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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Neoadjuvant Therapy of Breast Cancer

edited by

Hiroyuki Takei

and Takaaki Fujii

submission deadline 15 Jan 2026 | 9 articles | Viewed by 26250 | Submission Open

Keywords: neoadjuvant systemic therapy; chemotherapy; endocrine therapy; molecular targeted therapy; molecular subtypes; response-guided therapy; clinical trials

(This special issue belongs to the Section Cancer Therapy)

Cervical Cancer: Study on Molecular Landscape and Protein Biomarkers. Current Diagnostic and Therapeutic Capabilities

edited by

Christopher Kobierzycki

and

Piotr Dzięgiel

submission deadline 15 Jan 2026 | 7 articles | Viewed by 16349 | Submission Open

Keywords: cervical cancer; cervical dysplasia; human papilloma virus (HPV); tumor markers; cancerogenesis; genotyping

(This special issue belongs to the Section Molecular Cancer Biology)

Novel Advances in the Molecular Understanding of Myeloproliferative Neoplasms (MPNs)

edited by Wei Chen, Fei Li and

Qiang Jeremy Wen

submission deadline 15 Jan 2026 | 4 articles | Viewed by 12942 | Submission Open

Keywords: MPNs; ET; PV; PMF; post-PV-MF; post-ET-MF; MDS/MPN; JAK2

(This special issue belongs to the Section Molecular Cancer Biology)

New Insights into Cancer Immunotherapy: From Immune Cell to Clinical Practice

edited by Xiaotong Song

submission deadline 15 Jan 2026 | 6 articles | Viewed by 10009 | Submission Open

Keywords: T cell therapy; cancer immunotherapy; CAR T cells; immune checkpoint modulation; tumor microenvironment

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Clinical and Research Progress in the Resection of Gastro-Esophageal Cancer

edited by Biniam Kidane

submission deadline 15 Jan 2026 | 5 articles | Viewed by 9513 | Submission Open

(This special issue belongs to the Section Clinical Research of Cancer)

Cell Biology of Cancer Invasion: 2nd Edition

edited by

Hideki Yamaguchi

submission deadline 15 Jan 2026 | 2 articles | Viewed by 3574 | Submission Open

Keywords: invasion; metastasis; intravasation; extravasation; invadopodia; tumor microenvironment; epithelial– mesenchymal transition; cell migration; cytoskeleton; cell adhesion; extracellular matrix; matrix metalloprotease; cancer-associated fibroblast; tumor-associated macrophage

(This special issue belongs to the Section Cancer Metastasis)

Circulating Tumour DNA and Liquid Biopsy in Oncology

edited by

Yafeng Ma

and Kevin Spring

submission deadline 15 Jan 2026 | 3 articles | Viewed by 3308 | Submission Open

Keywords: cell-free DNA; circulating tumour DNA; liquid biopsy; mutation status; tumour mutational burden; methylation detection; fragmentomics; minimal residual disease; early detection

(This special issue belongs to the Section Cancer Biomarkers)

The Survival of Colon and Rectal Cancer (2nd Edition)

edited by

Susanne Merkel

submission deadline 15 Jan 2026 | 1 articles | Viewed by 1455 | Submission Open

Keywords: colorectal cancer; colorectal cancer surgery; multidisciplinary treatment; survival; prognostic factors; distant metastasis; locoregional recurrences; standardisation; individualisation

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Pediatric Cancer Research from Basic Biology to Experimental Therapy

edited by

Atif Ahmed

submission deadline 16 Jan 2026 | 4 articles | Viewed by 13398 | Submission Open

Keywords: pediatric tumors; solid cancers; leukemias; cancer predisposition syndromes; genetics; omics; immunotherapy; therapy resistance

(This special issue belongs to the Section Pediatric Oncology)

Survivorship Following Childhood, Adolescent and Young Adult Cancer

edited by Magdalena Balcerek and Judith Gebauer

submission deadline 20 Jan 2026 | 1 articles | Viewed by 2838 | Submission Open

Keywords: cancer survivorship; late effects; long-term follow-up care; supportive care; health prevention and promotion

