Although serrated polyps were historically considered to pose little risk, it is now understood that progression down the serrated pathway could account for as many as 15%–35% of colorectal cancers. The sessile serrated adenoma/polyp (SSA/P) is the m...
Colorectal cancer (CRC) is a leading cause of cancer death worldwide. It includes different subtypes that differ in their clinical and prognostic features. In the past decade, in addition to the conventional adenoma-carcinoma model, an alternative mu...
Until 2010, colorectal serrated lesions were generally considered as harmless lesions and reported as hyperplastic polyps (HPs) by pathologists and gastroenterologists. However, recent evidence showed that they may bear the potential to develop into...
The clinicopathologic and molecular features of serrated lesions with dysplasia in inflammatory bowel disease (IBD) remain poorly understood. We examined a total of 2396 patients treated for IBD at the University of Szeged between 2011 and 2023. Amon...
Background and Objectives: Serrated adenocarcinoma (SAC) is a distinctive neoplasm that is histopathologically characterized by the presence of epithelial serration, an eosinophilic cytoplasm, and a vesicular nucleus. However, the literature data con...
Accounting for 15–30% of colorectal cancer cases, the serrated pathway remains poorly characterized compared to the adenoma–carcinoma sequence. It involves sessile serrated lesions as precursors and is characterized by BRAF mutations (BRA...
Arsenite-resistance protein 2, also known as serrate RNA effector molecule (ARS2/SRRT), is known to be involved in cellular proliferation and tumorigenicity. However, its role in prostate cancer (PCa) has not yet been established. We investigated the...
Sessile serrated lesions (SSLs) are well-known precursors of colorectal cancer in the general population, but their role in inflammatory bowel disease (IBD) is less clear. This narrative review summarizes what is known about the prevalence, molecular...
Heat treatments, including solution treatment and isothermal heat treatment, were conducted to investigate the grain boundary serration of GH4975 superalloy. The two different heat treatment processes could both promote the formation of serrated grai...
Activated TGFβ signaling in the tumor microenvironment, which occurs independently of epithelial cancer cells, has emerged as a key driver of tumor progression in late-stage colorectal cancer (CRC). This study aimed to elucidate the contribution...
Background and aim: Olympus Corporation released the texture and color enhancement imaging (TXI) technology as a novel image-enhancing endoscopic technique. We investigated the effectiveness of TXI in the imaging of serrated colorectal polyps, includ...
The mechanisms of serrated flow and microstructural evolution in MarBN steel were studied under two strain rates (5 × 10−3 s−1 and 5 × 10−5 s−1) at room temperature and high temperatures (430 °C and 630 °C)...
As a bionic flow control structure, leading-edge serrations have been proven to effectively suppress the aerodynamic noise of airfoils. Compared with single-wavelength serrations, a greater noise reduction potential can be obtained for airfoils with...
The mechanical response of a servo-hydraulic testing system is affected by the stiffness of test specimens. An adaptive controller helps in auto-tuning the system by setting the optimal proportional-integral-derivative values for the subsequent test...
The strain-rate-dependent plasticity under uniaxial compression at the strain rates of 2 × 10−3, 2 × 10−4 and 2 × 10−5 s−1 in a Pd77.5Cu6Si16.5 alloy is investigated. At different strain rates, the serration events exhibit different amplitudes and ti...
High-entropy alloys (HEAs) are a novel class of alloys that have many desirable properties. The serrated flow that occurs in high-entropy alloys during mechanical deformation is an important phenomenon since it can lead to significant changes in the...
The dominant aeroacoustic mechanisms of serrated leading edges, subjected to highly turbulent inflow conditions, can be compressed to spanwise decorrelation effects as well as effects of destructive interference. For single aerofoils, the resulting b...
Background/Objectives: Colorectal serrated lesions are highly heterogeneous at the micromorphological level. Their morphology can range from seemingly harmless, as in the case of hyperplastic polyps with little to no neoplastic potential, to lesions...
Biodiversity in plant shape is mainly attributable to the diversity of leaf shape, which is largely determined by the transient morphogenetic activity of the leaf margin that creates leaf serrations. However, the precise mechanism underlying the esta...
Trailing-edge serrations have proven to be valid applications of trailing edge noise mitigation for an airfoil, while the physical noise reduction mechanism has not been adequately studied. We performed simulations employing Large-eddy simulation and...
26 February 2023
Serrated lesions in the colorectum include all epithelial neoplastic lesions, which show a sawtooth-like morphology in the epithelial crypts. Classification systems nosologically divide colon serrated polyps into three different categories, primarily...
The increasing deployment of wind energy has brought renewed attention to aeroacoustic noise generated by wind turbine blades, where broadband noise is primarily associated with vortex shedding at the trailing edge (TE) and leading edge (LE) of airfo...
Rod–airfoil configurations are commonly used to study turbulence–structure interaction noise, which is a major contributor to aerodynamic noise in various engineering applications. In this work, noise mitigation by regular and irregular l...
This study aims to highlight the noise reduction achieved through the integration of serrated blades on the leading and trailing edges within a small-scale cascade configuration relevant to turbomachinery contexts. Experiments were conducted using a...
Serrated colorectal lesions are important precursors of colorectal cancer, but their tissue proteomic and circulating metabolic characteristics remain incompletely defined. This exploratory study contextualised targeted proteomics in 17 paired lesion...
