Skip to Content
You are currently on the new version of our website. Access the old version .

34 Results Found

  • Article
  • Open Access

Generative-AI learning systems typically centralize conversational information in one agent or use multiple agents primarily as tutors or collaborators. This study presents a distributed multi-agent generative-AI architecture in which role-specific A...

(This article belongs to the Special Issue Disruptive Technologies: Big Data, AI, IoT, Games, and Mixed Reality)
  • Article
  • Open Access
5 Citations
6,661 Views
21 Pages

Design and Evaluation of a Generative AI-Enhanced Serious Game for Digital Literacy: An AI-Driven NPC Approach

  • Suepphong Chernbumroong,
  • Kannikar Intawong,
  • Udomchoke Asawimalkit,
  • Kitti Puritat and
  • Phichete Julrode

The rapid proliferation of misinformation on social media underscores the urgent need for scalable digital-literacy instruction. This study presents the design and evaluation of a Generative AI-enhanced serious game system that integrates Large Langu...

(This article belongs to the Special Issue Generative AI in Higher Education: Applications, Implications, and Future Directions)
  • Article
  • Open Access
5 Citations
4,036 Views
25 Pages

AI-Driven Drug Target Screening Platform Identified Oncogene CACNA2D1 Activated by Enhancer Infestation in Epstein-Barr Virus-Associated Nasopharyngeal Carcinoma

  • Dittman Lai-Shun Chung,
  • Geoffrey Ho Duen Leung,
  • Songran Liu,
  • Sarah Wing Yan Lok and ,
  • Ying Xin,
  • Yunfei Xia,
  • Alex Zhavoronkov,
  • Frank W. Pun,
  • Wai-Tong Ng and
  • Wei Dai
  • + 5 authors+ 0 author

The management of nasopharyngeal cancer (NPC) is rapidly evolving, with immune checkpoint inhibitors emerging as a prominent treatment approach. However, drug development targeting specific molecular and cellular abnormalities in NPC has slowed. Rece...

(This article belongs to the Special Issue Recent Advances in Molecular Targets for Treatment and Drug Delivery in Tumors)
  • Article
  • Open Access
1,201 Views
26 Pages

A Mixed-Methods Feasibility Pilot Study of Medimon for High School Endocrine Education

  • Sebastian Svoboda-Powell,
  • Shane Mitchell,
  • Ciara Bordeaux,
  • Emma Ferguson and ,
  • Joscelyn Coad,
  • Alexandra Silalahi,
  • Cameron Bowman,
  • Jessi Holte,
  • Patryk Kosmulski and
  • Tyler Bland
  • + 5 authors+ 0 author

Medimon is an educational role-playing game that integrates visual mnemonics, collectible creatures, disease states, treatment items, and artificial intelligence-powered non-player characters (AI-NPCs) to teach biomedical concepts. This single-arm mi...

(This article belongs to the Special Issue Technology-Enhanced Game-Based Approaches in Education: Learning, Emotions, and Motivation)
  • Article
  • Open Access
33 Citations
6,001 Views
22 Pages

Integrating Artificial Intelligence (AI) and Extended Reality (XR) technologies into agriculture presents a transformative opportunity to modernize education and sustainable food production. Traditional agriculture training remains resource-intensive...

(This article belongs to the Special Issue Advanced Technologies and Methodologies in Education 4.0)
  • Article
  • Open Access
992 Views
25 Pages

Personality-driven dialogue generation is essential for creating believable non-player characters (NPCs) in games. This study aims to (1) generate short NPC-like dialogue conditioned on predefined personality traits and (2) quantitatively evaluate wh...

(This article belongs to the Special Issue Next-Generation Machine Learning and Deep Learning Models for Complex Data, Vision, and Intelligent Applications)
  • Review
  • Open Access
18 Citations
6,420 Views
16 Pages

Cholesterol is a foundational molecule of biology. There is a long-standing interest in understanding how cholesterol metabolism is intertwined with cancer biology. In this review, we focus on the known connections between lung cancer and molecules m...

