Lipid transfer proteins (LTPs) are recognized as key players in the inter-organelle trafficking of lipids and are rapidly gaining attention as a novel molecular target for medicinal products. In mammalian cells, ceramide is newly synthesized in the e...
Sphingolipids are a class of essential lipids implicated in constructing cellular membranes and regulating nearly all cellular functions. Sphingolipid metabolic network is centered with the ceramide–sphingomyelin axis. Ceramide is well-recogniz...
Ceramide transport protein (CERT) mediates ceramide transfer from the endoplasmic reticulum to the Golgi for sphingomyelin (SM) biosynthesis. CERT is inactivated by multiple phosphorylation at the serine-repeat motif (SRM), and mutations that impair...
In 1999, Goodpasture antigen-binding protein (GPBP) was identified as a protein interacting with the N-terminal region of the human Goodpasture antigen, linked to collagen IV in patients with Goodpasture syndrome, an autoimmune disease. In 2003, a sp...
(1) Background: Ceramides are a new kind of lipid biomarker and have already been demonstrated to be valuable risk predictors in coronary patients. Patients with peripheral artery disease (PAD) are a population with a worse prognosis and higher morta...
Ceramides and other sphingolipids are implicated in vascular dysfunction and inflammation. They have been suggested as potential biomarkers for hypertension. However, their specific association with hypertension prevalence and onset requires further...
To improve arthroplasty care quality, the EndoCert initiative focuses on structural, processual, and surgeon-related quality assurance. The aim of this study was to assess the impact of a surgeon’s case load in certified centers on quality of c...
Ceramide risk score (CERT1, ceramide test 1), based on specific ceramides (Cers) and their corresponding ratios in the plasma, has been reported as a promising biochemical marker for primary and secondary prediction of cardiovascular disease (CVD) ri...
Cardiovascular disease (CVD) is the leading cause of death worldwide, yet roughly 70% of major adverse cardiovascular events occur in statin-treated patients with optimized Low-density lipoprotein cholesterol (LDL-C), a gap that cholesterol-based ris...
Diet is a major modifiable risk factor for cardiovascular disease (CVD). One explanation for this is its effect on specific lipids. However, knowledge on how the lipidome is affected is limited. We aimed to investigate if diet can change the new cera...
The obligate intracellular bacterium Chlamydia trachomatis is the major causative agent of bacterial sexually transmitted diseases worldwide. In infected cells, the ceramide transport protein (CERT) is recruited to inclusions, where C. trachomatis re...
User Behaviour Analytics (UBA) relies heavily on sequential data to detect anomalies such as insider threats. Traditional approaches often model user behaviour as discrete sequences of events using Recurrent Neural Networks (RNNs) like Long Short-Ter...
The ceramide transport protein (CERT) delivers ceramide from the endoplasmic reticulum (ER) to the Golgi apparatus, where ceramide is converted to sphingomyelin (SM). The function of CERT is regulated in two distinct phosphorylation-dependent events:...
Ceramide is a common precursor of sphingomyelin (SM) and glycosphingolipids (GSLs) in mammalian cells. Ceramide synthase 2 (CERS2), one of the six ceramide synthase isoforms, is responsible for the synthesis of very long chain fatty acid (C20–26 fatt...
Cybersecurity insider threats remain a significant challenge for modern organisations due to their potential to cause substantial financial and reputational damage. This paper presents a systematic review of insider-threat research (2019–2026)...
Background: Shoulder impingement syndrome (SIS) is a prevalent condition among overhead athletes, often managed through therapeutic exercise interventions. However, the quality of reporting in exercise protocols significantly impacts their reproducib...
Background/Objectives: According to the guidelines of the EndoCert initiative, certified maximum-care arthroplasty centers (ACmax) are obliged to admit patients from certified arthroplasty centers (AC) if these patients need to be transferred to the...
Cooperative perception can improve the situational awareness of connected and autonomous vehicles by exchanging complementary sensing information among nearby agents. However, systematic multi-vehicle cooperation also increases vehicle-to-everything...
Introduction: Timely detection of clinical deterioration in hospitalized patients remains a challenge, often limited by intermittent vital signs (VS) monitoring and delayed escalation. Remote patient monitoring (RPM) offers a medium of high-frequency...
Insider threats remain particularly challenging to detect because malicious activity can be carried out by authorised users with legitimate credentials and established access to organisational systems. Conventional population- and peer-based anomaly...
As regulatory requirements increasingly shape automated lending decisions, fairness remains a critical challenge in high-stakes domains, particularly credit scoring. Although artificial intelligence models can achieve strong predictive performance, t...
Certification as a prostate cancer center requires the offer of several supportive measures to patients undergoing radical prostatectomy (RP). However, it remains unclear how patients estimate the relevance of these measures and whether the availabil...
Global warming threatens sustainable human development, and carbon emission rights trading (CERT) has emerged as a key market-based tool for reducing emissions. Yet evidence on how CERT affects corporate green innovation—especially high-quality...
Stress corrosion cracking (SCC) of metals is an issue of major concern in engineering since this phenomenon causes many catastrophic failures of structural components in aggressive environments. SCC is even more harmful under cathodic conditions prom...