(This special issue belongs to the Section Pediatric Oncology)

Recent Trends in the Development of Theranostics and Multifunctional Tracers in Oncology

edited by

Olaf Prante

submission deadline 20 Jan 2026 | Viewed by 250 | Submission Open

Keywords: multifunctional radiopharmaceuticls; PET/CT; multimodal imaging; cancer treatment

(This special issue belongs to the Section Methods and Technologies Development)

The Prospect of Nanobiotechnology in Cancers

edited by

Wenpan Li

submission deadline 20 Jan 2026 | Viewed by 215 | Submission Open

Keywords: nanobiotechnology; cancer therapy; targeted drug delivery; tumor microenvironment

(This special issue belongs to the Section Methods and Technologies Development)

Recent Updates on Imaging and Staging of Gynecologic Cancers

edited by

David Mutch

and Alexander B. Olawaiye

submission deadline 21 Jan 2026 | 2 articles | Viewed by 2955 | Submission Open

Keywords: imaging; surgical staging; molecular prognostic features; mortality; prognosis

(This special issue belongs to the Section Methods and Technologies Development)

Roles of the Tumor Microenvironment on Liquid Biopsy (2nd Edition)

edited by

Dario Marchetti

submission deadline 22 Jan 2026 | 1 articles | Viewed by 918 | Submission Open

Keywords: liquid biopsy; CTCs; CTC characterization and CTC clustering; ctDNA and ctDNA profiling; exosomes/extracellular vesicles and biology; tumor microenvironment; bone marrow cellular/molecular heterogeneity; CTCs/blood/BM cells crosstalk; analytical validity; clinical validity; and clinical utility of liquid biopsy; liquid biopsy interplaying dormancy and metastasis

(This special issue belongs to the Section Tumor Microenvironment)

Advancements in Salivary Gland Tumors Management: From Diagnostic Imaging to Treatment Strategies

edited by Wioletta Pietruszewska, Małgorzata Wierzbicka and

Boguslaw Mikaszewski

submission deadline 22 Jan 2026 | Viewed by 292 | Submission Open

Keywords: salivary gland tumors; MRI; CT; and PET; minimally invasive approaches

(This special issue belongs to the Section Cancer Therapy)

Innovative Immunotherapies: CAR-T Cell Therapy for Cancers: 2nd Edition

edited by

Shebli Atrash

submission deadline 23 Jan 2026 | 3 articles | Viewed by 9802 | Submission Open

Keywords: CAR-T; NK-CAR; immunotherapy; cancer; resistance mechanisms

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Targeting Hallmarks of Cancer

edited by

Carlos Pérez Plasencia

submission deadline 25 Jan 2026 | Viewed by 777 | Submission Open

Keywords: epigenetic regulators; organotypic culture models; anticancer drugs; hallmarks of cancer

(This special issue belongs to the Section Cancer Biomarkers)

Towards a Personalized Medicine for the Diagnosis and Management of Gynecological Cancers

edited by

Diego Raimondo

and Gabriele Centini

submission deadline 30 Jan 2026 | 3 articles | Viewed by 22446 | Submission Open

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

The Advance of Pencil Beam Scanning Proton Beam Therapy in Cancers

edited by

Haibo Lin

, Richard A. Amos and Heng Li

submission deadline 30 Jan 2026 | 7 articles | Viewed by 16947 | Submission Open

Keywords: proton therapy; pencil beam scanning; robustness; adaptive radiotherapy; imaging guidance; radiobiological model; FLASH radiotherapy; spatially fractionated radiotherapy (SFRT); proton arc

(This special issue belongs to the Section Cancer Therapy)

Cancer Disparities: Biological, Social, and Environmental Determinants

edited by

Riffat Mehboob

and

Miguel Muñoz

submission deadline 30 Jan 2026 | 3 articles | Viewed by 7639 | Submission Open

Keywords: cancer epidemiology; cancer etiology; environmental factors; screening and diagnostics; SDGs

