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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Research on Early-Stage Breast Cancer: Management and Treatment
edited by Ernyu Tan
submission deadline 15 Aug 2025 | 7 articles | Viewed by 16987 | Submission Open
Keywords: early-stage breast cancer; adjuvant treatment; systemic therapy; risk stratification; survival
(This special issue belongs to the Section Cancer Therapy)
Advancements in Lung Cancer Surgical Treatment and Prognosis
edited by Sai Yendamuri and
submission deadline 15 Aug 2025 | 9 articles | Viewed by 16284 | Submission Open
Keywords: lung cancer; surgical techniques; targeted therapies; immunotherapies; accurate staging; biomarker detection; clinical trials; multimodality therapy; artificial intelligence (AI) in thoracic oncology; enhanced recovery after thoracic surgery (ERATS)
(This special issue belongs to the Section Cancer Therapy)
Clinical Surgery for Hepato-Pancreato-Biliary (HPB) Cancer submission deadline 15 Aug 2025 | 8 articles | Viewed by 8755 | Submission Open
Keywords: pancreatic malignancies; HPB malignancies; pancreatic ductal adenocarcinoma; liver cholangiocarcinoma; HPB surgery; liver resection; pancreatic resection
(This special issue belongs to the Section Cancer Therapy)
Impact of Social Determinants on Cancer Care
edited by
submission deadline 15 Aug 2025 | 4 articles | Viewed by 6282 | Submission Open
Keywords: social determinants of health; cancer disparities; socioeconomic status; transportation barriers; stress genomics; health equity; cancer outcomes
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Advances in Esophageal Cancer
edited by Sacheen Kumar
submission deadline 15 Aug 2025 | 2 articles | Viewed by 2628 | Submission Open
Keywords: esophageal adenocarcinoma; esophageal squamous cell carcinoma; long-term survival; biomarkers; disease surveillance; treatment response
(This special issue belongs to the Section Cancer Therapy)
Robot-Assisted Surgery for Urologic Cancer
edited by Gabriele Sorce, Francesco Pellegrino and Ettore Di Trapani
submission deadline 15 Aug 2025 | 1 articles | Viewed by 811 | Submission Open
Keywords: robot-assisted surgery; urologic oncology; minimally invasive surgery; prostate cancer surgery; kidney cancer surgery; bladder cancer surgery; robotic platforms; robotic surgery training
(This special issue belongs to the Section Cancer Therapy)
Role of Autophagy in Cancer Stem Cells and the Tumor Microenvironment: New Frontiers in Cancer Drug Discovery
edited by Yasser Heakal, and
submission deadline 15 Aug 2025 | Viewed by 486 | Submission Open
Keywords: autophagy; cancer stem cells; tumor microenvironment; therapeutic resistance; metastasis
(This special issue belongs to the Section Tumor Microenvironment)
Breast Conservation and Radiotherapy in the Era of De-Escalation of Breast Cancer Treatments submission deadline 15 Aug 2025 | Viewed by 403 | Submission Open
Keywords: breast cancer; breast conserving treatment; mastectomy; radiotherapy; neoadjuvant treatment; psychology; quality of life; breast imaging
(This special issue belongs to the Section Cancer Therapy)
Palliative Radiotherapy of Cancer submission deadline 15 Aug 2025 | Viewed by 288 | Submission Open
Keywords: palliative radiotherapy; cancer pain management; advanced radiotherapy techniques; multidisciplinary cancer care; stereotactic body radiotherapy (SBRT); quality of life in cancer; cancer symptom management
(This special issue belongs to the Section Cancer Therapy)
Antioxidants in Cancers
edited by Asif Raza
submission deadline 15 Aug 2025 | Viewed by 261 | Submission Open
