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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Breast Cancer and Hormone-Related Therapy
edited by
submission deadline 10 Aug 2025 | 12 articles | Viewed by 45644 | Submission Open
Keywords: breast cancer; estrogen receptor; hormone activated transcription factors; hormonal therapy; molecular mechanisms
(This special issue belongs to the Section Cancer Therapy)
Epigenetic Regulation in Cancers
edited by and
submission deadline 10 Aug 2025 | 3 articles | Viewed by 6539 | Submission Open
Keywords: oncogenes; tumor suppressor genes; tumor microenvironment; cancer therapy; DNA and histone methylation; microRNAs; epitranscriptomics; RNA modifications; modifying proteins
(This special issue belongs to the Section Tumor Microenvironment)
Alternative Cell Death Modes in Regulating Cancer Stem Cells and Therapeutic Strategies
edited by Mun-Ock Kim and
submission deadline 10 Aug 2025 | 2 articles | Viewed by 5364 | Submission Open
Keywords: cancer stem cell; alternative cell death mode; tumor microenvironment; immune mechanism; cellular basis of cancer therapy resistance; cellular transformation; small-molecule-based therapeutics
(This special issue belongs to the Section Molecular Cancer Biology)
Cutting-Edge Nanomedicine Advancements in Cancer Disease submission deadline 10 Aug 2025 | Viewed by 235 | Submission Open
Keywords: active targeting; breast cancer; drug delivery; liposomes; lung cancer; metallic nanoparticles; polymeric nanoparticles; theragnostic
(This special issue belongs to the Section Methods and Technologies Development)
Advances in Skin Cancer: Diagnosis, Treatment and Prognosis
edited by Iris Zalaudek and
submission deadline 15 Aug 2025 | 12 articles | Viewed by 20120 | Submission Open
Keywords: skin cancer; melanoma; basal cell carcinoma; cutaneous squamous cell carcinoma; diagnosis; noninvasive imaging; therapy; prognosis; immunotherapy; targeted therapy
(This special issue belongs to the Section Cancer Therapy)
Research on Early-Stage Breast Cancer: Management and Treatment
edited by Ernyu Tan
submission deadline 15 Aug 2025 | 7 articles | Viewed by 16624 | Submission Open
Keywords: early-stage breast cancer; adjuvant treatment; systemic therapy; risk stratification; survival
(This special issue belongs to the Section Cancer Therapy)
Advancements in Lung Cancer Surgical Treatment and Prognosis
edited by Sai Yendamuri and
submission deadline 15 Aug 2025 | 9 articles | Viewed by 15959 | Submission Open
Keywords: lung cancer; surgical techniques; targeted therapies; immunotherapies; accurate staging; biomarker detection; clinical trials; multimodality therapy; artificial intelligence (AI) in thoracic oncology; enhanced recovery after thoracic surgery (ERATS)
(This special issue belongs to the Section Cancer Therapy)
Clinical Surgery for Hepato-Pancreato-Biliary (HPB) Cancer submission deadline 15 Aug 2025 | 8 articles | Viewed by 8533 | Submission Open
Keywords: pancreatic malignancies; HPB malignancies; pancreatic ductal adenocarcinoma; liver cholangiocarcinoma; HPB surgery; liver resection; pancreatic resection
(This special issue belongs to the Section Cancer Therapy)
Impact of Social Determinants on Cancer Care
edited by
submission deadline 15 Aug 2025 | 4 articles | Viewed by 6003 | Submission Open
Keywords: social determinants of health; cancer disparities; socioeconomic status; transportation barriers; stress genomics; health equity; cancer outcomes
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Advances in Esophageal Cancer
edited by Sacheen Kumar
submission deadline 15 Aug 2025 | 2 articles | Viewed by 2439 | Submission Open
Keywords: esophageal adenocarcinoma; esophageal squamous cell carcinoma; long-term survival; biomarkers; disease surveillance; treatment response
(This special issue belongs to the Section Cancer Therapy)
Oligometastases Hypothesis to Advancing New Perspectives on Cancer: Oligo-Reurrence submission deadline 15 Aug 2025 | 1 articles | Viewed by 991 | Submission Open
Keywords: oligometastases; oligo-recurrence; sync-oligometastases
(This special issue belongs to the Section Cancer Metastasis)
Robot-Assisted Surgery for Urologic Cancer
edited by Gabriele Sorce, Francesco Pellegrino and Ettore Di Trapani
submission deadline 15 Aug 2025 | 1 articles | Viewed by 787 | Submission Open
Keywords: robot-assisted surgery; urologic oncology; minimally invasive surgery; prostate cancer surgery; kidney cancer surgery; bladder cancer surgery; robotic platforms; robotic surgery training
