Women

Physical activity (PA) participation among university women is influenced by behavioural, psychosocial, and contextual factors. This study aimed to identify hierarchical profiles associated with PA participation using exploratory segmentation methods. A multicentre cross-sectional study was conducted with 417 university women from Chile, Spain, Italy, and Mexico (mean age = 22.2 ± 5.1 years). Participants completed validated questionnaires assessing habitual PA (IPAQ-SF), perceived barriers to PA (BBAQ-21), dietary quality (HEI), and health-related characteristics. Classification and Regression Trees (CART) and Exhaustive Chi-square Automatic Interaction Detection (CHAID) analyses were performed. Self-reported PA change since the pandemic emerged as the first-order segmentation variable within both exploratory models. Women reporting reduced PA since the pandemic had lower observed compliance with WHO recommendations (62.7%) than those reporting stable or increased PA (85.8%). Lack of energy (χ² = 18.61, p < 0.001) and lack of willpower (χ² = 28.63, p < 0.001) were the barriers most strongly associated with less favourable PA profiles. These findings support the value of segmentation-oriented approaches for understanding behavioural heterogeneity and informing gender-sensitive health-promotion initiatives in higher education settings. Given the cross-sectional and self-reported design, findings should be interpreted as exploratory segmentation patterns rather than predictive or causal evidence. Full article

Toxoplasmosis remains one of the most common parasitic infections affecting humans, with significant implications for pregnancy and fetal health. Maternal primary infection during gestation can result in transplacental transmission of Toxoplasma gondii, leading to a wide spectrum of congenital disease. The risk of vertical transmission increases with gestational age, whereas disease severity is inversely related—early infections causing severe neurological and ocular damage, and late infections often resulting in subclinical forms. Advances in serological testing, including IgG avidity assays and molecular diagnostics such as PCR on amniotic fluid, have improved early detection and management. Prenatal treatment with spiramycin or pyrimethamine–sulfadiazine–folinic acid combinations has been associated with reduced transmission and less severe fetal disease in several studies, although the magnitude of benefit remains debated. Long-term follow-up is essential, as late-onset manifestations, particularly chorioretinitis and neurodevelopmental impairment, are common. This narrative review was based on a comprehensive literature search of major medical databases and summarizes current knowledge on the epidemiology, pathophysiology, diagnosis, treatment, and outcomes of toxoplasmosis in pregnancy. Particular emphasis is placed on high-prevalence countries, where greater parasite genetic diversity, distinct epidemiological patterns, and a higher burden of congenital disease pose unique clinical and public health challenges. Despite progress in understanding parasite biology, pathogenesis, and treatment efficacy, congenital toxoplasmosis continues to be underdiagnosed and underreported, especially in low-resource settings. Ongoing challenges include optimizing screening strategies, ensuring access to standardized therapies, and strengthening surveillance systems. Full article

Menopause marks a complex biopsychosocial transition defined by the permanent cessation of menstruation resulting from the loss of ovarian follicular activity. South Asian women tend to experience menopause earlier (45–47 years) than North American women, yet limited culturally appropriate interventions exist to address their symptoms. While hormone replacement therapy can reduce discomfort, its associated risks and limited cultural feasibility restrict its use in this population. There is a growing need to explore non-pharmacological and culturally relevant alternatives. Physical activity has been associated with potential well-being benefits during menopause. This study examined the prospective acceptability of a pedometer-based walking intervention, encouraging 10,000 steps daily, among South Asian immigrant women. The study was conducted in 2024 and completed within approximately seven months. A cross-sectional survey was conducted with 64 South Asian women aged 40–70+ years, who completed a questionnaire assessing the prospective acceptability and perceived barriers to participation. Overall, participants reported moderate to high levels of acceptability of the proposed walking intervention. Some participants perceived potential benefits for well-being; however, given the study design, effectiveness and symptom management outcomes were not assessed. Sociocultural factors—such as family responsibilities, modesty concerns, and limited access to supportive environments—were identified as potential barriers to participation. These findings suggest that a pedometer-based walking intervention may be acceptable to some South Asian immigrant women, though acceptability was not uniform and may be influenced by contextual factors, including opportunity costs. Further research using longitudinal or interventional designs is needed to evaluate feasibility, uptake, and effectiveness. Full article

