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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Breast Cancer and Hormone-Related Therapy

edited by

John R. Hawse

submission deadline 10 Aug 2025 | 12 articles | Viewed by 45672 | Submission Open

Keywords: breast cancer; estrogen receptor; hormone activated transcription factors; hormonal therapy; molecular mechanisms

(This special issue belongs to the Section Cancer Therapy)

Epigenetic Regulation in Cancers

edited by

Sudhir Rai

and

Seema Kumari

submission deadline 10 Aug 2025 | 3 articles | Viewed by 6545 | Submission Open

Keywords: oncogenes; tumor suppressor genes; tumor microenvironment; cancer therapy; DNA and histone methylation; microRNAs; epitranscriptomics; RNA modifications; modifying proteins

(This special issue belongs to the Section Tumor Microenvironment)

Alternative Cell Death Modes in Regulating Cancer Stem Cells and Therapeutic Strategies

edited by Mun-Ock Kim and

Shazib Pervaiz

submission deadline 10 Aug 2025 | 2 articles | Viewed by 5365 | Submission Open

Keywords: cancer stem cell; alternative cell death mode; tumor microenvironment; immune mechanism; cellular basis of cancer therapy resistance; cellular transformation; small-molecule-based therapeutics

(This special issue belongs to the Section Molecular Cancer Biology)

Cutting-Edge Nanomedicine Advancements in Cancer Disease

edited by

Ana Isabel Torres-Suárez

and

Ana Isabel Fraguas-Sánchez

submission deadline 10 Aug 2025 | Viewed by 235 | Submission Open

Keywords: active targeting; breast cancer; drug delivery; liposomes; lung cancer; metallic nanoparticles; polymeric nanoparticles; theragnostic

(This special issue belongs to the Section Methods and Technologies Development)

Advances in Skin Cancer: Diagnosis, Treatment and Prognosis

edited by Iris Zalaudek and

Roberta Giuffrida

submission deadline 15 Aug 2025 | 12 articles | Viewed by 20140 | Submission Open

Keywords: skin cancer; melanoma; basal cell carcinoma; cutaneous squamous cell carcinoma; diagnosis; noninvasive imaging; therapy; prognosis; immunotherapy; targeted therapy

(This special issue belongs to the Section Cancer Therapy)

Research on Early-Stage Breast Cancer: Management and Treatment

edited by Ernyu Tan

submission deadline 15 Aug 2025 | 7 articles | Viewed by 16633 | Submission Open

Keywords: early-stage breast cancer; adjuvant treatment; systemic therapy; risk stratification; survival

(This special issue belongs to the Section Cancer Therapy)

Advancements in Lung Cancer Surgical Treatment and Prognosis

edited by Sai Yendamuri and

Kenneth Patrick Seastedt

submission deadline 15 Aug 2025 | 9 articles | Viewed by 15982 | Submission Open

Keywords: lung cancer; surgical techniques; targeted therapies; immunotherapies; accurate staging; biomarker detection; clinical trials; multimodality therapy; artificial intelligence (AI) in thoracic oncology; enhanced recovery after thoracic surgery (ERATS)

(This special issue belongs to the Section Cancer Therapy)

Clinical Surgery for Hepato-Pancreato-Biliary (HPB) Cancer

edited by

Gennaro Nappo

and

Michele Pagnanelli

submission deadline 15 Aug 2025 | 8 articles | Viewed by 8540 | Submission Open

Keywords: pancreatic malignancies; HPB malignancies; pancreatic ductal adenocarcinoma; liver cholangiocarcinoma; HPB surgery; liver resection; pancreatic resection

(This special issue belongs to the Section Cancer Therapy)

Impact of Social Determinants on Cancer Care

edited by

Mohamad El Moheb

submission deadline 15 Aug 2025 | 4 articles | Viewed by 6011 | Submission Open

Keywords: social determinants of health; cancer disparities; socioeconomic status; transportation barriers; stress genomics; health equity; cancer outcomes

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Advances in Esophageal Cancer

edited by Sacheen Kumar

submission deadline 15 Aug 2025 | 2 articles | Viewed by 2442 | Submission Open

Keywords: esophageal adenocarcinoma; esophageal squamous cell carcinoma; long-term survival; biomarkers; disease surveillance; treatment response

