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264 Results Found

  • Article
  • Open Access
3 Citations
2,581 Views
16 Pages

19 September 2024

This study explores the enhanced removal of refractory organic compounds from coking wastewater using polyaluminum chloride (PACl) with two different basicity levels (0.5 and 2.5), in combination with coagulant aids such as cationic polyacrylamide (C...

  • Article
  • Open Access
3 Citations
4,476 Views
15 Pages

18 February 2019

The effects of refractory metals on physical and thermodynamic properties of X3Ir (X = Ti, V, Cr, Nb and Mo) compounds were investigated using local density approximation (LDA) and generalized gradient approximation (GGA) methods within the first-pri...

  • Review
  • Open Access
211 Citations
16,725 Views
12 Pages

A Comprehensive Review on Catalytic Oxidative Desulfurization of Liquid Fuel Oil

  • Muhammad Nobi Hossain,
  • Hoon Chae Park and
  • Hang Seok Choi

2 March 2019

The production of green fuel oil is of the utmost importance for maintaining a healthy life and environment in the current world. Effective and complete removal of sulfur refractory compounds (such as 4,6-dimethyldibenzothiophene and other alkyl-subs...

  • Article
  • Open Access
21 Citations
7,246 Views
12 Pages

Faecal Scent as a Novel Non-Invasive Biomarker to Discriminate between Coeliac Disease and Refractory Coeliac Disease: A Proof of Principle Study

  • Maxine D. Rouvroye,
  • Alfian Wicaksono,
  • Sofie Bosch,
  • Edo Savelkoul,
  • James A. Covington,
  • Hanneke Beaumont,
  • Chris J. Mulder,
  • Gerd Bouma,
  • Tim G.J. de Meij and
  • Nanne K.H. de Boer

Currently, the gold standard for diagnosis of coeliac disease (CD) is based on serology and gastroduodenoscopy with histology of duodenal mucosal biopsies. The aim of this study was to evaluate the potential of faecal volatile organic compounds (VOCs...

  • Article
  • Open Access
203 Views
22 Pages

Effect of V Content on Microstructure and Properties of TiNbZrVx Medium-Entropy Alloy Coatings on TC4 Substrate by Laser Cladding

  • Wen Zhang,
  • Ying Wu,
  • Chuan Yang,
  • Yongsheng Zhao,
  • Zhenhong Wang,
  • Jia Yang,
  • Wei Feng,
  • Yang Deng,
  • Junjie Zhang and
  • Hui Chen
  • + 3 authors

22 January 2026

In order to improve the wear resistance of titanium alloy and apply it to the high-speed train brake disc, TiNbZrVx (x = 0, 0.2, 0.4, 0.6, 0.8) refractory medium-entropy alloy coatings were prepared on Ti-6Al-4V (TC4) substrate. The effect of V conte...

  • Article
  • Open Access
9 Citations
3,599 Views
16 Pages

27 March 2019

Due to its availability and high storage capacity, Mg is an ideal material in hydrogen storage applications. In practice, doping Mg/MgH2 with catalyst(s) is necessary in enhancing the de/rehydrogenation kinetics and minimizing both of decomposition t...

  • Feature Paper
  • Article
  • Open Access
3 Citations
3,672 Views
42 Pages

2 September 2024

Abstract: The refractory complex concentrated alloy (RCCA) 5Al–5Cr–5Ge–1Hf–6Mo–33Nb–19Si–20Ti–5Sn–1W (at.%) was studied in the as-cast and heat-treated conditions. The partitioning of solutes in t...

  • Article
  • Open Access
7 Citations
4,423 Views
23 Pages

High-Strength, Chemical Industry Wastewater Treatment Feasibility Study for Energy Recovery

  • Riccardo Tinivella,
  • Riccardo Bargiggia,
  • Giampiero Zanoni,
  • Arianna Callegari and
  • Andrea G. Capodaglio

24 November 2023

This paper presents an experimental study on the treatment of industrial chemical wastewater with a high organic load; it is aimed at process cost optimization and possible energy and resources recovery. The facility generates five separate streams o...