(This special issue belongs to the Section Cancer Therapy)
Prostate Cancer Epidemiology and Genetics: 2nd Edition
edited by
submission deadline 15 Aug 2025 | 1 articles | Viewed by 772 | Submission Open
Keywords: prostate cancer; epidemiology; clinical genetics; aging; population-level databases
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Role of Autophagy in Cancer Stem Cells and the Tumor Microenvironment: New Frontiers in Cancer Drug Discovery
edited by Yasser Heakal, and
submission deadline 15 Aug 2025 | Viewed by 475 | Submission Open
Keywords: autophagy; cancer stem cells; tumor microenvironment; therapeutic resistance; metastasis
(This special issue belongs to the Section Tumor Microenvironment)
Breast Conservation and Radiotherapy in the Era of De-Escalation of Breast Cancer Treatments submission deadline 15 Aug 2025 | Viewed by 390 | Submission Open
Keywords: breast cancer; breast conserving treatment; mastectomy; radiotherapy; neoadjuvant treatment; psychology; quality of life; breast imaging
(This special issue belongs to the Section Cancer Therapy)
Palliative Radiotherapy of Cancer submission deadline 15 Aug 2025 | Viewed by 283 | Submission Open
Keywords: palliative radiotherapy; cancer pain management; advanced radiotherapy techniques; multidisciplinary cancer care; stereotactic body radiotherapy (SBRT); quality of life in cancer; cancer symptom management
(This special issue belongs to the Section Cancer Therapy)
Antioxidants in Cancers
edited by Asif Raza
submission deadline 15 Aug 2025 | Viewed by 251 | Submission Open
Keywords: antioxidants in cancer; oxidative stress and cancer; tumor microenvironment; cancer prevention strategies; therapy resistance and antioxidants; reactive oxygen species (ROS); natural antioxidants; synthetic antioxidants; precision oncology; chemoprevention
(This special issue belongs to the Section Cancer Therapy)
Radiotherapy for Sarcoma
edited by Safia K. Ahmed and Miranda Lam
submission deadline 15 Aug 2025 | Viewed by 153 | Submission Open
Keywords: soft tissue sarcoma; bone sarcoma; advanced sarcoma; radiation therapy; particle therapy; multidisciplinary sarcoma care
(This special issue belongs to the Section Cancer Therapy)
Immunotherapy of Glioblastoma
edited by
submission deadline 16 Aug 2025 | Viewed by 243 | Submission Open
Keywords: glioblastoma; immunotherapy; antigen presentation; CNS lymphatic system; adoptive cell therapy; cancer vaccine; checkpoint blockage
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Bone and Spine Metastases submission deadline 20 Aug 2025 | 9 articles | Viewed by 17047 | Submission Open
Keywords: bone metastases; spinal metastases; stereotactic body radiotherapy; conventional radiotherapy; spine surgery; spondylectomy; minimally invasive surgery; particle-beam radiotherapy; systemic agents; microenvironment
(This special issue belongs to the Section Cancer Metastasis)
Cell Migration and Invasion in Cancer
edited by
submission deadline 20 Aug 2025 | 3 articles | Viewed by 7523 | Submission Open
Keywords: cell migration; invasion; tumor; metastasis; genes; microRNA
(This special issue belongs to the Section Molecular Cancer Biology)
Radiation Exposure, Inflammation and Cancers
edited by
submission deadline 20 Aug 2025 | 3 articles | Viewed by 4537 | Submission Open
Keywords: radiation; DNA damage response; inflammation; oxidative stress; senescence and cancer
(This special issue belongs to the Section Tumor Microenvironment)
Ultrasonography for Pancreatobiliary Cancer
edited by
submission deadline 20 Aug 2025 | 2 articles | Viewed by 2073 | Submission Open
Keywords: endoscopic ultrasonography; abdominal ultrasonography; early diagnosis project; screening; EUS-FNA; interventional EUS; enhancement EUS; EUS-RFA
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Research on New Drugs and Drug Targets in Melanoma submission deadline 20 Aug 2025 | 2 articles | Viewed by 1666 | Submission Open
Keywords: melanoma; new drugs; drug targets; mechanism of action; substances with anti-melanoma potential
(This special issue belongs to the Section Cancer Drug Development)
Protein Kinases and Their Impact on Tumor Growth: Mechanisms and Therapeutic Targets submission deadline 20 Aug 2025 | 1 articles | Viewed by 1469 | Submission Open
Keywords: protein kinases; PI3K-Akt signaling; MAPK signaling; kinase inhibitors; drug resistance; crosstalk
(This special issue belongs to the Section Methods and Technologies Development)
New Insights into Esophageal Cancer Chemotherapy
edited by Kenneth Meredith
submission deadline 20 Aug 2025 | Viewed by 378 | Submission Open