When women choose a contraceptive method, the decision depends not only on what they prefer but also on the quality of the information they encounter online and on how confident they feel about using a method. We examined how exposure to inaccurate online contraceptive information (“digital misinformation”) and uncertainty about contraceptive decisions (“decisional conflict”) related to mental health and quality of life in women with and without a history of abortion. This was a cross-sectional study of 134 women aged 18–42 years attending obstetrics–gynecology or family-planning services at one Romanian tertiary center. Women were grouped as having no prior abortion (n = 41), one prior abortion (n = 53), or repeat abortion (n = 40). We measured a study-specific digital misinformation index, an access barrier index, contraceptive self-efficacy, reproductive autonomy, depression (PHQ-9), anxiety (GAD-7), well-being (WHO-5), quality of life (WHOQOL-BREF), and current use of highly effective contraception. We compared groups and used regression, mediation, and exploratory profiling. Women with repeat abortion reported the most online misinformation (10.0 ± 2.0), the most decisional conflict (43.9 ± 9.3), the lowest quality of life (61.3 ± 5.6), and the lowest use of highly effective contraception (45.0%). More misinformation and more access barriers were each associated with greater decisional conflict, while higher self-efficacy was associated with less. In this cross-sectional sample, online misinformation and decisional uncertainty were associated with reproductive vulnerability more closely than abortion count alone. Findings are associational and require prospective confirmation. Full article

Pregnancy-related low back pain (LBP) is a highly prevalent condition with substantial consequences. However, its relationship with objective perinatal outcomes has been scarcely investigated. The aim of this study was to analyze the association between the presence and intensity of pregnancy-related LBP with delivery and perinatal outcomes. An analysis of a prospective cohort was performed including 147 physically active (PA) pregnant women, defined as those meeting the World Health Organization recommendations for PA (≥600 MET·min/week), assessed using the short version of the International PA Questionnaire. Participants were classified according to the presence (64.6%) or absence of LBP during pregnancy. Umbilical artery pH was significantly lower in neonates born to women with LBP compared with those without LBP (7.24 ± 0.10 vs. 7.29 ± 0.06; p < 0.001). Within the LBP group, higher pain intensity was moderately and inversely correlated with umbilical artery pH (Spearman ρ = −0.42, p = 0.037) and remained independently associated with lower umbilical artery pH values in multivariable linear regression analysis after adjustment for relevant maternal characteristics and PA. Apgar scores were globally normal, with no clinically relevant differences between groups. No significant differences were observed in other delivery and perinatal outcomes. These findings suggest an association between pregnancy-related LBP and subtle changes in fetal acid-base status at birth but should be interpreted cautiously from a clinical perspective. Full article

Intimate partner violence (IPV) against women is recognized as a public health and human rights issue globally. Nigeria continues to experience a substantial burden of IPV. This study analyzed patterns and multilevel factors associated with violence against women in Nigeria, including emotional, physical, and sexual violence. This study analyzed data from 5458 women aged 15 to 49 years who participated in the 2024 Nigeria Demographic and Health Survey (NDHS). We computed multivariable binary logistic regression and Firth logistic regression (for relatively rare events). Women whose partners consumed alcohol had higher odds of experiencing emotional violence (AOR = 2.97), less severe physical violence (AOR = 3.11), severe physical violence (AOR = 3.22), and sexual violence (AOR = 2.07). Partner controlling behaviors, including restricting contact with family or friends, was also consistently linked to elevated IPV risk. Women living with a partner had higher odds of severe physical and sexual violence. Higher education and greater household wealth were associated with lower IPV outcomes. Our study provides practice-relevant evidence and policy implications, including the need for integrated prevention strategies that address behavioral risk factors, strengthen early screening for controlling behaviors, and promote women’s socioeconomic empowerment. Full article