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Advances in the Treatment of Upper Gastrointestinal Cancer

edited by Sang-ho Jeong and

Jae-seok Min

submission deadline 30 Jan 2026 | 2 articles | Viewed by 5924 | Submission Open

Keywords: upper gastrointestinal cancer; surgery therapy; chemotherapy therapy; radiation therapy

(This special issue belongs to the Section Cancer Therapy)

Protein Structure and Cancer—2nd Edition

edited by

Michalis Aivaliotis

submission deadline 30 Jan 2026 | Viewed by 240 | Submission Open

Keywords: protein structure dynamics; structural cancer biology; protein pathways in cancer; structure– function alterations; in silico protein structure prediction; protein interactions; cancer mutations and protein structure alterations

(This special issue belongs to the Section Molecular Cancer Biology)

Advances in Drug Delivery for Cancer Therapy

edited by

Ashakumary Lakshmikuttyamma

submission deadline 31 Jan 2026 | 9 articles | Viewed by 45081 | Submission Open

Keywords: cancer; oncology; therapeutic target; drug resistance; immunotherapy; chemotherapy; small molecule inhibitors; drug delivery; nanoparticle

(This special issue belongs to the Section Cancer Drug Development)

How COVID-19 Affects Cancer Patients

edited by

Maria Fiore

submission deadline 31 Jan 2026 | 15 articles | Viewed by 37576 | Submission Open

Keywords: COVID-19; pandemic; cancer; impact; incidence; mortality; lethality; disparities; gender

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Surgical Advances in Cancer Treatments: Exploring Innovative Approaches and Emerging Perspectives

edited by

and

submission deadline 31 Jan 2026 | 17 articles | Viewed by 36445 | Submission Open

Keywords: surgical oncology; surgical innovation; image-guided surgery; robotic-assisted surgery; multidisciplinary oncology; surgical outcomes research; precision surgery; healthcare economics; surgical training and simulation

(This special issue belongs to the Section Cancer Therapy)

Genetics and Epigenetics of Gynecological Cancer

edited by

Carmela De Marco

submission deadline 31 Jan 2026 | 10 articles | Viewed by 32892 | Submission Open

Keywords: gynecologic cancers; epigenetics; genetics; immunogenetics; predisposing mutations; biomarkers; targeted therapies; chemoresistance

(This special issue belongs to the Section Cancer Pathophysiology)

CAR T Cells in Lymphoma and Multiple Myeloma

edited by

Javier Munoz

and

Julia Erin Wiedmeier-Nutor

submission deadline 31 Jan 2026 | 7 articles | Viewed by 28867 | Submission Open

Keywords: multiple myeloma; lymphoma; CAR T therapy; bi-specific antibodies; cellular therapy

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Screening, Early Detection and Prevention of Hepato-Pancreato-Biliary (HPB) Cancers

edited by Zaed Z.R. Hamady

submission deadline 31 Jan 2026 | 7 articles | Viewed by 26560 | Submission Open

Keywords: hepatobiliary cancer; pancreatic cancer; early detection; diagnosis; screening; prevention

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Thyroid Cancer: Diagnosis, Prognosis and Treatment (2nd Edition)

edited by

Luca Giovanella

and

Petra Petranović Ovčariček

submission deadline 31 Jan 2026 | 9 articles | Viewed by 20233 | Submission Open

Keywords: thyroid cancer; ultrasound; molecular imaging; fine-needle aspiration cytology; thyroidectomy; radioactive iodine; radioiodine-refractory thyroid cancer; tyrosine kinase inhibitors

(This special issue belongs to the Section Cancer Therapy)

Emerging Research on Primary Brain Tumors

edited by Jacob S Young and Mitchel S. Berger

submission deadline 31 Jan 2026 | 6 articles | Viewed by 19435 | Submission Open

Keywords: molecular biomarkers; drug delivery; immunotherapy; personalized medicine; targeted therapies; glioma

