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1,136 Results Found

  • Article
  • Open Access
42 Citations
9,301 Views
25 Pages

1 May 2018

A mathematical model for a transmission of TB-HIV/AIDS co-infection that incorporates prevalence dependent behaviour change in the population and treatment for the infected (and infectious) class is formulated and analyzed. The two sub-models, when e...

(This article belongs to the Special Issue Modeling & Control of Disease States)
  • Article
  • Open Access
14 Citations
5,115 Views
14 Pages

Screening for Tuberculosis in Migrants: A Survey by the Global Tuberculosis Network

  • Lia D’Ambrosio,
  • Rosella Centis,
  • Claudia C. Dobler,
  • Simon Tiberi,
  • Alberto Matteelli,
  • Justin Denholm,
  • Dominik Zenner,
  • Seif Al-Abri,
  • Fatma Alyaquobi and
  • Giovanni Battista Migliori
  • + 26 authors

5 November 2021

Tuberculosis (TB) does not respect borders, and migration confounds global TB control and elimination. Systematic screening of immigrants from TB high burden settings and—to a lesser degree TB infection (TBI)—is recommended in most countries with a l...

(This article belongs to the Special Issue Antibiotics and Infectious Respiratory Diseases)
  • Article
  • Open Access
9 Citations
4,353 Views
14 Pages

Control of Particle Size in Flame Spray Pyrolysis of Tb–doped Y2O3 for Bio-Imaging

  • Sovann Khan,
  • Yunseok Choi,
  • Hak-Young Ahn,
  • Jae Hyun Han,
  • Byeong-Kwon Ju,
  • Jaewon Chung and
  • So-Hye Cho

4 July 2020

Recently, the use of oxide-based nanomaterials for bio-imaging has received great attention owing to their remarkable stabilities as compared to those of conventional organic dyes. Therefore, the development of scalable methods for highly luminescent...

(This article belongs to the Section Advanced Nanomaterials and Nanotechnology)
  • Article
  • Open Access
3 Citations
3,732 Views
21 Pages

17 November 2024

Tuberculosis (TB) is a regional and global bacterial illness that has been expanding and affecting individuals in every generation. An unknown percentage of asymptomatic hosts have TB, and the infection can spread while exhibiting no symptoms. These...

(This article belongs to the Special Issue Mathematical Modeling of the Infectious Diseases and Their Controls)
  • Article
  • Open Access
3 Citations
3,973 Views
15 Pages

Occupational Risk of Airborne Mycobacterium tuberculosis Exposure: A Situational Analysis in a Three-Tier Public Healthcare System in South Africa

  • Dikeledi O. Matuka,
  • Thabang Duba,
  • Zethembiso Ngcobo,
  • Felix Made,
  • Lufuno Muleba,
  • Tebogo Nthoke and
  • Tanusha S. Singh

This study aimed to detect airborne Mycobacterium tuberculosis (MTB) at nine public health facilities in three provinces of South Africa and determine possible risk factors that may contribute to airborne transmission. Personal samples (n = 264) and...

(This article belongs to the Special Issue State of the Art of Occupational and Environmental Health in South Africa)
  • Article
  • Open Access
22 Citations
5,453 Views
13 Pages

Public Awareness of Tuberculosis in Southeast China: A Population-Based Study

  • Xinyi Chen,
  • Wei Wang,
  • Xiaomeng Wang,
  • Chengliang Chai,
  • Kui Liu,
  • Ying Peng,
  • Fei Wang,
  • Bin Chen and
  • Jianmin Jiang

Few provinces in China have recently conducted population-based surveys on tuberculosis (TB) awareness at the provincial level. Hence, we conducted a population-based, cross-sectional study to evaluate the level of awareness of TB knowledge among res...

(This article belongs to the Section Infectious Disease Epidemiology)
  • Article
  • Open Access
3 Citations
2,123 Views
11 Pages

In the present work, we report the synthesis of isomeric heteronuclear terbium(III) and yttrium(III) triple-decker phthalocyaninates [(BuO)8Pc]M[(BuO)8Pc]M*[(15C5)4Pc] (M = Tb, M* = Y or M = Y, M* = Tb, [(BuO)8Pc]2−–octa-n-butoxyphthalocy...

(This article belongs to the Special Issue Macrocyclic Compounds: Derivatives and Applications)
  • Article
  • Open Access
24 Citations
7,215 Views
22 Pages

19 March 2018

Optimal control of reservoirs is a challenging task due to conflicting objectives, complex system structure, and uncertainties in the system. Real time control decisions suffer from streamflow forecast uncertainty. This study aims to use Probabilisti...

