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Correlation between Nutrition, Oxidative Stress and Disease 2.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: closed (31 July 2020) | Viewed by 20566

Special Issue Editors

Department of Medicine and Science of Aging, University “G. D’Annunzio”, 66100 Chieti, Italy
Interests: nutrition; oxidative stress; cellular biology; disease; antioxidant; bioactive vegetable; molecules; endogenous antioxidant enzymes; vegetable food; nitric oxide; inflammation diseases, inflammatory bowel disease
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Special Issue Information

Dear Colleagues,

When the regulation of homeostasis of radicals in tissues or cells do not function correctly, a situation of stress can come about, due to the increased presence of oxidative radicals. In these cases, the term “oxidative stress” is often used to indicate an imbalance towards major oxidation of tissue, measured by the appearance of oxidized species present in the main elements of a cell, that is, lipids, proteins, DNA, and carbohydrates. A strong relationship exists between nutrition and oxidative stress. Works that have been published in recent years, in the field of human health, demonstrate that the production, transformation, and metabolism of free radicals are finely regulated processes, and that the malfunction of these inevitably leads to inflammatory tissue damage. On the other hand, oxidative stress does not only have to be considered as a negative event, as it also has physiological functions: For example, a transient situation of oxidative stress constitutes one of the fundamental mechanisms of functioning to answer or to send many types of signals (hormones, neurotransmitters, cytokine, etc.), to defend oneself from infective agents and to alter the redox state, which is necessary to start up a differentiated process. On the other hand, the chronicity of oxidative stress constitutes a condition of risk for degenerative processes and can lead to a pathological situation. A varied, balanced, and good-quality diet can produce a majority of antioxidant substances that can act in synergy to obstruct the excessive presence of free radicals. In addition, it is essential that diet be rich in foods of vegetable origin, which are the true allies in tackling the damages associated with an alteration of the redox cellular state.

Prof. Dr. Lorenza Speranza
Prof. Dr. Sara Franceschelli
Guest Editors

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Keywords

  • nutrition
  • oxidative stress
  • disease
  • antioxidant
  • bioactive vegetable molecules
  • superoxide dismutase
  • catalase
  • vegetable food
  • polyphenol
  • α-mangostin

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Published Papers (6 papers)

