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ESC, ALK, HOT and LOT: Three Letter Acronyms of Emerging Renal Entities Knocking on the Door of the WHO Classification

Department of Pathology and Laboratory Medicine, University of Calgary and Alberta Precision Laboratories, Rockyview General Hospital, 7007 14 Street, Calgary, AB T2V 1P9, Canada
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Cancers 2020, 12(1), 168; https://doi.org/10.3390/cancers12010168
Received: 4 December 2019 / Revised: 3 January 2020 / Accepted: 6 January 2020 / Published: 9 January 2020
(This article belongs to the Special Issue Renal Cell Carcinoma)
Kidney neoplasms are among the most heterogeneous and diverse tumors. Continuous advancement of this field is reflected in the emergence of new tumour entities and an increased recognition of the expanding morphologic, immunohistochemical, molecular, epidemiologic and clinical spectrum of renal tumors. Most recent advances after the 2016 World Health Organization (WHO) classification of renal cell tumors have provided new evidence on some emerging entities, such as anaplastic lymphoma kinase rearrangement-associated RCC (ALK-RCC), which has already been included in the WHO 2016 classification as a provisional entity. Additionally, several previously unrecognized entities, not currently included in the WHO classification, have also been introduced, such as eosinophilic solid and cystic renal cell carcinoma (ESC RCC), low-grade oncocytic renal tumor (LOT) and high-grade oncocytic renal tumor (HOT) of kidney. Although pathologists play a crucial role in the recognition and classification of these new tumor entities and are at the forefront of the efforts to characterize them, the awareness and the acceptance of these entities among clinicians will ultimately translate into more nuanced management and improved prognostication for individual patients. In this review, we summarise the current knowledge and the novel data on these emerging renal entities, with an aim to promote their increased diagnostic recognition and better characterization, and to facilitate further studies that will hopefully lead to their formal recognition and consideration in the future classifications of kidney tumors. View Full-Text
Keywords: kidney; emerging entity; new entity; oncocytic renal tumor; unclassified renal cell carcinoma; unclassified renal tumor; anaplastic lymphoma kinase rearrangement; ALK; ESC; HOT; LOT kidney; emerging entity; new entity; oncocytic renal tumor; unclassified renal cell carcinoma; unclassified renal tumor; anaplastic lymphoma kinase rearrangement; ALK; ESC; HOT; LOT
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Siadat, F.; Trpkov, K. ESC, ALK, HOT and LOT: Three Letter Acronyms of Emerging Renal Entities Knocking on the Door of the WHO Classification. Cancers 2020, 12, 168.

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