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Special Issue "RNA Interference"
Deadline for manuscript submissions: closed (29 April 2015).
Faculty of Health and Applied Sciences, University of the West of England, Bristol; Frenchay Campus, Coldharbour Lane, Bristol BS16 1QY, UK
Interests: RNA biology; RNA binding proteins; alternative splicing; splice factors; splice factor kinases; mRNA translation; microRNAs
Special Issues and Collections in MDPI journals
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Special Issue in Genes: Aberrant Pre-mRNA Splicing in Disease
Special Issue in Non-Coding RNA: Regulation of Alternative Splicing through Long Noncoding RNAs (lncRNAs)
Special Issue in Non-Coding RNA: Regulation of Alternative Splicing through Non-Coding RNAs
In 2006, Craig Fire and Andrew Mello shared a Nobel Prize in Physiology or Medicine for their pioneering work on the nematode Caenorhabditis elegans that led to the discovery of RNA interference. Other groups, working on plants, fruit flies and other organisms also contributed, causing huge excitement in the field because it became obvious that small noncoding RNAs play important roles in gene regulation. These noncoding RNAs include siRNAs (small interfering RNAs derived from dsRNA precursors through cleaved by Dicer) and microRNAs (transcribed from endogenous genes and processed in the nucleus). They bind to target mRNAs, typically the 3'UTR, causing the translational repression or even active degradation of target mRNAs. RNA interference is an ancient process thought to have evolved in order to defend cells against the havoc caused by viruses, parasites and transposons. MicroRNA research has boomed impressively; it is very clear that these noncoding RNAs have critically important developmental roles. The misexpression of microRNAs is associated with several important diseases including cancer, diabetes, and neurodegenerative disorders amongst many others. The ability to detect microRNAs in the blood provides further opportunities for diagnostic testing. RNA interference technology has provided outstanding opportunities in functional genomics, and potentially even novel therapeutic strategies. The purpose of this Special Issue is to highlight recent, exciting advances in RNA interference research. We want to highlight significant applications of RNA interference in biomedical science, agriculture and other areas. In doing so, we plan to underline both the enormous potential and significant practical difficulties in implementing this technology. We also invite articles on the latest developments in terms of understanding the molecular mechanisms that underpin RNA interference: for example, how is the expression of the complex machinery of RNA interference regulated? And how do siRNAs and microRNAs find their correct targets in vivo?
Dr. Michael R. Ladomery
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
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- RNA interference
- short noncoding RNAs
- RISC complex