(This article belongs to the Special Issue Adaptive Catchment Management and Reservoir Operation)
  • Article
  • Open Access
25 Citations
5,287 Views
9 Pages

Correlation of CpG Island Methylation of the Cytochrome P450 2E1/2D6 Genes with Liver Injury Induced by Anti-Tuberculosis Drugs: A Nested Case-Control Study

  • Jinling Zhang,
  • Xuebin Zhu,
  • Yuhong Li,
  • Lingyan Zhu,
  • Shiming Li,
  • Guoying Zheng,
  • Qi Ren,
  • Yonghong Xiao and
  • Fumin Feng

This study investigated the role of CpG island methylation of the CYP2E1 and CYP2D6 genes in liver injury induced by anti-TB drugs from an epigenetic perspective in a Chinese cohort. A 1:1 matched nested case-control study design was applied. Pulmona...

  • Article
  • Open Access
334 Views
23 Pages

24 August 2026

Background: Patient-specific targeted radionuclide therapy (TRT) requires consideration not only of administered activity but also of the spatial distribution of radiopharmaceutical uptake and radionuclide-specific energy deposition. This study devel...

(This article belongs to the Section Oncology)
  • Article
  • Open Access
3 Citations
1,772 Views
12 Pages

Theta Burst TMS over the Pre-SMA Improves Inhibitory Control in Gambling Disorder Subjects as Assessed with Stop Signal Task

  • Gioele Gavazzi,
  • Carlo Cavaliere,
  • Marco Salvatore,
  • Nikolaos Makris and
  • Stefano Pallanti

Background. Inhibitory control failure represents a central trait in substance and behavioral addictions, which includes patients affected with gambling disorder (GD). In GD patients, research on this trait of the addiction cycle has primarily focuse...

(This article belongs to the Special Issue Brain Stimulation for Psychiatric Disorders: Emerging Evidence and New Perspectives—2nd Edition)
  • Article
  • Open Access
17 Citations
4,691 Views
17 Pages

Bovine Tuberculosis (Mycobacterium bovis) Outbreak Duration in Cattle Herds in Ireland: A Retrospective Observational Study

  • Andrew W. Byrne,
  • Damien Barrett,
  • Philip Breslin,
  • Jamie M. Madden,
  • James O'Keeffe and
  • Eoin Ryan

5 October 2020

Bovine tuberculosis (bTB) outbreaks, caused by Mycobacterium bovis infection, are a costly animal health challenge. Understanding factors associated with the duration of outbreaks, known as breakdowns, could lead to better disease management policy d...

(This article belongs to the Special Issue Tuberculosis Epidemiology and Control in Multi-Host Systems)
  • Article
  • Open Access
5 Citations
3,867 Views
10 Pages

A Communication-Based Intervention Study for Reducing Stigma and Discrimination against Tuberculosis among Thai High-School Students

  • Saowaluk Moonsarn,
  • Yuthichai Kasetjaroen,
  • Anne-Marie Bettex-Baars and
  • Anuchit Phanumartwiwath

The current study aims to explore the effectiveness of communication-based intervention on the reduction in TB stigma and discrimination among high-school students in Bangkok, Thailand, during the COVID-19 outbreak. This study is quasi-experimental i...

  • Article
  • Open Access
9 Citations
3,993 Views
13 Pages

Background: Tuberculosis (TB) remains a serious public health challenge despite enormous eradication efforts. Indigenous groups worldwide have a higher TB incidence and associated delayed sputum–smear conversion. The aim of this case–cont...

  • Article
  • Open Access
11 Citations
3,620 Views
18 Pages

Investigating Farm Fragmentation as a Risk Factor for Bovine Tuberculosis in Cattle Herds: A Matched Case-Control Study from Northern Ireland

  • Georgina Milne,
  • Jordon Graham,
  • John McGrath,
  • Raymond Kirke,
  • Wilma McMaster and
  • Andrew William Byrne

26 February 2022

Bovine tuberculosis remains a challenging endemic pathogen of cattle in many parts of the globe. Spatial clustering of Mycoacterium bovis molecular types in cattle suggests that local factors are the primary drivers of spread. Northern Ireland’...

