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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Viral Oncogenes and Their Role in Cancer Pathogenesis

edited by

Ronen Borenstein

and Yosef Sabo

submission deadline 21 May 2026 | 3 articles | Viewed by 9635

Keywords: viral oncogenes; cancer pathogenesis; cellular regulation; tumorigenesis mechanisms; antiviral and anticancer strategies

(This special issue belongs to the Section Infectious Agents and Cancer)

Next-Generation Automation in Radiation Oncology: Innovations in Planning, Informatics, and Clinical Workflow

edited by

Ozgur Ates

and Jared Becksfort

submission deadline 22 May 2026 | Viewed by 319 | Submission Open

Keywords: radiation oncology; radiotherapy automation; autosegmentation; rapid automated treatment planning; zero-click quality assurance; fast clinical workflow; artificial intelligence; machine learning; clinical decision support; radiomics; image-guided radiotherapy; adaptive radiation therapy; human-in-the-loop automation; healthcare informatics

(This special issue belongs to the Section Methods and Technologies Development)

Inhibitors in Thyroid Carcinoma (2nd Edition)

edited by

Alessandro Antonelli

submission deadline 24 May 2026 | Viewed by 342 | Submission Open

Keywords: thyroid carcinoma; immune checkpoint inhibitors; tyrosine kinase inhibitors; sorafenib; lenvatinib

(This special issue belongs to the Section Tumor Microenvironment)

Study on Acute Myeloid Leukemia

edited by Olga K. Weinberg

submission deadline 25 May 2026 | 4 articles | Viewed by 11552 | Submission Open

Keywords: acute myeloid leukemia (AML); cancer treatment; genetic

(This special issue belongs to the Section Cancer Therapy)

Advances in Molecular Mechanisms of Gastrointestinal Tumors (2nd Edition)

edited by

Shihori Tanabe

submission deadline 25 May 2026 | 5 articles | Viewed by 8525 | Submission Open

Keywords: molecular mechanism; gastrointestinal tumor; gastric cancer; colorectal cancer; esophageal cancer; tumor microenvironment; molecular network; molecular pathway; pathway network; signal transduction

(This special issue belongs to the Section Molecular Cancer Biology)

Clinical Advances and State-of-the-Art Management in Genitourinary Cancers

edited by

Jad Chahoud

and Adnan Fazili

submission deadline 25 May 2026 | 2 articles | Viewed by 7415 | Submission Open

Keywords: genitourinary malignancies; tumor– immune microenvironment (TIME); tumor biology; genomic characterization; targeted drug therapy; immunotherapy

(This special issue belongs to the Section Clinical Research of Cancer)

Colorectal Cancer: Risk Factors and Underlying Mechanisms

edited by David Achaintre

submission deadline 25 May 2026 | 1 articles | Viewed by 2380 | Submission Open

Keywords: colorectal cancer; diet; environmental factors; microbiome; inflammation

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Primary and Recurrent Gynecological Cancer: Epidemiology, Management and New Therapies

edited by Nithya Ratnavelu and Ioannis Biliatis

submission deadline 28 May 2026 | 4 articles | Viewed by 12488 | Submission Open

Keywords: ovarian cancer; endometrial cancer; cervical cancer; vulva cancer; vaginal cancer; gynecological cancer

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Combination Therapy in Geriatric Population with Cancer (2nd Edition)

edited by

Lore Decoster

submission deadline 28 May 2026 | 3 articles | Viewed by 5919 | Submission Open

Keywords: older patients with cancer; surgery; radiotherapy; chemotherapy; immunotherapy; targeted therapy

(This special issue belongs to the Section Cancer Therapy)

New Approaches in Radiotherapy for Cancer

edited by Dandan Zheng, Alexander Podgorsak and Olga Maria Dona Lemus

submission deadline 30 May 2026 | 27 articles | Viewed by 117006 | Submission Open

Keywords: adaptive radiotherapy; FLASH; artificial intelligence; SFRT; particle therapy; proton therapy; SRS; SBRT; HDR; 3D printing; immuno-radiotherapy; radiogenmics

(This special issue belongs to the Section Cancer Therapy)