This prospective observational study investigated secondhand smoke (SHS) exposure levels across gestational stages and identified longitudinal associated factors among pregnant women in Darkhan-Uul Province, Mongolia. Participants recruited between October 2019 and September 2020 answered a self-administered questionnaire and provided spot urine samples at each trimester. SHS exposure was assessed via urinary cotinine (UC) levels, and generalized estimating equations were used to identify associated factors. The final sample included 526 participants. UC levels ≥ 5 ng/mL were observed in 40.1%, 32.0%, and 29.0% of participants in the first, second, and third trimesters, respectively. Compared to the first trimester, the risk of SHS exposure was significantly lower in the second (adjusted odds ratio [AOR]: 0.70; 95% confidence interval [CI]: 0.54–0.91) and third trimesters (AOR: 0.59; 95% CI: 0.45–0.77). Additionally, compared to smoke-free households, those permitting smoking in designated areas (AOR: 1.70; 95% CI: 1.28–2.26) or having no restrictions (AOR: 2.54; 95% CI: 1.29–4.96) showed higher odds of exposure. These results highlight the importance of household smoking restrictions and should be disseminated among pregnant women, their families, and healthcare providers to reduce risk of SHS exposure. Full article

This study aimed to evaluate the effectiveness of counseling and educational interventions delivered during pregnancy and early motherhood in promoting maternal health knowledge, self-care behaviors, and related health outcomes among adolescent and young women. A systematic review of randomized controlled trials and quasi-experimental studies published in English or Spanish was conducted using Medline, Web of Science, Scopus, Cinahl, and the Cochrane Library. Methodological quality was assessed using Joanna Briggs Institute critical appraisal tools, and risk of bias was evaluated using the Risk-of-Bias 2 and ROBINS-I tools. Data were synthesized narratively and in tables. When comparable outcomes were reported, preliminary meta-analyses were performed using standardized mean differences with random-effects models. The certainty of evidence was assessed using the GRADE approach. Seven studies (n = 7) involving 776 participants were included. Interventions consisted of counseling or educational programs delivered through face-to-face sessions, group activities, or digital resources. Overall, the interventions were associated with improvements in pregnancy-related knowledge, self-care behaviors, psychological outcomes, and maternal health practices and attitudes; however, the certainty of evidence was low to very low and a high risk of bias was identified across studies. Meta-analysis suggested a possible beneficial effect favoring the intervention for pregnancy-related health knowledge (SMD = 1.90; 95% CI: −0.02 to 3.83) and self-care behaviors (SMD = 2.39; 95% CI: 0.29 to 4.49), although substantial heterogeneity was observed. Counseling and educational interventions during pregnancy may contribute to improvements in pregnancy-related health knowledge and self-care among pregnant adolescents and young women; however, the current evidence is limited and of low certainty. Further well-designed studies conducted in diverse settings are needed to confirm these findings and strengthen the evidence base. Full article

Maternal hemorrhage (MH) remains a leading preventable cause of maternal health, yet global disparities on its burden remain poorly quantified. Using the Global Burden of Disease 2021 data, we analyzed global, regional, and national trends in age-standardized maternal mortality ratio (ASR_MMR) attributed to MH from 1990 to 2021. We applied Joinpoint regression, age–period–cohort modeling, inequality indices and frontier analysis. This descriptive–analytical ecological study is based on modeled secondary data. Globally, the proportion of ASR_MMR attributed to MH declined from 33.31% in 1990 to 24.52% in 2021 (relative reduction: 24.24%). ASR_MMR attributed to MH consistently declined, with an estimated annual percentage change (EAPC) of −3.17 (95% UI: −3.42, −2.91). In 2021, Central and West Africa countries reported ASR_MMR attributed to MH exceeding 300 per 100,000 live births, while the Caribbean experienced a temporary increase. ASR_MMR attributed to MH was strongly inversely correlated with the socio-demographic index (SDI). Absolute inequality (slope index of inequality) narrowed by 49.4%, while relative inequality (concentration index) increased by approximately 27.5%. Countries with the largest negative deviations from the frontier included Somalia, the Central African Republic, Chad, Nigeria, and Afghanistan. While substantial global progress has been made, socioeconomic inequities continue to drive persistent disparities in MMR attributed to MH. Policies must not only address average reductions but also the widening relative gap between advantaged and disadvantaged populations. Full article