(This article belongs to the Section Bacterial Pathogens)
  • Article
  • Open Access
5 Citations
2,961 Views
9 Pages

Tuberculosis among Ambulatory People Living with HIV in Guangxi Province, China: A Longitudinal Study

  • Zhezhe Cui,
  • Fei Huang,
  • Dabin Liang,
  • Yan Huang,
  • Huifang Qin,
  • Jing Ye,
  • Liwen Huang,
  • Chongxing Zhou,
  • Minying Huang and
  • Mei Lin
  • + 3 authors

Background: This study aims to determine the prevalence of TB among ambulatory people living with HIV in Guangxi Province, which experienced the biggest HIV epidemic in China. Methods: We undertook a longitudinal study in five HIV/AIDS designated hos...

(This article belongs to the Section Reproductive Health)
  • Article
  • Open Access
4 Citations
4,593 Views
14 Pages

Comparing Additionality of Tuberculosis Cases Using GeneXpert or Smear-Based Active TB Case-Finding Strategies among Social Contacts of Index Cases in Nepal

  • Suman Chandra Gurung,
  • Kritika Dixit,
  • Rajan Paudel,
  • Manoj Kumar Sah,
  • Ram Narayan Pandit,
  • Tara Prasad Aryal,
  • Shikha Upadhyay Khatiwada,
  • Govind Majhi,
  • Raghu Dhital and
  • Maxine Caws
  • + 13 authors

This study compares the yield and additionality of community-based active tuberculosis (TB) active case-finding strategies using either smear microscopy or GeneXpert as the TB diagnostic test. Active case-finding strategies screened social contacts o...

(This article belongs to the Section Infectious Diseases)
  • Article
  • Open Access
27 Citations
4,295 Views
12 Pages

Controlled Synthesis of Tb3+/Eu3+ Co-Doped Gd2O3 Phosphors with Enhanced Red Emission

  • Dong Zhu,
  • Jinkai Li,
  • Xiangyang Guo,
  • Qinggang Li,
  • Hao Wu,
  • Lei Meng and
  • Zongming Liu

20 February 2019

(Gd0.93−xTb0.07Eux)2O3 (x = 0–0.10) phosphors shows great potential for applications in the lighting and display areas. (Gd0.93−xTb0.07Eux)2O3 phosphors with controlled morphology were prepared by a hydrothermal method, followed by...

  • Article
  • Open Access
8 Citations
4,567 Views
10 Pages

Impact of the Stool-Based Xpert Test on Childhood Tuberculosis Diagnosis in Selected States in Nigeria

  • Nkiru Nwokoye,
  • Bethrand Odume,
  • Peter Nwadike,
  • Ikechukwu Anaedobe,
  • Zirra Mangoro,
  • Michael Umoren,
  • Chidubem Ogbudebe,
  • Ogoamaka Chukwuogo,
  • Sani Useni and
  • Mustapha Gidado
  • + 4 authors

Background: In Nigeria, most children with tuberculosis (TB) present at primary health clinics where there are limited personnel skilled in collecting appropriate respiratory specimens from those who cannot produce sputum. KNCV Nigeria, in collaborat...

(This article belongs to the Section Infectious Diseases)
  • Article
  • Open Access
9 Citations
7,651 Views
16 Pages

Data Quality: A Negotiator between Paper-Based and Digital Records in Pakistan’s TB Control Program

  • Syed Mustafa Ali,
  • Farah Naureen,
  • Arif Noor,
  • Maged N. Kamel Boulos,
  • Javariya Aamir,
  • Muhammad Ishaq,
  • Naveed Anjum,
  • John Ainsworth,
  • Aamna Rashid and
  • Irum Fatima
  • + 1 author

19 July 2018

Background: The cornerstone of the public health function is to identify healthcare needs, to influence policy development, and to inform change in practice. Current data management practices with paper-based recording systems are prone to data quali...

  • Article
  • Open Access
29 Citations
4,902 Views
12 Pages

Spatiotemporal Patterns of Tuberculosis in Hunan Province, China

  • Kefyalew Addis Alene,
  • Zuhui Xu,
  • Liqiong Bai,
  • Hengzhong Yi,
  • Yunhong Tan,
  • Darren J. Gray,
  • Kerri Viney and
  • Archie C. A. Clements

Tuberculosis (TB) is the leading cause of death from a bacterial pathogen worldwide. China has the third highest TB burden in the world, with a high reported burden in Hunan Province (amongst others). This study aimed to investigate the spatial distr...