Skin Cancer Prevention: Strategies, Challenges and Future Directions

edited by Véronique del Marmol, Mariano Suppa, Ana-Maria Forsea and Alexander Stratigos

submission deadline 30 May 2026 | 8 articles | Viewed by 12664 | Submission Open

Keywords: skin cancer prevention; photoprotection; early detection; screening; epidemiology; public health; behavioral interventions; sun exposure; artificial intelligence; risk factors

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Advances in the Surgical Treatment of Spinal Tumors

edited by Daniel Lubelski

submission deadline 30 May 2026 | 4 articles | Viewed by 7386 | Submission Open

Keywords: spinal tumors; spinal metastases; minimally invasive spine surgery; radiosurgery; histology-specific treatment; prognostic modeling; machine learning; deep learning; spinal reconstruction; quality of life

(This special issue belongs to the Section Cancer Therapy)

Endoscopic Management of Pancreatic Neoplasms (2nd Edition)

edited by

Nam Quoc Nguyen

submission deadline 30 May 2026 | 2 articles | Viewed by 6599 | Submission Open

Keywords: pancreatic cancer; pancreatic neoplasm; endoscopic retrograde cholangiopancreatography; endoscopic ultrasound; fine needle aspiration/biopsy; local treatment; biliary stent; biliary drainage; contrast enhancement

(This special issue belongs to the Section Methods and Technologies Development)

Advances in the Diagnosis and Treatment of Prostate Cancer: From Biomarkers to Precision Surgery

edited by Stamatios N. Katsimperis and

Lazaros Tzelves

submission deadline 30 May 2026 | 6 articles | Viewed by 5547 | Submission Open

Keywords: prostate cancer; precision medicine; molecular biomarkers; risk stratification; robotic surgery; artificial intelligence; genomics; personalized treatment; imaging modalities; multidisciplinary approach

(This special issue belongs to the Section Cancer Therapy)

Genetics of Ovarian Cancer (2nd Edition)

edited by

Stergios Boussios

and

Sola Adeleke

submission deadline 30 May 2026 | 2 articles | Viewed by 2820 | Submission Open

Keywords: epithelial ovarian cancer; genomics; epigenetics; translational research; biomarkers; DNA damage response; PARP inhibitors

(This special issue belongs to the Section Cancer Pathophysiology)

New and Future Focused Therapies for Thyroid Cancer

edited by

Alessandro Antonelli

, Poupak Fallahi, Silvia Martina Ferrari and Giusy Elia

submission deadline 30 May 2026 | 1 articles | Viewed by 2800 | Submission Open

Keywords: aggressive differentiated thyroid carcinoma; anaplastic thyroid cancer; tyrosine kinase inhibitors; immunotherapy; personalized medicine

(This special issue belongs to the Section Cancer Therapy)

Current Advances in Management of Neuroendocrine Neoplasms

edited by Ashley Kieran Clift and

Andrea Frilling

submission deadline 30 May 2026 | 1 articles | Viewed by 2483 | Submission Open

Keywords: neuroendocrine tumours; epidemiology; clinical prediction models; machine learning; personalised medicine; novel biomarkers; diagnostics; treatment; artificial intelligence

(This special issue belongs to the Section Cancer Therapy)

Liquid Biopsy for Lung Cancer Treatment (2nd Edition)

edited by

Maria Palmieri

and Frullanti Elisa

submission deadline 30 May 2026 | 1 articles | Viewed by 1287 | Submission Open

Keywords: cancer; lung cancer; new strategies; liquid biopsy; CTC; exosomes; Cf-NA; DdPCR; NGS

(This special issue belongs to the Section Cancer Biomarkers)

Integrating Radiomics and Radiotherapy in Cancer Care: Quantitative Imaging and Efficacy Assessment

edited by

Savino Cilla

submission deadline 30 May 2026 | 1 articles | Viewed by 929 | Submission Open

Keywords: radiomics; radiogenomics; radiation oncology; imaging biomarkers; predictive models; machine learning; precision radiotherapy; quantitative imaging

(This special issue belongs to the Section Methods and Technologies Development)