(This article belongs to the Section Biochemistry)
  • Review
  • Open Access
60 Citations
11,130 Views
32 Pages

A Comprehensive Review on Radiomics and Deep Learning for Nasopharyngeal Carcinoma Imaging

  • Song Li,
  • Yu-Qin Deng,
  • Zhi-Ling Zhu,
  • Hong-Li Hua and
  • Ze-Zhang Tao

Nasopharyngeal carcinoma (NPC) is one of the most common malignant tumours of the head and neck, and improving the efficiency of its diagnosis and treatment strategies is an important goal. With the development of the combination of artificial intell...

(This article belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)
  • Review
  • Open Access
5 Citations
3,428 Views
14 Pages

Integrating Radiomics and Deep-Learning for Prognostic Evaluation in Nasopharyngeal Carcinoma

  • Irina Maria Pușcaș,
  • Anda Gâta,
  • Alexandra Roman,
  • Silviu Albu and ,
  • Vlad Alexandru Gâta and
  • Alexandru Irimie
  • + 1 author+ 0 author

21 July 2025

Nasopharyngeal carcinoma (NPC) represents a prevalent malignant tumor within the head and neck region, and enhancing the precision of prognostic assessments is a critical objective. Recent advancements in the integration of artificial intelligence (A...

(This article belongs to the Section Oncology)
  • Proceeding Paper
  • Open Access
3,685 Views
11 Pages

Chatbot-Enhanced Non-Player Characters Bridging Game AI and Conversational Systems

  • Gina Purnama Insany,
  • Maulana Ibrahim,
  • Yayang Rega Abdilah and
  • Rizki Panca Pamungkas

25 September 2025

Non-player characters (NPCs) play a crucial role in creating engaging and immersive experiences in role playing games (RPGs). Traditional NPC interactions often rely on scripted dialogues, which can limit their ability to adapt dynamically to player...

(This article belongs to the Proceedings of The 7th International Global Conference Series on ICT Integration in Technical Education & Smart Society)
  • Review
  • Open Access
29 Citations
5,655 Views
24 Pages

24 April 2023

Artificial intelligence (AI) is an interdisciplinary field that encompasses a wide range of computer science disciplines, including image recognition, machine learning, human−computer interaction, robotics and so on. Recently, AI, especially de...

(This article belongs to the Special Issue Clinical Application of Artificial Intelligence in Cancer Research, Diagnosis and Therapy)
  • Article
  • Open Access
24 Citations
5,105 Views
29 Pages

28 February 2025

Background/Objectives: The integration of Augmented Reality (AR) and Artificial Intelligence (AI) in educational applications presents an opportunity to enhance learning outcomes in young users. This study focuses on ARFood, a serious game designed t...

(This article belongs to the Section Sustainable Education and Approaches)
  • Article
  • Open Access
1 Citations
706 Views
13 Pages

Background: Accurate evaluation of the Near Point of Convergence (NPC) is essential for diagnosing and managing convergence insufficiency (CI). Conventional assessment relies on the patient’s verbal feedback and the examiner’s visual obse...

  • Article
  • Open Access
6 Citations
3,154 Views
19 Pages

Non-keratinizing carcinoma is the most common subtype of nasopharyngeal carcinoma (NPC). Its poorly differentiated tumor cells and complex microenvironment present challenges to pathological diagnosis. AI-based pathological models have demonstrated p...

(This article belongs to the Special Issue Biomedical Imaging and Data Analytics for Disease Diagnosis and Treatment, 2nd Edition)
  • Article
  • Open Access
23 Citations
10,649 Views
27 Pages

Unlocking Patient Resistance to AI in Healthcare: A Psychological Exploration

  • Abu Elnasr E. Sobaih,
  • Asma Chaibi,
  • Riadh Brini and
  • Tamer Mohamed Abdelghani Ibrahim

Artificial intelligence (AI) has transformed healthcare, yet patients’ acceptance of AI-driven medical services remains constrained. Despite its significant potential, patients exhibit reluctance towards this technology. A notable lack of compr...

