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Future Challenges of Targeted Therapy of Cancers, 3rd Edition

A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Molecular Medicine".

Deadline for manuscript submissions: 30 June 2026 | Viewed by 1193

Special Issue Editor


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Guest Editor
Department of Pathology, George Emil Palade University of Medicine, Pharmacy, Sciences and Technology, 38 Gheorghe Marinescu Street, 540139 Targu Mures, Romania
Interests: hepatocellular carcinoma; histology; molecular biology; individualized therapy; epithelial mesenchymal transition
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Special Issue Information

Dear Colleagues,

This Special Issue is a continuation of our previous Special Issue, “Future Challenges of Targeted Therapy of Cancers: 2nd Edition” (https://www.mdpi.com/journal/cimb/special_issues/73S5X6A77H).

The aim of this Special Issue is to gather together papers providing updates on targeted therapies for cancers. As individualized therapy is predicted to be mainly based on gene profiles, a deeper understanding of the genetic background is essential, spanning from cell lines to circulating tumor cells and tissue biomarkers. Data concerning the heterogeneity of tumors and a deep understanding of their environment could also have therapeutic impacts. Any research or review papers with potential implications for improving oncologic therapy are welcome, and we encourage the presentation of clinical trial results. If a submitted paper focuses mainly on in silico analyses or the examination of public gene databases, it should also include external validation of its study cohorts.

Prof. Dr. Simona Gurzu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Current Issues in Molecular Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomarkers
  • tumor tissue
  • individualized therapy
  • gene profile
  • epithelial–mesenchymal transition
  • immunotherapy
  • angiogenesis
  • metastases
  • oncology
  • pathology

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Published Papers (2 papers)

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Research

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15 pages, 1502 KB  
Article
Association of Serum ELMO-3 Levels with Metastatic Status and Survival Outcomes in Non-Small Cell Lung Cancer
by Hilal Oğuz Soydinç, Murat Serilmez, Ceren Tilgen Yasasever, Elif Bilgin Doğru, Uğur Gezer, Şule Karaman, Nergiz Dağoğlu Sakin and Derya Duranyıldız
Curr. Issues Mol. Biol. 2026, 48(4), 427; https://doi.org/10.3390/cimb48040427 - 21 Apr 2026
Viewed by 190
Abstract
Non-small cell lung cancer remains one of the leading causes of cancer-related mortality worldwide, and identifying molecular markers associated with tumor progression and metastasis is important for improving patient management. This study investigated serum ELMO-3 levels in patients with NSCLC and evaluated their [...] Read more.
Non-small cell lung cancer remains one of the leading causes of cancer-related mortality worldwide, and identifying molecular markers associated with tumor progression and metastasis is important for improving patient management. This study investigated serum ELMO-3 levels in patients with NSCLC and evaluated their relationship with clinicopathological characteristics. Serum samples from 50 NSCLC patients and 20 healthy controls were analyzed. ELMO-3 concentrations were measured using an enzyme-linked immunosorbent assay. Statistical analyses included non-parametric group comparisons, receiver operating characteristic curve analysis, Kaplan–Meier survival analysis, and multivariate Cox proportional hazards regression. The mean ELMO-3 level was 0.409 ± 0.543, which was used as the cutoff value to categorize patients into low- and high-ELMO-3 groups; 76% of patients were classified as low-ELMO-3 and 24% as high-ELMO-3. The results showed that serum ELMO-3 levels did not differ significantly between NSCLC patients and healthy controls and were not associated with metastatic status. However, a significant association was observed between ELMO-3 expression status and tumor histopathology. Survival analysis demonstrated that distant metastasis and radiotherapy were significantly associated with overall survival. In multivariate analysis, age, operability, distant metastasis, and serum ELMO-3 levels were identified as independent factors associated with survival. These findings suggest that circulating ELMO-3 may have potential prognostic relevance; however, the results should be interpreted with caution and require validation in larger, independent cohorts. Full article
(This article belongs to the Special Issue Future Challenges of Targeted Therapy of Cancers, 3rd Edition)
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Review

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22 pages, 647 KB  
Review
IL-18-Mediated Tumor Immune Evasion
by Shuai Li, Chenxia Gao, Hongyu Zhao, Didi Wang and Shuang Liu
Curr. Issues Mol. Biol. 2026, 48(2), 202; https://doi.org/10.3390/cimb48020202 - 12 Feb 2026
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Abstract
Immune response evasion is one of the hallmark features of cancer, which is not only the basis for cancer progression and metastasis but also affects the clinical management of cancer. Tumor immune evasion is mainly attributed to the dynamic and immunosuppressive tumor microenvironment [...] Read more.
Immune response evasion is one of the hallmark features of cancer, which is not only the basis for cancer progression and metastasis but also affects the clinical management of cancer. Tumor immune evasion is mainly attributed to the dynamic and immunosuppressive tumor microenvironment (TME), which is regulated by a complex system including immunosuppressive cells and cytokines. Interleukin-18 (IL-18) is an important cytokine that plays a multifaceted role in immune system regulation, and its function is strictly regulated by the natural antagonist IL-18 binding protein (IL-18BP). IL-18 exhibits context-dependent immunoregulatory characteristics (acting as a “context resistor”) during tumor occurrence and progression, which is closely related to cancer type, stage, and the signaling network of the tumor microenvironment. The multifaceted functions of IL-18 have been utilized in cancer treatment to reduce the phenomenon of immune escape of tumors. With the latest advancements in cancer research related to IL-18, it is necessary to integrate the latest research findings to deepen the understanding of the mechanism of tumor immune escape and promote the improvement of cancer treatment levels. This review will systematically elaborate on the action mode, core regulatory mechanism and key signaling pathways of IL-18 in tumor immune evasion, analyze the heterogeneity patterns associated with its context-dependent effects, comprehensively sort out the core obstacles in clinical translation, and at the same time, envision new precision treatment strategies based on IL-18 regulation. Full article
(This article belongs to the Special Issue Future Challenges of Targeted Therapy of Cancers, 3rd Edition)
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