(This article belongs to the Section Infectious Disease Epidemiology)
  • Article
  • Open Access
5 Citations
4,996 Views
12 Pages

Challenges of Screening and Investigations of Contacts of Patients with Tuberculosis in Oyo and Osun States, Nigeria

  • Aderonke Agbaje,
  • Patrick Dakum,
  • Olugbenga Daniel,
  • Anyaike Chukwuma,
  • Obioma Chijoke-Akaniro,
  • Evaezi Okpokoro,
  • Samuel Akingbesote,
  • Christian Anyomi,
  • Adekola Adekunle and
  • Ademola Adelekan
  • + 6 authors

Tuberculosis (TB) remains a significant public health challenge in Nigeria, with high rates of transmission and low case detection rates. This paper presents the challenges of screening and investigation of contacts of patients with TB in Oyo and Osu...

(This article belongs to the Section Infectious Diseases)
  • Article
  • Open Access
13 Citations
3,279 Views
12 Pages

15 January 2022

Developing rare-earth doped oxysulfide phosphors with diverse morphologies has significant value in many research fields such as in displays, medical diagnosis, and information storage. All of the time, phosphors with spherical morphology have been d...

(This article belongs to the Topic Synthesis, Characterization and Performance of Materials for a Sustainable Future)
  • Article
  • Open Access
460 Views
30 Pages

Bayesian Analysis of Tuberculosis Spread Scenarios in Regions of Russian Federation

  • Olga Krivorotko,
  • Andrei Neverov,
  • Yakov Schwartz,
  • Grigoriy Kaminskiy,
  • Nikolay Zyatkov and
  • Zhanna Laushkina

8 May 2026

Understanding the heterogeneous spread of tuberculosis (TB), particularly multidrug-resistant (MDR) forms and the role of subclinical infection, is critical for achieving the WHO End TB strategy. This study develops a novel compartmental model that e...

(This article belongs to the Special Issue Recent Advances in Mathematical Epidemiology and Applications)
  • Article
  • Open Access
12 Citations
3,849 Views
16 Pages

Genomic Analysis of Mycobacterium tuberculosis Strains Resistant to Second-Line Anti-Tuberculosis Drugs in Lusaka, Zambia

  • Joseph Yamweka Chizimu,
  • Eddie Samuneti Solo,
  • Precious Bwalya,
  • Thoko Flav Kapalamula,
  • Kaemba Kunkuta Mwale,
  • David Squarre,
  • Misheck Shawa,
  • Patrick Lungu,
  • David Atomanyi Barnes and
  • Yasuhiko Suzuki
  • + 11 authors

The emergence of pre-extensively drug-resistant tuberculosis (pre-XDR-TB) is a threat to TB control programs in developing countries such as Zambia. Studies in Zambia have applied molecular techniques to understand drug-resistance-associated mutation...

(This article belongs to the Section Mechanism and Evolution of Antibiotic Resistance)
  • Article
  • Open Access
5 Citations
2,272 Views
26 Pages

Micro-Inclusion Engineering via Sc Incompatibility for Luminescence and Photoconversion Control in Ce3+-Doped Tb3Al5−xScxO12 Garnet

  • Karol Bartosiewicz,
  • Robert Tomala,
  • Damian Szymański,
  • Benedetta Albini,
  • Justyna Zeler,
  • Masao Yoshino,
  • Takahiko Horiai,
  • Paweł Socha,
  • Shunsuke Kurosawa and
  • Akira Yoshikawa
  • + 3 authors

5 June 2024

Aluminum garnets display exceptional adaptability in incorporating mismatching elements, thereby facilitating the synthesis of novel materials with tailored properties. This study explored Ce3+-doped Tb3Al5−xScxO12 crystals (where x ranges from 0.5 t...

(This article belongs to the Section Optical and Photonic Materials)
  • Article
  • Open Access
4 Citations
3,357 Views
15 Pages

Genotypic Distribution and the Epidemiology of Multidrug Resistant Tuberculosis in Upper Northern Thailand

  • Sukanya Saikaew,
  • Aksara Thongprachum,
  • Rodjana Pongsararuk,
  • Aungkana Thanraka,
  • Naowarat Kunyanone,
  • Boonchai Chaiyasirinroje,
  • Praphan Luangsook,
  • Bordin Butr-Indr,
  • Ponrut Phunpae and
  • Usanee Wattananandkul

1 December 2022

The epidemiology and genotypes of multidrug-resistant tuberculosis (MDR-TB), a global public health threat, remain limited. The genotypic distribution and factors associated with MDR-TB in upper northern Thailand between 2015 and 2019 were investigat...