(This article belongs to the Special Issue Application of Artificial Intelligence in the Health Field or Education)
  • Systematic Review
  • Open Access
2 Citations
1,829 Views
22 Pages

Advancing Nasopharyngeal Carcinoma Diagnosis: A Systematic Review of AI-Driven Machine Learning Techniques for CT, MRI, and WSI Imaging in Bioengineering

  • Muhammad Kabir Abdullahi,
  • Arbab Sufyan Wadood,
  • Md Serajun Nabi,
  • Sarina Binti Mansor and
  • Mohammad Faizal Ahmad Fauzi

Background: Nasopharyngeal carcinoma (NPC) presents significant diagnostic and therapeutic challenges, often due to late-stage detection and its complex anatomical location. The increasing integration of artificial intelligence (AI) into oncology off...

  • Article
  • Open Access
5 Citations
4,120 Views
13 Pages

18 December 2023

Nasopharyngeal carcinoma (NPC) is an epithelial cancer originating in the nasopharynx epithelium. Nevertheless, annotating pathology slides remains a bottleneck in the development of AI-driven pathology models and applications. In the present study,...

(This article belongs to the Special Issue Applications of Artificial Intelligence in Healthcare Monitoring)
  • Systematic Review
  • Open Access
1 Citations
1,843 Views
27 Pages

24 June 2026

Background: AI-supported game-based learning (AI-GBL) integrates artificial intelligence mechanisms, including adaptive difficulty adjustment, large language model (LLM) scaffolding, intelligent non-player characters (NPCs), and stealth assessment, i...

(This article belongs to the Special Issue AI Use and Academic Development)
  • Article
  • Open Access
3 Citations
2,114 Views
13 Pages

Nucleoporin Nup358 Downregulation Tunes the Neuronal Excitability in Mouse Cortical Neurons

  • Vladimir A. Martínez-Rojas,
  • Francesca Pischedda,
  • Isabel Romero-Maldonado,
  • Bouchra Khalaf and ,
  • Giovanni Piccoli,
  • Paolo Macchi and
  • Carlo Musio
  • + 2 authors+ 0 author

22 August 2023

Nucleoporins (NUPs) are proteins that comprise the nuclear pore complexes (NPCs). The NPC spans the nuclear envelope of a cell and provides a channel through which RNA and proteins move between the nucleus and the cytoplasm and vice versa. NUP and NP...

(This article belongs to the Special Issue Ion Channels and Neurological Disease)
  • Article
  • Open Access
1 Citations
3,484 Views
11 Pages

AI-Powered Smartphone Diagnostics for Convergence Insufficiency

  • Ahmad Khatib,
  • Shmuel Raz,
  • Haia Nasser,
  • Haneen Jabaly-Habib and
  • Ilan Shimshoni

Background: This study innovatively combines Artificial Intelligence (AI) algorithms with smartphone technology, automatically detecting the Near Point of Convergence (NPC) and diagnosing Convergence Insufficiency (CI) without the need for extra diag...

  • Article
  • Open Access
1 Citations
719 Views
15 Pages

AI-Guided Home-Based Therapy for Convergence Insufficiency: A Comparative Feasibility Study with Pencil Push-Ups

  • Ahmad Khatib,
  • Shmuel Raz,
  • Elad Shvartz,
  • Ilan Shimshoni and
  • Haneen Jabaly-Habib

Background: Convergence insufficiency (CI) is a common binocular vision disorder that causes eye strain, headaches, and blurriness. Although pencil push-ups (PPU) are widely used to treat CI, their real-world effectiveness may be limited by inconsist...

