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2009	Inaugural issue was released, initially published as a quarterly journal.
2013	Indexed by PubMed (NLM) and Scopus.
2015	Changed to publish in article number order instead of in page range order.
2016	Changed to a monthly publication schedule. The Travel Awards project was launched to support young researchers in the field. The journal Twitter account was established.
2017	Covered by the Science Citation Index Expanded (SCIE).
2018	Cancers received a first Impact Factor of 5.326. The journal ranks 44/222 (Q1) in the 'Oncology' category.
2019	Cancers received an Impact Factor of 6.162. The journal ranks 31/229 (Q1) in the 'Oncology' category in JCR. Cancers published more than 2000 papers in the year of 2019. Cancers became an affiliated journal of Signal Transduction Society (STS).
2020	Cancers established the following topical sections: Molecualr Cancer Biology Cancer Immunology and Immunotherapy Cancer Biomarkers Cancer Epidemiology and Prevention Cancer Pathophysiology Tumor Microenvironment Cancer Causes, Screening and Diagnosis Cancer Nursing and Care Cancer Therapy Clinical Trials of Cancer Systematic Review or Meta-Analysis in Cancer Research Methods and Technologies Development Cancer Informatics and Big Data Cancers announced the Outstanding Reviewer Awards and Young Investigator Awards
2021	Cancers starts to be published semi-monthly online since January 2021.

2009–October 2015	Founding Editor-in-Chief: Prof. Dr. Robert H. Weiss
December 2015–Present	Editor-in-Chief: Prof. Dr. Samuel C. Mok
January 2016–Present	Associate Editor: Prof. Dr. David Wong
December 2017–Present	Associate Editor: Dr. Deepak Nagrath
April 2020-Present	Section EiC Dr. Carlos S. Moreno
May 2020–Present	Associate Editor: Prof. Dr. Mary Frances McMullin
May 2020-Present	Associate Section EiC Dr. Subree Subramanian
August 2020-Present	Section EiC Prof. Dr. Donat Kögel
August 2020-Present	Section EiC Dr. Barbara Wegiel
August 2020-Present	Section EiC Prof. Dr. Eduardo Nagore
September 2020-Present	Section EiC Dr. Nicola Amodio
September 2020-Present	Section EiC Prof. Dr. Sanjay Gupta
September 2020-Present	Associate Section EiC Prof. Dr. Dario Marchetti
September 2020-Present	Associate Section EiC Dr. Giovanna Tosato
September 2020-Present	Section EiC Dr. Kevin Camphausen
September 2020-Present	Section EiC Prof. Dr. Alexandre Escargueil
September 2020-Present	Section EiC Prof. Dr. Massimo Di Maio
September 2020-Present	Section EiC Prof. Dr. Fiona M. Lyng
September 2020-Present	Section EiC Dr. Jason Roszik
September 2020-Present	Associate Section EiC Dr. J. Chad Brenner
October 2020-Present	Section EiC Prof. Dr. Massoud Mirshahi
January 2021-Present	Section Editor-in-Chief Prof. Dr. Antoine Italiano