High hydrodynamic noise is a threat to the survival of underwater vehicles. We investigated a noise suppression mechanism by putting leading-edge serrations on the sail hull of a scaled SUBOFF model, through numerical calculation and an experimental...
Leading edge serration is now a well-established and effective passive control device for the reduction of turbulence–leading edge interaction noise, and for the suppression of boundary layer separation at high angle of attack. It is envisaged that l...
Leaf margin serration is a morphological characteristic in plants. The CUC2 (CUP-SHAPED COTYLEDON 2) gene plays an important role in the outgrowth of leaf teeth and enhances leaf serration via suppression of growth in the sinus. In this study, we iso...
The microstructures and mechanical properties of the hot-rolled Fe-6.5wt.%Si sheet are analyzed. The microstructure of the hot-rolled sheet is layered along the thickness direction. The surface exhibits fine and equiaxed grains, whereas the center pa...
Serrated flow and work-hardening behavior (by Voce equation) of China low activation martensitic (CLAM) steel were investigated in the temperature range of 300–923 K (27 °C to 650 °C). The steel exhibited serrated flow at intermediate t...
The rising use of UAVs in various applications has underscored the critical challenge of noise pollution and aerodynamic efficiency. This study explores the dual integration of winglets and serrations on UAV propellers to address these challenges sim...
For this study, the effects of thermal annealing and compressive strain rate on the complexity of the serration behavior in a Zr-based bulk metallic glass (BMG) was investigated. Here, as-cast and thermally-annealed (300 °C, 1 week) Zr52.5Cu17.9N...
Temperature- and strain-rate-dependent serrated flow, localized plastic instability, and qualitative microcrack evolution in Mn13 Hadfield steel were investigated using stress–strain analysis and in situ tensile observation. Solution treatment...
Suppressing shock-induced flow separation has been a long-standing problem in the design of supersonic vehicles. To reduce the structural and design complexity of control devices, a passive control technique based on micro-serrations is proposed and...
Serrated plastic deformation is an intense phenomenon in CoCrFeMnNi at and below 35 K with stress amplitudes in excess of 100 MPa. While previous publications have linked serrated deformation to dislocation pile ups at Lomer–Cottrell (LC) locks...
Aluminum–magnesium alloys show the Portevin–Le Chatelier (PLC) effect. The aim of this publication is to provide a detailed analysis of the evaluation methods of this phenomenon using tensile tests at a strain rate range of 10−3 s&m...
Serration phenomena, in which stress fluctuates in a saw-tooth shape, occur when a uniaxial test is performed on an aluminum alloy containing a solid solution of solute atoms. The appearance of the serrations is affected by the strain rate and temper...
Background and Clinical Significance: Superficially serrated adenoma (SuSA) is a recently recognized colorectal serrated lesion characterized by superficial serration and adenoma-like deep glands. Its clinicopathological significance in ulcerative co...
Previous studies have reported significant differences in the Johnson-Cook (J-C) parameters of Ti6Al4V alloy. Thus, various serrated chip morphologies, cutting forces, and cutting temperatures are obtained when different constitutive parameters are u...
Background: Sessile serrated adenomas are important precursors to colorectal cancers and account for 30% of colorectal cancers. The United States Multi-Society Task Force recommends that patients with sessile serrated adenomas undergo surveillance si...
Structural joint configurations realized with serrated steel surfaces have started to be used in the construction fields to assemble the primary and the secondary structural members of civil engineering structures. The main advantages of these joint...
Powder metallurgy superalloys are attracting great attention due to their unique performance advantages, such as good oxidation resistance, corrosion resistance, excellent tensile behavior, durability, fatigue properties, and long-term tissue stabili...
This study explores the aeroacoustic influence of leading-edge serrations applied to stator blades subjected to turbulent inflow, which is representative of rotor–stator interaction in turbomachinery. A set of serrated geometries—75 mm sp...
Selective laser melting (SLM) has significant advantages in the near net shape manufacturing of metal parts with complex geometries. However, SLM parts usually have problems such as poor surface quality and low dimensional accuracy, which require pos...
For the rotor, achieving relatively high aerodynamic performance in specific wind conditions is a long-term goal. Inspired by the remarkable flight characteristics of owls, an optimal trailing edge serration design is investigated and proposed for a...
The serrated pathway represents a significant route to colorectal cancer (CRC), accounting for approximately 15–30% of cases, yet the specific epithelial cell subpopulations driving this pathway remain poorly understood. This study explores the...
This study presents a semi-empirical approach to generalizing the acoustic radiation generated by serrated airfoil configurations, based on small-scale aerodynamic/acoustic experiments and functional regression techniques. In the context of passive n...
The formation of serrated chips is an important feature during machining of difficult-to-cut materials, such as titanium alloy, nickel based alloy, and some steels. In this study, Ti6Al4V alloys with equiaxial and acicular martensitic microstructures...
The serrated structural plane is the basic unit of structural plane morphology. However, the understanding of its internal stress distribution, failure mode and crack evolution law was not clear enough in previous studies. In this paper, the shear me...
Serrated polyposis syndrome (SPS) implies a slightly elevated risk of colorectal cancer (CRC) during endoscopic follow-up, but its natural course is still not well known. The main objective of this study was to describe the long-term risk of developi...
of 9