(This article belongs to the Section Biosignal Processing)
  • Article
  • Open Access
7 Citations
4,067 Views
12 Pages

Identification of NP Protein-Specific B-Cell Epitopes for H9N2 Subtype of Avian Influenza Virus

  • Xiangyu Huang,
  • Jingwen Huang,
  • Guihu Yin,
  • Yiqin Cai and ,
  • Mengli Chen,
  • Jianing Hu and
  • Xiuli Feng
  • + 2 authors+ 0 author

28 May 2022

Avian Influenza (AI) caused by the H9N2 subtype of the avian influenza virus (AIV) poses a serious threat to both the poultry industry and to public health safety. NP is one of the major structural proteins in influenza viruses. B-cell determinants l...

(This article belongs to the Topic Veterinary Infectious Diseases)
  • Article
  • Open Access
2 Citations
3,572 Views
23 Pages

Comparative Analysis of SAAS Model and NPC Integration for Enhancing VR Shopping Experiences

  • Surasachai Doungtap,
  • Jenq-Haur Wang and
  • Varinya Phanichraksaphong

27 July 2024

This article examines the incorporation of the Shopping Assistance Automatic Suggestion (SAAS) model into Virtual Reality (VR) environments in order to improve the online shopping experience. The SAAS model employs sophisticated deep learning methods...

(This article belongs to the Special Issue Enhancing User Experience in Virtual Reality Environments: Innovative Interaction Design Strategies)
  • Review
  • Open Access
130 Views
23 Pages

Nasopharyngeal Carcinoma Risk Stratification: Current Evidence and Emerging Approaches

  • Maria Alina Marin,
  • Oana Silvana Sarău,
  • Andra Ardelean,
  • Delia Ioana Horhat and ,
  • Cristian Andrei Sarău,
  • Sergio Liga and
  • Nicolae Constantin Balica
  • + 2 authors+ 0 author

3 November 2026

Nasopharyngeal carcinoma is characterized by marked biological and clinical heterogeneity that is only partly captured by conventional anatomical staging. This narrative review examines how circulating biomarkers, radiomics, artificial intelligence (...

(This article belongs to the Section Head and Neck Oncology)
  • Review
  • Open Access
17 Citations
5,913 Views
18 Pages

Hepatic Zonation in MASLD: Old Question, New Challenge in the Era of Spatial Omics

  • Erika Paolini,
  • Miriam Longo,
  • Marica Meroni and
  • Paola Dongiovanni

3 November 2025

Hepatic zonation reflects the concept that hepatocytes and nonparenchymal cells (NPCs) perform distinct metabolic functions, depending on their spatial localization along the porto-central axis. The maintenance of this fine-tuned organization is esse...

(This article belongs to the Special Issue Molecular Advances and Insights into Liver Diseases)
  • Article
  • Open Access
29 Citations
6,853 Views
20 Pages

An Architecture for Intelligent Tutoring in Virtual Reality: Integrating LLMs and Multimodal Interaction for Immersive Learning

  • Mohamed El Hajji,
  • Tarek Ait Baha,
  • Anas Berka,
  • Hassan Ait Nacer and ,
  • Houssam El Aouifi and
  • Youssef Es-Saady
  • + 1 author+ 0 author

29 June 2025

Immersive learning has been recognized as a promising paradigm for enhancing educational experiences through the integration of VR. We propose an architecture for intelligent tutoring in immersive VR environments that employs LLM-based non-playable c...

(This article belongs to the Special Issue Interactive Learning: Human in the Loop System Design for Active Human–Computer Interactions)
  • Article
  • Open Access
929 Views
23 Pages

A Persistent Multi-User Virtual Reality Garden: Architecture, Traceability, and Technical Validation

  • Giovanni Giuliodori,
  • Erica Santaguida,
  • Chiara Evangelista and
  • Massimo Bergamasco

Virtual reality (VR) applications are often designed as episodic experiences, with limited support for persistence, longitudinal revisitation, and structured integration of interaction data across sessions. This paper presents a persistent multi-user...

