Chicken (Gallus gallus) pluripotent embryonic stem cells (ESCs) and primordial germ cells (PGCs) can be broadly applied in the research of developmental and embryonic biology, but the difference between amphoteric ESCs and PGCs is still elusive. This...
Hemophilia B (HB) is an X-linked recessive bleeding disorder, caused by F9 gene deficiency. Gene therapy combined with the CRISPR/Cas9 technology offers a potential cure for hemophilia B. Now the Cas9 nickase (Cas9n) shows a great advantage in reduci...
The European Society of Cardiology (ESC) has dedicated itself to the publication and dissemination of clinical practice guidelines. This is regarded one of the core products generated within the ESC, and is intended to reflect updated, topic-related...
Several surveys demonstrated in the past a large heterogeneity of cardiology training and education in European countries. Taking into consideration the reality of the free movement of doctors and patients across borders, the cardiology community fee...
Traditionally, human disorders were studied using animal models or somatic cells taken from patients. Such studies enabled the analysis of the molecular mechanisms of numerous disorders, and led to the discovery of new treatments. Yet, these system...
Precise regulation of the cell cycle of embryonic stem cells (ESCs) is critical for their self-maintenance and differentiation. The cell cycle of ESCs differs from that of somatic cells and is different depending on the cell culture conditions. Howev...
The emergence of extended-spectrum cephalosporin (ESC)-resistant Escherichia coli is a global concern. This study aimed to assess the prevalence and transmission of ESC-resistant E. coli in the Danish broiler production system. Samples from two verti...
Bivalent chromatin, marked by H3K4me3 and H3K27me3, contributes to maintaining developmental genes in a poised state. However, it remains unclear whether sheep embryonic stem cells (ESCs) establish bivalent domains. In this study, we identified bival...
The new guidelines for the management of arterial hypertension were released in 2013 by the European Society of Hypertension (ESH) and the European Society of Cardiology (ESC). The purpose of this review is to highlight some of the changes in these...
This study investigates the deposition of silicon nitride (SiN) thin films for advanced semiconductor applications, with a specific focus on overcoming thermal challenges in plasma-enhanced atomic layer deposition (PE-ALD) at an elevated temperature...
Protein degradation systems, such as auxin-inducible degron (AID) and dTAG-mediated degradation, have become essential tools in molecular biology. Their primary advantage lies in the rapid and efficient elimination of proteins, which facilitates the...
Cardiovascular magnetic resonance (CMR) imaging is a key component of current diagnostic pathways in subjects with acute myocarditis. The 2020 ESC Guidelines on Sports Cardiology recommend athletes with acute myocarditis to abstain from sports during...
The emergence of multidrug-resistant Pseudomonas aeruginosa strains is increasingly becoming a critical threat to global health. Among the resistance mechanisms, the MexAB–OprM efflux pump confers P. aeruginosa with an efficient method to expor...
The fibroblast growth factor (FGF) and the transforming growth factor-β (TGF-β) pathways are both involved in the maintenance of human embryonic stem cells (hESCs) and regulate the onset of their differentiation. Their converging functions...
Background: Despite ongoing advancements in healthcare, acute coronary syndromes (ACS) remain a leading cause of morbidity and mortality. The 2023 European Society of Cardiology (ESC) guidelines have introduced significant improvements in ACS managem...
Epigenetic regulation, particularly DNA methylation, plays a crucial role in embryonic development by controlling gene expression patterns. The disruption of this regulation by environmental factors can have long-lasting consequences. Opioid drugs, s...
Tooth development and regeneration occur through reciprocal interactions between epithelial and ectodermal mesenchymal stem cells. However, the current studies on tooth development are limited, since epithelial stem cells are relatively difficult to...
A new insight into oxidative stress is based on oxidative deoxyribonucleic acid (DNA) damage. DNA is the pivotal biopolymer for life and health. Arterial hypertension (HT) is a globally common disease and a major risk factor for numerous cardiovascul...
Atherosclerosis is a systemic disorder, yet patients with coronary, cerebrovascular, and lower-extremity peripheral artery disease (PAD) are commonly managed through separate territory-specific pathways. Polyvascular atherosclerotic disease, defined...
Proper telomere length is essential for indefinite self-renewal of embryonic stem (ES) cells and cancer cells. Telomerase-deficient late generation mouse ES cells and human ALT cancer cells are able to propagate for numerous passages, suggesting telo...
Embryonic stem cells (ESCs) are derived from the inner cell mass (ICM) of the blastocyst. ESCs have two distinctive properties: ability to proliferate indefinitely, a feature referred as “self-renewal”, and to differentiate into different...
Large language models (LLMs), including ChatGPT, Gemini, and DeepSeek, are increasingly used in medicine; however, their performance across multiple clinically relevant domains remains incompletely understood. This cross-sectional comparative study e...
Kidney neoplasms are among the most heterogeneous and diverse tumors. Continuous advancement of this field is reflected in the emergence of new tumour entities and an increased recognition of the expanding morphologic, immunohistochemical, molecular,...
Over the past few years, the study of environmental sound classification (ESC) has become very popular due to the intricate nature of environmental sounds. This paper reports our study on employing various acoustic features aggregation and data enhan...
Liver cancer is one of the most lethal malignant cancers worldwide. However, the therapeutic options for advanced liver cancers are limited and reveal scant efficacy. The current study investigated the effects of nivolumab (Niv) and escitalopram oxal...
