Single-celled eukaryote genomes predominantly replicate through multiple origins. Although origin usage during the S-phase has been elucidated in some of these organisms, few studies have comparatively approached this dynamic. Here, we developed a us...
Eukaryotes duplicate their chromosomes during the cell cycle S phase using thousands of initiation sites, tunable fork speed and megabase-long spatio-temporal replication programs. The duration of S phase is fairly constant within a given cell type,...
The duration of the cell cycle has been extensively studied and a wide degree of variability exists between cells, tissues and organisms. However, the duration of S phase has often been neglected, due to the false assumption that S phase duration is...
Tritiated thymidine autoradiography, 5-bromo-2′-deoxyuridine (BrdU) 5-chloro-2′-deoxyuridine (CldU), 5-iodo-2′-deoxyuridine (IdU), and 5-ethynyl-2′-deoxyiridine (EdU) labeling have been used for identifying the fraction of cel...
Cells have evolved elaborate mechanisms to regulate DNA replication machinery and cell cycles in response to DNA damage and replication stress in order to prevent genomic instability and cancer. The E3 ubiquitin ligase SCFDia2 in S. cerevisiae is inv...
UV-induced DNA damage response and repair are extensively studied processes, as any malfunction in these pathways contributes to the activation of tumorigenesis. Although several proteins involved in these cellular mechanisms have been described, the...
Chemotherapy has been the predominant treatment modality for cancer patients, but its overall performance is still modest. Difficulty in penetration of tumor tissues, a toxic profile in high doses, multidrug resistance in an array of tumor types, and...
The aim of this research is to verify whether there is a difference in the average duration of the active and passive phases of the game between volleyball and beach volleyball. A total of 2392 active and passive phases were measured during high-leve...
The movement of a wheelchair with manual propulsion depends on the kinematics of the human body and the forces exerted by the muscles. To design innovative wheelchair propulsion systems, the biomechanical parameters resulting from human interaction i...
The self-priming pump is a kind of centrifugal pump product with self-priming function, and the structural parameters of its reflux hole determine the performance. In order to reveal the mechanism of the self-priming process, we summarized the influe...
The aim of this work is to compare the time of surgical phases and the cumulative dissipated energy (CDE) of the phacoemulsification phase in femtosecond laser-assisted cataract surgery (FLACS) and in standard surgical procedures of phacoemulsificati...
A pilot study was conducted with the aim of adapting the processing of “Kraški pršut”, dry-cured ham, for thighs from heavy pigs. The focus was on the effect of ham weight and salting duration on the quality of dry-cured ham...
The ionospheric response to the major geomagnetic storm (SYM-H = −518 nT) of 10–11 May 2024 was investigated using total electron content (TEC) observations from the Central Asian (CAR) and East Asian (EAR) regions. In the CAR region, sho...
The energy consumption in buildings is high currently, leading to the development of the building envelope with phase change material (PCM), while the application of PCMs to the building envelope has the potential to effectively regulate the temperat...
The forehand jump smash is an essential attacking stroke within a badminton player’s repertoire. A key determinate of the stroke’s effectiveness is post-impact shuttlecock speed, and therefore awareness of critical technique factors that...
In this present study, the influence of isothermal aging temperature and duration on microstructural and mechanical properties of a hot-deformed UNS S32750 super duplex stainless steel (SDSS) alloy was investigated by SEM-EBSD (scanning electron micr...
The development of Li-ion battery cases requires superior electrical conductivity, strength, and corrosion resistance for both cathode and anode to enhance safety and performance. Among the various battery case materials, super duplex stainless steel...
Urbanised city transportation simulation needs a wide range of factors to reflect the influence of certain real-life events accurately. The vehicle composition and the timing of the traffic light signal scheduling play an important role in controllin...
We study two-machine shop-scheduling problems provided that lower and upper bounds on durations of n jobs are given before scheduling. An exact value of the job duration remains unknown until completing the job. The objective is to minimize the makes...
Background: During an apnea, oxygen depletion occurs at all tissue levels, so apnea duration is influenced by the mammalian dive reflex, which includes a bradycardia resulting in reduced cardiac oxygen consumption. This study aimed to examine the rel...
Optimum stiffness and linear deformation in the unloading phase are fundamental properties of asphalt mixtures required for the durability of flexible pavements. In this research, blends of six different aggregate gradations were used for two base co...
Endodontic preparation with ultrasonic instruments can lead to temperature rise (TR) on the external root surface (ERF), which may damage the periodontium. The aim was to measure the TR due to the ultrasonic preparation applied at different energy le...
Para swimmers categorized as S10 and S12 are of particular interest due to their disability grading being closest to that of able-bodied swimmers, making them an ideal group for investigating disparities in limb coordination patterns. This study aime...
This study describes a triathlete with effort-provoked atrioventricular nodal re-entrant tachycardia (AVNRT), diagnosed six years ago, who ineffectively controlled his training load via heart-rate monitors (HRM) to avoid tachyarrhythmia. Of the 1800...
Background: This retrospective study aimed to analyze the frequency and extent of apical root resorptions (EARR) during orthodontic treatment in the upper and lower incisors, as well as lower molars, using orthopantomograms (OPG). Potential influenci...