Period poverty, defined as difficulty affording menstrual products, is increasingly recognized as a basic needs issue among students in the United States. However, evidence on the prevalence and awareness of this phenomenon among both undergraduate and graduate populations remains limited. Therefore, the aim of this descriptive cross-sectional study is to describe period poverty experiences and awareness levels among menstruating college students at a public university in South Florida. An online survey was administered to menstruating undergraduate and graduate students (n = 151). Period poverty was assessed using a past-year affordability question, while awareness of period poverty was measured descriptively through seven items derived from a previous study on period poverty in U.S. college students. Overall, 13.9% of respondents reported past-year period poverty. Awareness of period poverty was limited, despite high support for policies providing free menstrual products. Only 16.67% perceived period poverty to be highly prevalent in developed countries, and only 8% believed that it existed in their local area. Three fourths (75.00%) of the sample strongly supported policies to provide free menstrual products. Finally, over half of the respondents felt “not at all embarrassed” (55.07%) towards buying menstrual products, while just over one fourth reported being “fairly embarrassed” (28.26%). The discrepancy between the number of students experiencing period poverty and the levels of awareness of the issue shows a clear need for evidence-based educational interventions and menstrual resources on college campuses to improve overall menstrual well-being. Full article

Attention deficit/hyperactivity disorder (ADHD) is a neurodevelopmental condition frequently associated with psychiatric comorbidity, including disordered eating. Adult women remain under-recognized and underrepresented in ADHD research, and emerging evidence suggests that symptom expression may be shaped by gendered social factors, ovarian hormone fluctuations, and metabolic health. In this manuscript, we provide a gender-focused theoretical overview of the literature linking ADHD to binge eating symptoms in adult women, with attention to underdiagnosis, menstrual cycle-related symptom variability, and obesity-related metabolic risk, and empirically test the association between a self-reported ADHD diagnosis and binge eating symptoms in an online cross-sectional sample of adult women. Women reporting an ADHD diagnosis (n = 140) were compared with a random subsample of n = 140 women without ADHD drawn from the same survey; comparability between groups on age, education, and employment was formally verified; and binge eating symptoms were assessed with the Binge Eating Scale (BES) as a continuous outcome and as an ordered three-category variable. Women reporting an ADHD diagnosis showed significantly higher BES scores than controls (rank-biserial r = 0.28, 95% CI 0.15–0.41), and a higher proportion of severe binge eating symptomatology (BES ≥ 27; 22.1% vs. 11.4%; OR = 2.20, 95% CI 1.14–4.25) than controls. The association remained significant in a sensitivity analysis adjusting for age and BMI. Taken together, our findings support the need for routine, gender-sensitive screening for binge eating symptoms in women with ADHD, as well as ADHD screening in women presenting with binge eating and obesity. Full article