(This article belongs to the Section Antibiotic Therapy in Infectious Diseases)
  • Article
  • Open Access
9 Citations
4,253 Views
17 Pages

Tuberculosis (TB) is an infectious disease caused by bacteria that primarily target the lungs. The transmission of this disease occurs through the air in the form of droplet nuclei. Unfortunately, there has been an emergence of resistance to strains...

  • Article
  • Open Access
3 Citations
3,562 Views
15 Pages

Mapping Drug-Resistant Tuberculosis Treatment Outcomes in Hunan Province, China

  • Temesgen Yihunie Akalu,
  • Archie C. A. Clements,
  • Zuhui Xu,
  • Liqiong Bai and
  • Kefyalew Addis Alene

Background: Drug-resistant tuberculosis (DR-TB) remains a major public health challenge in China, with varying treatment outcomes across different regions. Understanding the spatial distribution of DR-TB treatment outcomes is crucial for targeted int...

(This article belongs to the Section Infectious Diseases)
  • Article
  • Open Access
7 Citations
3,500 Views
12 Pages

Whole-Genome Sequencing Reveals Recent Transmission of Multidrug-Resistant Mycobacterium tuberculosis CAS1-Kili Strains in Lusaka, Zambia

  • Joseph Yamweka Chizimu,
  • Eddie Samuneti Solo,
  • Precious Bwalya,
  • Wimonrat Tanomsridachchai,
  • Herman Chambaro,
  • Misheck Shawa,
  • Thoko Flav Kapalamula,
  • Patrick Lungu,
  • Yukari Fukushima and
  • Yasuhiko Suzuki
  • + 3 authors

Globally, tuberculosis (TB) is a major cause of death due to antimicrobial resistance. Mycobacterium tuberculosis CAS1-Kili strains that belong to lineage 3 (Central Asian Strain, CAS) were previously implicated in the spread of multidrug-resistant (...

(This article belongs to the Section Mechanism and Evolution of Antibiotic Resistance)
  • Article
  • Open Access
290 Views
26 Pages

Development and Preliminary Evaluation of RR-TB GoldDx and Hr-TB GoldDx: Rapid Visual RPA-Gold Nanoparticle Assays for Detecting Rifampicin- and Isoniazid-Resistance-Associated Mutations in Mycobacterium tuberculosis

  • Usanee Wattananandkul,
  • Sukanya Saikaew,
  • Sirikwan Sangboonruang,
  • Rodjana Pongsararuk,
  • Prapaporn Srilohasin,
  • Bordin Butr-Indr,
  • Sorasak Intorasoot,
  • Chayada Sitthidet Tharinjaroen,
  • Natthawat Semakul and
  • Khajornsak Tragoolpua
  • + 2 authors

10 September 2026

Drug-resistant tuberculosis remains a major challenge to tuberculosis control, particularly in settings with limited access to conventional molecular testing. This study developed and preliminarily evaluated RR-TB GoldDx and Hr-TB GoldDx, rapid visua...

(This article belongs to the Special Issue Point-of-Care Testing: Advances and Perspectives)
  • Article
  • Open Access
1,405 Views
12 Pages

Genetic Characterization of First-Line Drug-Resistance Mutations in Multidrug-Resistant Mycobacterium tuberculosis

  • Maryam Gul,
  • Sajid Ali,
  • Abdul Rehman,
  • Muhammad Qasim,
  • Roomana Ali,
  • Jody E. Phelan,
  • Aiman Waheed,
  • Sajjad Ahmad,
  • Mubbashir Hussain and
  • Taj Ali Khan
  • + 2 authors

Background: Resistance to first-line anti-tuberculosis drugs in Mycobacterium tuberculosis represents a significant public health challenge, particularly in high-burden tuberculosis (TB) settings such as Pakistan, where multidrug-resistant (MDR) form...

(This article belongs to the Section Bacterial Pathogens)
  • Article
  • Open Access
9 Citations
8,260 Views
14 Pages

TB Hackathon: Development and Comparison of Five Models to Predict Subnational Tuberculosis Prevalence in Pakistan

  • Sandra Alba,
  • Ente Rood,
  • Fulvia Mecatti,
  • Jennifer M. Ross,
  • Peter J. Dodd,
  • Stewart Chang,
  • Matthys Potgieter,
  • Gaia Bertarelli,
  • Nathaniel J. Henry and
  • Abdullah Latif
  • + 9 authors

Pakistan’s national tuberculosis control programme (NTP) is among the many programmes worldwide that value the importance of subnational tuberculosis (TB) burden estimates to support disease control efforts, but do not have reliable estimates....

