- Article
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Winning one or two games during a Major League Baseball (MLB) season is often the difference between a team advancing to post-season play, or “waiting until next year”. Technology advances have made it feasible to augment historical data with in-game...
DNA methylation plays a significant role in transcriptional regulation by repressing activity. Change of the DNA methylation level is an important factor affecting the expression of target genes and downstream phenotypes. Because current experimental...
The low complexity domain (LCD) sequence has been defined in terms of entropy using a 12 amino acid sliding window along a protein sequence in the study of disease-related genes. The amyotrophic lateral sclerosis (ALS)-related TDP-43 protein sequence...
Multiple pathways and outcomes are common in evolutionary sequences for biological and other environmental systems due to nonlinear complexity, historical contingency, and disturbances. From any starting point, multiple evolutionary pathways are poss...
The eigenvalue is one of the important cryptographic complexity measures for sequences. However, the eigenvalue can only evaluate sequences with finite symbols—it is not applicable for real number sequences. Recently, chaos-based cryptography h...
Linear complexity is an important pseudo-random measure of the key stream sequence in a stream cipher system. The 1-error linear complexity is used to measure the stability of the linear complexity, which means the minimal linear complexity of the ne...
We explore the realm of uncertainty theory by investigating diverse notions of convergence and statistical convergence concerning complex uncertain sequences. Complex uncertain variables can be described as measurable functions mapping from an uncert...
Binary sequences are algebraic structures currently used as security elements in Internet of Things devices, sensor networks, e-commerce, and cryptography. In this work, a contribution to the evaluation of such sequences is introduced. In fact, we pr...
Linear complexity is an important criterion to characterize the unpredictability of pseudo-random sequences, and large linear complexity corresponds to high cryptographic strength. Pseudo-random Sequences with a large linear complexity property are o...
Linear complexity is an important property to measure the unpredictability of pseudo-random sequences. Trace representation is helpful for analyzing cryptography properties of pseudo-random sequences. In this paper, a class of new Ding generalized cy...
Pseudorandom binary sequences have important uses in many fields, such as spread spectrum communications, statistical sampling and cryptography. There are two kinds of method in evaluating the properties of sequences, one is based on the probability...
Complex structural chromosome abnormalities such as chromoanagenesis have been reported in acute myeloid leukemia (AML). They are usually not well characterized by conventional genetic methods, and the characterization of chromoanagenesis structural...
In this paper, a three-dimensional chaotic system with a hidden attractor is introduced. The complex dynamic behaviors of the system are analyzed with a Poincaré cross section, and the equilibria and initial value sensitivity are analyzed by t...
In medium- and low-voltage three-phase distribution networks, the load imbalance among the phases may compromise the network voltage symmetry. Inverter-interfaced distributed energy resources (DERs) can contribute to compensating for such imbalances...
Organometallic ruthenium(II) complexes [(η6-arene)Ru(en)Cl][PF6] (arene = benzene (1), p-cymene (2), indane (3), and biphenyl (4); en = ethylenediamine) are promising anticancer drug candidates both in vitro and in vivo. In this paper, the intera...
Targeted sequencing has been widely utilized for genomic molecular diagnostics and the emerging DNA data storage paradigm. However, the probe sequences used to enrich regions of interest have different hybridization kinetic properties, resulting in p...
Recently, when forming radar video frames for surface mapping, group-interacting compact onboard radar systems (CORS) are increasingly being utilized. In this context, for the cooperative functioning of the group, each compact radar should use its ow...
Developing objective and interpretable neurophysiological measures is important for characterizing Parkinson’s disease (PD). EEG microstates capture sub-second large-scale brain-state dynamics, while sequence-level measures provide complementar...
In the present paper, we obtain a result on the rate-distortion function (RDF) of wide sense stationary (WSS) vector processes that allows us to reduce the complexity of coding those processes. To achieve this result, we propose a sequence of block c...
Directed grey-box fuzzers focus on testing specific target code. They have been utilized in various security applications, such as reproducing known crashes and identifying vulnerabilities resulting from incomplete patches. Distance-guided directed f...
Neurotoxin complex (NTC) genes are arranged in two known hemagglutinin (HA) and open reading frame X (ORFX) clusters. NTC genes have been analyzed in four serotypes A, B, E and F of Clostridium botulinum causing human botulism. Analysis of amino acid...
Multi-omics approaches, which integrate genomics, transcriptomics, proteomics, and metabolomics, have emerged as powerful tools in the diagnosis of rare diseases. We used untargeted metabolomics and whole-genome sequencing (WGS) to gain a more compre...
Background In the analysis of complex forensic material evidence, conventional detection methods for highly degraded, trace, or mixed samples present several limitations, such as low typing success rates and limited information dimensions. Methods Th...
This work extends an earlier proposed universal random-coding ensemble for sample-wise lossy compression of individual sequences to the two-stage (successive-refinement) setting—an extension that is not quite straightforward, as explained in th...
Background: False-positive variant calls generated within low-complexity regions (LCRs) remain a persistent bottleneck in clinical genomics, complicating downstream analysis. This study evaluates a targeted spatial masking strategy designed to suppre...
