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53 Results Found

  • Article
  • Open Access
4 Citations
3,643 Views
17 Pages

Partial Inhibition of Calcineurin Activity by Rcn2 as a Potential Remedy for Vps13 Deficiency

  • Patrycja Wardaszka,
  • Piotr Soczewka,
  • Marzena Sienko,
  • Teresa Zoladek and
  • Joanna Kaminska

26 January 2021

Regulation of calcineurin, a Ca2+/calmodulin-regulated phosphatase, is important for the nervous system, and its abnormal activity is associated with various pathologies, including neurodegenerative disorders. In yeast cells lacking the VPS13 gene (v...

  • Article
  • Open Access
1 Citations
1,345 Views
16 Pages

30 December 2024

The prerequisite for breeding a plant to be used in phytoremediation is its high tolerance to grow normally in soil contaminated by certain heavy metals. As mechanisms of plant uptake and transport of nickel (Ni) are not fully understood, it is of si...

  • Article
  • Open Access
14 Citations
3,725 Views
19 Pages

EGFRvIII Promotes Cell Survival during Endoplasmic Reticulum Stress through a Reticulocalbin 1-Dependent Mechanism

  • Juliana Gomez,
  • Zammam Areeb,
  • Sarah F. Stuart,
  • Hong P. T. Nguyen,
  • Lucia Paradiso,
  • Ahmad Zulkifli,
  • Sonakshi Madan,
  • Vijay Rajagopal,
  • Magdalene K. Montgomery and
  • Rodney B. Luwor
  • + 5 authors

10 March 2021

Reticulocalbin 1 (RCN1) is an endoplasmic reticulum (ER)-residing protein, involved in promoting cell survival during pathophysiological conditions that lead to ER stress. However, the key upstream receptor tyrosine kinase that regulates RCN1 express...

  • Article
  • Open Access
27 Citations
5,369 Views
13 Pages

18 February 2019

Regenerated cellulose nanoparticles (RCNs) reinforced waterborne polyurethanes (WPU) were developed to improve mechanical properties as well as biodegradability by using a facile, eco-friendly approach, and introducing much stronger chemical bonding...

  • Article
  • Open Access
17 Citations
5,876 Views
11 Pages

Alternative splicing (AS) is an important molecular mechanism by which single genes can generate multiple mRNA isoforms. We reported previously that, in Oryza sativa, the cyclophilin 19-4 (OsCYP19-4.1) transcript was significantly upregulated in resp...

  • Article
  • Open Access
537 Views
33 Pages

17 December 2025

Advances in visual recognition have relied on increasingly deep and wide convolutional neural networks (CNNs), which often introduce substantial computational and memory costs. This review summarizes recent progress in parameter-efficient CNN design...

  • Article
  • Open Access
12 Citations
4,230 Views
18 Pages

Adversarial Reconstruction-Classification Networks for PolSAR Image Classification

  • Yanqiao Chen,
  • Yangyang Li,
  • Licheng Jiao,
  • Cheng Peng,
  • Xiangrong Zhang and
  • Ronghua Shang

18 February 2019

Polarimetric synthetic aperture radar (PolSAR) image classification has become more and more widely used in recent years. It is well known that PolSAR image classification is a dense prediction problem. The recently proposed fully convolutional netwo...

  • Review
  • Open Access
8 Citations
4,194 Views
21 Pages

Potential Antifungal Targets for Aspergillus sp. from the Calcineurin and Heat Shock Protein Pathways

  • Robert Ancuceanu,
  • Marilena Viorica Hovaneț,
  • Maria Cojocaru-Toma,
  • Adriana-Iuliana Anghel and
  • Mihaela Dinu

19 October 2022

Aspergillus species, especially A. fumigatus, and to a lesser extent others (A. flavus, A. niger, A. terreus), although rarely pathogenic to healthy humans, can be very aggressive to immunocompromised patients (they are opportunistic pathogens). Alth...

  • Article
  • Open Access
3 Citations
2,552 Views
21 Pages

Single-frame circulation aquaculture belongs to the important category of sustainable agriculture development. In light of the visual-detection problem related to survival rate of Portunus in single-frame three-dimensional aquaculture, a fusion recog...