Minimally Invasive Surgery and Robotic Techniques in GI Cancer Treatment

edited by Luca Milone and Abid Qureshi

submission deadline 30 May 2026 | 1 articles | Viewed by 909 | Submission Open

Keywords: minimally invasive surgery; robotic surgery; gastrointestinal cancer; surgical oncology; laparoscopic surgery; advanced surgical technology; robotic-assisted procedures; AI in robotic surgery

(This special issue belongs to the Section Methods and Technologies Development)

Updates on Depression Among Cancer Patients (2nd Edition)

edited by Wen-Yu Hu,

Yun-Chen Chang

and

Elsa Vitale

submission deadline 30 May 2026 | Viewed by 320 | Submission Open

Keywords: depression; psychotherapy; oncology nursing

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Revolutionizing Cancer Treatment: Advances in Radiation Therapy

edited by

Hans Christiansen

submission deadline 30 May 2026 | 1 articles | Viewed by 314 | Submission Open

Keywords: radiation therapy; radiooncology; radiobiology; radiosensitivity; high-precision radiotherapy; stereotactic radiotherapy; particle therapy; FLASH radiotherapy; image-guided radiotherapy (IGRT); radiochemotherapy; radioimmunotherapy; translational research; clinical outcome

(This special issue belongs to the Section Cancer Therapy)

Blood Stem Cell and Hematological Malignancies (Second Edition)

edited by Dirk Loeffler

submission deadline 30 May 2026 | Viewed by 258 | Submission Open

Keywords: hematopoietic stem cells; hematological malignancies; clonal hematopoiesis; clonal evolution; preleukemia and leukemia; self-renewal and differentiation; asymmetric cell division; cell polarity; therapy resistance; transformation

(This special issue belongs to the Section Molecular Cancer Biology)

Health Services Research in Cancer Care

edited by

Francesco Giusti

and

Carmen Martos

submission deadline 31 May 2026 | 7 articles | Viewed by 20593 | Submission Open

Keywords: cancer care; cancer care outcomes; cancer care services; cancer costs; treatment; health systems; quality; survival; indicators; health technology assessments

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Developments in the Management of Gastrointestinal Malignancies (2nd Edition)

edited by Zachary J. Brown

submission deadline 31 May 2026 | 9 articles | Viewed by 19696 | Submission Open

Keywords: gastrointestinal malignancies; multimodal therapy; chemotherapy; radiotherapy; immunotherapy; localized and metastatic

(This special issue belongs to the Section Cancer Therapy)

Breast Cancer Survivorship: Challenges and Innovations from Treatment to Long-Term Care

edited by Médéa Locquet

submission deadline 31 May 2026 | 12 articles | Viewed by 18398 | Submission Open

Keywords: breast cancer survivorship; cancer treatments; late effects: societal impact; supportive care; psychosocial well-being; cancer treatment optimization; interventions

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Gut Microbiome, Diet and Cancer Risk

edited by

Byeongsang Oh

submission deadline 31 May 2026 | 5 articles | Viewed by 13342 | Submission Open

Keywords: gut microbiome; cancer; diet; dysbiosis; immunity; dietary fiber; probiotic; short-chain fatty acids (SCFAs)

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Cancer Biomarkers—Detection and Evaluation of Response to Therapy

edited by

Giulio Francia

and

Jianying Zhang

submission deadline 31 May 2026 | 5 articles | Viewed by 11542 | Submission Open

Keywords: biomarkers; cancer detection; biomarkers of response to antineoplastic drugs; biomarkers of resistance to chemotherapy; biomarkers for targeted therapies

(This special issue belongs to the Section Cancer Biomarkers)

Advances in Treatment of Uveal Melanoma

edited by

Bożena Romanowska-Dixon

and

Michał S. Nowak

submission deadline 31 May 2026 | 5 articles | Viewed by 11015 | Submission Open

Keywords: uveal melanoma; distant metastases; treatment modalities

(This special issue belongs to the Section Cancer Therapy)