(This article belongs to the Special Issue New Tools and Approaches to End TB)
  • Article
  • Open Access
979 Views
18 Pages

Analysis of Adolescent HIV Care Cascade Outcomes in PEPFAR-Supported Programs in Central America, October 2020–September 2024

  • Lissette Raquel Chang,
  • Cristine Gutierrez,
  • Jose Rodas,
  • Nancy Aitcheson,
  • Nasim Farach,
  • Carlos Castaneda,
  • Andres Azmitia Rugg and
  • Benjamin Ryan Phelps

To better understand recent adolescent (10–19 years) HIV trends in Central America, we analyzed routine data from countries supported by the United States President’s Emergency Plan for AIDS Relief (PEPFAR): Guatemala, El Salvador, Hondur...

(This article belongs to the Special Issue Adolescent HIV Care and Transition Strategies: Challenges, Outcomes, and Interventions)
  • Article
  • Open Access
12 Citations
5,944 Views
13 Pages

Monitoring the Production of High Diffraction-Quality Crystals of Two Enzymes in Real Time Using In Situ Dynamic Light Scattering

  • Raphaël de Wijn,
  • Kévin Rollet,
  • Sylvain Engilberge,
  • Alastair G. McEwen,
  • Oliver Hennig,
  • Heike Betat,
  • Mario Mörl,
  • François Riobé,
  • Olivier Maury and
  • Claude Sauter
  • + 3 authors

23 January 2020

The reproducible preparation of well-diffracting crystals is a prerequisite for every structural study based on crystallography. An instrument called XtalController has recently been designed that allows the monitoring of crystallization assays using...

(This article belongs to the Special Issue Advanced Methods to Monitor and Control the Crystallisation Environment)
  • Article
  • Open Access
8 Citations
6,398 Views
14 Pages

Spatiotemporal Distribution of Tuberculosis in the Oromia Region of Ethiopia: A Hotspot Analysis

  • Dereje Bekele,
  • Solomon Aragie,
  • Kefyalew Addis Alene,
  • Tariku Dejene,
  • Samson Warkaye,
  • Melat Mezemir,
  • Dereje Abdena,
  • Tesfaye Kebebew,
  • Abera Botore and
  • Ketema Tafess
  • + 10 authors

Tuberculosis (TB) is a major public health concern in low- and middle-income countries including Ethiopia. This study aimed to assess the spatiotemporal distribution of TB and identify TB risk factors in Ethiopia’s Oromia region. Descriptive an...

(This article belongs to the Special Issue Spatial and Spatiotemporal Analysis of Infectious Diseases)
  • Perspective
  • Open Access
6 Citations
4,028 Views
14 Pages

Evidence to Action: Translating Innovations in Management of Child and Adolescent TB into Routine Practice in High-Burden Countries

  • Brittany K. Moore,
  • Riitta A. Dlodlo,
  • John Paul Dongo,
  • Sabine Verkuijl,
  • Moorine P. Sekadde,
  • Charles Sandy and
  • Susan A. Maloney

Child and adolescent tuberculosis (TB) has been long neglected by TB programs but there have been substantive strides in prioritizing TB among these populations in the past two decades. Yet, gaps remain in translating evidence and policy to action at...

(This article belongs to the Special Issue Recent Advances and Ongoing Challenges in the Management of Tuberculosis in Children and Adolescents)
  • Article
  • Open Access
23 Citations
12,015 Views
13 Pages

Magnetic Nanoparticle-Based Biosensing Assay Quantitatively Enhances Acid-Fast Bacilli Count in Paucibacillary Pulmonary Tuberculosis

  • Cristina Gordillo-Marroquín,
  • Anaximandro Gómez-Velasco,
  • Héctor J. Sánchez-Pérez,
  • Kasey Pryg,
  • John Shinners,
  • Nathan Murray,
  • Sergio G. Muñoz-Jiménez,
  • Allied Bencomo-Alerm,
  • Adriana Gómez-Bustamante and
  • Evangelyn C. Alocilja
  • + 4 authors

12 December 2018

A new method using a magnetic nanoparticle-based colorimetric biosensing assay (NCBA) was compared with sputum smear microscopy (SSM) for the detection of pulmonary tuberculosis (PTB) in sputum samples. Studies were made to compare the NCBA against S...