  • Article
  • Open Access
2,044 Views
31 Pages

This study identified 13 endoplasmic reticulum stress (ERS)-related biomarkers associated with multiple sclerosis (MS) through integrated bioinformatics analysis (including weighted gene co-expression network analysis and machine learning algorithms)...

  • Feature Paper
  • Article
  • Open Access
10 Citations
3,425 Views
13 Pages

Reticulocalbin 2 as a Potential Biomarker and Therapeutic Target for Atherosclerosis

  • Jing Li,
  • Angela M. Taylor,
  • Ani Manichaikul,
  • John F. Angle and
  • Weibin Shi

25 March 2022

Vascular inflammation initiated by oxidized lipoproteins drives initiation, progression, and even rupture of atherosclerotic plaques. Yet, to date, no biomarker is directly linked to oxidized lipid-induced vascular inflammation. Reticulocalbin 2 (RCN...

  • Article
  • Open Access
3 Citations
3,631 Views
12 Pages

Impact of Molecular Modifications on the Immunogenicity and Efficacy of Recombinant Raccoon Poxvirus-Vectored Rabies Vaccine Candidates in Mice

  • Carly M. Malavé,
  • Jaime Lopera-Madrid,
  • Lex G. Medina-Magües,
  • Tonie E. Rocke and
  • Jorge E. Osorio

4 December 2021

Rabies is an ancient disease that is responsible for approximately 59,000 human deaths annually. Bats (Order Chiroptera) are thought to be the original hosts of rabies virus (RABV) and currently account for most rabies cases in wildlife in the Americ...

  • Article
  • Open Access
3 Citations
3,100 Views
15 Pages

Reticulocalbin 3 Is a Novel Mediator of Glioblastoma Progression

  • Yi He,
  • Salvador Alejo,
  • Jessica D. Johnson,
  • Sridharan Jayamohan and
  • Gangadhara R. Sareddy

28 March 2023

Glioblastoma is the most common malignant primary brain tumor. Molecular mechanisms underlying the pathobiology of glioblastoma are incompletely understood, emphasizing an unmet need for the identification of new therapeutic candidates. Reticulocalbi...

  • Article
  • Open Access
14 Citations
4,408 Views
28 Pages

Lung and Colon Cancer Detection Using a Deep AI Model

  • Nazmul Shahadat,
  • Ritika Lama and
  • Anna Nguyen

20 November 2024

Lung and colon cancers are among the leading causes of cancer-related mortality worldwide. Early and accurate detection of these cancers is crucial for effective treatment and improved patient outcomes. False or incorrect detection is harmful. Accura...

  • Article
  • Open Access
629 Views
11 Pages

Comparing Cytoreductive Nephrectomy with Tumor Thrombectomy Between Open, Laparoscopic, and Robotic Approaches

  • Maxwell Sandberg,
  • Gregory Russell,
  • Phillip Krol,
  • Mitchell Hayes,
  • Randall Bissette,
  • Reuben Ben David,
  • Kartik Patel,
  • Brejjette Aljabi,
  • Seok-Soon Byun and
  • Alejandro R. Rodriguez
  • + 11 authors

30 October 2025

Background/Objectives: For surgical candidates with metastatic renal cell carcinoma with a tumor thrombus (mRCC-TT), surgery is cytoreductive nephrectomy with tumor thrombectomy (CN-TT). This is carried out through an open (OCN-TT), laparoscopic (LCN...

  • Article
  • Open Access
4 Citations
1,633 Views
30 Pages

5 November 2024

This study introduces a global land cover clustering using an unsupervised algorithm, incorporating the novel step of filtering data to retain only temporally stable pixels before applying K-means clustering. Unlike previous approaches that did not a...

  • Article
  • Open Access
26 Citations
7,672 Views
13 Pages

27 October 2014

In previous studies, we demonstrated in mice and prairie dogs that simultaneous administration of two recombinant raccoon poxviruses (rRCN) expressing Yersinia pestis antigens (F1 and V307—a truncated version of the V protein) provided superior prote...

  • Article
  • Open Access
10 Citations
3,146 Views
29 Pages

10 January 2023

The COVID-19 epidemic has created highly unprocessed emotions that trigger stress, anxiety, or panic attacks. These attacks exhibit physical symptoms that may easily lead to misdiagnosis. Deep-learning (DL)-based classification approaches for emotion...