Exploring the Interplay of Glioblastoma Angiogenesis, ROS, and Tumor Microenvironment: Advancements in Combination Therapy and Bioinformatics Approaches

edited by

Md. Ataur Rahman

submission deadline 31 May 2026 | 1 articles | Viewed by 10413 | Submission Open

Keywords: glioblastoma; angiogenesis; reactive oxygen species (ROS); hypoxia-inducible factors (HIFs); radiotherapy (RT); bioactive natural compounds; tumor microenvironment (TME); cancer immunotherapy; combination therapy; autophagy; apoptosis; in silico and network pharmacology; bioinformatics

(This special issue belongs to the Section Cancer Metastasis)

Local Management of Breast Cancer: The Evolving Relationship Between Radiotherapy and Surgery

edited by Shengyang Peter Wu

submission deadline 31 May 2026 | 3 articles | Viewed by 9871 | Submission Open

Keywords: biomarker-guided personalized breast treatment; targeted axillary dissection; neoadjuvant therapy; local therapy; radiotherapy reduction; ultrahypofractionated partial breast irradiation

(This special issue belongs to the Section Cancer Therapy)

Advances in Proton Therapy for Head and Neck Cancer: Techniques, Outcomes and Planning Variations

edited by Jun Zhou

submission deadline 31 May 2026 | 3 articles | Viewed by 9652 | Submission Open

Keywords: proton head and neck cancer therapy; protons vs. photons for head and neck cancer treatment; adaptive proton therapy; robustness in proton head and neck cancer therapy; online vs. offline adaptation in proton head and neck cancer therapy

(This special issue belongs to the Section Cancer Therapy)

Updates on Thyroid Cancer

edited by

Kwangsoon Kim

and

Ja Seong Bae

submission deadline 31 May 2026 | 4 articles | Viewed by 8495 | Submission Open

Keywords: thyroid cancer; surgery; updates; diagnosis; molecular biology; personalized medicine; artificial intelligence; novel therapeutic strategies; patient outcomes

(This special issue belongs to the Section Cancer Therapy)

MicroRNA in Cancer: From Molecular Mechanisms to Therapeutic Applications

edited by Girish Shukla and

Sivakumar Vijayaraghavalu

submission deadline 31 May 2026 | 6 articles | Viewed by 7081 | Submission Open

Keywords: microRNA (miRNA) therapeutics; cancer biomarkers; oncogenic and tumor-suppressive miRNAs; miRNA delivery systems; precision oncology

(This special issue belongs to the Section Cancer Biomarkers)

Prostate Cancer and Inflammation

edited by Takuji Hayashi

submission deadline 31 May 2026 | 2 articles | Viewed by 6211 | Submission Open

Keywords: prostate cancer; inflammation; immune cells; cytokine; chemokine; anti-inflammatory agents; diet; microbiome

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Quality of Life in Patients with Brain Tumors

edited by Priya U. Kumthekar, Akanksha Sharma and Margaret Johnson

submission deadline 31 May 2026 | 5 articles | Viewed by 6029 | Submission Open

Keywords: quality of life; palliative care; patient reported outcomes; survivorship; caregiver distress; symptom management

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Advances in Targeted Therapies in Cancer (2nd Edition)

edited by

Bulent Ozpolat

submission deadline 31 May 2026 | 3 articles | Viewed by 5603 | Submission Open

Keywords: targeted therapy; cancer; antibody therapy; small molecule inhibitor; RNAi therapy; cell-based therapy

(This special issue belongs to the Section Cancer Therapy)

Radiotherapy for the Management of Brain Metastases

edited by Alla Gabriella Wernicke

submission deadline 31 May 2026 | 2 articles | Viewed by 5445 | Submission Open

Keywords: brain metastases; molecular profiles; imaging advancements; systemic treatment options; radiotherapeutic techniques; primary irradiation; re-irradiation; cutting-edge clinical research

(This special issue belongs to the Section Cancer Metastasis)

Molecular Pathways in Cancers (2nd Edition)

edited by

Ion Cristóbal

and

Marta Rodríguez Moreno

submission deadline 31 May 2026 | 2 articles | Viewed by 5201 | Submission Open

Keywords: highly prevalent cancers; tumor microenvironment; oncogenesis; progression; novel targeted therapy; prognosis

(This special issue belongs to the Section Molecular Cancer Biology)