  • Feature Paper
  • Article
  • Open Access
8 Citations
4,377 Views
20 Pages

Preparation of Granulated Biomass Carbon Catalysts—Structure Tailoring, Characterization, and Use in Catalytic Wet Air Oxidation of Bisphenol A

  • Riikka Juhola,
  • Anne Heponiemi,
  • Sari Tuomikoski,
  • Tao Hu,
  • Mika Huuhtanen,
  • Davide Bergna and
  • Ulla Lassi

13 February 2021

New carbonized biomass–metakaolin (PSD/MK_Fe) granular composite catalyst materials were manufactured for the catalytic wet air oxidation (CWAO) of bisphenol A (BPA). These catalysts were characterized using different analytical and spectroscopic tec...

  • Article
  • Open Access
3 Citations
2,201 Views
23 Pages

Treatment of Effluent Containing p-Cresol through an Advanced Oxidation Process in a Batch Reactor: Kinetic Optimization

  • Julierme G. C. Oliveira,
  • Yana B. Brandão,
  • Dinaldo C. Oliveira,
  • Jailson R. Teodosio,
  • Cristiane M. Moraes,
  • Attilio Converti,
  • Alessandro Alberto Casazza,
  • Leonie Asfora Sarubbo and
  • Mohand Benachour

28 June 2023

The present research is related to the study of p-cresol oxidation reaction in aqueous phase. Firstly, the conventional advanced oxidation process (AOP) in a lab-scale batch reactor was used, seeking to identify the most impacting process variables a...

  • Article
  • Open Access
9 Citations
2,672 Views
11 Pages

Metamaterial Solar Absorber Based on Refractory Metal Titanium and Its Compound

  • Zijun Song,
  • Guolu Ma,
  • Zao Yi,
  • Jianguo Zhang and
  • Yong Zhao

30 June 2022

Metamaterials refers to a class of artificial materials with special properties. Through its unique geometry and the small size of each unit, the material can acquire unique electromagnetic field properties that conventional materials do not have. Ba...

  • Review
  • Open Access
7 Citations
3,172 Views
48 Pages

4 December 2024

Coatings based on refractory metals and compounds have been used in various industries since the last century due to their high thermal and heat resistance, as well as their excellent mechanical and tribological properties. Advances have made it poss...

  • Feature Paper
  • Article
  • Open Access
11 Citations
5,721 Views
10 Pages

1 March 2018

Amphiphilic phosphotungstic acid (A-PTA) and Ni2P/SBA-15 catalysts were prepared to apply for selective oxidation of refractory sulfur compounds in light cycle oils and hydrotreating of the oxidized S compounds, respectively. Physical properties of t...

  • Review
  • Open Access
32 Citations
6,490 Views
20 Pages

Epothilones as Natural Compounds for Novel Anticancer Drugs Development

  • Cecilia Villegas,
  • Iván González-Chavarría,
  • Viviana Burgos,
  • Héctor Iturra-Beiza,
  • Henning Ulrich and
  • Cristian Paz

Epothilone is a natural 16-membered macrolide cytotoxic compound produced by the metabolism of the cellulose-degrading myxobacterium Sorangium cellulosum. This review summarizes results in the study of epothilones against cancer with preclinical resu...

  • Feature Paper
  • Review
  • Open Access
14 Citations
5,509 Views
26 Pages

Advances and Prospects in Electrocatalytic Processes for Wastewater Treatment

  • Xince Zhou,
  • Jiajie Yang,
  • Jiahuan Guo,
  • Wei Xiong and
  • Michael K. H. Leung

1 August 2024

Wastewater pollution is severe, with various refractory compounds extensively used and discharged into sewage, posing risks to the environment and human health. Electrocatalytic technologies including direct and indirect electrocatalytic oxidation, e...

  • Case Report
  • Open Access
1,029 Views
11 Pages

Refractory CMV Enteritis in Small Bowel Transplantation: A Case Highlighting the Challenges of Balancing Immunosuppression and Novel Antiviral Therapies

  • Abdulrahman A. Al-Saud,
  • Ehab H. Abufarhaneh,
  • Madain S. Alsanea,
  • Reem M. Alameer,
  • Amani H. Yamani,
  • Fatimah S. Alhamlan and
  • Reem S. Almaghrabi

15 October 2025

Background: Cytomegalovirus (CMV) remains a formidable complication in small bowel transplantation (SBT) due to the graft’s high immunogenicity and profound immunosuppression required, with refractory disease representing a particularly devasta...