The United States faces a worsening maternal mortality crisis that starkly contrasts with trends in other high-income nations. Maternal mortality rates (MMRs) have more than doubled over the past two decades, rising from 9.65 deaths per 100,000 live births in 1999–2002 to 23.6 in 2018–2021, with approximately 700 deaths annually. Black and American Indian/Alaska Native women experience maternal mortality rates two to three times higher than their White counterparts, reflecting persistent structural inequities rather than biological differences. This narrative review synthesizes current evidence on the underlying drivers of racial inequities in maternal mortality and evaluates evidence-based interventions and policy strategies to address these disparities. A comprehensive literature review between 2000 and 2025 was conducted using databases including PubMed, Scopus, Web of Science, and Google Scholar, focusing on studies examining clinical, social, and structural determinants of maternal health outcomes, as well as evidence-based interventions and maternal health policy. Targeted searches of policy reports and grey literature were also performed to identify relevant policy initiatives and system-level interventions. Key contributors to disparities include underlying health conditions, postpartum mental health inequities, provider shortages, and limited access to postpartum care, with pregnancy-associated breast cancer (PABC) representing a less common but clinically significant risk factor that warrants further investigation in the context of racial inequities. Structural racism and socioeconomic disparities further exacerbate inequities through differential access to care, treatment bias, and barriers to healthcare utilization. System-level challenges, including workforce shortages, maternity care deserts, and the absence of federally mandated paid maternity leave, disproportionately impact marginalized populations. Although policy initiatives such as Medicaid postpartum coverage extensions, the Maternal Health Momnibus Act, and Maternal Mortality Review Committees represent important progress, they remain insufficient without broader structural reform. Evidence-based interventions, including midwife- and doula-led care, community-based peer support, and culturally tailored mental health programs, demonstrate measurable improvements in maternal outcomes. Outcomes of this review highlight the need for a comprehensive, equity-centered approach to reducing maternal mortality disparities, emphasizing structural reform, expanded access to care, strengthened data systems, and community-driven solutions. Full article

Emerging evidence suggests that psychological trauma, chronic stress, and unresolved emotional conflict may influence cancer-related processes through neuroendocrine and immunological pathways. However, the clinical relevance of trauma-related psychological profiles in oncology remains insufficiently defined, particularly in women with breast and gynecological cancers. This exploratory observational study included 135 women with breast, cervical, ovarian, and endometrial cancers undergoing multimodal oncological treatment. Psychological assessments were performed using validated instruments, including the PTSD Checklist (PCL), Hamilton Anxiety and Depression Scales (HAM-A, HAM-D), the Adult Attachment Scale (AAS), and a Lazarus-based checklist of stressful life events to assess cumulative stress exposure. Descriptive and exploratory analyses were conducted to identify clinically relevant patterns. A high prevalence of anxiety, depressive symptoms, and trauma-related distress was observed. Insecure attachment patterns were frequent and associated with increased psychological burden. Many patients reported moderate-to-high cumulative stress exposure, suggesting broader vulnerability profiles characterized by emotional dysregulation. These findings support a biopsychosocial model in which trauma, attachment insecurity, and cumulative stress are associated with psychological vulnerability in oncology. Although causal relationships cannot be established, these factors may influence coping and adaptation to disease. Integrating trauma-informed psychological assessment into oncology care may enhance patient-centered management. Full article

Systemic inflammation plays a key role in the pathophysiology of pre-eclampsia (PE) and gestational diabetes mellitus (GDM). Recently, the Systemic Immune Inflammation (SII) and Systemic Inflammation Response Index (SIRI) indices have emerged as potential risk predictors, but current evidence shows mixed results. The aim of this meta-analysis was to assess the association between elevated SII/SIRI levels and the development of both complications. In accordance with the PRISMA guidelines, a search was conducted in PubMed, Scopus and Web of Science (up to February 2026). Observational studies linking the SII and SIRI indices to PE and GDM were included. Methodological quality (NHLBI tools) and evidence (GRADE) were assessed, and a random-effects meta-analysis was applied to synthesise the measures of association. Thirteen studies involving more than 150,000 pregnant women were included. The meta-analyses demonstrated that elevated levels of SII and SIRI are associated with an increased risk of GDM by 28% (OR = 1.28; 95% CI: 1.16–1.42) and 27% (OR = 1.27; 95% CI: 1.11–1.48) respectively, albeit with considerable heterogeneity. They also increase the risk of PE by 16% (OR = 1.16; 95% CI: 1.08–1.24) and 21% (OR = 1.21; 95% CI: 1.05–1.40), without significant heterogeneity. Although the quality of the studies was good, the strength of the evidence was low for GDM and very low for PE. Therefore, while these indices show potential as early biomarkers, these findings should be considered suggestive and require further validation and standardisation across diverse populations. Full article