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Research

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19 pages, 3296 KiB  
Article
Unique Role of Caffeine Compared to Other Methylxanthines (Theobromine, Theophylline, Pentoxifylline, Propentofylline) in Regulation of AD Relevant Genes in Neuroblastoma SH-SY5Y Wild Type Cells
by Daniel Janitschke, Anna A. Lauer, Cornel M. Bachmann, Martin Seyfried, Heike S. Grimm, Tobias Hartmann and Marcus O. W. Grimm
Int. J. Mol. Sci. 2020, 21(23), 9015; https://doi.org/10.3390/ijms21239015 - 27 Nov 2020
Cited by 10 | Viewed by 2645
Abstract
Methylxanthines are a group of substances derived from the purine base xanthine with a methyl group at the nitrogen on position 3 and different residues at the nitrogen on position 1 and 7. They are widely consumed in nutrition and used as pharmaceuticals. [...] Read more.
Methylxanthines are a group of substances derived from the purine base xanthine with a methyl group at the nitrogen on position 3 and different residues at the nitrogen on position 1 and 7. They are widely consumed in nutrition and used as pharmaceuticals. Here we investigate the transcriptional regulation of 83 genes linked to Alzheimer’s disease in the presence of five methylxanthines, including the most prominent naturally occurring methylxanthines—caffeine, theophylline and theobromine—and the synthetic methylxanthines pentoxifylline and propentofylline. Methylxanthine-regulated genes were found in pathways involved in processes including oxidative stress, lipid homeostasis, signal transduction, transcriptional regulation, as well as pathways involved in neuronal function. Interestingly, multivariate analysis revealed different or inverse effects on gene regulation for caffeine compared to the other methylxanthines, which was further substantiated by multiple comparison analysis, pointing out a distinct role for caffeine in gene regulation. Our results not only underline the beneficial effects of methylxanthines in the regulation of genes in neuroblastoma wild-type cells linked to neurodegenerative diseases in general, but also demonstrate that individual methylxanthines like caffeine mediate unique or inverse expression patterns. This suggests that the replacement of single methylxanthines by others could result in unexpected effects, which could not be anticipated by the comparison to other substances in this substance class. Full article
(This article belongs to the Special Issue Correlation between Nutrition, Oxidative Stress and Disease 2.0)
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16 pages, 3498 KiB  
Article
Resveratrol, Curcumin and Piperine Alter Human Glyoxalase 1 in MCF-7 Breast Cancer Cells
by Betina Schmidt, Christian Ferreira, Carlos Luan Alves Passos, Jerson Lima Silva and Eliane Fialho
Int. J. Mol. Sci. 2020, 21(15), 5244; https://doi.org/10.3390/ijms21155244 - 24 Jul 2020
Cited by 24 | Viewed by 3622
Abstract
Breast cancer is the leading cause of cancer mortality in women worldwide. Conventional cancer treatment is costly and results in many side effects. Dietary bioactive compounds may be a potential source for breast cancer prevention and treatment. In this scenario, the aim of [...] Read more.
Breast cancer is the leading cause of cancer mortality in women worldwide. Conventional cancer treatment is costly and results in many side effects. Dietary bioactive compounds may be a potential source for breast cancer prevention and treatment. In this scenario, the aim of this study was to investigate the effects of the bioactive compounds resveratrol, curcumin and piperine (R-C-P) on MCF-7 breast cancer cells and to associate them to Glyoxalase 1 (GLO1) activity. The findings indicate that R-C-P exhibits cytotoxicity towards MCF-7 cells. R-C-P decreased mitochondrial membrane potential (ΔΨm) by 1.93-, 2.04- and 1.17-fold, respectively. Glutathione and N-acetylcysteine were able to reverse the cytotoxicity of the assessed bioactive compounds in MCF-7 cells. R-C-P reduced GLO1 activity by 1.36-, 1.92- and 1.31-fold, respectively. R-C-P in the presence of antimycin A led to 1.98-, 1.65- and 2.16-fold decreases in D-lactate levels after 2 h of treatment, respectively. Glyoxal and methylglyoxal presented cytotoxic effects on MCF-7 cells, with IC50 values of 2.8 and 2.7 mM and of 1.5 and 1.4 mM after 24 and 48 h of treatment, respectively. In conclusion, this study demonstrated that R-C-P results in cytotoxic effects in MCF-7 cells and that this outcome is associated with decreasing GLO1 activity and mitochondrial dysfunction. Full article
(This article belongs to the Special Issue Correlation between Nutrition, Oxidative Stress and Disease 2.0)
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14 pages, 4835 KiB  
Article
Salvianolic Acid B Slows the Progression of Breast Cancer Cell Growth via Enhancement of Apoptosis and Reduction of Oxidative Stress, Inflammation, and Angiogenesis
by Mohamed A. Katary, Rafik Abdelsayed, Abdulmohsin Alhashim, Mohamed Abdelhasib and Ahmed A. Elmarakby
Int. J. Mol. Sci. 2019, 20(22), 5653; https://doi.org/10.3390/ijms20225653 - 12 Nov 2019
Cited by 41 | Viewed by 3441
Abstract
Breast cancer is the current leading cause of cancer death in females worldwide. Although current chemotherapeutic drugs effectively reduce the progression of breast cancer, most of these drugs have many unwanted side effects. Salvianolic acid B (Sal-B) is a bioactive compound isolated from [...] Read more.
Breast cancer is the current leading cause of cancer death in females worldwide. Although current chemotherapeutic drugs effectively reduce the progression of breast cancer, most of these drugs have many unwanted side effects. Salvianolic acid B (Sal-B) is a bioactive compound isolated from the root of Danshen Radix with potent antioxidant and anti-inflammatory properties. Since free radicals play a key role in the initiation and progression of tumor cells growth and enhance their metastatic potential, the current study was designed to investigate the antitumor activity of Sal-B and compare it with the antitumor activity of the traditional anticancer drug, cisplatin. In vitro, Sal-B decreased the human breast cancer adenocarcinoma (MCF-7) cells proliferation in a concentration and time dependent manner. In vivo and similar to cisplatin treatment, Sal-B significantly reduced tumor volume and increased the median survival when compared to tumor positive control mice group injected with Ehrlich solid carcinoma cell line (ESC). Sal-B decreased plasma level of malondialdehyde as a marker of oxidative stress and increased plasma level of reduced glutathione (GSH) as a marker of antioxidant defense when compared to control ESC injected mice. Either Sal-B or cisplatin treatment decreased tumor tissue levels of tumor necrosis factor (TNF-α), matrix metalloproteinase-8 (MMP-8), and Cyclin D1 in ESC treated mice. Contrary to cisplatin treatment, Sal-B did not decrease tumor tissue Ki-67 protein in ESC injected mice. Immunohistochemical analysis revealed that Sal-B or cisplatin treatment increased the expression of the apoptotic markers caspase-3 and P53. Although Sal-B or cisplatin significantly reduced the expression of the angiogenic factor vascular endothelial growth factor (VEGF) in ESC injected mice, only Sal-B reduced expression level of COX-2 in ESC injected mice. Our data suggest that Sal-B exhibits antitumor features against breast cancer cells possibly via enhancing apoptosis and reducing oxidative stress, inflammation, and angiogenesis. Full article
(This article belongs to the Special Issue Correlation between Nutrition, Oxidative Stress and Disease 2.0)
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18 pages, 2427 KiB  
Article
Modulation of CAT-2B-Mediated l-Arginine Uptake and Nitric Oxide Biosynthesis in HCT116 Cell Line Through Biological Activity of 4′-Geranyloxyferulic Acid Extract from Quinoa Seeds
by Sara Franceschelli, Daniela Maria Pia Gatta, Mirko Pesce, Alessio Ferrone, José Luis Quiles, Salvatore Genovese, Francesco Epifano, Serena Fiorito, Vito Alessandro Taddeo, Antonia Patruno, Alfredo Grilli, Mario Felaco and Lorenza Speranza
Int. J. Mol. Sci. 2019, 20(13), 3262; https://doi.org/10.3390/ijms20133262 - 02 Jul 2019
Cited by 8 | Viewed by 2753
Abstract
Chenopodium quinoa Wild is a “pseudocereal” grain which attracts a lot of attention in the scientific community as it has a positive effect on health. Here, we investigate the presence of biologically active O-prenylated phenylpropanoids in the ethanol extract of commercially available quinoa [...] Read more.
Chenopodium quinoa Wild is a “pseudocereal” grain which attracts a lot of attention in the scientific community as it has a positive effect on health. Here, we investigate the presence of biologically active O-prenylated phenylpropanoids in the ethanol extract of commercially available quinoa seeds. We claim that 4′-Geranyloxyferulic acid (GOFA) was the only phytochemical product found that belongs to quinoa’s group secondary metabolites. We studied the changes in the oxidative and inflammatory status of the cellular environment in HCT 116 cell line processed with quinoa extract and its component GOFA; the implementation was done through the analysis of the antioxidant enzymes (SOD and CAT), the pro-inflammatory components (iNOS, IL-6 and TNF-α), and the products of intermediary metabolism (ONOO, O2). Moreover, the l-arginine uptake was proposed as a target of the tested compounds. We demonstrated that the GOFA, through a decrease of the CAT-2B expression, leads to a reduction of the l-arginine uptake, downregulating the harmful iNOS and restoring the altered redox state. These results propose a new molecular target involved in the reduction of the critical inflammatory process responsible for the cancer progression. Full article
(This article belongs to the Special Issue Correlation between Nutrition, Oxidative Stress and Disease 2.0)
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Review