(This special issue belongs to the Section Cancer Therapy)

Oligometastases Hypothesis to Advancing New Perspectives on Cancer: Oligo-Reurrence

edited by

Yuzuru Niibe

Dai Sonoda

and

Tadahiko Shien

submission deadline 15 Aug 2025 | 1 articles | Viewed by 994 | Submission Open

Keywords: oligometastases; oligo-recurrence; sync-oligometastases

(This special issue belongs to the Section Cancer Metastasis)

Robot-Assisted Surgery for Urologic Cancer

edited by Gabriele Sorce, Francesco Pellegrino and Ettore Di Trapani

submission deadline 15 Aug 2025 | 1 articles | Viewed by 788 | Submission Open

Keywords: robot-assisted surgery; urologic oncology; minimally invasive surgery; prostate cancer surgery; kidney cancer surgery; bladder cancer surgery; robotic platforms; robotic surgery training

(This special issue belongs to the Section Cancer Therapy)

Prostate Cancer Epidemiology and Genetics: 2nd Edition

edited by

Steven Narod

submission deadline 15 Aug 2025 | 1 articles | Viewed by 772 | Submission Open

Keywords: prostate cancer; epidemiology; clinical genetics; aging; population-level databases

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Role of Autophagy in Cancer Stem Cells and the Tumor Microenvironment: New Frontiers in Cancer Drug Discovery

edited by Yasser Heakal,

Alakananda Basu

and

Kasper M. Rouschop

submission deadline 15 Aug 2025 | Viewed by 475 | Submission Open

Keywords: autophagy; cancer stem cells; tumor microenvironment; therapeutic resistance; metastasis

(This special issue belongs to the Section Tumor Microenvironment)

Breast Conservation and Radiotherapy in the Era of De-Escalation of Breast Cancer Treatments

edited by

Alessandro Fancellu

submission deadline 15 Aug 2025 | Viewed by 390 | Submission Open

Keywords: breast cancer; breast conserving treatment; mastectomy; radiotherapy; neoadjuvant treatment; psychology; quality of life; breast imaging

(This special issue belongs to the Section Cancer Therapy)

Palliative Radiotherapy of Cancer

edited by

Alessio Giuseppe Morganti

Costanza Maria Donati

, Romina Rossi and

Marco Maltoni

submission deadline 15 Aug 2025 | Viewed by 283 | Submission Open

Keywords: palliative radiotherapy; cancer pain management; advanced radiotherapy techniques; multidisciplinary cancer care; stereotactic body radiotherapy (SBRT); quality of life in cancer; cancer symptom management

(This special issue belongs to the Section Cancer Therapy)

Antioxidants in Cancers

edited by Asif Raza

submission deadline 15 Aug 2025 | Viewed by 251 | Submission Open

Keywords: antioxidants in cancer; oxidative stress and cancer; tumor microenvironment; cancer prevention strategies; therapy resistance and antioxidants; reactive oxygen species (ROS); natural antioxidants; synthetic antioxidants; precision oncology; chemoprevention

(This special issue belongs to the Section Cancer Therapy)

Radiotherapy for Sarcoma

edited by Safia K. Ahmed and Miranda Lam

submission deadline 15 Aug 2025 | Viewed by 153 | Submission Open

Keywords: soft tissue sarcoma; bone sarcoma; advanced sarcoma; radiation therapy; particle therapy; multidisciplinary sarcoma care

(This special issue belongs to the Section Cancer Therapy)

Immunotherapy of Glioblastoma

edited by

Mao Li

submission deadline 16 Aug 2025 | Viewed by 243 | Submission Open

Keywords: glioblastoma; immunotherapy; antigen presentation; CNS lymphatic system; adoptive cell therapy; cancer vaccine; checkpoint blockage

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Bone and Spine Metastases

edited by

Kenichiro Kakutani

and

Yutaro Kanda

submission deadline 20 Aug 2025 | 9 articles | Viewed by 17052 | Submission Open

Keywords: bone metastases; spinal metastases; stereotactic body radiotherapy; conventional radiotherapy; spine surgery; spondylectomy; minimally invasive surgery; particle-beam radiotherapy; systemic agents; microenvironment