Gender-based violence constitutes a major public health and social concern, with particularly complex implications in structurally vulnerable contexts such as rural settings. However, empirical evidence regarding the specific profile and risk perception of women experiencing gender-based violence in small municipalities remains limited. The aim of this study was to analyze the sociodemographic characteristics of women victims of gender-based violence residing in small rural municipalities and to examine their associations with mental health indicators and perceived risk of future violence. The sample comprised 30 women receiving support at a Specialized Care Centre for Victims of Gender-Based Violence (CAVI) serving three small municipalities in the Vega Media region (Region of Murcia, Spain). Standardized measures of depression, anxiety, and stress were administered, together with an assessment of perceived risk. The findings suggest a specific sociodemographic profile characterized by moderate levels of depression, anxiety, and stress symptoms and generally low perceived risk. Women without children reported higher levels of psychological distress and perceived risk than those with children, although these differences should be interpreted with caution given the sample size. Overall, these findings provide preliminary insights into the characteristics and risk perception of women experiencing gender-based violence in rural settings and highlight the need for context-sensitive prevention and intervention strategies. Full article

Motherhood is a profoundly transformative stage, associated with both emotional fulfillment and psychological and physical vulnerability. The aim of this study was to assess the perceptions, difficulties and resources needed by mothers in the experience of motherhood. We conducted an exploratory cross-sectional observational study, based on an online questionnaire administered to 172 mothers. We analyzed socio-demographic data, experiences related to pregnancy and childbirth, perceived level of support, emotional difficulties, and resources considered useful in the role of motherhood. Most participants were women aged 30 to 45, with university or postgraduate education, married and with one or more children. Although motherhood was predominantly described in positive terms such as “fulfillment”, “love” and “joy”, a significant percentage of mothers reported increased fatigue, lack of personal time and emotional difficulties. The resources considered essential for maternal balance were family support, personal time, emotional support and access to clear and empathetic medical information. In conclusion motherhood is perceived as a complex experience, in which fulfillment frequently coexists with emotional overload and vulnerability. This exploratory study highlights the complex emotional and psychosocial dimensions of motherhood among Romanian women. The findings suggest the need for accessible emotional and social support resources. A comprehensive approach addressing both emotional and practical needs may contribute to improved maternal well-being. Full article

The Latin American Development Group for Maturity (GDLAM) protocol has been widely used to assess functional autonomy (FA) in community-dwelling older adults. However, to date, no percentile-based rating scale has been established for older Chilean women living in the community. The aim was to create a percentile-based rating scale for the GDLAM protocol in community-dwelling older Chilean women. 347 older women volunteered for this study. The sample was divided into five groups by age ranges (G1: 60.0–64.9 years, G2: 65.0–69.9 years, G3: 70.0–74.9 years, G4: 75.0–79.9 years, and G5: ≥80.0 years). The research had an observational, cross-sectional design with a descriptive strategy. The GDLAM protocol included (a) Putting on and taking off a T-shirt (PTS), (b) Standing up from the sitting position (SSP), (c) Standing up from the prone position (SPP), (d) Walking 10 m (W10 m), and (e) Sit-ting and getting up from the chair and moving around the house (SCMA), all assessed in seconds (s), while the General Index of Autonomy (GI) was calculated in points (p). The percentile-based classification was developed with the following thresholds: percentile ≤ 0.15: “Very Good,” percentile 0.16–0.49: “Good,” percentile 0.50–084: “Regular,” and percentile ≥ 0.85: “Poor.” After creating the percentile-based ranking scale for the five age ranges, it was observed that the older the age, the lower the FA, as represented by the five tests and the GI. The percentile-based ranking scale presented in this research will enable us to accurately assess and interpret the FA of older and community-dwelling women in Chile. However, the study is limited to women and cannot be generalized to older adults in general. Full article

