms of thiol assay each utilizing different chemistries. The c...

The performance of proton exchange membrane fuel cells (PEMFCs) is directly affected by the nonlinear variations in water content. To study the variation in water content and its effect on PEMFC performance, the water condensation rate (WCR) model is...

Proton exchange membrane (PEM) fuel cells have emerged as a viable alternative energy production source for stationary and transportation applications. Reliable and sustainable fuel cell operation requires effective water management. Membrane water c...

Stone cells are a distinctive characteristic of pears and their formation negatively affects the quality of the fruit. To evaluate the stone cell content (SCC) of Korla fragrant pears, we developed a Vis/NIR spectroscopy system that allowed for the a...

While bulk water and hydration water coexist in cells to support the expression of biological macromolecules, how the dynamics of water molecules, which have long been only a minor role in molecular biology research, relate to changes in cellular sta...

This paper presents the results of an extensive countrywide investigation performed in 325 dairy sheep flocks and 119 goat herds throughout Greece. The objectives of the study were (a) to investigate fat and protein content in the bulk-tank raw milk...

Tumor organoids have been pushed forward as advanced model systems for in vitro oncology drug testing, with the eventual goal to direct personalized cancer treatments. However, drug testing efforts suffer from a large variation in experimental condit...

With the explosive growth of micro-video applications, the transmission burden of fronthaul and backhaul links is increasing, and meanwhile, a lot of energy consumption is also generated. For reducing energy consumption and transmission delay burden,...

The impact of preoperative malnutrition and sarcopenia on survival in oral squamous cell carcinoma (OSCC) patients remains controversial. We investigated the effects of the preoperative nutritional status and abnormalities in body composition on the...

The generation of isogenic induced pluripotent stem cell (iPSC) lines using CRISPR-Cas9 technology is a technically challenging, time-consuming process with variable efficiency. Here we use fluorescence-activated cell sorting (FACS) to sort biallelic...

The depletion degree of reduced glutathione is a critical indicator for assessing the toxicity of alkylating agents. In the present research, we have developed a novel method to evaluate the glutathione (GSH) depletion induced by a series of alkylati...

Mitochondrial dynamics and bioenergetics are central to glucose-stimulated insulin secretion by pancreatic beta cells. Previously, we demonstrated that a disturbance in glucose-invoked fission impairs insulin secretion by compromising glucose catabol...

Membrane water content is of vital importance to the freezing durability of proton exchange membrane fuel cells (PEMFCs). Excessive water freezing could cause irreversible degradation to the cell components and deteriorate the cell performance and li...

Drug-induced liver injury (DILI) remains a major cause of drug development failure, post-marketing warnings and restriction of use. An improved understanding of the mechanisms underlying DILI is required for better drug design and development. Enhanc...

Green roofs have many benefits, but in countries with semiarid climates the amount of water needed for irrigation is a limiting factor for their maintenance. The use of drought-tolerant plants such as Sedum species, reduces the water requirements in...

Malignant pleural mesothelioma (MPM) is a highly aggressive cancer with limited therapy options and dismal prognosis. In recent years, the role of immune cells within the tumor microenvironment (TME) has become a major area of interest. In this revie...

Unmanned aerial vehicles (UAVs), featured by the high-mobility and high-quality propagation environment, have shown great potential in wireless communication applications. In this paper, a novel UAV-aided small-cell content caching network is propose...

Acetic acid is a major inhibitory compound in several industrial bioprocesses, in particular in lignocellulosic yeast biorefineries. Cell envelope remodeling, involving cell wall and plasma membrane composition, structure and function, is among the m...

Cytokinins (CKs), a class of phytohormone, regulate root growth in a dose-dependent manner. A certain threshold content of CK is required for rapid root growth, but supraoptimal CK content inhibits root growth, and the mechanism of this inhibition re...

Virus replication displays a large cell-to-cell heterogeneity; yet, not all sources of this variability are known. Here, we study the effect of defective interfering (DI) particle (DIP) co-infection on cell-to-cell variability in influenza A virus (I...

A photometric flow cell for the in-line determination of the biomass content in a microalgae Nannochloropsis sp. cultivation has been constructed, integrated into the photobioreactor and tested. This process is used for the development of third-gener...

In this work we conducted a quantitative analysis of the nuclear DNA-content of developing sperm cells of the plant Brassica campestris L. The sperm cells were in young pollen grain, mature pollen grain and pollen tubes. When generative cells, at the...

Recent evidence suggests that lipid composition in cancer tissues may undergo multiple alterations. However, no comprehensive analysis of various lipid groups in colorectal cancer (CRC) tissue has been conducted thus far. To address the problem in qu...

The anode recirculation mode is increasingly being adopted in today’s fuel cell systems. The recycling of hydrogen gas can effectively improve fuel utilization and the wider economy. However, using the purge strategy for the recirculation exhau...