The Internet of Things (IoT) is expanding rapidly, but the security of IoT devices remains a noteworthy concern due to resource limitations and existing security conventions. This research investigates and proposes the use of a Light certificate with...
Psoriasis is a chronic, complex, immunological disorder, which may lead to many different systemic complications. Sphingolipids, including ceramide, are bioactive lipids, which take part in the regulation of immune reactions, cell growth, and apoptos...
Today’s applications and providers are very interested in knowing the social aspects of users in order to customize the services they provide and to be more effective. Among the others, the most frequented places and the paths to reach them are...
Low-alloy reactor pressure vessel steels have a rather low susceptibility to stress corrosion cracking (SCC) in a boiling water reactor (BWR) environment if the high-temperature water contains no anionic impurities. Recent investigations revealed tha...
Legionella pneumophila is the primary causative agent of Legionnaires’ disease. The mutant-type strain interrupted in the ORF7 gene region responsible for the lipopolysaccharide biosynthesis of the L. pneumophila strain Heysham-1, lacking the O...
Eukaryotes possess seven different phosphoinositides (PIPs) that help form the unique signatures of various intracellular membranes. PIPs serve as docking sites for the recruitment of specific proteins to mediate membrane alterations and integrate va...
Animal studies have demonstrated that energy-restricted diets and exercise affect the gut microbiome and are positively linked to physical health; however, less is known about the impacts of various patterns of dietary restriction combined with exerc...
With the consideration of randomness of distributed generations and loads, this paper has proposed a method for vulnerability assessment of microgrids based on complex network theory and entropy theory, which can explain the influence of the inherent...
Background and objectives: People with multiple sclerosis (MS) often experience limitations in joint range of motion, which is linked to spasticity and continued inactivity. Low flexibility levels in this population have been linked to postural probl...
This work evaluates the effect of film-forming amines (FFA) on the acidic stress-corrosion cracking (SCC) resistance of NiCrMoV turbine steel. Contact angle measurements show an increased hydrophobicity of the surface when coating the steel with oley...
Youth use of electronic cigarettes (e-cigarettes or vaping) has skyrocketed in recent years, resulting in a youth vaping epidemic. To combat this epidemic, a coalition of U.S.-based researchers created the Rapidly Advancing Discovery to Arrest the Ou...
The influence of hydrogen on the mechanical performance of a hot-rolled martensitic steel was studied by means of constant extension rate test (CERT) and constant load test (CLT) followed with thermal desorption spectroscopy measurements. The steel s...
17 April 2022
Current scientific evidence supports the recommendation to initiate or continue physical exercise in healthy pregnant women. Group exercise programs have positive effects on improving health, well-being, and social support. In 2015, a systematic revi...
Insider threats remain one of the most challenging security risks in modern enterprises due to their subtle behavioral patterns and the difficulty of distinguishing malicious intent from legitimate activity. This paper presents a unified and adaptive...
While airlines can directly quantify carbon emissions based on flight-specific fuel burn data, such data, along with data on other gaseous emissions that do not scale linearly with fuel consumption, are often unavailable to external stakeholders, nec...
Liquid lead-bismuth eutectic (LBE) is one of the candidate materials for advanced nuclear systems. The structural materials used in contact with LBE are selected according to the resistance to liquid metal corrosion, irradiation embrittlement, and co...
18 April 2022
Physical activity during pregnancy is a public health issue. In the view of reproducibility and the successful implementation of exercise interventions, reporting the quality of such study design must be ensured. The objective of this study was to de...
Despite the beneficial effect of exercise, children treated for cancer do not engage in sufficient physical activity. It is necessary to search for attractive forms of physical activity, including interactive video games (IVGs). The aim of this study...
2 February 2022
Background: Stroke is the leading cause of chronic physical disability in Western industrialised nations. Despite clear guidelines for exercise in individuals with many non-communicable diseases, the guidance for people with stroke (PwS) who frequent...
Insider threats pose a critical challenge for securing computer networks and systems. They are malicious activities by authorised users that can cause extensive damage, such as intellectual property theft, sabotage, sensitive data exposure, and web a...
Cultures of primary human nasal epithelial cells (hNECs) differentiated at the air–liquid interface (ALI) represent a sophisticated and widely used model of the human upper respiratory epithelium. Despite the availability of various cell cultur...
The most common causes of short stature (SS) in children are familial short stature (FSS) and idiopathic short stature (ISS). Recently, growth plate dysfunction has been recognized as the genetic cause of FSS or ISS. The aim of this study was to inve...
One of the biggest cybersecurity challenges in recent years has been the risk that insiders pose. Internet consumers are susceptible to exploitation due to the exponential growth of network usage. Malware attacks are a major concern in the digital wo...
Intrusion detection systems can defectively perform when they are adjusted with datasets that are unbalanced in terms of attack data and non-attack data. Most datasets contain more non-attack data than attack data, and this circumstance can introduce...
Phishing attacks often rely on impersonating a legitimate entity, such as a well-known company or a bank, with the intent to deceive individuals. A common tactic used by cybercriminals to conduct such an attack is to register a specific domain to hos...
Background: Although Toxoplasma gondii has been recognized as an obligate intracellular parasite, the lipid metabolic alterations it induces in colonic contents during acute infection remain poorly characterized. Methods: An acute infection model was...
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