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Cancers, Volume 16, Issue 20

October-2 2024 - 123 articles

Cover Story: Tumors of the central nervous system (CNS) are complex and challenging to treat. This review highlights the importance of the epigenetic marker H3K27me3—the trimethylation of lysine 27 on histone H3—in CNS tumors. H3K27me3 regulates gene expression and chromatin structure. Reduced gene expression levels, often due to mutations like H3F3A and HIST1H3B, are linked to aggressive brain tumors, such as diffuse midline glioma and posterior fossa ependymomas. The loss of H3K27me3 in meningiomas predicts worse outcomes, especially in grade 2 cases. Ultimately, research into H3K27me3 is vital for improving CNS tumor diagnostics, treatment, and personalized medicine. View this paper
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Articles (123)

  • Article
  • Open Access
1 Citations
2,105 Views
11 Pages

21 October 2024

Background: Microcystic, elongated, and fragmented (MELF) invasion is a special invasion pattern in endometrioid endometrial cancer (EEC). This study aimed to investigate the clinical, pathological, and molecular features of the MELF pattern and its...

  • Correction
  • Open Access
1 Citations
1,074 Views
2 Pages

Correction: Becker et al. Identifying Predictive Biomarkers for Head and Neck Squamous Cell Carcinoma Response. Cancers 2023, 15, 5597

  • Anne-Sophie Becker,
  • Cornelius Kluge,
  • Carsten Schofeld,
  • Annette Helene Zimpfer,
  • Björn Schneider,
  • Daniel Strüder,
  • Caterina Redwanz,
  • Julika Ribbat-Idel,
  • Christian Idel and
  • Claudia Maletzki

21 October 2024

In the original publication [...]

  • Article
  • Open Access
2 Citations
2,108 Views
17 Pages

Impact of the Immune Landscape in Follicular Lymphoma: Insights into Histological Transformation in the Rituximab Era

  • Marie Hairing Enemark,
  • Maja Lund Jensen,
  • Maja Dam Andersen,
  • Trine Lindhardt Plesner,
  • Stephen Hamilton-Dutoit and
  • Maja Ludvigsen

21 October 2024

Background: Follicular lymphoma (FL) presents significant clinical heterogeneity, with some patients experiencing transformation into an aggressive disease, a key contributor to FL-related mortality. Based on gene expression profiles, this study aime...

  • Article
  • Open Access
1 Citations
1,753 Views
13 Pages

Introduction of an Educational Video to Enhance the Informed Consent Process in Postoperative Radiation Therapy of Breast Cancer Patients

  • Samuel M. Vorbach,
  • Martin Pointner,
  • Jens Lehmann,
  • Julian Mangesius,
  • Tilmann Hart,
  • Claudia Gstir,
  • Theresa Rändler,
  • Thomas Seppi,
  • Ute Ganswindt and
  • Siegfried Kollotzek

21 October 2024

Background/Objectives: Informed consent is crucial in medical practice, especially for complex treatments such as postoperative radiotherapy for patients with breast cancer. Conventional consent procedures are often based on verbal declarations with...

  • Systematic Review
  • Open Access
6 Citations
3,365 Views
16 Pages

Stereotactic Radiosurgery for Intracranial Breast Metastases: A Systematic Review and Meta-Analysis

  • Neil D. Almeida,
  • Cathleen Kuo,
  • Tyler V. Schrand,
  • Julia Rupp,
  • Venkatesh S. Madhugiri,
  • Victor Goulenko,
  • Rohil Shekher,
  • Chirag Shah and
  • Dheerendra Prasad

21 October 2024

Background/Objectives: To determine the impact of stereotactic radiosurgery on outcomes of metastatic breast cancer with intracranial metastases. Methods: We systematically searched the PubMed and EMBASE databases for studies published between 1 Janu...

  • Article
  • Open Access
2 Citations
1,267 Views
11 Pages

Reduction of Blood Oxidative Stress Following Colorectal Cancer Resection

  • Katsuji Sawai,
  • Takanori Goi,
  • Youhei Kimura and
  • Kenji Koneri

21 October 2024

Background: Colorectal cancer is a major global health burden, with surgical resection being the standard treatment aimed at curative tumor removal. Oxidative stress plays a crucial role in colorectal cancer progression and prognosis. This study hypo...

  • Article
  • Open Access
1,639 Views
16 Pages

The Neoangiogenic Transcriptomic Signature Impacts Hepatocellular Carcinoma Prognosis and Can Be Triggered by Transarterial Chemoembolization Treatment

  • Rosina Maria Critelli,
  • Federico Casari,
  • Alberto Borghi,
  • Grazia Serino,
  • Cristian Caporali,
  • Paolo Magistri,
  • Annarita Pecchi,
  • Endrit Shahini,
  • Fabiola Milosa and
  • Lorenza Di Marco
  • + 9 authors

21 October 2024

Background/Objectives: We evaluated the relationship between the neoangiogenic transcriptomic signature (nTS) and clinical symptoms, treatment outcomes, and survival in hepatocellular carcinoma (HCC) patients. Methods: This study prospectively follow...

  • Review
  • Open Access
8 Citations
7,617 Views
19 Pages

21 October 2024

Inhibition of multiple cancer-related pathways has made niclosamide a promising candidate for the treatment of various cancers. However, its clinical application has been significantly limited by poor bioavailability. This review will discuss current...

  • Review
  • Open Access
14 Citations
5,312 Views
22 Pages

21 October 2024

Emerging evidence highlights the crucial role of gastrointestinal microbiota in the pathogenesis of gastric cancer. Helicobacter pylori (H. pylori) infection stands out as a primary pathogenic factor. However, interventions such as anti-H. pylori the...

  • Article
  • Open Access
2,190 Views
18 Pages

Comparative Study of Cutaneous Squamous Cell Carcinogenesis in Different Hairless Murine Models

  • Georgios Gkikas,
  • Dimitrios Katsiris,
  • Andreas Vitsos,
  • Anna Gioran,
  • Dimitra Ieronymaki,
  • Maria Kostaki,
  • Georgios Ladopoulos,
  • Vaya Ioannidou,
  • Elisavet Theodoraki and
  • Niki Chondrogianni
  • + 3 authors

21 October 2024

Background: In recent decades, a significant global increase in the incidence of non-melanoma skin cancer has been observed. To explore the pathogenesis of and potential therapeutic approaches for squamous cell carcinoma, various in vivo studies usin...

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Cancers - ISSN 2072-6694