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19 pages, 986 KiB  
Review
Early-Life Programming and Reprogramming of Adult Kidney Disease and Hypertension: The Interplay between Maternal Nutrition and Oxidative Stress
by Chien-Ning Hsu and You-Lin Tain
Int. J. Mol. Sci. 2020, 21(10), 3572; https://doi.org/10.3390/ijms21103572 - 18 May 2020
Cited by 18 | Viewed by 3444
Abstract
Kidney disease and hypertension both have attained the status of a global pandemic. Altered renal programming resulting in kidney disease and hypertension can begin in utero. Maternal suboptimal nutrition and oxidative stress have important implications in renal programming, while specific antioxidant nutrient supplementations [...] Read more.
Kidney disease and hypertension both have attained the status of a global pandemic. Altered renal programming resulting in kidney disease and hypertension can begin in utero. Maternal suboptimal nutrition and oxidative stress have important implications in renal programming, while specific antioxidant nutrient supplementations may serve as reprogramming strategies to prevent kidney disease and hypertension of developmental origins. This review aims to summarize current knowledge on the interplay of maternal nutrition and oxidative stress in response to early-life insults and its impact on developmental programming of kidney disease and hypertension, covering two aspects. Firstly, we present the evidence from animal models supporting the implication of oxidative stress on adult kidney disease and hypertension programmed by suboptimal maternal nutrition. In the second part, we document data on specific antioxidant nutrients as reprogramming strategies to protect adult offspring against kidney disease and hypertension from developmental origins. Research into the prevention of kidney disease and hypertension that begin early in life will have profound implications for future health. Full article
(This article belongs to the Special Issue Correlation between Nutrition, Oxidative Stress and Disease 2.0)
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17 pages, 852 KiB  
Review
Tea and Its Components Prevent Cancer: A Review of the Redox-Related Mechanism
by Xiangbing Mao, Xiangjun Xiao, Daiwen Chen, Bing Yu and Jun He
Int. J. Mol. Sci. 2019, 20(21), 5249; https://doi.org/10.3390/ijms20215249 - 23 Oct 2019
Cited by 27 | Viewed by 4121
Abstract
Cancer is a worldwide epidemic and represents a major threat to human health and survival. Reactive oxygen species (ROS) play a dual role in cancer cells, which includes both promoting and inhibiting carcinogenesis. Tea remains one of the most prevalent beverages consumed due [...] Read more.
Cancer is a worldwide epidemic and represents a major threat to human health and survival. Reactive oxygen species (ROS) play a dual role in cancer cells, which includes both promoting and inhibiting carcinogenesis. Tea remains one of the most prevalent beverages consumed due in part to its anti- or pro-oxidative properties. The active compounds in tea, particularly tea polyphenols, can directly or indirectly scavenge ROS to reduce oncogenesis and cancerometastasis. Interestingly, the excessive levels of ROS induced by consuming tea could induce programmed cell death (PCD) or non-PCD of cancer cells. On the basis of illustrating the relationship between ROS and cancer, the current review discusses the composition and efficacy of tea including the redox-relative (including anti-oxidative and pro-oxidative activity) mechanisms and their role along with other components in preventing and treating cancer. This information will highlight the basis for the clinical utilization of tea extracts in the prevention or treatment of cancer in the future. Full article
(This article belongs to the Special Issue Correlation between Nutrition, Oxidative Stress and Disease 2.0)
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