Advances in Gastrointestinal Pathology

Dear Colleagues,

Gastrointestinal pathology is continuously developing at a higher rate than other fields of pathology as a consequence of changes in the epidemiology of certain diseases. In general, there is a need to reduce subjectivity in diagnosis, as well as to set more precise criteria for the objectification of diagnostic histolomorphological parameters in the form of new guides, protocols, and recommendations. In modern research, both known and new histopathological entities are being defined more and more precisely. Of course, the focus should be on the most common diseases of the gastrointestinal system, from gastroesophageal reflux disease (GERD), Barrett's metaplasia, and cancer of the esophagus and gastroesophageal junction to special forms of esophagitis, “post-helicobacter pylori gastritis” and “focally enhanced gastritis”, in pediatric patients. Another focus should be the adequate immunohistochemical and molecular profiling of intestinal and non-intestinal types of dysplasia. As far as intestinal pathology is concerned, celiac disease is increasingly common in practice, an increase in incidence of which is also being seen in the adult population of all ages, providing new challenges in classifying and grading micromorphological types of mucosal changes as accurately as possible. An emphasis should also be placed on the diagnostic criteria for certain forms of colitis, as well as inflammatory bowel disease (IBD), from the perspective of epidemiological and genetic studies. Possible directions of research include intestinal carcinogenesis as a result of colonic microbiota dysbiosis and dysplasia as a precursor lesion in relation to inflammatory atypia in the mucosal epithelium. Finally, the explication of the molecular pathogenesis of colorectal cancer, the most common entity in oncopathologies of the gastrointestinal system, is of particular importance.

Dr. Ivan R. Ilić
Dr. Pavle Randjelovic
Guest Editors

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