Keywords: antioxidants in cancer; oxidative stress and cancer; tumor microenvironment; cancer prevention strategies; therapy resistance and antioxidants; reactive oxygen species (ROS); natural antioxidants; synthetic antioxidants; precision oncology; chemoprevention
(This special issue belongs to the Section Cancer Therapy)
Radiotherapy for Sarcoma
edited by Safia K. Ahmed and Miranda Lam
submission deadline 15 Aug 2025 | Viewed by 165 | Submission Open
Keywords: soft tissue sarcoma; bone sarcoma; advanced sarcoma; radiation therapy; particle therapy; multidisciplinary sarcoma care
(This special issue belongs to the Section Cancer Therapy)
Immunotherapy of Glioblastoma
edited by
submission deadline 16 Aug 2025 | Viewed by 252 | Submission Open
Keywords: glioblastoma; immunotherapy; antigen presentation; CNS lymphatic system; adoptive cell therapy; cancer vaccine; checkpoint blockage
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Bone and Spine Metastases submission deadline 20 Aug 2025 | 9 articles | Viewed by 17238 | Submission Open
Keywords: bone metastases; spinal metastases; stereotactic body radiotherapy; conventional radiotherapy; spine surgery; spondylectomy; minimally invasive surgery; particle-beam radiotherapy; systemic agents; microenvironment
(This special issue belongs to the Section Cancer Metastasis)
Cell Migration and Invasion in Cancer
edited by
submission deadline 20 Aug 2025 | 3 articles | Viewed by 7731 | Submission Open
Keywords: cell migration; invasion; tumor; metastasis; genes; microRNA
(This special issue belongs to the Section Molecular Cancer Biology)
Radiation Exposure, Inflammation and Cancers
edited by
submission deadline 20 Aug 2025 | 3 articles | Viewed by 4591 | Submission Open
Keywords: radiation; DNA damage response; inflammation; oxidative stress; senescence and cancer
(This special issue belongs to the Section Tumor Microenvironment)
Research on New Drugs and Drug Targets in Melanoma submission deadline 20 Aug 2025 | 2 articles | Viewed by 1772 | Submission Open
Keywords: melanoma; new drugs; drug targets; mechanism of action; substances with anti-melanoma potential
(This special issue belongs to the Section Cancer Drug Development)
Protein Kinases and Their Impact on Tumor Growth: Mechanisms and Therapeutic Targets submission deadline 20 Aug 2025 | 1 articles | Viewed by 1528 | Submission Open
Keywords: protein kinases; PI3K-Akt signaling; MAPK signaling; kinase inhibitors; drug resistance; crosstalk
(This special issue belongs to the Section Methods and Technologies Development)
New Insights into Esophageal Cancer Chemotherapy
edited by Kenneth Meredith
submission deadline 20 Aug 2025 | Viewed by 381 | Submission Open
Keywords: esophageal cancer; chemotherapy; treatment
(This special issue belongs to the Section Cancer Therapy)
Novel Insights into Microenvironment of Leukemia submission deadline 20 Aug 2025 | Viewed by 216 | Submission Open
Keywords: stromal microenvironment; genetic and epigenetic alterations; bone marrow; chronic and acute leukemia; hematological malignancies
(This special issue belongs to the Section Tumor Microenvironment)
Surgical Treatment of Bone Metastases: 2nd Edition submission deadline 29 Aug 2025 | 2 articles | Viewed by 4199 | Submission Open
Keywords: metastatic bone disease; bone metastasis; pathological fractures; surgical treatment; patients survival; implant survival; functional results; surgical technique
(This special issue belongs to the Section Cancer Therapy)
New Challenges in Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia
edited by Federico Mosna and Irene Cavattoni
submission deadline 29 Aug 2025 | 1 articles | Viewed by 1079 | Submission Open
Keywords: acute myeloid leukemia (AML); allogeneic hematopoietic stem cells transplantation (allo-HSCT); immunotherapy; leukemic stem cells; graft versus host disease (GVHD); infections in immunodepressed patients; immune reconstitution; post-transplant management; long-term results; clinical