Tissue-culture adaptation of viruses can modulate infection. Laboratory passage and bacterial artificial chromosome (BAC)mid cloning of human cytomegalovirus, HCMV, resulted in genomic deletions and rearrangements altering genes encoding the virus en...
Non-attributed graph sequence offers a powerful formalism for modeling the structural dynamics of complex systems—such as social networks, urban infrastructures, and document transmission pathways—where vertex interactions evolve over tim...
Herpesviruses uniquely express two essential nuclear egress-regulating proteins forming a heterodimeric nuclear egress complex (core NEC). These core NECs serve as hexameric lattice-structured platforms for capsid docking and recruit viral and cellul...
Background/Objectives: The Stenotrophomonas maltophilia complex (Smc) comprises opportunistic bacteria with substantial antimicrobial resistance and genomic diversity. This study investigated the antimicrobial susceptibility and genomic characteristi...
Routine identification of Corynebacterium species can be challenging and may complicate investigation of suspected healthcare-associated transmission. We investigated a suspected cluster of blood culture isolates routinely identified as Corynebacteri...
The global rise of drug resistant tuberculosis has highlighted the need for improved diagnostic technologies that provide rapid and reliable drug resistance results. Here, we develop and validate a whole genome sequencing (WGS)-based test for identif...
Cryptic species are common in lichen-forming fungi and have been reported from different genera in the most speciose family, Parmeliaceae. Herein, we address species delimitation in a group of mainly asexually reproducing Parmelina species. The morph...
Telomeres are specialized nucleoprotein complexes, localized at the physical ends of chromosomes, that contribute to the maintenance of genome stability. One of the features of chronic myeloid leukemia (CML) cells is a reduction in telomere length wh...
Horadam sequence is a general recurrence of second order in the complex plane, depending on four complex parameters (two initial values and two recurrence coefficients). These sequences have been investigated over more than 60 years, but new properti...
The output sequence of the shrinking generator can be considered as an interleaving of determined shifted versions of a single PN -sequence. In this paper, we present a study of the interleaving of a PN-sequence and shifted versions of itself. We ana...
Binary PN-sequences generated by LFSRs exhibit good statistical properties; however, due to their intrinsic linearity, they are not suitable for cryptographic applications. In order to break such a linearity, several approaches can be implemented. Fo...
Oxford Nanopore Technologies (ONT) long-read sequencing (LRS) has emerged as a promising genomic analysis tool, yet comprehensive benchmarks with established platforms across diverse datasets remain limited. This study aimed to benchmark LRS performa...
Protein–protein interactions (PPIs) are fundamental to many biological processes. The coevolution-based prediction of interacting residues has made great strides in protein complexes that are known to interact. A multiple sequence alignment (MS...
The nature of changes involved in crossed-sequence scale and inner-sequence scale is very challenging in protein biology. This study is a new attempt to assess with a phenomenological approach the non-stationary and nonlinear fluctuation of changes e...
The deep-sequencing of small RNAs has revealed that different numbers and proportions of miRNA variants called isomiRs are formed from single miRNA genes and that this effect is attributable mainly to imprecise cleavage by Drosha and Dicer. Factors t...
There is a deep need to navigate within our genomic data to find, understand and pave the way for disease-specific treatments, as the clinical diagnostic journey provides only limited guidance. The human genome is enclosed in every nucleated cell, an...
Burkholderia cepacia complex (BCC) is a group of closely related bacteria with widespread environmental distribution. BCC bacteria are opportunistic pathogens that cause nosocomial infections in patients, especially cystic fibrosis (CF). Multilocus s...
Grid-connected inverters with LCL filters regulate the inverter-side current in industrial products. Their small-signal impedance becomes frequency-coupled because of the phase-locked loop (PLL), and the remaining industrial control functions—a...
Ken Breslauer began studies on the thermodynamics of small cationic molecules binding in the DNA minor groove over 30 years ago, and the studies reported here are an extension of those ground-breaking reports. The goals of this report are to develop...
Major histocompatibility complex (MHC) genes are widely recognised as valuable markers for wildlife genetic studies given their extreme polymorphism and functional importance in fitness-related traits. Newly developed genotyping methods, which rely o...
In this paper, we generalize the permutation entropy (PE) measure to binary sequences, which is based on Shannon’s entropy, and theoretically analyze this measure for random binary sequences. We deduce the theoretical value of PE for random binary se...
This study presents a numerical framework for offline three-objective hole-sequence planning for an AC dual-rotary-head five-axis system. A double-curvature surface containing 48 staggered holes is used as a numerical case. For each hole, one represe...
Myosin, a superfamily of motor proteins, obtain the energy they require for movement from ATP hydrolysis to perform various functions by binding to actin filaments. Extensive studies have clarified the diverse functions performed by the different iso...
Escherichia coli is an indicator micro-organism in One Health antibiotic resistance surveillance programs. The purpose of the study was to describe and compare E. coli isolates obtained from pigs and human contacts from a commercial farm in Sout...
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