Special Issue "iPS Cells for Modelling and Treatment of Human Diseases"
Deadline for manuscript submissions: closed (31 July 2014)
A printed edition of this Special Issue is available here.
Dr. Michael J. Edel
Principle Scientist, Department of Biomedicine, Institute of Neuroscience, University of Barcelona, Spain
Website | E-Mail
Interests: induced pluripotency stem cells (iPSC); neural stem cells; cardiac stem cells; direct cell reprogramming with synthetic mRNA; embryological development; cell cycle; cancer biology; 3D organ bioengineering; clinical grade cell replacement therapy
Dear Colleagues,The field of reprogramming somatic cells into induced pluripotent stem cells (iPSC) has moved very quickly, from bench to bedside in just eight years since its first discovery. The best example of this is the RIKEN clinical trial this year in Japan, which will use iPSC derived retinal pigmented epithelial (RPE) cells to treat macular degeneration (MD). This is the first human disease to be tested for regeneration and repair by iPSC-derived cells and others will follow in the near future. Currently, there is an intense worldwide research effort to bring stem cell technology to the clinic for application to treat human diseases and pathologies. Human tissue diseases (including those of the lung, heart, brain, spinal cord, and muscles) drive organ bioengineering to the forefront of technology concerning cell replacement therapy. Given the critical mass of research and translational work being performed, iPSCs may very well be the cell type of choice for regenerative medicine in the future. Also, basic science questions, such as efficient differentiation protocols to the correct cell type for regenerating human tissues, the immune response of iPSC replacement therapy and genetic stability of iPSC-derived cells, are currently being investigated for future clinical applications. Please join us in presenting this Special Issue on the state of the art research currently being performed worldwide to bring iPSC to the clinic so as to help understand and treat various human diseases.
Dr. Michael J. Edel
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- induced pluripotent stem cells
- adult stem cell
- human disease
- clinical application
- immune response
- genetic cell stability