  • Article
  • Open Access
23 Citations
8,796 Views
17 Pages

Prediction of Short-Time Cloud Motion Using a Deep-Learning Model

  • Xinyue Su,
  • Tiejian Li,
  • Chenge An and
  • Guangqian Wang

26 October 2020

A cloud image can provide significant information, such as precipitation and solar irradiation. Predicting short-time cloud motion from images is the primary means of making intra-hour irradiation forecasts for solar-energy production and is also imp...

  • Article
  • Open Access
2,011 Views
12 Pages

Region Collaborative Network for Detection-Based Vision-Language Understanding

  • Linyan Li,
  • Kaile Du,
  • Minming Gu,
  • Fuyuan Hu and
  • Fan Lyu

30 August 2022

Given a query language, a Detection-based Vision-Language Understanding (DVLU) system needs to respond based on the detected regions (i.e.,bounding boxes). With the significant advancement in object detection, DVLU has witnessed great improvements in...

  • Article
  • Open Access
6 Citations
2,796 Views
17 Pages

20 March 2023

The development of waterborne polyurethane (WPU) has been stimulated as an alternative to solvent-based polyurethanes due to low-VOC alternatives and reduced exposure to solvents. However, their relatively low mechanical performance and degradation h...

  • Article
  • Open Access
19 Citations
3,566 Views
18 Pages

23 February 2021

Video captioning is a popular task which automatically generates a natural-language sentence to describe video content. Previous video captioning works mainly use the encoder–decoder framework and exploit special techniques such as attention mechanis...

  • Article
  • Open Access
10 Citations
3,313 Views
17 Pages

Genomic Analysis of a mcr-9.1-Harbouring IncHI2-ST1 Plasmid from Enterobacter ludwigii Isolated in Fish Farming

  • Vera Manageiro,
  • Vanessa Salgueiro,
  • Tânia Rosado,
  • Narcisa M. Bandarra,
  • Eugénia Ferreira,
  • Terry Smith,
  • Elsa Dias and
  • Manuela Caniça

10 September 2022

This study analyzed the resistome, virulome and mobilome of an MCR-9-producing Enterobacter sp. identified in a muscle sample of seabream (Sparus aurata), collected in a land tank from multitrophic fish farming production. Average Nucleotide Identity...

  • Article
  • Open Access
3 Citations
1,675 Views
15 Pages

27 August 2024

In dairy-based imitation mozzarella cheese (IMC) formulations, intact casein is critical and imparts IMC with a firm and elastic, stringy, melted texture. Rennet casein (RCN) is the desired ingredient to provide intact casein in IMC and is preferred...

  • Article
  • Open Access
6 Citations
2,429 Views
15 Pages

Berberine Improves Cancer-Derived Myocardial Impairment in Experimental Cachexia Models by Targeting High-Mobility Group Box-1

  • Kei Goto,
  • Rina Fujiwara-Tani,
  • Shota Nukaga,
  • Yoshihiro Miyagawa,
  • Isao Kawahara,
  • Ryoichi Nishida,
  • Ayaka Ikemoto,
  • Rika Sasaki,
  • Ruiko Ogata and
  • Hiroki Kuniyasu
  • + 4 authors

Cardiac disorders in cancer patients pose significant challenges to disease prognosis. While it has been established that these disorders are linked to cancer cells, the precise underlying mechanisms remain elusive. In this study, we investigated the...

  • Article
  • Open Access
15 Citations
7,862 Views
18 Pages

12 March 2013

P index is a management tool commonly used to identify critical source areas (CSAs) in agro-catchments. We tested the applicability of several P-index models adjusted to Eastern Mediterranean conditions. On the basis of model structure and data requi...

  • Article
  • Open Access
4 Citations
2,683 Views
13 Pages

Influence of Steric Effect on the Pseudo-Multicomponent Synthesis of N-Aroylmethyl-4-Arylimidazoles

  • Nerith Rocio Elejalde-Cadena,
  • Mayra García-Olave,
  • David Figueroa,
  • Pietro Vidossich,
  • Gian Pietro Miscione and
  • Jaime Portilla

9 February 2022

A pseudo-three-component synthesis of N-aroylmethylimidazoles 3 with three new C–N bonds formed regioselectively under microwave conditions was developed. Products were obtained by reacting two equivalents of aroylmethyl bromide (ArCOCH2Br, 1)...