Ten eleven translocation 1 (Tet1) is a DNA dioxygenase that promotes DNA demethylation by oxidizing 5-methylcytosine. It can also partner with chromatin-activating and repressive complexes to regulate gene expressions independent of its enzymatic act...
Embryonic stem cells (ESCs) are a type of cells capable of self-renewal and multi-directional differentiation. The self-renewal of ESCs is regulated by factors including signaling pathway proteins, transcription factors, epigenetic regulators, cytoki...
Pluripotent embryonic stem cells (ESCs) can self-renew indefinitely and are able to differentiate into all three embryonic germ layers. Synaptosomal-associated protein 29 (Snap29) is implicated in numerous intracellular membrane trafficking pathways,...
Mixed-lineage leukemia 1 (MLL1) introduces 1-, 2- and 3-methylation into histone H3K4 through the evolutionarily conserved set domain. In this study, bovine embryonic stem cells (bESCs, known as bESCs-F7) were established from in vitro-fertilized (IV...
Background: The importance of embryonic stem cells (ESCs) in chickens is undeniable, as they can be applied across various fields, including animal modeling, developmental biology, cell fate research, drug screening, toxicity testing, and gene functi...
Embryonic stem cells (ESCs) are pluripotent cells with indefinite self-renewal ability and differentiation properties. To function properly and maintain genomic stability, ESCs need to be endowed with an efficient repair system as well as effective r...
Mouse embryonic stem cells (mESCs) possess the remarkable characteristics of unlimited self-renewal and pluripotency, which render them highly valuable for both fundamental research and clinical applications. A comprehensive understanding of the mole...
This paper first identifies and analyzes the phenomenon of output-voltage collapse under step load perturbations in dual-bridge converters where an extremum seeking control (ESC) optimization algorithm is employed. Although ESC is an effective online...
Human embryonic stem cells (hESCs) are increasingly used in clinical trials as they can change the outcome of treatment for many human diseases. They are used as a starting material for further differentiation into specific cell types and to achieve...
This study introduces a decentralized control framework designed to improve energy efficiency in vehicle platooning by optimizing inter-vehicle gaps to minimize aerodynamic drag, a significant factor in energy consumption. The proposed framework inte...
Human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) can be differentiated into cardiomyocytes (hESC-CMs and iPSC-CMs, respectively), which hold great promise for cardiac regenerative medicine and disease modeling efforts. Ho...
Regulation of histone acetylation dictates patterns of gene expression and hence cell identity. Due to their clinical relevance in cancer biology, understanding how human embryonic stem cells (hESCs) regulate their genomic patterns of histone acetyla...
Since the COVID-19 epidemic swept the world, the emergency supply chain (ESC) has faced serious uncertainty risks. To maintain the stability of the emergency supply, risk prevention and contingency measures must be prepared. In this paper, the author...
Purpose: Retinal pigment epithelial (RPE) cells are highly specialized neural cells with several functions essential for vision. Progressive deterioration of RPE cells in elderly individuals can result in visual impairment and, ultimately, blinding d...
Land use change is the second largest source of greenhouse gas emissions after fossil combustion, which can hurt ecological environment severely. Intensive study on land use carbon emissions is of great significance to alleviate environmental pressur...
Inefficient removal of dying retinal pigment epithelial (RPE) cells by professional phagocytes can result in debris formation and development of age-related macular degeneration (AMD). Chronic oxidative stress and inflammation play an important role...
Extended-spectrum cephalosporin-resistant Escherichia coli (ESC-EC) poses a significant public health concern, with its presence increasingly detected in healthy humans and various animal species. This study explores the transmission dynamic of ESC-E...
The OSGEP gene encodes O-sialoglycoprotein endopeptidase, a catalytic unit of the highly conserved KEOPS complex (Kinase, Endopeptidase, and Other Proteins of small Size) that regulates the second biosynthetic step in the formation of N-6-threonylcar...
Breast cancer is the current leading cause of cancer death in females worldwide. Although current chemotherapeutic drugs effectively reduce the progression of breast cancer, most of these drugs have many unwanted side effects. Salvianolic acid B (Sal...
During the development of a multicellular organism, the specification of different cell lineages originates in a small group of pluripotent cells, the epiblasts, formed in the preimplantation embryo. The pluripotent epiblast is protected from prematu...
Education – the mission of the ESC. The education of trainees, postgraduate and established cardiologists alike has always been a critical component of the mission of the European Society of Cardiology (ESC) [...]
Eosinophilic solid and cystic renal cell carcinoma (ESC-RCC) is a novel and uncommon type of renal cell carcinoma, which has been recently recognized and introduced as a distinct entity in the WHO 2022 kidney tumor classification. Previously known as...
Background and Objectives: Individuals with long-standing type 1 diabetes (T1D) remain at elevated cardiovascular risk (CVR). Adiponectin (ADNC) and leptin (LEP) are adipokines involved in metabolic and vascular homeostasis, yet their relevance for C...
Zearalenone (ZEA) is a fungal mycotoxin known to exert strong reproductive toxicity in animals. As a newly identified type of programmed cell death, necroptosis is regulated by receptor-interacting protein kinase 1 (RIPK1), receptor-interacting prote...
Background/Objectives: Infants exposed to opioids in utero are at risk of neonatal opioid withdrawal syndrome (NOWS). We compared clinical, family-related, and classification-derived resource outcomes before and after implementation of Eat, Sleep, Co...
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