Proteasomes are intracellular structures responsible for protein degradation. The 20S proteasome is a core catalytic element of the proteasome assembly. Variations of catalytic subunits generate different forms of 20S proteasomes including immunoprot...

The zinc transporter ZnT8 (SLC30A8) localises to insulin secretory granules of β-cells where it facilitates zinc uptake for insulin crystallisation. ZnT8 abundance has been linked to β-cell survival and functional phenotype. However, the co...

The morphological features and relative number of mast cells (MCs) were studied in the skin and exorbital lacrimal glands of hypothyroid Wistar rats, Rattus norvegicus. Hypothyroidism significantly increased the number of MCs (up to 4.5-fold) and his...

Rice (Oryza sativa L.) seedlings grown under nitrogen (N) deficiency conditions show a foraging response characterized by increased root length. However, the mechanism underlying this developmental plasticity is still poorly understood. In this study...

Glioblastoma is an aggressive type of CNS tumor. The aim was to evaluate the antitumor activity of Taraxacum officinale (TO) extracts on U-138 MG glial cells and correlate it with the concentration of chicoric (ChA), chlorogenic (CGA), and caftaric (...

In this study, isosorbide (ISB), a bio-based compound derived from the dehydration of D-sorbitol, was used as a sustainable resource to produce various types of rigid polyurethane foams (RPUFs). Featuring a rigid bicyclic structure and two hydroxyl g...

The storage of frequently requested multimedia content at small-cell base stations (BSs) can reduce the load of macro-BSs without relying on high-speed backhaul links. In this work, the optimal operation of a system consisting of a cache-aided small-...

Lycopene is more bioavailable in processed tomato products than in raw tomatoes, since arrangement of cis-isomers of lycopene during food processing and storage may increase its biological activity. The aim of the study is evaluate the influence of l...

Remote ischemic conditioning (RIC) is a procedure that can attenuate ischemic-reperfusion injury by conducting brief cycles of ischemia and reperfusion in the arm or leg. Extracellular vesicles (EVs) circulating in the bloodstream can release their c...

The aim of the experiment was to determine the effect of foliar application of Tytanit, a stimulator based on titanium, on the content of fibrous fractions, cellulose, and hemicellulose in the cell walls of h. alfalfa and r. clover. The experimental...

The proliferation of the internet of things (IoT) and other low-power devices demands the development of energy harvesting solutions to alleviate IoT hardware dependence on single-use batteries, making their deployment more sustainable. The propagati...

By means of their pivotal role in the outbreak of a variety of diseases, such as, recently, COVID-19, the molecular aspects of cell membrane function have gained considerable attention from researchers in recent decades. The resulting information exp...

Although a mild degree of anemia is common in the third trimester of pregnancy, it remains a challenge to establish whether a decrease in hemoglobin (Hb) concentration is physiological or pathological. The World Health Organization suggested a Hb con...

The lipid content of nine dinoflagellates was analyzed using flow cytometry to compare lipid levels. Additionally, the correlation between lipid content, cell size, and carbon content in dinoflagellates was evaluated using BODIPY 505/515 staining. Th...

Using supercritical nitrogen as the physical foaming agent, microcellular polypropylene (PP) nanocomposites were prepared in microcellular injection molding. The main purpose of this work is to study effects of content of nano-CaCO₃ on the crystalliz...

Melanin, which determines the color of the skin and hair, is initially synthesized to protect the skin from ultraviolet light; however, excessive melanin pigmentation caused by abnormal cell proliferation can result in various melanocytic lesions. Cy...

Magnetically labelled cells are used for in vivo cell tracking by MRI, used for the clinical translation of cell-base therapies. Studies involving magnetic labelled cells may include separation of labelled cells, targeted delivery and controlled rele...

Maternal diet during pregnancy and early postnatal life influences the setting up of normal physiological functions in the offspring. Epigenetic mechanisms regulate cell differentiation during embryonic development and may mediate gene/environment in...

Mutations in the SLC25A38 gene are responsible for the second most common form of congenital sideroblastic anemia (CSA), a severe condition for which no effective treatment exists. We developed and characterized a K562 erythroleukemia cell line with...

Chronic blood transfusions in patients with sickle cell anemia (SCA) cause iron overload, which occurs with a degree of interpatient variability in serum ferritin and liver iron content (LIC). Reasons for this variability are unclear and may be influ...

The use of microfragmented adipose tissue (µFAT) for the treatment of musculoskeletal disorders, especially osteoarthritis (OA), is gaining popularity, following positive results reported in recent case series and clinical trials. Although these outc...

Shape Memory Polymers (SMPs) are smart materials that can recall their shape upon the application of a stimulus, which makes them appealing materials for a variety of applications, especially in biomedical devices. Most prior SMP research has focused...