  • Article
  • Open Access
1,109 Views
14 Pages

Assessment of Gait Disorders in Cerebral Small Vessel Disease: Advantages of Different Clinical Scales

  • Larisa A. Dobrynina,
  • Elina T. Bitsieva,
  • Kamila V. Shamtieva,
  • Maryam R. Zabitova and
  • Marina V. Krotenkova

19 September 2025

Background/Objectives: Cerebral small vessel disease (cSVD) is one of the leading causes of gait disorders (GDs) in the elderly. Clinical diversity and lack of standardization in assessment of GDs in cSVD patients are associated with late diagnosis....

  • Article
  • Open Access
4 Citations
2,705 Views
16 Pages

MoCbp7, a Novel Calcineurin B Subunit-Binding Protein, Is Involved in the Calcium Signaling Pathway and Regulates Fungal Development, Virulence, and ER Homeostasis in Magnaporthe oryzae

  • Zi-He Wang,
  • Zi-Fang Shen,
  • Jing-Yi Wang,
  • Ying-Ying Cai,
  • Lin Li,
  • Jian Liao,
  • Jian-Ping Lu,
  • Xue-Ming Zhu,
  • Fu-Cheng Lin and
  • Xiao-Hong Liu

Calcineurin, a key regulator of the calcium signaling pathway, is involved in calcium signal transduction and calcium ion homeostasis. Magnaporthe oryzae is a devastating filamentous phytopathogenic fungus in rice, yet little is known about the funct...

  • Article
  • Open Access
3 Citations
3,524 Views
14 Pages

18 September 2021

Medical image registration is an essential technique to achieve spatial consistency geometric positions of different medical images obtained from single- or multi-sensor, such as computed tomography (CT), magnetic resonance (MR), and ultrasound (US)...

  • Article
  • Open Access
3 Citations
3,972 Views
20 Pages

Microstructural Characterization of High-Protein Dairy Powders

  • Prafulla Salunke,
  • Athira Syamala and
  • Lloyd E. Metzger

4 August 2023

Dairy proteins are potential and multipurpose ingredients used to prepare various food products. It exhibits many beneficial functionalities and bioactivities in the processing of food products. All the functionalities of different dairy proteins dep...

  • Review
  • Open Access
26 Citations
6,867 Views
16 Pages

Advances in Schiff Base and Its Coating on Metal Biomaterials—A Review

  • Zhiqiang Zhang,
  • Qingya Song,
  • Yubin Jin,
  • Yashan Feng,
  • Jingan Li and
  • Kun Zhang

13 February 2023

In recent years, metal biomaterials have emerged one after another, and have many excellent properties, playing a great role in medicine. However, these coatings cannot meet the medical needs in every aspect. Schiff base is an important organic synth...

  • Article
  • Open Access
8 Citations
7,881 Views
22 Pages

Interdisciplinarity as an Emergent Property: The Research Project “CINTERA” and the Study of Marine Eutrophication

  • Jennifer Bailey,
  • Murat Van Ardelan,
  • Klaudia L. Hernández,
  • Humberto E. González,
  • José Luis Iriarte,
  • Lasse Mork Olsen,
  • Hugo Salgado and
  • Rachel Tiller

15 July 2015

Research projects combining different disciplines are increasingly common and sought after by funding agencies looking for ways to achieve environmental, social, and economic sustainability. Creating and running a truly integrated research project th...

  • Article
  • Open Access
2 Citations
2,264 Views
15 Pages

Gene and Protein Accumulation Changes Evoked in Porcine Aorta in Response to Feeding with Two Various Fructan Sources

  • Marta Marynowska,
  • Agnieszka Herosimczyk,
  • Adam Lepczyński,
  • Marcin Barszcz,
  • Adrianna Konopka,
  • Aleksandra Dunisławska and
  • Małgorzata Ożgo

14 November 2022

In this study, two different ITFs sources were incorporated into a cereal-based diet to evaluate possible aortic protein and gene changes in nursery pigs. The animals were fed two different experimental diets from the 10th day of life, supplemented w...

