Congenital insensitivity to pain is a rare human condition in which affected individuals do not experience pain throughout their lives. This study aimed to identify the molecular etiology of congenital insensitivity to pain in two Thai patients. Clin...
The plectin (PLEC) gene is crucial in regulating muscle development and maintaining the cytoskeleton. An abnormal expression of PLEC can lead to muscle atrophy and muscular dystrophy. In a previous study, we found that Leizhou black goats exhibit abu...
We identified the known c.1_9del mutation in the PLEC gene in four unrelated females from consanguineous families of Turkish origin. All individuals presented with slowly progressive limb-girdle weakness without any dermatological findings, and dystr...
Hardware-in-the-loop (HIL) simulation is an essential tool for rapid and cost-effective development and validation of power-electronic systems. The primary objective of this work is to validate and fine-tune a PLECS-based HIL model of a single dual a...
Papillary thyroid carcinoma (PTC) typically exhibits a favorable prognosis; however, lymph node and distant metastases continue to present significant clinical challenges. Plectin isoform 1d (PLEC 1d) contributes to myofiber integrity and is implicat...
Background: Diabetic retinopathy (DR), a leading cause of blindness, lacks early biomarkers and mechanism-targeted therapies. While oxidative stress drives DR pathogenesis, the role of oxeiptosis—a reactive oxygen species-induced, caspase-indep...
This paper provides an overview of an early attempt at developing a simulation model on a solid-state transformer (SST) based on input-serial and output-parallel (ISOP) topology. The proposed SST is designed as a base for a smart grid (SG). The paper...
Epidermolysis bullosa (EB) includes a group of rare gesnodermatoses that result in blistering and erosions of the skin and mucous membranes. Genetically, pathogenic variants in around 20 genes are known to alter the structural and functional integrit...
The paper discusses the methods of fast analysis of DC–DC converters dedicated to computer programmes. Literature methods of such an analysis are presented, which enable determination of the characteristics of the considered converters in the s...
The design of modern power electronics converters requires accurate electrothermal device models enabling a straightforward parameter estimation and fast, yet accurate, circuit simulations. In this paper, a novel electrothermal averaged model of a di...
The growing share of photovoltaic generation in power grids intensifies the need for converter architectures capable of combining efficient energy conversion, DC-bus stability, and ancillary service provision at the grid coupling point. This paper pr...
To address the issues of high switching losses in power devices and device temperature rise caused by hard switching in conventional plasma power supplies, this study presents a dielectric barrier discharge plasma power supply system based on a zero-...
The utilization of photovoltaic (PV) generation to charge storage batteries in recreational vehicles (RVs) is becoming increasingly prevalent. However, the performance of PV generation systems is hindered by the mismatch caused by different module ty...
Distributed energy resources (DERs), such as photovoltaic (PV) sources, together with storage systems, such as battery energy storage systems (BESS), are increasingly present and necessary in our electricity distribution networks. Furthermore, the ne...
This paper presents a perturb-and-observe-based optimization approach for efficiency maximization and total harmonic distortion (THD) minimization in a 3 × 3 matrix converter under varying D-axis current references (
Urban lakes mitigate the negative impacts on the hydrological cycle and improve the quality of life in cities. Worldwide, the concern increases for the protection and management of urban water bodies. Since the physical-chemical and biological condit...
Multilevel inverters are proficient in achieving a high-quality staircase output voltage waveform with a lower amount of harmonic content. In this paper, a new hybrid multilevel inverter topology based on the T-type and H-bridge module is presented....
A fast modelling framework is presented for loss estimation in current-source microinverters. The power stage is modelled with ideal switches and simplified magnetics to keep simulations lightweight, while dedicated estimators reconstruct core, condu...
Ovarian cancer is the most lethal gynecological cancer. Up to 75% of cases are high-grade serous ovarian cancer (HGSOC) that have high chemosensitivity to first-line platinum-based therapies. However, 75% of patients will become chemoresistant follow...
“Production–Living–Ecological” spatial conflicts (PLECs) are critical issues arising from regional land development, affecting economic, social, and ecological security. Identifying and analyzing these conflicts’ spatiot...
Plectin is a giant cytoskeletal crosslinker and intermediate filament stabilizing protein. Mutations in the human plectin gene (PLEC) cause several rare diseases that are grouped under the term plectinopathies. The most common disorder is autosomal r...
This paper starts by analysing the equivalent circuit model of a Thermoelectric Module (TEM) with PLECS simulation by using the PLECS thermal block-set. The approach enables the evaluation of power-module losses when mounted on a sandwich assembly of...
Epithelial ovarian cancer is aggressive and causes high mortality among women worldwide. Members of the plakin family are essential to maintain cytoskeletal integrity and key cellular processes. In this study we characterised the expression of plakin...
Currently, the auxiliary converter in the auxiliary power supply system of a modern tram adopts Si IGBT as its switching device and with the 1700 V/225 A SiC MOSFET module commercially available from Cree, an auxiliary converter using all SiC devices...
This paper concerns the modeling of the static and dynamic characteristics of the SEPIC converter. Simulation models of this system were developed for three different programs: SPICE, PLECS, and ANSYS Simplorer. These models utilized the built-in mod...