Keywords: esophageal cancer; chemotherapy; treatment
(This special issue belongs to the Section Cancer Therapy)
Novel Insights into Microenvironment of Leukemia submission deadline 20 Aug 2025 | Viewed by 211 | Submission Open
Keywords: stromal microenvironment; genetic and epigenetic alterations; bone marrow; chronic and acute leukemia; hematological malignancies
(This special issue belongs to the Section Tumor Microenvironment)
Clinical Advances and State-of-Art Management in Genitourinary Cancers
edited by and Adnan Fazili
submission deadline 25 Aug 2025 | 1 articles | Viewed by 1858 | Submission Open
Keywords: genitourinary malignancies; tumor– immune microenvironment (TIME); tumor biology; genomic characterization; targeted drug therapy; immunotherapy
(This special issue belongs to the Section Clinical Research of Cancer)
Surgical Treatment of Bone Metastases: 2nd Edition submission deadline 29 Aug 2025 | 2 articles | Viewed by 4015 | Submission Open
Keywords: metastatic bone disease; bone metastasis; pathological fractures; surgical treatment; patients survival; implant survival; functional results; surgical technique
(This special issue belongs to the Section Cancer Therapy)
New Challenges in Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia
edited by Federico Mosna and Irene Cavattoni
submission deadline 29 Aug 2025 | 1 articles | Viewed by 1055 | Submission Open
Keywords: acute myeloid leukemia (AML); allogeneic hematopoietic stem cells transplantation (allo-HSCT); immunotherapy; leukemic stem cells; graft versus host disease (GVHD); infections in immunodepressed patients; immune reconstitution; post-transplant management; long-term results; clinical
(This special issue belongs to the Section Cancer Therapy)
CRISPR in Cancer Biology and Therapy: 2nd Edition
edited by
submission deadline 29 Aug 2025 | Viewed by 251 | Submission Open
Keywords: cancer drug resistance; CRISPR screens; CRISPR-related technology; base editing; prime editing; off-target analysis; adeno-associated virus
(This special issue belongs to the Section Methods and Technologies Development)
Advances in Drug Repurposing to Overcome Cancers
edited by
submission deadline 30 Aug 2025 | 6 articles | Viewed by 12030 | Submission Open
Keywords: drug development; drug repurposing; drug resistance; pharmacological; cancers therapy
(This special issue belongs to the Section Cancer Drug Development)
Advances in Lung Ultrasound in Cancer Patients
edited by Helmut Prosch and
submission deadline 30 Aug 2025 | 4 articles | Viewed by 3015 | Submission Open
Keywords: lung ultrasound; neoplastic pleuro-pulmonary lesions; lung cancer; oncologic imaging; ultrasound; CEUS; elastography
(This special issue belongs to the Section Methods and Technologies Development)
Advances in Tumor Vascular Imaging
edited by
submission deadline 30 Aug 2025 | 1 articles | Viewed by 2293 | Submission Open
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Pathology of Acute Myeloid Leukemia (AML)
edited by Olga K. Weinberg
submission deadline 30 Aug 2025 | Viewed by 1160 | Submission Open
(This special issue belongs to the Section Cancer Pathophysiology)
Breast Cancer Biomarkers and Clinical Translation: 2nd Edition
edited by and Carmine De Angelis
submission deadline 30 Aug 2025 | 1 articles | Viewed by 777 | Submission Open
Keywords: breast cancer diagnosis; cancer risk; cell reprogramming; biomarkers; resistance; precision therapy
(This special issue belongs to the Section Clinical Research of Cancer)
Chemo-Radio-Immunotherapy for Colorectal Cancer
edited by Shoichi Hazama
submission deadline 30 Aug 2025 | Viewed by 220 | Submission Open
Keywords: colorectal cancer; immunotherapy; chemotherapy; radiotherapy; combination therapy; neoadjuvant therapy; biomarkers for treatment response; anal cancer; squamous cell carcinoma; minimally invasive surgery; conversion surgery
(This special issue belongs to the Section Cancer Therapy)
Surgical Treatment of Oral Squamous Cell Carcinoma
edited by Kai-Ping Chang and Huang-Kai Kao
submission deadline 30 Aug 2025 | Viewed by 196 | Submission Open
Keywords: oral cavity; squamous cell carcinoma; OSCC; surgery; head and neck; resection; reconstruction; oncology
(This special issue belongs to the Section Clinical Research of Cancer)
Oncology: State-of-the-Art Research in Germany submission deadline 31 Aug 2025 | 26 articles | Viewed by 52511 | Submission Open
Keywords: cancer; oncology; research; Germany; cancer care
New Concepts and Recent Advances in the Management of Skin Cancer submission deadline 31 Aug 2025 | 13 articles | Viewed by 31901 | Submission Open
