The metal fibre surface combustion structure has the characteristics of strong thermal matching ability, short response time, and strong shape adaptability. It has more advantages in the thermal test of complex hypersonic vehicle surface inlet, leadi...
Ni-Ti alloys are widely used for biomedical applications due to their superelastic properties, which are especially convenient for endovascular devices that require minimally invasive insertion and durable effects, such as peripheral/carotid stents a...
(1) Development of radiofrequency ablation (RFA) systems for pulmonary lesions is restricted by availability of human tumor specimens and limited comparability of animal tissue. We aimed to develop a new surrogate tissue overcoming these drawbacks. (...
The development of human body simulators that can be used as surrogates for testing protective devices and measures requires selecting synthetic materials with mechanical properties closely representative of the human tissues under consideration. For...
In this paper, an optimization approach was presented for the flexural strength and stiffness design of reinforced concrete beams. Surrogate modeling based on machine learning was applied to predict the responses of the structural system in three-poi...
Meniscal root repair is not routinely recommended for patients over 75 years old, yet surrogate age-unrestricted human or porcine models are used for its evaluation. This study assesses the suitability of older human or porcine meniscus models for in...
To investigate the failure behavior of Ti6Al4V alloy under complex stress states, this study designed tensile specimens with different notches to achieve high, medium, and low stress triaxiality conditions. By adjusting the width of the notch spacing...
In this paper, aimed at the problem of large temperature gradient thermal testing with the typical sharp wedge leading edge structure of a hypersonic vehicle, a subsonic high-temperature combustion gas heating (SHCH) test device is used to conduct a...
Background: Activating mutations of the epidermal growth factor receptor (EGFR) gene are known to drive a proportion of non-small-cell lung cancers. Identification of lung cancers harbouring such mutations can lead to effective treatment using one of...
Introduction: The presence of Mycobacterium tuberculosis in a respiratory specimen is diagnostic in patients with pleural effusion. It is difficult to obtain sputum even after induction in these patients. An alternative method of acquiring respirator...
Estimation of biodiversity patterns in poorly known areas is hampered by data availability and biased collecting efforts. To overcome the former, patterns can be estimated at higher taxonomic levels and larger spatial units. To deal with the latter,...
9 March 2022
We propose a field procedure for estimating the dry biomass of stream macroinvertebrates. Estimates are calculated using the mean values of the a and b regression coefficients from unpublished data and an extensive review of the relevant literature....
Manufacturing defects, such as porosity and inclusions, can significantly compromise the structural integrity and performance of additively manufactured parts by acting as stress concentrators and potential initiation sites for failure. This paper in...
Risk factors for hepatic immune-related adverse events (HIRAEs) in patients with advanced/unresectable hepatocellular carcinoma (HCC) treated with immune checkpoint inhibitors (ICIs) are unclear. We investigated: (i) clinical and morpho-pathological...
Quantitative and reliable monitoring of osseointegration will help further evaluate the integrity of the orthopaedic construct to promote novel prosthesis design and allow early mobilisation. Quantitative assessment of the degree or the lack of osseo...
In nature, rock masses often exhibit fissures, and varying external forces lead to different rates of loading on fissured rock masses. By studying the influence of the loading rate on the mechanical properties of fractured rock mass and AE characteri...
Several of the human-pathogenic arenaviruses cause hemorrhagic fever and have to be handled under biosafety level 4 conditions, including Lassa virus. Rapid and safe inactivation of specimens containing these viruses is fundamental to enable downstre...
Body size is the most essential feature that significantly correlates with insects’ longevity, fecundity, metabolic rate, and sex ratio. Numerous biogeographical rules have been proposed to illustrate the correlation between the body sizes of d...
We sought to find further evidence showing the increase in PCa aggressiveness as PI-RADS score increases from four surrogates of PCa aggressiveness: i. prostate biopsy GG (≤3 vs. >3), ii. type of pathology in surgical specimens (favourable vs....
In order to obtain the optimal cladding process parameters for repairing the inner wall of the cylinder, 316L stainless steel powder was laser clad onto 27SiMn steel, which is the base material of the inner wall of the cylinder. The CCD (Central Comb...
Assays to simultaneously detect multiple potential agents of bioterrorism are limited. Two multiplex PCR and RT-PCR enzyme hybridization assays (mPCR-EHA, mRT-PCR-EHA) were developed to simultaneously detect many of the CDC category “A” bioterrorism...
Ultraviolet (UV) photofunctionalization counteracts the biological aging of titanium to increase the bioactivity and osseointegration of titanium implants. However, UV photofunctionalization currently requires long treatment times of between 12 min a...
Due to the COVID-19 pandemic, researchers have focused on new preventive measures to limit the spread of SARS-CoV-2. One promising application is the usage of antimicrobial materials on often-touched surfaces to reduce the load of infectious virus pa...
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a hereditary disease of the heart muscle. Clinical challenges remain, however, in identifying patients with ARVC in the early or concealed stages with subtle clinical manifestations. Therefore...
The purpose of this study was to compare a novel bone marrow device with the standard marrow needle in a prospective, randomized study in a teaching hospital employing hematologists- in-training. The new device, the OnControl Bone Marrow (OBM) Biopsy...
Standard clinical MRI techniques provide morphologic insights into knee joint pathologies, yet do not allow evaluation of ligament functionality or joint instability. We aimed to study valgus stress MRI, combined with sophisticated image post-process...