  • Review
  • Open Access
16 Citations
4,328 Views
35 Pages

19 February 2021

The paper reflects on the usefulness of the alloy design methodology NICE (Niobium Intermetallic Composite Elaboration) for the development of new Nb-containing metallic ultra-high-temperature materials (UHTMs), namely refractory metal (Nb) intermeta...

  • Article
  • Open Access
7 Citations
4,121 Views
13 Pages

Effect of Erosion Behavior of FeO-CaO-SiO2-MgO-Al2O3 Blast Furnace Primary Slag on Al2O3 Substrate

  • Xiangyang Pan,
  • Fengman Shen,
  • Qiangjian Gao,
  • Xin Jiang and
  • Haiyan Zheng

16 August 2021

Al2O3 substrate is widely used as a lining refractory material throughout the blast furnace (BF) process. Accordingly, the erosion of Al2O3 refractory by molten slag has a negative influence on the running cost and smooth operation of BFs. The effect...

  • Article
  • Open Access
9 Citations
5,339 Views
12 Pages

Heterogeneous Catalytic Ozonation of p-Chlorobenzoic Acid in Aqueous Solution by FeMnOOH and PET

  • Savvina Psaltou,
  • Stylianos Stylianou,
  • Manasis Mitrakas and
  • Anastasios Zouboulis

The oxidation of p-chlorobenzoic acid (p-CBA), used as a typical-model refractory organic compound, in aqueous solutions during the heterogeneous catalytic ozonation treatment process by applying the hydrophilic tetravalent manganese feroxyhyte (TMFx...

  • Review
  • Open Access
38 Citations
14,049 Views
35 Pages

11 September 2024

Whereas aGVHD has strong inflammatory components, cGVHD displays autoimmune and fibrotic features; incidence and risk factors are similar but not identical; indeed, the aGVHD is the main risk factor for cGVHD. Calcineurin Inhibitors (CNI) with either...

  • Article
  • Open Access
8 Citations
3,629 Views
12 Pages

Simulation of Diffusion Bonding of Different Heat Resistant Nickel-Base Alloys

  • Albert R. Khalikov,
  • Evgeny A. Sharapov,
  • Vener A. Valitov,
  • Elvina V. Galieva,
  • Elena A. Korznikova and
  • Sergey V. Dmitriev

Currently, an important fundamental problem of practical importance is the production of high-quality solid-phase compounds of various metals. This paper presents a theoretical model that allows one to study the diffusion process in nickel-base refra...

  • Article
  • Open Access
6 Citations
3,235 Views
13 Pages

6 October 2020

For arc welding of high-strength and cold-resistant steels, the author developed an advanced design of steel wire with a micro-composite coating of a nickel matrix and nanoparticles of LaF3 and LaB6, which improves the metallurgical influence of rare...

  • Review
  • Open Access
10 Citations
4,147 Views
17 Pages

Insight into Drug Resistance in Status Epilepticus: Evidence from Animal Models

  • Fei Wang,
  • Qingyang Zhang,
  • Yu Wang,
  • Junzi Chen and
  • Yi Wang

20 January 2023

Status epilepticus (SE), a condition with abnormally prolonged seizures, is a severe type of epilepsy. At present, SE is not well controlled by clinical treatments. Antiepileptic drugs (AEDs) are the main therapeutic approaches, but they are effectiv...

  • Article
  • Open Access
8 Citations
3,790 Views
15 Pages

2 August 2020

Coal fly ash and kaolin are ceramic compounds utilized as raw materials in the production of refractories. Fly ash is an environmental pollutant that emanates abundantly from coal thermal power plants. The management of the large amounts of fly ash p...

  • Review
  • Open Access
29 Citations
10,443 Views
36 Pages

Current Research on Antiepileptic Compounds

  • Cheng-Xi Wei,
  • Ming Bian and
  • Guo-Hua Gong

20 November 2015

Epilepsy affects about 1% of the world’s population. Due to the fact all antiepileptic drugs (AEDs) have some undesirable side effects and about 30% of epileptic patients are not seizure-free with the existing AEDs, there is still an urgent need for...