(This special issue belongs to the Section Cancer Therapy)

Empowering Cancer Survivors: A Comprehensive Approach to Supportive Care Through Pharmacological and Non-Pharmacological Approaches Including Exercise, Physical Activity and Nutrition

edited by Kellie Toohey

submission deadline 31 Jan 2026 | 11 articles | Viewed by 17435 | Submission Open

Keywords: cancer; physical activity; exercise; supportive care; holistic care; rehabilitation

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Pathology and Treatment of Triple-Negative Breast Cancer

edited by

Ramadevi Subramani

submission deadline 31 Jan 2026 | 4 articles | Viewed by 13102 | Submission Open

(This special issue belongs to the Section Cancer Pathophysiology)

The Tumor Microenvironment: Interplay Between Immune Cells

edited by Jared Rowe and Kristen E. Pauken

submission deadline 31 Jan 2026 | 5 articles | Viewed by 11482 | Submission Open

Keywords: tumor immune microenvironment; metabolic microenvironment; immune cells

(This special issue belongs to the Section Tumor Microenvironment)

Implementation of Physical Activity Promotion in Cancer Care

edited by Sarah Hardcastle

submission deadline 31 Jan 2026 | 4 articles | Viewed by 11183 | Submission Open

Keywords: physical activity; cancer survivors; behaviour change; interventions; cancer care; implementation; health

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Recent Advances and Challenges in Breast Cancer Surgery: 2nd Edition

edited by

Antonio Piñero-Madrona

submission deadline 31 Jan 2026 | 6 articles | Viewed by 9897 | Submission Open

Keywords: breast cancer surgery; axillary management; sentinel node oncoplastic surgery; reconstructive surgery; surgical technology; cancer risk reduction surgery; radio-guided surgery

(This special issue belongs to the Section Cancer Therapy)

Gynecological Cancer: Prevention, Diagnosis, Prognosis and Treatment

edited by Joanna P. Kacperczyk-Bartnik, Tibor Andrea Zwimpfer and

Michał Ciebiera

submission deadline 31 Jan 2026 | 7 articles | Viewed by 9793 | Submission Open

Keywords: gynecological cancer; ovarian cancer; cervical cancer; endometrial cancer; early diagnosis; cancer prevention; prognosis; molecular mechanisms; personalized medicine; novel therapies

(This special issue belongs to the Section Clinical Research of Cancer)

Recent Advances in Oncology Imaging: 2nd Edition

edited by

Li Liu

and

Yicheng Ni

submission deadline 31 Jan 2026 | 4 articles | Viewed by 8489 | Submission Open

Keywords: medical imaging; cancer; oncology; molecular imaging; theragnostics

(This special issue belongs to the Section Methods and Technologies Development)

Biomarkers and Targeted Therapy in Malignant Pleural Mesothelioma

edited by

Susana Cedrés

submission deadline 31 Jan 2026 | 4 articles | Viewed by 8292 | Submission Open

Keywords: malignant mesothelioma; target therapy; biomarkers

(This special issue belongs to the Section Cancer Biomarkers)

Cancer Screening and Primary Care

edited by Marievelisse Soto-Salgado

submission deadline 31 Jan 2026 | 6 articles | Viewed by 7357 | Submission Open

Keywords: screening amenable cancers; screening; primary care; disparities in cancer care; cancer outcomes

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Exploring Skin Cancer: Insights into New Diagnostic, Prognostic, and Therapeutic Strategies

edited by

Emi Dika

submission deadline 31 Jan 2026 | 5 articles | Viewed by 7185 | Submission Open

Keywords: melanoma; non-melanoma skin cancer; NMSC; Merkel cell carcinoma; tumor microenvironment; prognosis; treatment