The protective effect of physical activity on breast cancer recurrence may be mediated changes in by sex hormone levels. In this study, we examined the association between habitual physical activity and estrogen and androgen plasma levels in postmenopausal women with localised breast cancer. We conducted a cross-sectional study among 47 postmenopausal women who were breast cancer survivors with estrogen receptor-positive tumours (enrolled at the Medical Oncology Department of University Hospital Dr. Peset, Valencia, Spain). Habitual physical activity was assessed using the International Physical Activity Questionnaire (IPAQ), and a weighted estimate of total physical activity per week (MET∙min∙wk⁻¹) was calculated. Total plasma levels of estrone, 17β-estradiol, progesterone, androstenedione, testosterone, and dehydroepiandrosterone-sulphate (DHEA-sulphate) were measured. Bivariate analyses by the Spearman correlation test were done between physical activity and each hormone concentration. Multivariate analyses (linear regression) using concentration of each hormone as the dependent variable and physical activity, age, marital status, BMI, Charlson Comorbidity Index, tumour stage, previous radiotherapy, or previous chemotherapy as predictor variables. Estrone concentration was positively and significantly correlated with BMI (ρ = 0.332, p = 0.022), but no other correlations were found between BMI and the other hormone concentrations, nor were concentrations of any hormone associated with age or Charlson Comorbidity Index (p > 0.05 in all cases). Physical activity was significantly and inversely correlated with estrone concentration (ρ = −0.308; p = 0.035). Linear regression analysis confirmed a statistically significant association between estrone concentration and BMI and physical activity, after adjusting for all potential confounders (for BMI: standardised β coefficient = 0.407; non-standardised β coefficient = 1.054; t = 2.898; p = 0.006; 95% CI for non-standardised beta: 0.318- to 1.790; for physical activity: standardised β coefficient = −0.300; non-standardised β coefficient = −0.005; t = −2.135; p = 0.039; 95% CI for non-standardised beta: −0.010- to 0.000). The relationship between estrone concentration and physical activity may be further explored as a biomarker for evaluating the protective effect of physical activity against breast cancer recurrence in women receiving anti-estrogen therapies. Full article

Gestational diabetes mellitus (GDM) is a prevalent metabolic disorder associated with adverse maternal and fetal outcomes. However, current diagnostic strategies have a limited capacity to identify women at risk early in pregnancy. In this longitudinal prospective pilot study, 200 pregnant Mexican women were recruited at 11–14 weeks and underwent follow-up throughout pregnancy. Of these, 34 women (19 with GDM and 15 with normal glucose tolerance [NGT]) completed follow-up and were included in the final analyses. Most withdrawals were due to logistical constraints, although the reduced final sample size should be considered when interpreting generalizability. Nine serum proteins (ADIPOQ, AFM, FABP4, IGFBP-5, PAPP-A, PAPP-A2, RBP4, RETN, SHBG) were measured simultaneously using an antibody array and subsequently validated by ELISA. FABP4 showed the greatest increase in the first trimester (4.9-fold, p = 0.0105) and the highest apparent discriminative performance (AUC = 0.91), which declined in the second and third trimesters. Exploratory, hypothesis-generating multivariable analyses suggested a stronger association when FABP4 was combined with gravidity and serum triglycerides (AUC up to 0.97). Overall, FABP4 emerged as a promising candidate biomarker for early GDM detection in Mexican women; however, these findings are preliminary and require validation in larger, independent cohorts to support early risk stratification. Full article