Stem Cell Biology & Regenerative Medicine
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 86507
Special Issue Editor
Interests: reprogramming; differentiation; Brain Blood Barrier (BBB); iPSC; drug discovery; disease in a dish model
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
More than 50% of pre-clinical studies fail despite a long and expensive journey of drug discovery using animal models.
Currently there is a human-relevant replacement: human patient induced pluripotent stem cells (hiPSCs)/human embryonic stem cells (hESs) and their counterpart corrected cells using Crispr methodology, which enable the establishment of disease-in-a-dish models encompassing patients’ genetics.
We invite papers that use hiPSC/hES-derived cells (cardiomyocytes, fibroblasts, glial cells, neurons, astrocytes, brain microvascular endothelial cells and more) as disease models to screen leads for drugs.
We expect studies on models like (but not limited to):
- hiPSC/hES-derived microglia/glia/astrocytes as models for screening anti-inflammation compounds.
- New materials for establishing hiPSC-derived three-dimensional (3D) scaffolds as platforms for drug discovery.
- Compounds that act as neuro-regeneration activators for cases like traumatic brain injury (TBI), Alzheimer's disease, ALS, Parkinson’s disease and more.
- hiPSC/hES-based blood–brain barrier (BBB) model as a tool for distinguishing between drugs that can penetrate/damage the BBB and drugs that failed in preclinical studies because they cannot penetrate the BBB.
- Identifying pain relievers by screening cannabis-derived compounds and other pain relievers in the platform of hiPSC/hES-derived sensory cells.
- Crispr methods to accurately correct/generate disease-related mutations in hiPSC/hES.
- Unique markers for identifying hiPSC/hES-derived cells composing the 3D-scaffolds-based models.
Dr. Rivka Ofir
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- hiPSC
- hES
- Crispr
- BBB
- disease in a dish
- neuro-regeneration
- pain reliever
- scaffold
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.