  • Review
  • Open Access
16 Citations
5,317 Views
21 Pages

Novel Immunotherapies and Combinations: The Future Landscape of Multiple Myeloma Treatment

  • Sonia Morè,
  • Laura Corvatta,
  • Valentina Maria Manieri,
  • Erika Morsia,
  • Antonella Poloni and
  • Massimo Offidani

19 November 2023

In multiple myeloma impressive outcomes have improved with the introduction of new therapeutic approaches, mainly those including naked monoclonal antibodies such as daratumumab and isatuximab. However, moving to earlier lines of therapy with effecti...

  • Article
  • Open Access
23 Citations
3,109 Views
13 Pages

22 September 2022

High-entropy alloys (HEAs) are composed of 5–35 at% of five or more elements, have high configurational entropy, do not form intermetallic compounds, and have a single-phase face-centered cubic structure or body-centered cubic structure. In par...

  • Article
  • Open Access
2 Citations
1,314 Views
16 Pages

Chemical Interaction between the Sr4Al6O12SO4 Ceramic Substrate and Al–Si Alloys

  • José Amparo Rodríguez-García,
  • Carlos Adrián Calles-Arriaga,
  • Ricardo Daniel López-García,
  • José Adalberto  Castillo-Robles and
  • Enrique  Rocha-Rangel

5 March 2024

Samples of Sr4Al6O12SO4 are obtained through a solid-state reaction of Al2O3, SrSO4, and SrCO3. The samples are then made into 1 and 4 cm pellets by compacting them at 100MPa and sintering them at 1400 °C for 4 h. The compound is analyzed using X...

  • Feature Paper
  • Article
  • Open Access
1 Citations
1,940 Views
13 Pages

A binuclear dioxomolybdenum catalyst [(MoO2Cl2)2(L)] (1) (with L (1S,2S)-N,N′-bis(2-pyridinecarboxamide)-1,2-cyclohexane) was prepared and used as catalyst for the desulfurization of a multicomponent model fuel containing the most refractory su...

  • Review
  • Open Access
14 Citations
4,562 Views
30 Pages

Advances in Ablation or Oxidation Mechanisms and Behaviors of Carbon Fiber-Reinforced Si-Based Composites

  • Hongmei Zuo,
  • Fangtao Ruan,
  • Hongjie Wang,
  • He Wang,
  • Xu Wang,
  • Yufan Huang,
  • Rui Wang,
  • Lihua Zou,
  • Zhenzhen Xu and
  • Diansen Li

11 August 2023

Composites with excellent thermomechanical and thermochemical properties are urgently needed in the aerospace field, especially for structural applications under high-temperature conditions. Carbon fiber-reinforced Si-based composites are considered...

  • Article
  • Open Access
17 Citations
3,421 Views
19 Pages

4 February 2021

A simple one-pot method was used to successfully embed manganese ferrite (MnFe2O4) nanoparticles on the nitrogen-doped reduced graphene oxide matrix (NrGO), which was used to activate peroxymonosulfate to treat the landfill leachate nanofiltration co...

  • Review
  • Open Access
16 Citations
11,393 Views
14 Pages

Doxycycline and Tigecycline: Two Friendly Drugs with a Low Association with Clostridium Difficile Infection

  • Yuan-Pin Hung,
  • Jen-Chieh Lee,
  • Hsiao-Ju Lin,
  • Hsiao-Chieh Liu,
  • Yi-Hui Wu,
  • Pei-Jane Tsai and
  • Wen-Chien Ko

Clostridium difficile infection (CDI) is known to be associated with prior exposure to many classes of antibiotics. Standard therapy for CDI (i.e., metronidazole and vancomycin) is associated with high recurrence rates. Although tetracycline derivati...

  • Feature Paper
  • Article
  • Open Access
16 Citations
4,462 Views
11 Pages

Lindqvist versus Keggin-Type Polyoxometalates as Catalysts for Effective Desulfurization of Fuels

  • Simone Fernandes,
  • Fátima Mirante,
  • Baltazar de Castro,
  • Carlos M. Granadeiro and
  • Salete S. Balula

25 May 2022

A correlation between polyoxotungstate structures and their catalytic performance for oxidative desulfurization processes was investigated. Bridged lanthanopolyoxometalates that incorporate identical metallic centers with Keggin- Eu[PW11O39]11−...