Magnetic nanocomposites SmCo5/α-Fe were synthesized mechanically by high-energy ball milling (HEBM) from SmCo5 and 5%wt. of α-Fe powders. The X-ray diffraction analysis reveals the hexagonal 1:5 phase as the main one accompanied by the cubic α-Fe pha...
The outdoor thermal environment can be regarded as a significant factor influencing indoor thermal conditions. The application of phase change materials (PCMs) to the building envelope has the potential to improve the heat storage performance of buil...
In this study, an AQbD-compliant chaotropic chromatography method for ziprasidone and the determination of its five impurities was developed. The influence of critical method parameters (initial and final methanol fraction in the mobile phase, gradie...
Tonic immobility (TI) is a well-known anti-predator strategy adopted by diverse preys. Numerous studies on the cost–benefit involve in TI have been reported. Although, some studies have reported the effect of mating behavior on TI, few studies...
This study examined the relationship between front crawl trunk incline and the lower limbs’ biomechanics in non-expert swimmers. Eighteen male participants (19.22 ± 1.11 years) were recorded in the sagittal plane performing 2 × 25...
Position–time tracking of athletes during a race can provide useful information about tactics and performance. However, carrier-phase differential global navigation satellite system (dGNSS)-based tracking, which is accurate to about 5 cm, might also...
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Traffic accidents causing nonrecurrent congestion and road traffic injuries seriously affect public safety. It is helpful for traffic operation and management to predict the duration of traffic incidents. Most of the previous studies have been in a c...
Bi nanocrystalline films were formed from perchlorate electrolyte (PE) on Cu substrate via electrochemical deposition with different duration and current densities. The microstructural, morphological properties, and elemental composition were studied...
Spinocerebellar ataxia 38 (SCA 38) is a rare autosomal neurological disease whose clinical features include, among others, severe gait disturbances that have not yet been fully characterized. In this study, we employed a computerized 3D gait analysis...
With a rising demand of cocaine over the last years, it is likely that unregulated new psychoactive substances with similar effects such as indatraline ((1R,3S)-3-(3,4-dichlorophenyl)-N-methyl-2,3-dihydro-1H-inden-1-amine) and troparil (Methyl (1R,2S...
By linking computational intelligence technology directly to urban transportation systems, a framework for scheduling traffic lights is proposed to enhance their flexibility in adaptation to traffic fluctuation. First, based on the flexible neural tr...
In this paper, we propose to use permutation entropy to explore whether the changes in electroencephalogram (EEG) data can effectively distinguish different phases in human absence epilepsy, i.e., the seizure-free, the pre-seizure and seizure phases....
In this study we investigate the characteristics of the diurnal precipitation cycle including the Madden–Julian oscillation (MJO) and seasonal influences over a mountainous area in Sumatra Island based on the in situ measurement of precipitatio...
Tailoring the properties of hot-stamped components offers the potential to enhance crash performance while simultaneously improving downstream joining processes. In recent years, an innovative technology suited for achieving tailored properties invol...
Injuries to racehorses and their jockeys are not limited to the racetrack and high-speed work. To optimise racehorse-jockey dyads’ health, well-being, and safety, it is important to understand their kinematics under the various exercise conditi...
The aim of this contribution is to present a segmentation method for the identification of voluntary movements from inertial data acquired through a single inertial measurement unit placed on the subject’s wrist. Inertial data were recorded fro...
The surf pop-up is a unique and challenging skill, critical to successful surfing. Hypothesizing that anthropometric characteristics of surfers influence the pop-up performance, we aimed to measure kinematics and ground-reaction forces (GRF) during a...
To address the high power consumption associated with image refresh operations in EPDs, this paper proposes a low-power driving waveform that reduces the refresh power of EPDs by lowering the system’s peak power. Compared to traditional wavefor...
Objectives. The present study aimed to quantify changes in spinal kinematics during Nordic walking compared to regular walking (RW) for 60 s on a training path among physically fit young males (n = 20, aged 19–22 years). Methods. Two walking sp...
Time–space conflicts are one of the most common issues facing construction practices, impacting safety and productivity in several negative ways at construction sites. Therefore, implementing and developing methods to reduce the frequency of su...
Engineered loess-filled gullies, which are widely distributed across China’s Loess Plateau, face significant stability challenges under extreme rainfall conditions. To elucidate the regulatory mechanisms of antecedent rainfall on the erosion an...
Forecasting the final construction contract duration at an early stage plays a vital role in the progress of a project. An inaccurate project duration prediction may lead to the project’s benefits being lost. It is essential to precisely predic...
The aim of this work is to study the hardness of the ferrite, austenite and sigma phases of a UNS S32760 superduplex stainless steel submitted to different thermal treatments, thus leading to different percentages of the mentioned phases. A comparati...
The discrete Fourier transform is considered as one of the most powerful tools in digital signal processing, which enable us to find the spectrum of finite-duration signals. In this article, we introduce the notion of discrete quadratic-phase Fourier...
This systematic review and meta-analysis assesses the effectiveness of no or low-dose versus high-dose aspirin on the incidence of coronary artery aneurysms (CAAs), intravenous immunoglobulin (IVIG) resistance, hospital stay length, and fever duratio...
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