(This article belongs to the Special Issue Biosensors and Diagnostic Assays for Rapid Detection of Global Infectious Diseases and Antimicrobial Resistance)
  • Article
  • Open Access
16 Citations
5,226 Views
10 Pages

Can the High Sensitivity of Xpert MTB/RIF Ultra Be Harnessed to Save Cartridge Costs? Results from a Pooled Sputum Evaluation in Cambodia

  • Monyrath Chry,
  • Marina Smelyanskaya,
  • Mom Ky,
  • Andrew J Codlin,
  • Danielle Cazabon,
  • Mao Tan Eang and
  • Jacob Creswell

Despite the World Health Organization recommending the use of rapid molecular tests for diagnosing tuberculosis (TB), uptake has been limited, partially due to high cartridge costs. Other infectious disease programs pool specimens to save on diagnost...

(This article belongs to the Special Issue Innovation and Evidence for Achieving TB Elimination in the Asia–Pacific Region)
  • Article
  • Open Access
1,241 Views
14 Pages

Oral Islatravir in Macaques Decreases Lymphocytes and Monocytes and Is Associated with Immune Alterations

  • Michele B. Daly,
  • Daniel Kim,
  • Seidu Inusah,
  • Dawn Little,
  • Jiyoung S. Kim,
  • Natalia Makarova,
  • Tiancheng E. Edwards,
  • James Mitchell,
  • Walid Heneine and
  • J. Gerardo García-Lerma
  • + 2 authors

Background: Islatravir (ISL) is a first-in-class nucleoside reverse transcriptase translocation inhibitor with high potency and long half-life in peripheral blood mononuclear cells (PBMCs). However, treatment and prevention of HIV with oral ISL in hu...

(This article belongs to the Special Issue Advancing HIV Prevention and Treatment: Pharmacokinetics, Pharmacodynamics, Toxicokinetics, Formulation and Delivery of Antiretroviral Drugs)
  • Article
  • Open Access
14 Citations
5,034 Views
10 Pages

Tuberculosis Transmission in Households and Classrooms of Adolescent Cases Compared to the Community in China

  • Dongxiang Pan,
  • Mei Lin,
  • Rushu Lan,
  • Edward A Graviss,
  • Dingwen Lin,
  • Dabin Liang,
  • Xi Long,
  • Huifang Qin,
  • Liwen Huang and
  • Virasakdi Chongsuvivatwong
  • + 1 author

The aim of this paper is to evaluate the link between the history of exposure to tuberculosis (TB) in the household and diagnosed TB cases at school, and to compare the detection rate of active TB among household contacts and classroom contacts of ad...

  • Article
  • Open Access
15 Citations
4,746 Views
15 Pages

Comparative Study of Vitamin D Levels in Newly Diagnosed Tuberculosis and a Normal Population

  • Vasanth Kumar Mamadapur,
  • Shreesha Nagaraju and
  • Mukhyaprana M. Prabhu

23 April 2024

Background and Objectives: Tuberculosis (TB) is an ancient disease caused by Mycobacterium tuberculosis, a member of the Mycobacterium tuberculosis complex. It contributes to significant morbidity and mortality. Treatment of TB poses a considerable c...

(This article belongs to the Special Issue Infectious and Tropical Diseases: Symptoms, Diagnosis and Treatment)
  • Article
  • Open Access
1 Citations
1,446 Views
13 Pages

Risk Factors of Pulmonary Tuberculosis in Aseer Region, Saudi Arabia: A Case–Control Study

  • Faris Saeed Alsulayyim,
  • Abdullah Abdulmohsen Alsabaani,
  • Mohammad Abdullah Garnan,
  • Amna Babiker Alshash,
  • Asim Abdelwahid Elnoor Ali,
  • Mohammed Awthah Aldail,
  • Mazen Ali Asiri,
  • Faten Ali Nasser and
  • Syed Esam Mahmood

30 October 2025

Background: Tuberculosis (TB) constitutes one of the leading causes of morbidity and mortality worldwide. Due to adopted prevention measures, good public health practices, and better treatment, its incidence, prevalence, and case fatality rates stead...

  • Article
  • Open Access
3 Citations
3,455 Views
10 Pages

Controlling tuberculosis (TB) among immigrants from high-incidence countries presents a public health concern as well as a medical challenge. In this article, we investigate a TB outbreak in a community of people of Jewish descent who emigrated from...