The Role of Circulating Tumor Cells in Colorectal Cancer

edited by

Chiara Nicolazzo

submission deadline 31 May 2026 | 1 articles | Viewed by 4547 | Submission Open

Keywords: circulating tumor cells (CTC); colorectal cancer (CRC); liquid biopsy; biomarkers; tumor progression; personalized medicine; molecular profiling; metastasis; diagnostic techniques; prognostic evaluation

(This special issue belongs to the Section Cancer Biomarkers)

Focus on Focal Therapy for Prostate Cancer

edited by Abhinav Sidana and Samuel Tremblay

submission deadline 31 May 2026 | 2 articles | Viewed by 4488 | Submission Open

Keywords: focal therapy; prostate cancer treatment; image-guided therapy; oncological outcomes; functional outcome; patient selection; surveillance

(This special issue belongs to the Section Cancer Therapy)

Evolution of Cancer Therapies: Access of Developing Countries to Modern Oncology

edited by

Salem Chouaib

submission deadline 31 May 2026 | 3 articles | Viewed by 3999 | Submission Open

Keywords: conventional cancer therapies; modern oncology; recission medicine; cancer immunotherapy; artificial intelligence; targeted agents; equity and globally equal access

(This special issue belongs to the Section Cancer Therapy)

Therapeutic Optimization of Anti-Tumor Drugs Based on Pharmacokinetics

edited by Paula Fresco and Joaquim António Faria Monteiro

submission deadline 31 May 2026 | 1 articles | Viewed by 3825 | Submission Open

Keywords: anti-cancer drugs; pharmacokinetics; therapeutic drug monitoring; cancer; populational pharmacokinetics models

(This special issue belongs to the Section Cancer Drug Development)

The Future of Cancer Immunotherapy: Biomarkers, Tumor Microenvironment, and Precision Medicine

edited by Aftab Alam

submission deadline 31 May 2026 | 3 articles | Viewed by 3785 | Submission Open

Keywords: immunotherapy; genomics; proteomics checkpoint; CAR T cells; predictive biomarkers; resistance mechanisms; combination approaches; tumor microenvironment

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Survivorship and Quality of Life in Endometrial Cancer

edited by George Koukourakis,

Antonios Anagnostopoulos

, Georgios Angelopoulos and Anthi Miliadou

submission deadline 31 May 2026 | 3 articles | Viewed by 3657 | Submission Open

Keywords: endometrial cancer; quality of life; survivorship

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Current Issues, Innovations, and Emerging Therapies in Thoracic Surgical Oncology

edited by Inderpal S. Sarkaria and Shamus Carr

submission deadline 31 May 2026 | 3 articles | Viewed by 3423 | Submission Open

Keywords: non-small cell lung cancer; esophageal cancer; thymic epithelial tumors; BAP1 malignant mesothelioma; robotic surgery; immunotherapy; cellular therapies; molecular imaging

Advances in Cell and Gene Therapy in Tumors: From Bench to Bedside

edited by Shuhang Wang

submission deadline 31 May 2026 | 1 articles | Viewed by 3284 | Submission Open

Keywords: cell therapy; gene therapy; genetically engineered cells; cancer treatment; clinical trials; pre-clinical study

(This special issue belongs to the Section Cancer Therapy)

Primary Central Nervous System Lymphoma: A Challenging Disease

edited by

Roser Velasco

submission deadline 31 May 2026 | 2 articles | Viewed by 3091 | Submission Open

Keywords: primary central nervous system lymphoma (PCNSL); diffuse large B cell lymphoma (DLBCL); advanced imaging; novel therapies; prognostic markers

Lymphoid and Myeloid Leukemias—Current Progress in Biology and Treatment

edited by Ewa Robak and

Tadeusz Robak

submission deadline 31 May 2026 | 2 articles | Viewed by 3000 | Submission Open

Keywords: acute myeloid leukemia; promyelocytic leukemia; myelomonocytic leukemia; chronic lymphocytic leukemia; hairy cell leukemia; prolymphocytic leukemia; large granular lymphocyte leukemia; acute lymphoblastic leukemia

(This special issue belongs to the Section Molecular Cancer Biology)

Clinical and Translational Research of Urological Cancer

edited by