(This special issue belongs to the Section Cancer Metastasis)

Cell Migration and Invasion in Cancer

edited by

Suresh K Alahari

submission deadline 20 Aug 2025 | 3 articles | Viewed by 7533 | Submission Open

Keywords: cell migration; invasion; tumor; metastasis; genes; microRNA

(This special issue belongs to the Section Molecular Cancer Biology)

Radiation Exposure, Inflammation and Cancers

edited by

Santosh Kumar

submission deadline 20 Aug 2025 | 3 articles | Viewed by 4539 | Submission Open

Keywords: radiation; DNA damage response; inflammation; oxidative stress; senescence and cancer

(This special issue belongs to the Section Tumor Microenvironment)

Ultrasonography for Pancreatobiliary Cancer

edited by

Yasunobu Yamashita

submission deadline 20 Aug 2025 | 2 articles | Viewed by 2078 | Submission Open

Keywords: endoscopic ultrasonography; abdominal ultrasonography; early diagnosis project; screening; EUS-FNA; interventional EUS; enhancement EUS; EUS-RFA

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Research on New Drugs and Drug Targets in Melanoma

edited by

Paula Wróblewska Łuczka

and

Nicolas Dumaz

submission deadline 20 Aug 2025 | 2 articles | Viewed by 1670 | Submission Open

Keywords: melanoma; new drugs; drug targets; mechanism of action; substances with anti-melanoma potential

(This special issue belongs to the Section Cancer Drug Development)

Protein Kinases and Their Impact on Tumor Growth: Mechanisms and Therapeutic Targets

edited by

Arati Sharma

and

SubbaRao Madhunapantula

submission deadline 20 Aug 2025 | 1 articles | Viewed by 1470 | Submission Open

Keywords: protein kinases; PI3K-Akt signaling; MAPK signaling; kinase inhibitors; drug resistance; crosstalk

(This special issue belongs to the Section Methods and Technologies Development)

New Insights into Esophageal Cancer Chemotherapy

edited by Kenneth Meredith

submission deadline 20 Aug 2025 | Viewed by 378 | Submission Open

Keywords: esophageal cancer; chemotherapy; treatment

(This special issue belongs to the Section Cancer Therapy)

Novel Insights into Microenvironment of Leukemia

edited by

Francesco Bertolini

submission deadline 20 Aug 2025 | Viewed by 211 | Submission Open

Keywords: stromal microenvironment; genetic and epigenetic alterations; bone marrow; chronic and acute leukemia; hematological malignancies

(This special issue belongs to the Section Tumor Microenvironment)

Clinical Advances and State-of-Art Management in Genitourinary Cancers

edited by

Jad Chahoud

and Adnan Fazili

submission deadline 25 Aug 2025 | 1 articles | Viewed by 1859 | Submission Open

Keywords: genitourinary malignancies; tumor– immune microenvironment (TIME); tumor biology; genomic characterization; targeted drug therapy; immunotherapy

(This special issue belongs to the Section Clinical Research of Cancer)

Surgical Treatment of Bone Metastases: 2nd Edition

edited by

Michael Mørk Petersen

submission deadline 29 Aug 2025 | 2 articles | Viewed by 4024 | Submission Open

Keywords: metastatic bone disease; bone metastasis; pathological fractures; surgical treatment; patients survival; implant survival; functional results; surgical technique

(This special issue belongs to the Section Cancer Therapy)

New Challenges in Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia

edited by Federico Mosna and Irene Cavattoni

submission deadline 29 Aug 2025 | 1 articles | Viewed by 1056 | Submission Open

Keywords: acute myeloid leukemia (AML); allogeneic hematopoietic stem cells transplantation (allo-HSCT); immunotherapy; leukemic stem cells; graft versus host disease (GVHD); infections in immunodepressed patients; immune reconstitution; post-transplant management; long-term results; clinical

(This special issue belongs to the Section Cancer Therapy)