Keywords: skin cancer; basal cell carcinoma; cutaneous squamous cell carcinoma; melanoma; Merkel cell carcinoma; cutaneous sarcomas; treatment; checkpoint inhibitors; epidemiology; dermatologic surgery; extramammary paget's disease; cutaneous lymphoma
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Advances in Thoracic Oncology: A Multi-disciplinary Approach to Lung Cancer
edited by Percy Lee, Jyoti Malhotra and
submission deadline 31 Aug 2025 | 11 articles | Viewed by 24934 | Submission Open
Keywords: small cell lung cancer (SCLC); non-small cell lung cancer (NSCLC); thoracic radiotherapy; neoadjuvant therapies; oligometastatic disease; targeted therapy; immunotherapy; unresectable stage III NSCLC; brain-directed radiation therapy small cell lung cancer (SCLC); non-small cell lung cancer (NSCLC); thoracic radiotherapy; neoadjuvant therapies; oligometastatic disease; targeted therapy; immunotherapy; unresectable stage III NSCLC; brain-directed radiation therapy
(This special issue belongs to the Section Clinical Research of Cancer)
Cutaneous Lymphoma
edited by Michi M. Shinohara
submission deadline 31 Aug 2025 | 6 articles | Viewed by 20011 | Submission Open
Keywords: primary cutaneous lymphoma; cutaneous T-cell lymphoma; mycosis fungoides; Sé zary syndrome; health-related quality of life
(This special issue belongs to the Section Molecular Cancer Biology)
Gastrointestinal Malignancy: Epidemiology and Risk Factors
edited by Patrick Okolo and Chengu Niu
submission deadline 31 Aug 2025 | 5 articles | Viewed by 19953 | Submission Open
Keywords: gastrointestinal cancer; epidemiology; risk factors; molecular markers; genetic factors; therapeutic advancements; prevention strategies; public health; interdisciplinary approaches; clinical impact
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Advancing Horizons in Colorectal Surgery: Innovative Approaches and Outcomes
edited by Petros I. Bangeas and Vasileios N. Papadopoulos
submission deadline 31 Aug 2025 | 4 articles | Viewed by 11375 | Submission Open
Keywords: colorectal surgery; postoperative pain; surgical site infections; anastomotic leaks; minimally invasive techniques; robotic surgery
(This special issue belongs to the Section Cancer Therapy)
New Therapies and Immunological Findings in Nasopharyngeal Carcinoma
edited by Dora Kwong and Darren Wan Teck Lim
submission deadline 31 Aug 2025 | 4 articles | Viewed by 10750 | Submission Open
Keywords: EBV; tumor microenvironment; neoantigens; checkpoint inhibitors; cellular immunotherapy; vaccine; biomarkers
(This special issue belongs to the Section Cancer Therapy)
Lifestyle Choices and Endocrine Dysfunction on Cancer Onset and Risk submission deadline 31 Aug 2025 | 4 articles | Viewed by 7746 | Submission Open
Keywords: occupational exposure; obesity; nutrition; exercise; endocrine disruptors; reproduction; development; hormone
(This special issue belongs to the Section Tumor Microenvironment)
Pathogenesis and Treatment Strategies in Multiple Myeloma: From Basic Research to Real Life
edited by Shingen Nakamura
submission deadline 31 Aug 2025 | 4 articles | Viewed by 6068 | Submission Open
Keywords: myeloma bone disease; denosumab; bisphosphonate; infectious complication; proteasome inhibitor; IMiDs; anti-CD38 antibody; venetoclax; immunotherapy
(This special issue belongs to the Section Cancer Therapy)
Updates on Urologic Oncology: From Diagnosis to Localized and Systemic Therapy Options (2nd Edition)
edited by
submission deadline 31 Aug 2025 | 3 articles | Viewed by 6017 | Submission Open
Keywords: bladder cancer; prostate cancer; renal cancer; urologic cancer treatment; urologic cancer diagnosis; urologic cancer innovation; urologic neoplasm therapy; immunotherapy
(This special issue belongs to the Section Cancer Therapy)
Robotic Surgery for Gastrointestinal (GI) Malignancies submission deadline 31 Aug 2025 | 5 articles | Viewed by 5968 | Submission Open
Keywords: robotic surgery; colorectal cancer; gastric cancer; liver cancer; pancreatic cancer; esophageal cancer; robotic platform
(This special issue belongs to the Section Clinical Research of Cancer)
2nd Edition: Molecular Testing for Thyroid Nodules and Cancer submission deadline 31 Aug 2025 | 4 articles | Viewed by 5792 | Submission Open
Keywords: thyroid nodules; thyroid cancer; molecular testing; cytology; fine needle aspiration; personalized medicine; mutations
(This special issue belongs to the Section Methods and Technologies Development)
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