  • Article
  • Open Access
1 Citations
2,044 Views
24 Pages

101 Machine Learning Algorithms for Mining Esophageal Squamous Cell Carcinoma Neoantigen Prognostic Models in Single-Cell Data

  • Yingjie Sun,
  • Yuheng Tang,
  • Qi Qi,
  • Jianyu Pang,
  • Yongzhi Chen,
  • Hui Wang,
  • Jiaxiang Liang and
  • Wenru Tang

Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive malignant tumors in the digestive tract, characterized by a high recurrence rate and inadequate immunotherapy options. We analyzed mutation data of ESCC from public databases and...

  • Review
  • Open Access
18 Citations
5,537 Views
24 Pages

Yeast as a Model to Find New Drugs and Drug Targets for VPS13-Dependent Neurodegenerative Diseases

  • Joanna Kaminska,
  • Piotr Soczewka,
  • Weronika Rzepnikowska and
  • Teresa Zoladek

Mutations in human VPS13A-D genes result in rare neurological diseases, including chorea-acanthocytosis. The pathogenesis of these diseases is poorly understood, and no effective treatment is available. As VPS13 genes are evolutionarily conserved, th...

  • Article
  • Open Access
364 Views
17 Pages

Leveraging Climate Data Through Intelligent Systems for the Prediction of Arbovirus Transmission by Aedes aegypti

  • Clarisse Lins de Lima,
  • Karla Amorim Sancho,
  • Ana Clara Gomes da Silva,
  • Ranielle Vital,
  • Cecília Cordeiro da Silva,
  • Marcela Franklin Salvador de Mendonça,
  • Fabiano Tonaco Borges,
  • Carlos Eduardo Gomes Siqueira and
  • Wellington Pinheiro dos Santos

Arboviruses spread in urban tropics under climate change. At Aedes aegypti breeding sites in Recife, Brazil, we linked surveillance and climate data from the Pernambuco Water and Climate Agency (APAC), the Brazilian National Institute of Meteorology...

  • Article
  • Open Access
4 Citations
4,368 Views
19 Pages

An Approach for Analyzing Cyber Security Threats and Attacks: A Case Study of Digital Substations in Norway

  • Sule Yildirim Yayilgan,
  • Filip Holik,
  • Mohamed Abomhara,
  • Doney Abraham and
  • Alemayehu Gebremedhin

2 December 2022

In this paper, we provide an approach for analyzing cyber security threats and attacks in digital substations, which is based on several steps we performed within our work on two Research Council of Norway (RCN) projects. In the literature, there are...

  • Article
  • Open Access
1 Citations
2,030 Views
17 Pages

A Preliminary Study on the Identification of Genes Involved in Lignification in the Endocarp of Bared-Nut Walnut (Juglans regia L.) in Xinjiang, China

  • Shangqi Yu,
  • Jiazhi Fu,
  • Qian Ye,
  • Pengyu Wu,
  • Jianping Bao,
  • Haifang Hu,
  • Zhongzhong Guo,
  • Rui Zhang and
  • Qiang Jin

This study focused on the “Xinlu” walnut and explored the molecular regulatory mechanism of lignin synthesis in the endocarp, aiming to explain the formation of bared-nut walnuts through morphological, metabolomic, and transcriptomic tech...

  • Article
  • Open Access
1,468 Views
12 Pages

21 August 2025

Oral squamous cell carcinoma (OSCC) is a malignancy with a poor prognosis, and early diagnosis is essential for improving patient survival and quality of life. This study aimed to develop a non-invasive screening method based on salivary gene express...

  • Article
  • Open Access
2 Citations
1,782 Views
23 Pages

3 June 2025

The usable floor area is one of the key parameters when appraising residential property. In Poland, valuers have to base their analysis on data from the Real Estate Price Register (RCN) in order to value a property. Unfortunately, these data often tu...

  • Article
  • Open Access
1 Citations
3,276 Views
23 Pages

13 November 2023

This work reports the one-pot synthesis of sterically demanding aniline derivatives from aryllithium species utilising trimethylsilyl azide to introduce amine functionalities and conversions to new examples of a common N,N′-chelating ligand sys...

  • Article
  • Open Access
1,123 Views
16 Pages

21 May 2025

Shrub encroachment in coastal wetlands alters vegetation–soil interactions, yet its impacts on north temperate coastal wetland ecosystems remain poorly quantified. This study investigated the effects of Tamarix chinensis-dominated shrub en...