  • Feature Paper
  • Review
  • Open Access
86 Citations
6,174 Views
10 Pages

24 November 2018

Half-Heusler phases (space group F 4 ¯ 3 m , C1b) have recently captured much attention as promising thermoelectric materials for heat-to-electric power conversion in the mid-to-high temperature range. The most studied ones are the RNiS...

  • Review
  • Open Access
425 Views
11 Pages

Pterostilbene in the Management and Treatment of Multiple Myeloma

  • Benjamin S. Buehrer,
  • Adam R. Grden,
  • Ethan Johnson,
  • Manav Y. Patel and
  • Rupesh Raina

Multiple Myeloma is a malignancy of the plasma cells of the bone marrow. This cancer rapidly becomes refractory to many of the currently available chemotherapeutic regimens used against it, requiring an alternative option or supplementary therapy. Pt...

  • Article
  • Open Access
32 Citations
9,950 Views
16 Pages

Synthesis and Evaluation of Ciprofloxacin-Nitroxide Conjugates as Anti-Biofilm Agents

  • Anthony D. Verderosa,
  • Sarah C. Mansour,
  • César De la Fuente-Núñez,
  • Robert E. W. Hancock and
  • Kathryn E. Fairfull-Smith

As bacterial biofilms are often refractory to conventional antimicrobials, the need for alternative and/or novel strategies for the treatment of biofilm related infections has become of paramount importance. Herein, we report the synthesis of novel h...

  • Feature Paper
  • Article
  • Open Access
6 Citations
3,253 Views
13 Pages

22 March 2021

In refractory castables during heat treatment, there is a dynamic change from a hydraulic bond to a ceramic bond. During heating, the emission of water takes place; this changes the conditions inside the material to something similar to the hydrother...

  • Review
  • Open Access
33 Citations
13,272 Views
24 Pages

Molecular Pathways and Targeted Therapies for Malignant Ovarian Germ Cell Tumors and Sex Cord–Stromal Tumors: A Contemporary Review

  • Asaf Maoz,
  • Koji Matsuo,
  • Marcia A. Ciccone,
  • Shinya Matsuzaki,
  • Maximilian Klar,
  • Lynda D. Roman,
  • Anil K. Sood and
  • David M. Gershenson

29 May 2020

Non-epithelial ovarian tumors are heterogeneous and account for approximately 10% of ovarian malignancies. The most common subtypes of non-epithelial ovarian tumors arise from germ cells or sex cord and stromal cells of the gonads. These tumors are u...

  • Review
  • Open Access
11 Citations
3,111 Views
23 Pages

Research Progress in Photocatalytic-Coupled Microbial Electrochemical Technology in Wastewater Treatment

  • Qianhao Zeng,
  • Wenhui An,
  • Dongxiao Peng,
  • Qiting Liu,
  • Xu Zhang,
  • Haiyu Ge and
  • Hongbo Liu

16 January 2025

Photocatalytic-coupled microbial electrochemical systems (MESs) represent an emerging wastewater treatment technology which aims to address the limitations of traditional methods, such as the inadequate removal of refractory pollutants and excessive...

  • Proceeding Paper
  • Open Access
2,178 Views
5 Pages

Removal of Formaldehyde by CWO

  • Estefania Rodríguez-Carrasco,
  • Mirella Gutiérrez-Arzaluz,
  • Violeta Mugica-Álvarez and
  • Miguel Torres-Rodríguez

6 November 2018

A large part of the wastewater generated by the Chemical and Transformation Industries are discharged with the presence of organic pollutants, in many cases they contain refractory organic compounds such as formaldehyde in a very low concentration fo...

  • Review
  • Open Access
81 Citations
9,135 Views
33 Pages

Molecular Alterations in Thyroid Cancer: From Bench to Clinical Practice

  • Elena Tirrò,
  • Federica Martorana,
  • Chiara Romano,
  • Silvia Rita Vitale,
  • Gianmarco Motta,
  • Sandra Di Gregorio,
  • Michele Massimino,
  • Maria Stella Pennisi,
  • Stefania Stella and
  • Paolo Vigneri
  • + 4 authors

13 September 2019

Thyroid cancer comprises different clinical and histological entities. Whereas differentiated (DTCs) malignancies are sensitive to radioiodine therapy, anaplastic (ATCs) and medullary (MTCs) tumors do not uptake radioactive iodine and display aggress...

