Special Issue "Plectin in Health and Disease"
Deadline for manuscript submissions: closed (31 July 2021).
First identified in the early eighties, the intermediate filament (IF) linker protein plectin has emerged as a key player in cytoskeleton organization and dynamics. Owing to its structural diversity, functional versatility and broad interaction profile, it is involved in many fundamental cellular processes and plays an important role in human diseases. By networking IFs and targeting them to peripheral junctional complexes and internal organelles, plectin is crucial for the integrity and functionality of IF networks including cytoplasmic compartmentalization. Thus, in partnership with IFs, plectin affects the morphology and mechanical resilience of cells, the directionality of actomyosin-based contractile forces and the dynamics of microtubules, and it is involved in cellular signaling, especially mechanotransduction to the nucleus.
This special issue aims at presenting current status, recent developments, and future directions of plectin research with emphasis on the following topics:
- Plectin as cytoskeleton organizer and mechanotransducer
- Muscle-related plectinopathies
- Neuromuscular synapse-related plectinopathies
- Plectin in skin fragility disorders (EBS and paraneoplastic pemphigus)
- Plectin in cancer with focus on its role i) as biomarker and therapeutic target and ii) in epithelial-mesenchymal transition (EMT)and tumor cell migration
- Animal models to unveil physiological functions of plectin and disease mechanisms of plectinopathies
- Genome-wide association studies (GWAS) revealing PLEC as osteoarthritis susceptibility gene
- Plectin in the nervous system and a speculative role in brain astrocytes
Dr. Gerhard Wiche
Manuscript Submission Information
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- intermediate filaments
- muscular dystrophies
- skin fragilityl osteoarthritis