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Article

Scores of Health-Related Quality of Life Questionnaire Worsen Consistently in Patients of COPD: Estimating Disease Progression over 30 Years by SReFT with Individual Data Collected in SUMMIT Trial

1
Clinical Pharmacology and Pharmacometrics, Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba 260-8675, Japan
2
Clinical Operations, Japan Development, GlaxoSmithKline, Tokyo 107-0052, Japan
3
Department of Preventive Medicine and Public Health, Keio University School of Medicine, Tokyo 160-8582, Japan
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(8), 2676; https://doi.org/10.3390/jcm9082676
Received: 30 July 2020 / Revised: 11 August 2020 / Accepted: 14 August 2020 / Published: 18 August 2020
(This article belongs to the Special Issue Novel Biomarkers in Lung Cancer and Chronic Lung Diseases)
The aim of this study was to elucidate the lifelong disease progression of chronic obstructive pulmonary disease (COPD) with biomarker changes and identify their influencing factors, by utilizing a new analysis method, Statistical Restoration of Fragmented Time-course (SReFT). Individual patient data (n = 1025) participating in the Study to Understand Mortality and MorbidITy (SUMMIT, NCT01313676), which was collected within the observational period of 4 years, were analyzed. The SReFT analysis suggested that scores of St. George’s Respiratory Questionnaire and COPD assessment test, representative scores of the health-related quality of life (HRQOL) questionnaire, increased consistently for 30 years of disease progression, which was not detected by conventional analysis with a linear mixed effect model. It was estimated by the SReFT analysis that normalized forced expiratory volume in one second for age, sex, and body size (%FEV1) reduced for the initial 10 years from the onset of the disease but thereafter remained constant. The analysis of HRQOL scores and lung functions suggested that smoking cessation slowed COPD progression by approximately half and that exacerbation accelerated it considerably. In conclusion, this retrospective study utilizing SReFT elucidated the progression of COPD over 30 years and associated quantitative changes in the HRQOL scores and lung functions. View Full-Text
Keywords: chronic obstructive pulmonary disease; disease progression; health-related quality of life; smoking; statistical restoration of fragmented time-course chronic obstructive pulmonary disease; disease progression; health-related quality of life; smoking; statistical restoration of fragmented time-course
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MDPI and ACS Style

Kawamatsu, S.; Jin, R.; Araki, S.; Yoshioka, H.; Sato, H.; Sato, Y.; Hisaka, A. Scores of Health-Related Quality of Life Questionnaire Worsen Consistently in Patients of COPD: Estimating Disease Progression over 30 Years by SReFT with Individual Data Collected in SUMMIT Trial. J. Clin. Med. 2020, 9, 2676. https://doi.org/10.3390/jcm9082676

AMA Style

Kawamatsu S, Jin R, Araki S, Yoshioka H, Sato H, Sato Y, Hisaka A. Scores of Health-Related Quality of Life Questionnaire Worsen Consistently in Patients of COPD: Estimating Disease Progression over 30 Years by SReFT with Individual Data Collected in SUMMIT Trial. Journal of Clinical Medicine. 2020; 9(8):2676. https://doi.org/10.3390/jcm9082676

Chicago/Turabian Style

Kawamatsu, Shinya, Ryota Jin, Shogo Araki, Hideki Yoshioka, Hiromi Sato, Yasunori Sato, and Akihiro Hisaka. 2020. "Scores of Health-Related Quality of Life Questionnaire Worsen Consistently in Patients of COPD: Estimating Disease Progression over 30 Years by SReFT with Individual Data Collected in SUMMIT Trial" Journal of Clinical Medicine 9, no. 8: 2676. https://doi.org/10.3390/jcm9082676

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