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Journal of Clinical & Translational Ophthalmology

Journal of Clinical & Translational Ophthalmology is an international, peer-reviewed, open access journal on ophthalmology published quarterly online by MDPI.

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All Articles (62)

Background: Higher intake of omega-3 fatty acids from food sources is associated with a reduced risk of age-related macular degeneration (AMD), but there are no recommended parameters for omega-3 fatty acid supplementation. The purpose of our study was to investigate whether fish oil supplementation protects against development of AMD in the US Veteran Affairs (VA) Corporate Data Warehouse. Methods: Patients ≥ 55 years without an AMD diagnosis at the initial eye examination who also had a 5-year follow up eye examination were included in this retrospective cohort study. Patients receiving fish oil supplementation from the VA pharmacy were categorized into the fish oil exposure group and matched 1:1 to a non-exposure control group. All patients were assessed for AMD development at the 5-year follow up eye examination. Results: AMD developed in 772 of 16,172 patients (4.8%) with fish oil exposure and 635 of 16,093 (3.9%) without fish oil exposure (relative risk (RR) = 1.21, 95% confidence interval (CI) = 1.09–1.34, p = 0.0003). Compared to controls, AMD risk was similar in low-dose (RR = 0.91; 95% CI = 0.65–1.27) and moderate-dose (RR = 0.93; 95% CI = 0.79–1.10) fish oil supplementation but higher in high-dose fish oil supplementation (RR = 1.32; 95% CI = 1.19–1.47). Conclusions: Fish oil supplementation did not protect against AMD in a US veteran population.

9 March 2026

Flowchart describing the study cohort selection. AMD = age-related macular degeneration; MPR = medication possession rate; T0 = time of initial eye examination; T1 = time of follow-up eye examination; VA = Veterans Affairs.

Anterior Segment Variations After Cataract Surgery in Subjects with Primary Open-Angle Glaucoma

  • Antonio Martínez-Abad,
  • Maria José García-Corral and
  • Mario Cantó-Cerdán
  • + 6 authors

Background: The impact of cataract surgery on anterior segment structures in subjects affected by primary open-angle glaucoma (POAG) remains incompletely understood. The aim of this study was to characterize changes in anterior segment parameters after cataract surgery in POAG subjects compared with non-glaucoma subjects (control). Methods: A prospective comparative study was conducted, including patients scheduled for cataract surgery who underwent a comprehensive ophthalmic examination before and after surgery using anterior segment optical coherence tomography (OCT). Longitudinal changes and between-group comparisons were analyzed. Results: The results demonstrated a significant enlargement of the anterior chamber and iridocorneal angles after surgery in both groups (p < 0.05), with no significant differences between POAG and control eyes (p > 0.05). Several preoperative parameters, particularly angle-related metrics, were correlated with postoperative anatomical changes, suggesting their potential role as predictors of anterior segment variation (R > 0.50; p < 0.05). Conclusions: In conclusion, this study provides a detailed characterization of anterior segment changes in POAG subjects following cataract surgery, demonstrating anterior chamber enlargement comparable to that observed in non-glaucoma eyes, which may assist clinicians in the management of glaucoma.

13 February 2026

Example of anterior segment measurement by Casia2 device in a patient before the cataract surgery.

Purpose: This study evaluates the association between supervising attending surgeons’ post-residency experience and complication rates during resident-performed phacoemulsification (cataract extraction) surgeries, and to determine whether this relationship changes as the academic year progresses. Methods: A retrospective analysis of 1263 cataract surgeries performed by eight PGY-4 residents under 14 board-certified attendings was conducted at a New York City residency program over two years. Attendings were divided into four groups based on years of post-residency experience. Primary complications included posterior capsule (PC) tears, anterior vitrectomy (AV), capsulorrhexis extensions (CE), and inability to place a one-piece intraocular lens (IOL). Chi-square analyses compared complication rates between attending groups overall, and between the first and second halves of the academic year. Results: A total of 167 primary complications (13.2%) were identified. Attendings with the fewest years of experience (Group 1) supervised significantly more cases with PC tears (χ2 = 8.173, p = 0.004), AV usage (χ2 = 7.748, p = 0.005), and inability to place a one-piece IOL (χ2 = 4.753, p = 0.029), particularly during the first half of the academic year. Notably, supervising attending experience was not correlated with resident complications in the second half of the academic year. Conclusions: Early in the academic year, less experienced attendings supervised cases with higher complication rates, underscoring the critical role of strategic case assignment and targeted mentorship during early surgical training. These findings suggest that aligning resident progression with appropriate supervision can enhance outcomes and support skill development, optimizing both education and patient safety.

30 January 2026

Rates of primary resident cataract complications, subdivided by complication and attending group, over the full 2-year study period. Groups 1–4 represent supervising attendings with 0–2, 2–5, 5–25, and 25+ years of postgraduate experience, respectively.

Objective: Assess visual acuity (VA) and strabismus changes in children after Baerveldt 350 (BV350) device placement. Methods and Analysis: Retrospective cohort study of children (<21 years of age) who had superotemporal BV350 placement (2011–2023) and >6-month follow-up. Ocular diagnoses, surgical details, and preoperative and final follow-up exam findings were collected. In bilateral cases, first eye implanted was included in analysis. Results: Ninety-seven patients underwent BV350 surgery with median age of 6.7 (interquartile (IQR) 3.1, 11.2) years and with a median of 4.2 (IQR 1.8, 6.8) years of follow-up. Most common glaucomas were secondary to non-acquired ocular anomaly (n = 31) or primary congenital glaucoma (n = 21). There was no difference in preoperative and final VA (p = 0.6583). Twenty-seven (28%) and twenty-five (26%) patients were orthophoric preoperatively and at final follow-up, respectively. Orthophoria at final follow-up was associated with preoperative (odds ratio (OR)1.8 [1.2, 2.9]) and final VA (OR1.5 [1.1, 2.3]). At final follow-up, 13 patients (13%) and 19 patients (20%) showed worsened or improved horizontal deviation (>10 prism diopter (PD) change), respectively. No patients reported postoperative diplopia. Only four patients, all with esotropia, underwent subsequent strabismus surgery. Conclusions: Children who underwent BV350 placement did not have significant change in VA, and a high percentage of patients had strabismus prior to (72%) and following (74%) glaucoma surgery. Orthophoria was associated with better VA. The majority of patients did not show worsening of strabismus postoperatively, and none reported diplopia.

19 January 2026

Operative eye VA and strabismus.

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J. Clin. Transl. Ophthalmol. - ISSN 2813-1053