7,528 Results Found

Introduction: Hyperthermic IntraPEritoneal Chemotherapy (HIPEC) has evolved as a treatment for peritoneal carcinomatosis in various tumors after a careful and complete cytoreductive surgery, and it demonstrated much better and longer survival than mo...

This article discusses the increasing security risk for the Global Navigation Satellite System (GNSS) due to both unintentional and deliberate interference (attacks), which have gotten significantly worse in 2022 due to tense the international situat...

The kinematics of 3-PRS parallel mechanisms (PMs), an important category of 2R1T PMs, is very important for the motion control and error compensation of PMs. In order to produce a spindle head that could meet the requirements of various machining acc...

The evolution of 5G technology has led to significant advancements in high-accuracy positioning. However, the actual performance of 5G signals for user equipment (UE) positioning has not been thoroughly examined, especially under varying propagation...

To meet the demand for high-precision positioning in commercial industrial internet scenarios, 3GPP introduced the Positioning Reference Signal (PRS) in the 5G standard. However, the PRS signal occupies specific time and frequency resources for trans...

Breast cancer (BC) is the most prominent tumor type among women, accounting for 32% of newly diagnosed cancer cases. BC risk factors include inherited germline pathogenic gene variants and family history of disease. However, the etiology of the disea...

In this paper, a wideband and high-gain circular polarised Fabry–Perot Resonator Antenna (FPRA) with a single partially reflective surface (PRS) layer is automatically generated and optimised using a VBA-based interface system between CST Micro...

Although the incidence of new cases of human immunodeficiency virus (HIV) has decreased in the past decade, in 2018 more than 7000 women with HIV were diagnosed in the United States (US). Globally, per recent reports, 48% of the new HIV infections we...

Our research group has been developing a series of biological drugs produced by coculture techniques with M2-polarized macrophages with different primary tissue cells and/or mesenchymal stromal cells (MSC), generally from fat, to produce anti-inflamm...

(1) Background: In the U.S., men who have sex with men (MSM) account for the majority of new HIV infections. On the other hand, pre-exposure prophylaxis (PrEP) is an effective strategy to curb HIV transmission, but it is widely underutilized. It is u...

There are two central phenomena in prion disease: prion replication and prion neurotoxicity. Underlying them both is the conversion of a host-encoded ubiquitously expressed protein, prion protein (PrP^C), into a partially-protease resistant isoform, P...

PrP^Sc (scrapie isoform of the prion protein) prions are the infectious agent behind diseases such as Creutzfeldt–Jakob disease in humans, bovine spongiform encephalopathy in cattle, chronic wasting disease in cervids (deer, elk, moose, and reindeer),...

Tennessee is in the southern region of the United States and has not yet fully benefitted from HIV pre-exposure prophylaxis (PrEP). Relatively little research has focused on pivotal roles of PrEP navigators. This study examined PrEP navigator percept...

Dense Ce,Pr-doped YAG transparent ceramics (YAG:Ce,Pr) with enhanced red emission were fabricated by pressureless sintering in air at 1600 °C. Fine YAG powders containing 0.2 mol% Ce and varying amounts of Pr (0.04–0.32 mol%) were synthesiz...

Remote sensing precipitation products are essential for the systematic analysis of precipitation characteristics and changes. This study conducts a comparative evaluation of precipitation products from rain gauge stations, Climate Prediction Center m...

Cerebral cavernous malformations (CCMs) are characterized by abnormally dilated intracranial microvascular sinusoids that result in increased susceptibility to hemorrhagic stroke. It has been demonstrated that three CCM proteins (CCM1, CCM2, and CCM3...

Ending the HIV Epidemic is contingent upon the increased utilization of pre-exposure prophylaxis (PrEP). The majority of PrEP in the United States is prescribed in specialty care settings; however, to achieve national implementation goals, it is nece...

Cisgender Black women (CBW) experience 67% of new HIV diagnoses among women in the South. Progress toward ending the HIV epidemic requires researchers to explore perceptions of factors related to the decision to initiate pre-exposure prophylaxis (PrE...

The cellular prion protein (PrPc) is a cell surface glycoprotein that is highly expressed in a variety of cancer tissues in addition to the nervous system, and its elevated expression is correlated to poor prognosis in many cancer patients. Our team...

Anticancer drugs, such as fluorouracil (5-FU), oxaliplatin, and doxorubicin (Dox) are commonly used to treat colorectal cancer (CRC); however, owing to their low response rate and adverse effects, the development of efficient drug delivery systems (D...

Influenza remains a significant national health security threat, particularly for vulnerable populations, as existing control measures do not fully mitigate its impact. This gap in protection is especially pronounced early in a pandemic when a well-m...

Background: Effective HIV prevention in South Africa requires implementing pre-exposure prophylaxis (PrEP) service delivery options responsive to adolescents and young people (AYP) with diverse characteristics and needs. We aimed to identify characte...

A translucent Gd₂O₂S:Pr ceramic scintillator with an in-line transmittance of ~31% at 512 nm was successfully fabricated by argon-controlled sintering. The starting precipitation precursor was obtained by a chemical precipitation route at 80 °C u...

The functional characterization of PR10 proteins has been extensively studied in many plant species. However, little is known about the role of TdPR10 in the response of durum wheat (Triticum durum Desf.) to stress. In this study, we identified membe...

Studies on how SlPR5 genes are involved in Pst DC3000 disease resistance response are lacking. Here, 27 members of the tomato SlPR5 gene family were identified and analyzed. Analysis of conserved structural domains and promoter structure revealed tha...