In recent years, besides the consumption of fresh sea urchin specimens, the demand of minimally-processed roe has grown considerably. This product has made frequent consumption in restaurants possible and frauds are becoming widespread with the parti...
High-risk human papillomaviruses (HR-HPV) are the causal agents of an important subset of oropharyngeal cancers that has increased considerably in incidence in recent years. In this study, we evaluated the presence of HPV in 49 oropharyngeal cancers...
Consistent and reasonable characterization of the material behavior under the coupled effects of strain, strain rate and temperature on the material flow stress is remarkably crucial in order to design as well as optimize the process parameters in th...
SARS-CoV-2 infection was monitored in 1898 health care workers (HCWs) after receiving full vaccination with BNT162b2. Untill 30 June 2021, 10 HCWs tested positive for SARS-CoV-2 using real time RT-PCR, resulting in a 4-month cumulative incidence of 0...
Although infections with Cyclospora cayetanensis are prevalent worldwide, many aspects of this parasite’s life cycle and transmission remain unknown. Humans are the only known hosts of this parasite. Existing information on its endogenous devel...
Drug-metabolizing enzymes (DMEs) and transporters play a major role in drug efficacy and safety. They are regulated at multiple levels and by multiple factors. Estimating their expression and activity could contribute to predicting drug pharmacokinet...
An unidentified cause of functional dyspepsia (FD) is closely associated with medication resistance. Acid suppression is a traditional and preferential method for the treatment of FD, but the efficacy of this treatment varies between epigastric pain...
Rapid and accurate measurement of SARS-CoV-2 neutralizing antibodies (nAbs) can aid in understanding the development of immunity against COVID-19. This study evaluated the diagnostic performance of a rapid SARS-CoV-2 nAb detection test called the BZ...
Challenges associated with drug-releasing stents used in percutaneous transluminal coronary angioplasty (PTCA) encompass allergic reactions, prolonged endothelial dysfunction, and delayed stent clotting. Although absorbable stents made from magnesium...
This study proposes an RBF-PSO hybrid framework for efficient inversion analysis of hydration heat parameters in mass concrete temperature fields, addressing the computational inefficiency and accuracy limitations of traditional methods. By integrati...
mRNA vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), such as BNT162b2 (Comirnaty®), have proven to be highly immunogenic and efficient but also show marked reactogenicity, leading to adverse effects (AEs). Here, we anal...
A surrogate artificial neural network (ANN) model trained on the data generated from a computational finite element-based (FE-based) model is developed. The developed ANN model enables the estimation of the fatigue life (number of load cycles to fail...
Introduction: The association between human papilloma virus (HPV) and the pathogenesis of prostate cancer (PCa) is still controversial. Existing studies often lack information about clinical risk factors, are limited by their retrospective design or...
19 December 2022
SARS-CoV-2 RNA is frequently identified in patient rooms and it was speculated that the viral load quantified by PCR might correlate with infectivity of surfaces. To evaluate Ct values for the prediction of infectivity, we investigated contaminated s...
Cancer stem cells (CSCs) are accountable for the progress of head and neck squamous cell carcinoma (HNSCC). This exploratory study evaluated the expression of molecular CSC markers in different tissues of HNSCC patients. Tissue specimens of primary t...
Background and Objectives: Among breast cancer molecular types, HER2 positive and triple negative (TN) subtypes have the highest likelihood of pathological complete response (pCR), which is a surrogate marker for reduced recurrence and improved patie...
Circulating tumor DNA (ctDNA) has been suggested as a surrogate biomarker for early detection of cancer recurrence. We aimed to explore the utility of ctDNA as a noninvasive prognostic biomarker in newly diagnosed head and neck squamous cell carcinom...
This paper presents a new framework for lightweight optimisation of functionally graded lattice structures (FGLSs) with a particular focus on enhancing and guaranteeing structural safety through three main contributions. Firstly, a design strategy of...
Amyloidosis is a term referring to a group of various protein-misfolding diseases wherein normally soluble proteins form aggregates as insoluble amyloid fibrils. How, or whether, amyloid fibrils contribute to tissue damage in amyloidosis has been the...
Colorectal cancer (CRC) is a heterogeneous disease that can currently be subdivided into four distinct consensus molecular subtypes (CMS) based on gene expression profiling. The CMS4 subtype is marked by high expression of mesenchymal genes and is as...
Introduction: Neoadjuvant chemotherapy in breast cancer offers the possibility to facilitate breast and axillary surgery; it is a test of chemosensibility in vivo with significant prognostic value and may be used to tailor adjuvant treatment accordin...
The treatment landscape for metastatic prostate cancer has undergone significant changes in recent years. The availability of next-generation imaging techniques and the emergence of novel therapies have led to earlier and more aggressive treatment ap...
Gut microbiota might affect the severity and progression of metabolic dysfunction-associated steatotic liver disease (MASLD). We aimed to characterize gut dysbiosis and clinical parameters regarding fibrosis stages assessed by magnetic resonance elas...
Background: The prevalence and incidence of oropharyngeal squamous cell carcinomas (OPSCCs) driven by human papillomavirus (HPV) infection are increasing worldwide, being higher in high-income countries. However, data from Italy are scanty. p16INK4a...
of 2