(This special issue belongs to the Section Cancer Therapy)
CRISPR in Cancer Biology and Therapy: 2nd Edition
edited by
submission deadline 29 Aug 2025 | Viewed by 256 | Submission Open
Keywords: cancer drug resistance; CRISPR screens; CRISPR-related technology; base editing; prime editing; off-target analysis; adeno-associated virus
(This special issue belongs to the Section Methods and Technologies Development)
Advances in Drug Repurposing to Overcome Cancers
edited by
submission deadline 30 Aug 2025 | 6 articles | Viewed by 12432 | Submission Open
Keywords: drug development; drug repurposing; drug resistance; pharmacological; cancers therapy
(This special issue belongs to the Section Cancer Drug Development)
Advances in Lung Ultrasound in Cancer Patients
edited by Helmut Prosch and
submission deadline 30 Aug 2025 | 4 articles | Viewed by 3120 | Submission Open
Keywords: lung ultrasound; neoplastic pleuro-pulmonary lesions; lung cancer; oncologic imaging; ultrasound; CEUS; elastography
(This special issue belongs to the Section Methods and Technologies Development)
Advances in Tumor Vascular Imaging
edited by
submission deadline 30 Aug 2025 | 1 articles | Viewed by 2349 | Submission Open
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Pathology of Acute Myeloid Leukemia (AML)
edited by Olga K. Weinberg
submission deadline 30 Aug 2025 | Viewed by 1167 | Submission Open
(This special issue belongs to the Section Cancer Pathophysiology)
Breast Cancer Biomarkers and Clinical Translation: 2nd Edition
edited by and Carmine De Angelis
submission deadline 30 Aug 2025 | 1 articles | Viewed by 826 | Submission Open
Keywords: breast cancer diagnosis; cancer risk; cell reprogramming; biomarkers; resistance; precision therapy
(This special issue belongs to the Section Clinical Research of Cancer)
Chemo-Radio-Immunotherapy for Colorectal Cancer
edited by Shoichi Hazama
submission deadline 30 Aug 2025 | Viewed by 223 | Submission Open
Keywords: colorectal cancer; immunotherapy; chemotherapy; radiotherapy; combination therapy; neoadjuvant therapy; biomarkers for treatment response; anal cancer; squamous cell carcinoma; minimally invasive surgery; conversion surgery
(This special issue belongs to the Section Cancer Therapy)
Surgical Treatment of Oral Squamous Cell Carcinoma
edited by Kai-Ping Chang and Huang-Kai Kao
submission deadline 30 Aug 2025 | Viewed by 208 | Submission Open
Keywords: oral cavity; squamous cell carcinoma; OSCC; surgery; head and neck; resection; reconstruction; oncology
(This special issue belongs to the Section Clinical Research of Cancer)
Oncology: State-of-the-Art Research in Germany submission deadline 31 Aug 2025 | 26 articles | Viewed by 53365 | Submission Open
Keywords: cancer; oncology; research; Germany; cancer care
New Concepts and Recent Advances in the Management of Skin Cancer submission deadline 31 Aug 2025 | 13 articles | Viewed by 32431 | Submission Open
Keywords: skin cancer; basal cell carcinoma; cutaneous squamous cell carcinoma; melanoma; Merkel cell carcinoma; cutaneous sarcomas; treatment; checkpoint inhibitors; epidemiology; dermatologic surgery; extramammary paget's disease; cutaneous lymphoma
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Advances in Thoracic Oncology: A Multi-disciplinary Approach to Lung Cancer
edited by Percy Lee, Jyoti Malhotra and
submission deadline 31 Aug 2025 | 12 articles | Viewed by 25794 | Submission Open