CRISPR in Cancer Biology and Therapy: 2nd Edition

edited by

Shun-Qing Liang

submission deadline 29 Aug 2025 | Viewed by 251 | Submission Open

Keywords: cancer drug resistance; CRISPR screens; CRISPR-related technology; base editing; prime editing; off-target analysis; adeno-associated virus

(This special issue belongs to the Section Methods and Technologies Development)

Advances in Drug Repurposing to Overcome Cancers

edited by

Rafal Bartoszewski

submission deadline 30 Aug 2025 | 6 articles | Viewed by 12041 | Submission Open

Keywords: drug development; drug repurposing; drug resistance; pharmacological; cancers therapy

(This special issue belongs to the Section Cancer Drug Development)

Advances in Lung Ultrasound in Cancer Patients

edited by Helmut Prosch and

Ehsan Safai Zadeh

submission deadline 30 Aug 2025 | 4 articles | Viewed by 3019 | Submission Open

Keywords: lung ultrasound; neoplastic pleuro-pulmonary lesions; lung cancer; oncologic imaging; ultrasound; CEUS; elastography

(This special issue belongs to the Section Methods and Technologies Development)

Advances in Tumor Vascular Imaging

edited by

Eiichi Ishikawa

submission deadline 30 Aug 2025 | 1 articles | Viewed by 2293 | Submission Open

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Pathology of Acute Myeloid Leukemia (AML)

edited by Olga K. Weinberg

submission deadline 30 Aug 2025 | Viewed by 1160 | Submission Open

(This special issue belongs to the Section Cancer Pathophysiology)

Breast Cancer Biomarkers and Clinical Translation: 2nd Edition

edited by

Cristian Scatena

and Carmine De Angelis

submission deadline 30 Aug 2025 | 1 articles | Viewed by 778 | Submission Open

Keywords: breast cancer diagnosis; cancer risk; cell reprogramming; biomarkers; resistance; precision therapy

(This special issue belongs to the Section Clinical Research of Cancer)

Chemo-Radio-Immunotherapy for Colorectal Cancer

edited by Shoichi Hazama

submission deadline 30 Aug 2025 | Viewed by 220 | Submission Open

Keywords: colorectal cancer; immunotherapy; chemotherapy; radiotherapy; combination therapy; neoadjuvant therapy; biomarkers for treatment response; anal cancer; squamous cell carcinoma; minimally invasive surgery; conversion surgery

(This special issue belongs to the Section Cancer Therapy)

Surgical Treatment of Oral Squamous Cell Carcinoma

edited by Kai-Ping Chang and Huang-Kai Kao

submission deadline 30 Aug 2025 | Viewed by 196 | Submission Open

Keywords: oral cavity; squamous cell carcinoma; OSCC; surgery; head and neck; resection; reconstruction; oncology

(This special issue belongs to the Section Clinical Research of Cancer)

Oncology: State-of-the-Art Research in Germany

edited by

Orlando Guntinas-Lichius

submission deadline 31 Aug 2025 | 26 articles | Viewed by 52552 | Submission Open

Keywords: cancer; oncology; research; Germany; cancer care

New Concepts and Recent Advances in the Management of Skin Cancer

edited by

Rafael Salido-Vallejo

and

Pedro Redondo

submission deadline 31 Aug 2025 | 13 articles | Viewed by 31929 | Submission Open

Keywords: skin cancer; basal cell carcinoma; cutaneous squamous cell carcinoma; melanoma; Merkel cell carcinoma; cutaneous sarcomas; treatment; checkpoint inhibitors; epidemiology; dermatologic surgery; extramammary paget's disease; cutaneous lymphoma

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Advances in Thoracic Oncology: A Multi-disciplinary Approach to Lung Cancer

edited by Percy Lee, Jyoti Malhotra and

Arya Amini

submission deadline 31 Aug 2025 | 11 articles | Viewed by 24975 | Submission Open

Keywords: small cell lung cancer (SCLC); non-small cell lung cancer (NSCLC); thoracic radiotherapy; neoadjuvant therapies; oligometastatic disease; targeted therapy; immunotherapy; unresectable stage III NSCLC; brain-directed radiation therapy small cell lung cancer (SCLC); non-small cell lung cancer (NSCLC); thoracic radiotherapy; neoadjuvant therapies; oligometastatic disease; targeted therapy; immunotherapy; unresectable stage III NSCLC; brain-directed radiation therapy

