Tuberculosis among Ambulatory People Living with HIV in Guangxi Province, China: A Longitudinal Study
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design and Participants
2.2. Procedures
2.3. Statistical Analysis
2.4. Ethical Consideration
3. Results
3.1. TB Diagnosis
3.2. Demographics
3.3. Clinical Characteristics
4. Discussion
5. Conclusions
6. Limitation
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Appendix A
Age Group | HIV | AIDS | Total | |||
---|---|---|---|---|---|---|
Male | Female | Male | Female | Male | Female | |
0- | 11 | 7 | 2 | 1 | 13 | 8 |
15- | 90 | 13 | 5 | 7 | 95 | 20 |
25- | 321 | 98 | 66 | 48 | 387 | 146 |
35- | 447 | 330 | 231 | 181 | 678 | 511 |
45- | 422 | 248 | 310 | 158 | 732 | 406 |
55- | 279 | 178 | 210 | 127 | 489 | 305 |
65- | 186 | 123 | 187 | 102 | 373 | 225 |
75- | 53 | 14 | 49 | 14 | 102 | 28 |
85- | 12 | 3 | 5 | 1 | 17 | 4 |
Total | 1821 | 1014 | 1065 | 639 | 2886 | 1653 |
Year | TB | LTBI | Others |
---|---|---|---|
HIV | 299 (207–487) | 475 (286–645) | 418 (251–605) |
AIDS | 238 (177–412) | 379 (243–531) | 346 (224–504) |
Total | 241 (183–458) | 425 (268–606) | 387 (236–568) |
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Year | Total | Active TB | NTM | LTBI | |||||
---|---|---|---|---|---|---|---|---|---|
PTB (%) | EPTB (%) | Total (%) | p Value * | Total (%) | p Value | Total (%) | p Value | ||
2019 | 1865 | 22 (88.0) | 3 (12.0) | 25 (1.3) | 0.0005 | 43 (2.3) | <0.0001 | 426 (22.8) | 0.0540 |
2020 | 675 | 4 (100.0) | 0 (0.0) | 4 (0.6) | 16 (2.4) | 185 (27.4) | |||
2021 | 1999 | 6 (85.7) | 1 (14.3) | 7 (0.4) | 7 (0.4) | 493 (24.7) | |||
Total | 4539 | 32 (88.9) | 4 (11.1) | 36 (0.8) | 66 (1.5) | 1104 (24.3) |
Factors | Total | Active TB | LTBI | HIV Mono-Infection | |||
---|---|---|---|---|---|---|---|
n | p Value | n (%) | p Value | n (%) | p Value | ||
Gender | 0.0336 | 0.0256 | 0.0082 | ||||
Male | 2886 (63.6) | 29 (80.6) | 733 (66.4) | 2124 (62.5) | |||
Female | 1653 (26.4) | 7 (19.4) | 371 (33.6) | 1275 (37.5) | |||
Age | 0.9212 | 0.8918 | 0.8388 | ||||
0- | 21 (0.5) | 0 (0.0) | 4 (0.4) | 17 (0.5) | |||
15- | 1837 (40.5) | 13 (36.1) | 440 (39.9) | 1384 (40.7) | |||
45- | 1608 (35.4) | 14 (38.9) | 398 (36.1) | 1196 (35.2) | |||
60- | 1073 (23.6) | 9 (25.0) | 262 (23.7) | 802 (23.6) | |||
Marriage | 0.7046 | 0.4471 | 0.4045 | ||||
Married | 2857 (62.9) | 20 (55.6) | 694 (62.9) | 2143 (63.0) | |||
Unmarried | 996 (21.9) | 10 (27.8) | 234 (21.2) | 752 (22.1) | |||
Divorced/widowed | 641 (14.1) | 6 (16.7) | 168 (15.2) | 467 (13.7) | |||
Unknown | 45 (1.0) | 0 (0.0) | 8 (0.7) | 37 (1.1) | |||
Education | 0.3496 | 0.0818 | 0.0859 | ||||
Illiteracy | 321 (7.1) | 3 (8.3) | 77 (7.0) | 241 (7.1) | |||
Primary school | 1564 (34.5) | 17 (47.2) | 398 (36.1) | 1149 (33.8) | |||
