221 Results Found

The limitation in quantity and quality of climate data, in particular rainfall measurements, directly affects the reliability of hydrological models, which negatively impacts on the quality of water resources planning and management. This is obviousl...

Sterol regulatory element-binding proteins (SREBPs) regulate lipid homeostasis in mammals via sequential activation by the site-1 (S1P) and site-2 (S2P) proteases. In the yeast Phaffia rhodozyma, homologs of SREBP (Sre1) and S2P (Stp1) were identifie...

Precise 3D shape correspondence is a fundamental prerequisite for critical applications ranging from medical anatomical modeling to visual recognition. However, non-isometric 3D shape matching remains a challenging task due to the limited sensitivity...

The impact of an initial skeletal-related event (SRE) and denosumab adjuvant treatment on the survival outcome of epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC) patients with bone metastasis remains unclear. This r...

ZY1-02D is a Chinese hyperspectral satellite, which is equipped with a visible near-infrared multispectral camera and a hyperspectral camera. Its data are widely used in soil quality assessment, mineral mapping, water quality assessment, etc. However...

Background: This retrospective study compared the effectiveness and preliminary cost evaluation of denosumab and zoledronic acid (ZA) in patients with bone metastases from breast, prostate, and lung cancer. Methods: Patients treated with ZA or denosu...

The sparse representation error (SRE) exists when the images are represented sparsely. The SRE is particularly large in unmanned aerial vehicles (UAV) images due to the disturbance of the harsh environment or the instability of its flight, which will...

To tackle the intricate challenges associated with the low detection accuracy of images taken by unmanned aerial vehicles (UAVs), arising from the diverse sizes and types of objects coupled with limited feature information, we present the SRE-YOLOv8...

The sterol regulatory element-binding protein (SREBP) pathway is an integral cellular mechanism that regulates lipid homeostasis, in which transcriptional activator SREBPs regulate the expression of various genes. In the carotenogenic yeast Xanthophy...

Modern agriculture is expected to face an increasing global demand for food while also needing to comply with higher sustainability standards. Therefore, control of crop pathogens requires new, green alternatives to current methods. Potatoes are susc...

Security is crucial, especially as software systems become increasingly complex. Both practitioners and researchers advocate for the early integration of security requirements (SR) into the Software Development Life Cycle (SDLC). However, ensuring th...

Siderophores are compounds with low molecular weight with a high affinity and specificity for ferric iron, which is produced by bacteria and fungi. Fungal siderophores have been characterized and their feasibility for clinical applications has been i...

The underlying molecular mechanism and their general effect on the replication capacity of HIV 1 drug-resistance-associated mutations is often poorly understood. To elucidate the effect of two such mutations located in a region with a high density of...

Up to 80% of castration-resistant prostate cancer (CRPC) patients develop bone metastases during the natural history of disease and about 25% harbor mutations in DNA damage repair (DDR) genes. This retrospective observational study evaluated the prev...

Real estate needs to improve its adoption of disruptive technologies to move from traditional to smart real estate (SRE). This study reviews the adoption of disruptive technologies in real estate. It covers the applications of nine such technologies,...

Doxycycline is often used as a promoter of inducible gene expression in preclinical models; however, it can also have direct effects on tumor growth and survival. This is due in part to its ability to inhibit cell invasion and regulate matrix metallo...

As an energy-saving and efficient composites-forming technology, the properties of carbon fiber self-resistance electric (SRE) heating technology still need to be improved, which is not conducive to the popularization and application of this technolo...

The grey mould fungus Botrytis cinerea is a dangerous plant pathogen responsible for substantial agricultural losses worldwide. The pathogenic mechanisms still have many unclear aspects, and numerous new pathogenic genes remain to be identified. Here...

Building regional innovation systems (RISs) has become an important measure for China to implement an innovation-driven development strategy, but a moderately complex way to describe the characteristics of the RISs is needed for aiding the implementa...

ELK1 is a Transcription factor (TF) belonging to the ETS-domain TF family, mainly activated via RAS-RAF-MEK-ERK signaling. As a nethermost pathway molecule, ELK1 binds to Serum-response elements (SREs) and directly regulates the transcription of Imme...

Transcription of the HIV-1 provirus generates a viral pre-mRNA, which is alternatively spliced into more than 50 HIV-1 mRNAs encoding all viral proteins. Regulation of viral alternative splice site usage includes the presence of splicing regulatory e...

One of the recent advances in climate science research is the development of global general circulation models (GCMs) to simulate changes in climatic elements of the present and future, which helps us to determine consequences earlier and prepare for...

The aim of this study was to elucidate the lifelong disease progression of chronic obstructive pulmonary disease (COPD) with biomarker changes and identify their influencing factors, by utilizing a new analysis method, Statistical Restoration of Frag...

In this work, we discuss the results of numerical simulations performed with the regional model COSMO-CLM over the Mediterranean area at a spatial resolution of 14 km, employing an optimized model configuration. An assessment of model capabilities to...

Six members of the Hadley Centre’s Perturbed Physics Ensemble for the Quantifying Uncertainty in Model Predictions (QUMP) project are downscaled using the PRECIS (Providing Regional Climates for Impact Studies) RCM (Regional Climate Model). Climate s...