Advances in the Use of PET/CT and MRI in Prostate Cancer

edited by Carmelo Caldarella

submission deadline 31 Jan 2026 | 3 articles | Viewed by 5748 | Submission Open

Keywords: PET/CT; MRI; prostate cancer; radiomic; receptor-targeted radiopharmaceuticals

(This special issue belongs to the Section Methods and Technologies Development)

The Role of Apoptosis and Autophagy in Cancer

edited by

Souren Paul

submission deadline 31 Jan 2026 | 3 articles | Viewed by 5450 | Submission Open

Keywords: apoptosis; cell death; tumor

(This special issue belongs to the Section Molecular Cancer Biology)

Clinical Studies and Outcomes in Urologic Cancer

edited by Nikolaos Pyrgidis

submission deadline 31 Jan 2026 | 4 articles | Viewed by 5123 | Submission Open

Keywords: urologic cancer; clinical outcomes; prostate cancer; urothelial cancer; kidney cancer; survival analysis; treatment response; quality of life; novel therapies; oncology

(This special issue belongs to the Section Clinical Research of Cancer)

Prediction of Melanoma

edited by

Irene Stefanaki

submission deadline 31 Jan 2026 | 3 articles | Viewed by 4375 | Submission Open

Keywords: melanoma; melanoma genetics; biomarkers; predictive tools; risk prediction; risk factors; artificial intelligence

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Post-Neoadjuvant Strategies in Breast Cancer (2nd Edition)

edited by

Edwin Bölke

, Tanja Fehm and

Stefanie Corradini

submission deadline 31 Jan 2026 | 1 articles | Viewed by 3854 | Submission Open

Keywords: chemotherapy; prospective trials; clinical investigation; breast tumor; local recurrence; overall survival

(This special issue belongs to the Section Cancer Therapy)

Minimally Invasive Approaches in Urological Oncology: Current Trends and Innovations

edited by

Alchiede Simonato

and

Nicola Pavan

submission deadline 31 Jan 2026 | 3 articles | Viewed by 3404 | Submission Open

Keywords: minimally invasive; robotic; laparoscopic; uro-oncology; prostate cancer; bladder cancer; kidney cancer; testicular cancers; quality of life; penile cancer

(This special issue belongs to the Section Clinical Research of Cancer)

Recent Advances in Nanomedicine-Based Cancer Immunotherapy

edited by Navin Kumar Verma,

Rajeev Parameswaran

and

Manash Paul

submission deadline 31 Jan 2026 | 1 articles | Viewed by 2974 | Submission Open

Keywords: cancer nano-therapy; nano-enabled therapeutic; immune checkpoint inhibitors; tumor immunosuppression; adoptive cell therapy; CAR T-cell therapy; tumor-infiltrating lymphocyte therapy; monoclonal antibody therapy for cancer; cancer vaccines; immune system modulators

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Computational Research in Cancer Neuroscience

edited by Shaolei Teng

submission deadline 31 Jan 2026 | 1 articles | Viewed by 2951 | Submission Open

Keywords: machine learning; large language models; protein structure modeling; omics data analysis; neural– cancer communication; tumor microenvironments; personalized medicine; targeted therapies; cancer neuroscience

(This special issue belongs to the Section Methods and Technologies Development)

Novel Perspectives in Hepato-Biliary and Pancreatic Cancer

edited by Tudor Mocan and Emil-Ioan Moiș

submission deadline 31 Jan 2026 | 2 articles | Viewed by 2847 | Submission Open

Keywords: HCC; cholangiocarcinoma; surgery; biliary drainage; pancreatic cancer; combination therapies

(This special issue belongs to the Section Cancer Therapy)

Advances and Future Developments in Liver Transplantation for Cancers: 2nd Edition

edited by

Nicolas Golse

submission deadline 31 Jan 2026 | 2 articles | Viewed by 2725 | Submission Open

Keywords: machine perfusion; marginal graft; split liver; immunotherapy; auxiliary liver transplantation; digital twin; modeling; organoid

(This special issue belongs to the Section Transplant Oncology)

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