Junior high school | 1597 (35.2) | 12 (33.3) | 351 (31.8) | 1234 (36.3) | |||
High school | 586 (12.9) | 3 (8.3) | 157 (14.2) | 426 (12.5) | |||
Junior college/above | 471 (10.4) | 1 (2.8) | 121 (11.0) | 349 (10.3) | |||
Occupation | 0.0260 | 0.4583 | 0.5181 | ||||
Farmer | 2766 (60.9) | 23 (63.9) | 651 (59.0) | 2092 (61.5) | |||
Self-employed | 759 (16.7) | 2 (5.6) | 198 (17.9) | 559 (16.4) | |||
Unemployed | 527 (11.6) | 9 (25.0) | 132 (12.0) | 386 (11.4) | |||
Other | 487 (10.7) | 2 (5.6) | 123 (11.1) | 362 (10.7) |
Factors | Total | Active TB | LTBI | HIV Mono-Infection | |||
---|---|---|---|---|---|---|---|
n (%) | p Value | n (%) | p Value | n (%) | p Value | ||
HIV status | 0.0097 | 0.6446 | 0.9420 | ||||
HIV infected | 2835 (62.5) | 15 (46.9) | 696 (61.8) | 2124 (62.8) | |||
AIDS | 1704 (37.5) | 21 (65.6) | 408 (36.2) | 1275 (37.7) | |||
Comorbidity | 0.0347 | 0.6675 | 0.3915 | ||||
Yes | 421 (9.3) | 7 (19.4) | 106 (9.6) | 308 (9.1) | |||
No | 4118 (90.7) | 29 (80.6) | 998 (90.4) | 3091 (90.9) | |||
Close contact | 0.3555 | 0.7313 | 0.6305 | ||||
Yes | 157 (3.5) | 2 (5.6) | 40 (3.6) | 115 (3.4) | |||
No | 4382 (96.5) | 34 (94.4) | 1064 (96.4) | 3284 (96.6) | |||
Nine Symptoms | 0.0052 | 0.6504 | 0.8098 | ||||
Yes | 276 (6.1) | 7 (19.4) | 64 (5.8) | 205 (6) | |||
No | 4263 (93.9) | 29 (80.6) | 1040 (94.2) | 3194 (94) | |||
W4SS * | 0.0728 | 0.8812 | 0.8007 | ||||
Yes | 201 (4.4) | 4 (11.1) | 48 (4.3) | 149 (4.4) | |||
No | 4338 (95.6) | 32 (88.9) | 1056 (95.7) | 3250 (95.6) | |||
Chest x-ray | <0.0001 | 0.4773 | 0.0886 | ||||
Abnormal | 997 (22) | 20 (55.6) | 251 (22.7) | 726 (21.4) | |||
Normal | 3542 (78) | 16 (44.4) | 853 (77.3) | 2673 (78.6) |
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Cui, Z.; Huang, F.; Liang, D.; Huang, Y.; Qin, H.; Ye, J.; Huang, L.; Zhou, C.; Huang, M.; Liang, X.; et al. Tuberculosis among Ambulatory People Living with HIV in Guangxi Province, China: A Longitudinal Study. Int. J. Environ. Res. Public Health 2022, 19, 12280. https://doi.org/10.3390/ijerph191912280
Cui Z, Huang F, Liang D, Huang Y, Qin H, Ye J, Huang L, Zhou C, Huang M, Liang X, et al. Tuberculosis among Ambulatory People Living with HIV in Guangxi Province, China: A Longitudinal Study. International Journal of Environmental Research and Public Health. 2022; 19(19):12280. https://doi.org/10.3390/ijerph191912280
Chicago/Turabian StyleCui, Zhezhe, Fei Huang, Dabin Liang, Yan Huang, Huifang Qin, Jing Ye, Liwen Huang, Chongxing Zhou, Minying Huang, Xiaoyan Liang, and et al. 2022. "Tuberculosis among Ambulatory People Living with HIV in Guangxi Province, China: A Longitudinal Study" International Journal of Environmental Research and Public Health 19, no. 19: 12280. https://doi.org/10.3390/ijerph191912280