(This article belongs to the Special Issue Ending Tuberculosis Epidemic: Current Status and Future Prospects)
  • Article
  • Open Access
3 Citations
4,203 Views
16 Pages

Performance of T-Track® TB, a Novel Dual Marker RT-qPCR-Based Whole-Blood Test for Improved Detection of Active Tuberculosis

  • Johannes P. Meier,
  • Selina Möbus,
  • Florian Heigl,
  • Alexandra Asbach-Nitzsche,
  • Hans Helmut Niller,
  • Annelie Plentz,
  • Korkut Avsar,
  • Marion Heiß-Neumann,
  • Bernhard Schaaf and
  • Sascha Barabas
  • + 13 authors

16 February 2023

Tuberculosis (TB) is one of the leading causes of death by an infectious disease. It remains a major health burden worldwide, in part due to misdiagnosis. Therefore, improved diagnostic tests allowing the faster and more reliable diagnosis of patient...

(This article belongs to the Special Issue Detection and Surveillance of Tuberculosis)
  • Article
  • Open Access
8 Citations
3,254 Views
9 Pages

Risk of Herpes Zoster in Patients with Pulmonary Tuberculosis—A Population-Based Cohort Study

  • Chih-An Wang,
  • Chia-Hung Chen,
  • Wen-Che Hsieh,
  • Tzu-Ju Hsu,
  • Chung-Y. Hsu,
  • Yung-Chi Cheng and
  • Chao-Yu Hsu

Background: Pulmonary tuberculosis (TB), a global health problem, is typically caused by the bacterium Mycobacterium tuberculosis. Herpes zoster (HZ) is caused by the reactivation of the varicella-zoster virus (VZV). The reactivation of VZV can be ca...

(This article belongs to the Section Global Health)
  • Article
  • Open Access
22 Citations
5,910 Views
14 Pages

Vitamin D3 Status and the Association with Human Cathelicidin Expression in Patients with Different Clinical Forms of Active Tuberculosis

  • Senait Ashenafi,
  • Jolanta Mazurek,
  • Anders Rehn,
  • Beede Lemma,
  • Getachew Aderaye,
  • Amsalu Bekele,
  • Getachew Assefa,
  • Menberework Chanyalew,
  • Abraham Aseffa and
  • Susanna Brighenti
  • + 2 authors

4 June 2018

Low vitamin D (vitD3) is one of the most common nutritional deficiencies in the world known to be associated with numerous medical conditions including infections such as tuberculosis (TB). In this study, vitD3 status and its association with the ant...

  • Article
  • Open Access
10 Citations
3,321 Views
17 Pages

Adding a Second iTBS Block in 15 or 60 Min Time Interval Does Not Increase iTBS Effects on Motor Cortex Excitability and the Responder Rates

  • Ilya Bakulin,
  • Alfiia Zabirova,
  • Dmitry Sinitsyn,
  • Alexandra Poydasheva,
  • Dmitry Lagoda,
  • Natalia Suponeva and
  • Michael Piradov

11 August 2022

The use of metaplasticity-based intermittent theta-burst stimulation (iTBS) protocols including several stimulation blocks could be a possible approach to increasing stimulation effectiveness. Our aim was to investigate the neurophysiological effects...

(This article belongs to the Section Sensory and Motor Neuroscience)
  • Article
  • Open Access
26 Citations
7,015 Views
13 Pages

Tuberculosis (TB) is a leading killer from a single infectious agent globally. In 2019, Malaysia’s TB incidence rate was 92 per 100,000 population, and the TB mortality rate was estimated at 4 cases per 100,000 population per year. However, the state...

(This article belongs to the Special Issue Tuberculosis Program Implementation)
  • Article
  • Open Access
6 Citations
4,084 Views
14 Pages

TB Antigen-Stimulated CXCR3 Ligand Assay for Diagnosis of Tuberculous Lymphadenitis

  • Wou-Young Chung,
  • Keu-Sung Lee,
  • Joo-Hun Park,
  • Yun-Jung Jung,
  • Seung-Soo Sheen,
  • Ji-Eun Park,
  • Joo-Sung Sun,
  • Young-Hwa Ko and
  • Kwang-Joo Park

The diagnosis of tuberculous lymphadenitis (TB-LAP) is challenging. We evaluated the role of blood CXC chemokine receptor 3 (CXCR3) ligands in its diagnosis. A total of 65 lymphadenopathy patients were enrolled and lymph node sampling was performed....

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