Fibroblast growth factor (FGF) and transforming growth factor-beta (TGF-β) can regulate and/or dysregulate lens epithelial cell (LEC) behaviour, including proliferation, fibre differentiation, and epithelial–mesenchymal transition (EMT). E...
To improve the design of electric drives and to better predict the system performance, numerical simulation has been widely employed. Whereas in the majority of the approaches, the machines and the power electronics are designed and simulated separat...
The composite converter allows integrating the high-efficiency converter modules to achieve superior efficiency performance, becoming a prominent solution for electric transport power conversion. In this work, the versatile buck–boost dc–...
Artificial intelligence (AI) has revolutionized drug discovery by enhancing the efficiency and accuracy of structure-based virtual screening (SBVS) and binding affinity prediction. SBVS relies on scoring functions (SFs) to identify potential drug can...
Motor-drive systems have the most significant share in industrial energy consumption, which requires a deep study in every aspect of the field. This paper presents a synchronous reluctance motor (SynRM) drive system based on Plecs RT box 1. The syste...
Power electronics, as an enabling technology in most renewable energy systems, is gaining attention as the penetration of renewable energy sources increases. Wide-bandgap power electronics are of particular interest due to their superior voltage bloc...
The paper presents an analytical study and small-signal modeling of a non-inverting two-switch buck–boost converter based on the LM5118 controller, accounting for parasitic elements. The converter dynamics were analyzed using simulations in the...
In this paper, a universal H-bridge circuit is used as a loading emulator to investigate the loss and thermal models of the power semiconductor. Based on its operation principle and modulation method, the dominating factors’ (e.g., power factor...
This paper presents a comprehensive guide for the design and development of a power electronic converter, specifically focusing on the Buck converter. The guide aims to bridge the gap between theoretical knowledge and practical application, providing...
Many electronic power distribution systems have strong needs for highly efficient AC-DC conversion that can be satisfied by using a buck-boost converter at the core of the power factor correction (PFC) stage. These converters can regulate the input v...
Purpose: To study the time course of the differentiation process and its regulatory networks in primary limbal epithelial cells (pLECs) using serum-free, low calcium Keratocyte growth medium 3 (KGM3) and CnT-2D differentiation medium. Methods: pLECs...
Plectin is a multi-faceted, 500 kDa-large protein, which due to its expression in different isoforms and distinct organs acts diversely as a cytoskeletal crosslinker and signaling scaffold. It functions as a mediator of keratinocyte mechanical stabil...
The concept of more electric aircraft (MEA) has gained popularity over the last few decades. As the power level of electric loads is constantly increasing, the installation of advanced protection systems becomes of paramount importance. In this conte...
In this paper, an accurate efficiency evaluation of an innovative three-switch double input DC–DC converter for hybrid vehicle applications was carried out. The converter was used to interface two storages, (e.g., supercapacitor and battery) to...
This study proposes a novel modified Cuk converter. The proposed converter attempts to resolve the limitations of the conventional converters, such as voltage gain limitations of a canonical Cuk converter. Therefore, the mentioned improvement has mad...
The extended describing function (EDF) is a well-known method for modelling resonant converters due to its high accuracy. However, it requires complex mathematical formulation effort. This paper presents a simplified non-linear mathematical model of...
In this study, a double-input single-output bidirectional DC–DC converter is considered. This particular architecture allows less switches to be used than a conventional solution. A new feed-forward current control for this DC–DC converte...
The paper proposes a general description system of the five-phase two-level inverter. The two base methods are presented and discussed. The first one is based on the standard space vector transformation, while the other uses state vectors which enabl...
This paper describes the output voltage regulation control for an interleaved connected to a direct current (DC) microgrid considering bidirectional current flows. The proposed controller is based on an interconnection and damping passivity-based con...
The paper deals with a grid-connected single-phase battery charger integrated with photovoltaic generators (PVGs). The circuit topology consists of a multilevel architecture based on a Cascaded H-Bridge (CHB) rectifier. Its main task is to charge the...
This paper presents a small-signal model of a series resonant converter under continuous conduction mode, based on asymmetric pulse-width modulation, which is commonly used under light-load conditions. When controlled using conventional pulse-frequen...
This paper deals with the design and control of an enhanced grid-tied photovoltaic (PV) cascaded H-Bridge (CHB) inverter, which suffers from issues related to operation in the overmodulation region in the case of a deep mismatch configuration of PV g...
Since cancer treatment by radio- and chemotherapy has been linked to safety concerns, there is a need for new and alternative anticancer drugs; as such, compounds isolated from plants represent promising candidates. The current study investigates the...
We designed and implemented a single-switch step-up DC-DC converter based on cascaded boost and Luo converters. The proposed converter demonstrated a quadratic voltage gain and a high efficiency, which makes it suitable for renewable energy applicati...
In this paper, a new transformerless high voltage gain dc-dc converter is proposed for low and medium power application. The proposed converter has high quadratic gain and utilizes only two inductors to achieve this gain. It has two switches that are...
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