(This special issue belongs to the Section Clinical Research of Cancer)

Cutaneous Lymphoma

edited by Michi M. Shinohara

submission deadline 31 Aug 2025 | 6 articles | Viewed by 20042 | Submission Open

Keywords: primary cutaneous lymphoma; cutaneous T-cell lymphoma; mycosis fungoides; Sé zary syndrome; health-related quality of life

(This special issue belongs to the Section Molecular Cancer Biology)

Gastrointestinal Malignancy: Epidemiology and Risk Factors

edited by Patrick Okolo and Chengu Niu

submission deadline 31 Aug 2025 | 5 articles | Viewed by 19963 | Submission Open

Keywords: gastrointestinal cancer; epidemiology; risk factors; molecular markers; genetic factors; therapeutic advancements; prevention strategies; public health; interdisciplinary approaches; clinical impact

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Advancing Horizons in Colorectal Surgery: Innovative Approaches and Outcomes

edited by Petros I. Bangeas and Vasileios N. Papadopoulos

submission deadline 31 Aug 2025 | 4 articles | Viewed by 11379 | Submission Open

Keywords: colorectal surgery; postoperative pain; surgical site infections; anastomotic leaks; minimally invasive techniques; robotic surgery

(This special issue belongs to the Section Cancer Therapy)

New Therapies and Immunological Findings in Nasopharyngeal Carcinoma

edited by Dora Kwong and Darren Wan Teck Lim

submission deadline 31 Aug 2025 | 4 articles | Viewed by 10753 | Submission Open

Keywords: EBV; tumor microenvironment; neoantigens; checkpoint inhibitors; cellular immunotherapy; vaccine; biomarkers

(This special issue belongs to the Section Cancer Therapy)

Lifestyle Choices and Endocrine Dysfunction on Cancer Onset and Risk

edited by

Ariane Zamoner

Marco G. Alves

and

Ana Paula S. Perez

submission deadline 31 Aug 2025 | 4 articles | Viewed by 7753 | Submission Open

Keywords: occupational exposure; obesity; nutrition; exercise; endocrine disruptors; reproduction; development; hormone

(This special issue belongs to the Section Tumor Microenvironment)

Pathogenesis and Treatment Strategies in Multiple Myeloma: From Basic Research to Real Life

edited by Shingen Nakamura

submission deadline 31 Aug 2025 | 4 articles | Viewed by 6073 | Submission Open

Keywords: myeloma bone disease; denosumab; bisphosphonate; infectious complication; proteasome inhibitor; IMiDs; anti-CD38 antibody; venetoclax; immunotherapy

(This special issue belongs to the Section Cancer Therapy)

Updates on Urologic Oncology: From Diagnosis to Localized and Systemic Therapy Options (2nd Edition)

edited by

Giuseppe Palermo

submission deadline 31 Aug 2025 | 3 articles | Viewed by 6030 | Submission Open

Keywords: bladder cancer; prostate cancer; renal cancer; urologic cancer treatment; urologic cancer diagnosis; urologic cancer innovation; urologic neoplasm therapy; immunotherapy

(This special issue belongs to the Section Cancer Therapy)

Robotic Surgery for Gastrointestinal (GI) Malignancies

edited by

Yaron Rudnicki

and

Shmuel R. Avital

submission deadline 31 Aug 2025 | 5 articles | Viewed by 5973 | Submission Open

Keywords: robotic surgery; colorectal cancer; gastric cancer; liver cancer; pancreatic cancer; esophageal cancer; robotic platform

(This special issue belongs to the Section Clinical Research of Cancer)

2nd Edition: Molecular Testing for Thyroid Nodules and Cancer

edited by

Marc P. Pusztaszeri

and

Richard J. Payne

submission deadline 31 Aug 2025 | 4 articles | Viewed by 5804 | Submission Open

Keywords: thyroid nodules; thyroid cancer; molecular testing; cytology; fine needle aspiration; personalized medicine; mutations

(This special issue belongs to the Section Methods and Technologies Development)

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