(This article belongs to the Topic AI-Based Interactive and Immersive Systems)
  • Article
  • Open Access
24 Citations
8,219 Views
19 Pages

Metaverse and Digital Twins in the Age of AI and Extended Reality

  • Ming Tang,
  • Mikhail Nikolaenko,
  • Ahmad Alrefai and
  • Aayush Kumar

This paper explores the evolving relationship between Digital Twins (DT) and the Metaverse, two foundational yet often conflated digital paradigms in digital architecture. While DTs function as mirrored models of real-world systems—integrating...

(This article belongs to the Special Issue Shaping Architecture with Computation)
  • Feature Paper
  • Article
  • Open Access
30 Citations
7,706 Views
14 Pages

Associations of Lipids and Lipid-Lowering Drugs with Risk of Vascular Dementia: A Mendelian Randomization Study

  • Xiaoyu Zhang,
  • Tao Geng,
  • Ning Li,
  • Lijuan Wu and ,
  • Youxin Wang,
  • Deqiang Zheng,
  • Bo Guo and
  • Baoguo Wang
  • + 3 authors+ 0 author

23 December 2022

Accumulating observational studies suggested that hypercholesterolemia is associated with vascular dementia (VaD); however, the causality between them remains unclear. Hence, the aim of this study is to infer causal associations of circulating lipid-...

(This article belongs to the Section Lipids)
  • Article
  • Open Access
1,351 Views
25 Pages

A Belief Model for BDI Agents Derived from Roles and Personality Traits

  • Eduardo David Martínez-Hernández,
  • Bárbara María-Esther García-Morales,
  • María Lucila Morales-Rodríguez,
  • Claudia Guadalupe Gómez-Santillán and
  • Nelson Rangel-Valdez

Recent advancements in AI have enabled autonomous agents to interact within complex environments, with deliberative BDI (Belief–Desire–Intention) agents standing out for their human-inspired reasoning capabilities. However, defining the i...

(This article belongs to the Special Issue Numerical and Evolutionary Optimization 2025)
  • Article
  • Open Access
6 Citations
4,064 Views
15 Pages

A Pilot Metabolomic Study for Diagnosing Aspergillus Infection in Immunocompromised Pediatric Cancer Patients

  • Taghreed Khaled Abdelmoneim,
  • Asmaa Ramzy,
  • Mostafa Ahmed Zaki,
  • Ahmed Karam and ,
  • Ahmed Hesham,
  • Aya Osama,
  • Nabila Sabar,
  • Maha Mokhtar,
  • Nada A. Youssef and
  • Sameh Magdeldin
  • + 10 authors+ 5 authors

Fungal infection caused by invasive Aspergillus is a life-threatening complication in immunocompromised pediatric cancer patients. However, the early diagnosis of invasive infection remains a clinical challenge due to the lack of specific, non-invasi...

(This article belongs to the Special Issue Molecular Advances in Cancer and Cell Metabolism—2nd Edition)
  • Article
  • Open Access
3 Citations
3,041 Views
22 Pages

Reinforcement Learning Methods for Emulating Personality in a Game Environment

  • Georgios Liapis,
  • Anna Vordou,
  • Stavros Nikolaidis and
  • Ioannis Vlahavas

15 July 2025

Reinforcement learning (RL), a branch of artificial intelligence (AI), is becoming more popular in a variety of application fields such as games, workplaces, and behavioral analysis, due to its ability to model complex decision-making through interac...

(This article belongs to the Special Issue Innovative Artificial Intelligence Methods, Tools and Methodologies to Address Challenging Real-World Problems)
  • Systematic Review
  • Open Access
1 Citations
2,258 Views
27 Pages

23 April 2026

Single-player role-playing games (RPGs) combine two promises that do not always align: delivering a compelling narrative experience (world, characters, choices, and consequences) while sustaining a demanding ludic trajectory in which players face obs...

  • Article
  • Open Access
875 Views
22 Pages

This paper proposes a practical heuristic engineering strategy for automated capacity allocation in a multifunctional parallel active power filter (PAPF) that simultaneously provides harmonic and reactive power compensation. Unlike theoretically opti...

(This article belongs to the Special Issue Energy Consumption Management in Electronic Systems)