Keywords: small cell lung cancer (SCLC); non-small cell lung cancer (NSCLC); thoracic radiotherapy; neoadjuvant therapies; oligometastatic disease; targeted therapy; immunotherapy; unresectable stage III NSCLC; brain-directed radiation therapy small cell lung cancer (SCLC); non-small cell lung cancer (NSCLC); thoracic radiotherapy; neoadjuvant therapies; oligometastatic disease; targeted therapy; immunotherapy; unresectable stage III NSCLC; brain-directed radiation therapy
(This special issue belongs to the Section Clinical Research of Cancer)
Cutaneous Lymphoma
edited by Michi M. Shinohara
submission deadline 31 Aug 2025 | 6 articles | Viewed by 20763 | Submission Open
Keywords: primary cutaneous lymphoma; cutaneous T-cell lymphoma; mycosis fungoides; Sé zary syndrome; health-related quality of life
(This special issue belongs to the Section Molecular Cancer Biology)
Gastrointestinal Malignancy: Epidemiology and Risk Factors
edited by Patrick Okolo and Chengu Niu
submission deadline 31 Aug 2025 | 5 articles | Viewed by 20374 | Submission Open
Keywords: gastrointestinal cancer; epidemiology; risk factors; molecular markers; genetic factors; therapeutic advancements; prevention strategies; public health; interdisciplinary approaches; clinical impact
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Advancing Horizons in Colorectal Surgery: Innovative Approaches and Outcomes
edited by Petros I. Bangeas and Vasileios N. Papadopoulos
submission deadline 31 Aug 2025 | 4 articles | Viewed by 11570 | Submission Open
Keywords: colorectal surgery; postoperative pain; surgical site infections; anastomotic leaks; minimally invasive techniques; robotic surgery
(This special issue belongs to the Section Cancer Therapy)
New Therapies and Immunological Findings in Nasopharyngeal Carcinoma
edited by Dora Kwong and Darren Wan Teck Lim
submission deadline 31 Aug 2025 | 4 articles | Viewed by 10833 | Submission Open
Keywords: EBV; tumor microenvironment; neoantigens; checkpoint inhibitors; cellular immunotherapy; vaccine; biomarkers
(This special issue belongs to the Section Cancer Therapy)
Lifestyle Choices and Endocrine Dysfunction on Cancer Onset and Risk submission deadline 31 Aug 2025 | 4 articles | Viewed by 8003 | Submission Open
Keywords: occupational exposure; obesity; nutrition; exercise; endocrine disruptors; reproduction; development; hormone
(This special issue belongs to the Section Tumor Microenvironment)
Robotic Surgery for Gastrointestinal (GI) Malignancies submission deadline 31 Aug 2025 | 5 articles | Viewed by 6296 | Submission Open
Keywords: robotic surgery; colorectal cancer; gastric cancer; liver cancer; pancreatic cancer; esophageal cancer; robotic platform
(This special issue belongs to the Section Clinical Research of Cancer)
Pathogenesis and Treatment Strategies in Multiple Myeloma: From Basic Research to Real Life
edited by Shingen Nakamura
submission deadline 31 Aug 2025 | 4 articles | Viewed by 6234 | Submission Open
Keywords: myeloma bone disease; denosumab; bisphosphonate; infectious complication; proteasome inhibitor; IMiDs; anti-CD38 antibody; venetoclax; immunotherapy
(This special issue belongs to the Section Cancer Therapy)
Updates on Urologic Oncology: From Diagnosis to Localized and Systemic Therapy Options (2nd Edition)
edited by
submission deadline 31 Aug 2025 | 3 articles | Viewed by 6172 | Submission Open
Keywords: bladder cancer; prostate cancer; renal cancer; urologic cancer treatment; urologic cancer diagnosis; urologic cancer innovation; urologic neoplasm therapy; immunotherapy
(This special issue belongs to the Section Cancer Therapy)
2nd Edition: Molecular Testing for Thyroid Nodules and Cancer submission deadline 31 Aug 2025 | 4 articles | Viewed by 5956 | Submission Open
Keywords: thyroid nodules; thyroid cancer; molecular testing; cytology; fine needle aspiration; personalized medicine; mutations
(This special issue belongs to the Section Methods and Technologies Development)