  • Article
  • Open Access
30 Citations
4,714 Views
18 Pages

A Sustainable Decision Support System for Drinking Water Systems: Resiliency Improvement against Cyanide Contamination

  • Mohammad Gheibi,
  • Mohammad Eftekhari,
  • Mehran Akrami,
  • Nima Emrani,
  • Mostafa Hajiaghaei-Keshteli,
  • Amir M. Fathollahi-Fard and
  • Maziar Yazdani

Maintaining drinking water quality is considered important in building sustainable cities and societies. On the other hand, water insecurity is an obstacle to achieving sustainable development goals based on the issues of threatening human health and...

  • Article
  • Open Access
2 Citations
1,717 Views
21 Pages

Strain-Specific Infection of Phage AP1 to Rice Bacterial Brown Stripe Pathogen Acidovorax oryzae

  • Mengju Liu,
  • Yang Zhang,
  • Chunyan Gu,
  • Jinyan Luo,
  • Ying Shen,
  • Xuefang Huang,
  • Xinyan Xu,
  • Temoor Ahmed,
  • Hissah Abdulrahman Alodaini and
  • Bin Li
  • + 2 authors

13 November 2024

Bacteriophage (phage) AP1 has been reported to effectively lyse Acidovorax oryzae, the causative agent of bacterial brown stripe in rice. However, phage AP1 exhibits strain-specific lysis patterns. In order to enhance the potential of phages for biol...

  • Article
  • Open Access
40 Citations
5,939 Views
9 Pages

Emergence of a Multidrug-Resistant Enterobacter hormaechei Clinical Isolate from Egypt Co-Harboring mcr-9 and blaVIM-4

  • Ahmed M. Soliman,
  • Fumito Maruyama,
  • Hoda O. Zarad,
  • Atsushi Ota,
  • Hirofumi Nariya,
  • Toshi Shimamoto and
  • Tadashi Shimamoto

This study describes the first full genomic sequence of an mcr-9 and blaVIM-4-carrying multidrug-resistant Enterobacter hormaechei clinical isolate from Egypt. The strain was isolated in April 2015 from the sputum of a patient in Cairo, Egypt. The mc...

  • Article
  • Open Access
2 Citations
3,296 Views
23 Pages

Uncovering New Biomarkers for Prostate Cancer Through Proteomic and Network Analysis

  • Rossana Rossi,
  • Elena Monica Borroni,
  • Ishak Yusuf,
  • Andrea Lomagno,
  • Mohamed A. A. A. Hegazi,
  • Pietro Luigi Mauri,
  • Fabio Grizzi,
  • Gianluigi Taverna and
  • Dario Di Silvestre

4 March 2025

Background: Prostate cancer (PCa), is the second most prevalent solid tumor among men worldwide (7.3%), and the leading non-skin cancer in USA where it represents 14.9% of all new cancer cases diagnosed in 2024. This multifactorial disease exhibits s...

  • Article
  • Open Access
4 Citations
4,688 Views
17 Pages

Consolidation of the digital environment has become an irreversible global reality and, for the Colombian radio industry, it implies not only assuming a process of transformation in its actions, but, above all, continuous learning. Technological inno...

  • Article
  • Open Access
2,092 Views
13 Pages

Performance Characteristics of the Battery-Operated Silicon PIN Diode Detector with an Integrated Preamplifier and Data Acquisition Module for Fusion Particle Detection

  • Allan Xi Chen,
  • Benjamin F. Sigal,
  • John Martinis,
  • Alfred YiuFai Wong,
  • Alexander Gunn,
  • Matthew Salazar,
  • Nawar Abdalla and
  • Kai-Jian Xiao

We present the performance and application of a commercial off-the-shelf Si PIN diode (Hamamatsu S14605) as a charged particle detector in a compact ion beam system (IBS) capable of generating D–D and p–B fusion charged particles. This de...

  • Article
  • Open Access
5 Citations
2,151 Views
17 Pages

27 June 2025

Increasing soil organic carbon (SOC) storage is essential for improving soil fertility and mitigating climate change. The priming effect, which is regulated by physical, chemical and microbial interactions, plays a pivotal role in SOC turnover. Howev...

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