Assessing future challenges in water resources management is crucial to the Melka Kuntrie (MK) subbasin suffering water shortage. Impact assessments are evaluated by the HBV hydrological model with six scenarios, including two GCMs of AR4-A2 and two...

Politics around sexual health have been polarised in recent years, but the policy implications of this polarisation have not yet been examined in depth. Therefore, this article explores political challenges to a rights-based approach in sexual health...

Weather extremes and climate variability directly impact the hydrological cycle influencing agricultural productivity. The issues related to climate change are of prime concern for every nation as its implications are posing negative impacts on socie...

Assessing the effects of future land use and land cover change (LULC) on ecological processes and functions is crucial for improving regional sustainability in arid and semiarid areas. Taking the Agro-Pastoral Transitional Zone of Northern China (APT...

Reports of Intergovernmental Panel on Climate Change have set various greenhouse gas emissions scenarios, through which the evolution of the temperature of the planet can be estimated throughout the 21st century. The reduction of the emissions from t...

This study aimed to increase the understanding of health resource utilization (HRU) associated with skeletal-related events (SREs) occurring in patients with bone metastases secondary to advanced prostate cancer. A total of 120 patients from Germany,...

Contemporary information is sparse on the frequency of skeletal-related events (SREs) in multiple myeloma (MM) patients at a population-based level in the era of novel agents. In this context, we conducted this single-center, prospective, observation...

Scutellaria baicalensis Georgi and Raphanus Sativus Linne herbal mixture (SRE) is a Chinese herbal medicine. In this study, we aimed to evaluate the therapeutic efficacy of SRE as an active ingredient for 2,4-dinitrochlorobenzene (DNCB)-induced atopi...

This retrospective study assessed the potential of blood leukocyte ratios as diagnostic biomarkers in cats with chronic enteropathies (CE). Absolute neutrophil-to-lymphocyte (NLR), neutrophil-to-monocyte (NMR), and lymphocyte-to-monocyte (LMR) ratios...

Software project planning includes as one of its main activities software development effort prediction (SDEP). Effort (measured in person-hours) is useful to budget and bidding the projects. It corresponds to one of the variables most predicted, act...

Purpose: Soft robotic exoskeletons (SREs) are portable, lightweight assistive technology with therapeutic potential for improving lower limb motor function in children with cerebral palsy. To understand the effects of long-term SRE-assisted walking t...

We screened natural resources for estrogen receptor (ER)-activating and bone metabolism-promoting activities with the aim of finding potential treatments for osteoporosis. A screen of 1531 extracts from Ryukyu Arc plants using a luciferase reporter a...

The design of single-stage OTAs for accurate switched-capacitor circuits involves challenging trade-offs between speed and power consumption. The addition of a Slew-Rate Enhancer (SRE) circuit placed in parallel to the main OTA (parallel-type SRE) co...

The performance of Satellite Rainfall Estimate (SRE) products applied to flood inundation modelling was tested for the Mundeni Aru River Basin in eastern Sri Lanka. Three SREs (PERSIANN, TRMM, and GSMaP) were tested, with the Rainfall-Runoff-Inundati...

This study aimed to investigate the effects of diet supplementation with stevia residue extract (SRE) on growth performance, intestinal health, and antioxidant capacity of weaned piglets. A total of 144 weaned piglets (body weight 6.8 ± 0.5 kg...

Hypertension requires proper management because of the increased risk of cardiovascular disease and death. For this purpose, functional foods containing tannins have been considered an effective treatment. Sanguisorbae radix (SR) also contains variou...

Background and Objectives: Bone metastases in patients can cause significant quality-of-life declines due to skeletal-related events (SREs). SRE is defined as the occurrence of radiotherapy for bone pain, pathologic fracture, bone surgery, spinal cor...

Post-traumatic stress disorder (PTSD) is a prevalent mental disorder marked by psychological and behavioral changes. Currently, there is no consensus of preferred antipsychotics to be used for the treatment of PTSD. We aim to discover whether certain...

Nine out of ten metastatic prostate cancer (PCa) patients will develop osseous metastases. Of these, every second will suffer from skeletal-related events (SRE). SRE are associated with an increased risk for death, which is markedly increased in the...

Background and Objectives: Advanced solid organ tumors, particularly breast, lung, and prostate cancers, frequently metastasize to bone, leading to debilitating skeletal-related events (SREs). Denosumab, a RANKL inhibitor, is crucial in preventing SR...

Background: The term “super responder” identifies a group of patients who exhibit a rapid and optimal response to biological treatment compared to the overall treated population. The primary objective of our study is to characterize this...

Despite advances toward disability inclusion, high-quality sex and relationship education (SRE) is often inaccessible for disabled communities. Confounding this issue, each individual’s experience of SRE is shaped by aspects within their enviro...

This study aimed to develop novel bio-nanofluids using Solanum torvum extracts in synergy with nanoparticles of different chemical nature as a proposal sustainable for enhanced oil recovery (EOR) applications. For this, saponin-rich extracts (SRE) we...

The growth of a large number of poisonous plants is an indicator of grassland degradation. Releasing allelochemicals through root exudates is one of the strategies with which poisonous plants affect neighboring plants in nature. Arbuscular mycorrhiza...

Understanding rainfall processes as the main driver of the hydrological cycle is important for formulating future water management strategies; however, rainfall data availability is challenging for countries such as Ethiopia. This study aims to evalu...