Emerging Therapies in the Management of Gastrointestinal Malignancies (2nd Edition) submission deadline 31 Aug 2025 | 4 articles | Viewed by 5315 | Submission Open
Keywords: hepatocellular carcinoma; colorectal cancer; esophageal cancer; immunotherapy; targeted therapy
(This special issue belongs to the Section Cancer Therapy)
Advances in Proton Therapy for Head and Neck Cancer: Techniques, Outcomes and Planning Variations
edited by Jun Zhou
submission deadline 31 Aug 2025 | 2 articles | Viewed by 4966 | Submission Open
Keywords: proton head and neck cancer therapy; protons vs. photons for head and neck cancer treatment; adaptive proton therapy; robustness in proton head and neck cancer therapy; online vs. offline adaptation in proton head and neck cancer therapy
(This special issue belongs to the Section Cancer Therapy)
Diagnosis and Treatment of Gastroenteropancreatic Neuroendocrine Neoplasms (2nd Edition)
edited by Peter Stålberg
submission deadline 31 Aug 2025 | 2 articles | Viewed by 4838 | Submission Open
Keywords: biomarkers; imaging; gastric NETs; pancreatic NETs; small intestinal NETs; receptor-based therapy
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Recent Advances on the Role of Intensity–Modulated Radiotherapy in Cancer
edited by Taro Murai
submission deadline 31 Aug 2025 | 2 articles | Viewed by 4750 | Submission Open
Keywords: intensity modulated radiotherapy; medical physics; stereotactic radiotherapy; proton therapy; artificial intelligence
(This special issue belongs to the Section Cancer Therapy)
Liquid Biopsy in Breast Cancer (2nd Edition) submission deadline 31 Aug 2025 | 2 articles | Viewed by 4613 | Submission Open
Keywords: liquid biopsy; liquid biomarkers; precision oncology; disease monitoring; treatment monitoring; tumor heterogenei-ty; circulating tumor cells (CTCs); circulating tumor DNA (ctDNA); circulating miRNAs; exosomes; extracellular vesicles (EVs)
(This special issue belongs to the Section Cancer Biomarkers)
Paradigm Shifts in Gynaecological Oncology Surgery
edited by
submission deadline 31 Aug 2025 | 3 articles | Viewed by 4449 | Submission Open
Keywords: gynecological surgery; genomics risk management; survivorship health economics
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Combination Therapy in Lymphoma
edited by and Alberto Arribas
submission deadline 31 Aug 2025 | 2 articles | Viewed by 4314 | Submission Open
Keywords: combination therapy; non-Hodgkin lymphoma; Hodgkin lymphoma; targeted agents; antibody drug conjugates; bispecific agents; cellular therapies; immune checkpoint inhibitors and epigenetic agents
(This special issue belongs to the Section Cancer Therapy)
Advances in the Management of Prostate Cancer: New Insights into Biological and Clinical Factors
edited by Mutlay Sayan and
submission deadline 31 Aug 2025 | 2 articles | Viewed by 4293 | Submission Open
Keywords: prostate cancer; risk stratification; genomic alterations; radiation therapy; prostatectomy; androgen deprivation therapy
(This special issue belongs to the Section Cancer Therapy)
Exploring the Interplay of Glioblastoma Angiogenesis, ROS, and Tumor Microenvironment: Advancements in Combination Therapy and Bioinformatics Approaches
edited by
submission deadline 31 Aug 2025 | 1 articles | Viewed by 4000 | Submission Open
Keywords: glioblastoma; angiogenesis; reactive oxygen species (ROS); hypoxia-inducible factors (HIFs); radiotherapy (RT); bioactive natural compounds; tumor microenvironment (TME); cancer immunotherapy; combination therapy; autophagy; apoptosis; in silico and network pharmacology; bioinformatics
(This special issue belongs to the Section Cancer Metastasis)
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