Fatty acids play critical roles in plant growth and stress adaptation, primarily through modulating membrane fluidity. This study combined bioinformatics (genome-wide identification and chromosomal localization) with experimental techniques (RT-qPCR,...

Pathogenesis-related (PR) proteins are important in plant pathogenic resistance and comprise 17 families, including the PR4 family, with antifungal and anti-pathogenic functions. PR4 proteins contain a C-terminal Barwin domain and are divided into Cl...

The cellular prion protein (PrP^C) is a glycoprotein anchored to the cell surface by glycosylphosphatidylinositol (GPI). PrP^C is expressed both in the brain and in peripheral tissues. Investigations on PrP^C’s functions revealed its direct involv...

Background: Ivabradine reduces heart rate by inhibiting the “funny current” expressed on the sinoatrial node and improves mortality and morbidity in patients with systolic heart failure and sinus tachycardia. The funny current is known to...

Little knowledge about pre-exposure prophylaxis (PrEP) use in trans and gender diverse (TGD) communities in Germany exists. The PrApp Study collected data on PrEP use and sexual behaviour among PrEP users in Germany. Descriptive methods and logistic...

Protein phosphatase 2 regulatory subunit B, alpha (PPP2R3A), a regulatory subunit of protein phosphatase 2A (PP2A), is a major serine/threonine phosphatase that regulates crucial function in development and growth. Previous research has implied that...

Progesterone (PRG) is a key cyclical reproductive hormone that has a significant impact on female organs in vertebrates. It is mainly produced by the corpus luteum of the ovaries, but can also be generated from other sources such as the adrenal corte...

In this study, facile construction engineering of Pr₆O₁₁@C with efficient photocatalytic activity was established. Taking advantage of the flocculation of Pr³⁺ in the base medium, acid red 14 (AR14) was flocculated together with Pr(OH)₃ precipitate,...

The prion diseases are a collection of fatal, transmissible neurodegenerative diseases that cause rapid onset dementia and ultimately death. Uniquely, the infectious agent is a misfolded form of the endogenous cellular prion protein, termed PrP^Sc. De...

GmSNAP18 and GmSHMT08 are two major genes conferring soybean cyst nematode (SCN) resistance in soybean. Overexpression of either of these two soybean genes would enhance the susceptibility of Arabidopsis to beet cyst nematode (BCN), while overexpress...

The Arabidopsis thaliana pathogenesis-related 1 (PR1) is an important defense protein, so far it has only been detected in extracellular space and its subcellular sorting and transport remain unexplained. Using a green fluorescent protein (GFP) tagge...

The impact of rare earth oxide (REO) concentration on the deposition process and selective recovery of the metal being deposited from a molten fluoride salt system was investigated by applying deposition of Nd and Pr and varying the concentration of...

The pathological prion protein, PrP^Sc, displays various sizes of aggregates. In this study, we investigated the conformation, aggregation stability and proteinase K (PK)-sensitivity of small and large PrP^Sc aggregates of mouse-adapted prion strains....

This paper addresses the upconversion of blue light to ultraviolet-C (UVC) with Pr³⁺-activated materials for antibacterial applications of UVC. It discusses the processes through which UV radiation provides biocidal effects on microorganisms, along w...

Five samples of lanthanum pyrosilicate (La₂Si₂O₇) single crystals with 0.5–10.0% Praseodymium (Pr)-doping concentrations were synthesized by the floating-zone method. Photoluminescence and scintillation properties of these crystals were investi...

The misfolding of the cellular prion protein (PrP^C) into the disease-associated isoform (PrP^Sc) and its accumulation as amyloid fibrils in the central nervous system is one of the central events in transmissible spongiform encephalopathies (TSEs). Du...

PrEP uptake in the Netherlands is growing but remains at suboptimal levels. Hence, the analysis of hurdles is paramount. Given the initial focus of PrEP provision among men-who-have-sex-with-men (MSM) via a demonstration project that was launched in...

Background: The fetal mechanical PR interval (mPR), measured using pulsed-wave Doppler, is a widely used parameter to assess atrioventricular conduction in fetuses, particularly in cases at risk of developing atrioventricular (AV) block. However, the...

Bovine spongiform encephalopathy (BSE) belongs to the group of transmissible spongiform encephalopathies and is associated with the accumulation of a pathological isoform of the host-encoded glycoprotein, designated prion protein (PrP^Sc). Classical B...

We review an argument that bipartite “PR-box” correlations, though designed to respect relativistic causality, in fact violate relativistic causality in the classical limit. As a test of this argument, we consider Greenberger–Horne&...

In this study, the gene ZmPR5, associated with resistance to ear rot, was identified through transcriptome data analysis of the maize inbred line J1259. The gene was subsequently cloned and its function was investigated. The ZmPR5 gene comprises an o...

The most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is the presence of poly-PR/GR dipeptide repeats, which are encoded by the chromosome 9 open reading frame 72 (C9orf72) gene. Recently, it was shown...

The results presented in this communication concern visible and near-IR emission of Pr³⁺ ions in selected inorganic glasses, i.e., borate-based glass with Ga₂O₃ and BaO, lead-phosphate glass with Ga₂O₃, gallo-germanate glass modified by BaO/BaF₂, and...

The global fight against HIV/AIDS has been significantly bolstered by the development and implementation of pre-exposure prophylaxis (PrEP), yet innovation in PrEP interventions, improved adherence and greater access are still needed to maximize its...

Long-acting injectable HIV pre-exposure prophylaxis (LAI-PrEP) demonstrates superior efficacy to oral PrEP but faces a critical implementation challenge: 47% of patients fail to receive their first injection during the “bridge period” bet...