  • Article
  • Open Access
10 Citations
3,727 Views
30 Pages

Pharmaceuticals Removal by Ozone and Electro-Oxidation in Combination with Biological Treatment

  • Francesca Audino,
  • Judith Arboleda,
  • Mira Petrovic,
  • Ricard García Cudinach and
  • Sonia Sanchis Pérez

6 September 2023

This study investigated the efficiency of two advanced oxidation processes (AOPs), ozonation (O3), and electrochemical oxidation (EO), applied individually or in combination, in the removal of contaminants of emerging concern (CECs) contained in hosp...

  • Article
  • Open Access
42 Citations
6,480 Views
16 Pages

Nobiletin and Xanthohumol Sensitize Colorectal Cancer Stem Cells to Standard Chemotherapy

  • Alice Turdo,
  • Antonino Glaviano,
  • Giacomo Pepe,
  • Federica Calapà,
  • Stefania Raimondo,
  • Micol Eleonora Fiori,
  • Daniela Carbone,
  • Manuela Giovanna Basilicata,
  • Veronica Di Sarno and
  • Giorgio Stassi
  • + 18 authors

4 August 2021

Colorectal cancer (CRC) mortality is mainly caused by patient refractoriness to common anti-cancer therapies and consequent metastasis formation. Besides, the notorious toxic side effects of chemotherapy are a concurrent obstacle to be tackled. Thus,...

  • Article
  • Open Access
79 Citations
14,675 Views
26 Pages

2 November 2009

Members of the marine dinoflagellate genus Alexandrium are known to exude allelochemicals, unrelated to well-known neurotoxins (PSP-toxins, spirolides), with negative effects on other phytoplankton and marine grazers. Physico/chemical characterizatio...

  • Review
  • Open Access
3 Citations
4,092 Views
22 Pages

Double Strike in Chronic Lymphocytic Leukemia—The Combination of BTK and BCL2 Inhibitors in Actual and Future Clinical Practice

  • Przemyslaw Zygmunciak,
  • Hanna Dancewicz,
  • Katarzyna Stróżna,
  • Olga Błażowska,
  • Krzysztof Bieliński,
  • Tadeusz Robak and
  • Bartosz Puła

In the recent 2024 ESMO guidelines, the combination of venetoclax and ibrutinib was listed as one of the first-line treatment options for CLL patients. These drugs were first-in-class medicines that revolutionized CLL management, extending patients&r...

  • Article
  • Open Access
533 Views
15 Pages

21 December 2025

China is the world’s largest producer of acrylic fiber, and the wastewater generated from its production contains a significant amount of biologically refractory organic pollutants. However, comprehensive screening studies on organic compounds...

  • Proceeding Paper
  • Open Access
1 Citations
1,311 Views
9 Pages

30 September 2024

Bacterial leaching is a well-known green technology proposed for the extraction of valuable metals into solution. However, this biotechnology has some “bottle neck” problems too. Arsenopyrite, a gold-bearing ore, is a refractory mineral m...

  • Review
  • Open Access
13 Citations
7,680 Views
17 Pages

Mezigdomide—A Novel Cereblon E3 Ligase Modulator under Investigation in Relapsed/Refractory Multiple Myeloma

  • Monique A. Hartley-Brown,
  • Clifton C. Mo,
  • Omar Nadeem,
  • Shonali Midha,
  • Jacob P. Laubach and
  • Paul G. Richardson

15 March 2024

Mezigomide is an oral cereblon E3 ligase modulator (CELMoD) that is under clinical investigation in patients with relapsed/refractory (RR) multiple myeloma (MM). Like other CELMoD compounds, mezigdomide acts by altering the conformation of cereblon w...

  • Article
  • Open Access
16 Citations
3,933 Views
21 Pages

Piperine–Chlorogenic Acid Hybrid Inhibits the Proliferation of the SK-MEL-147 Melanoma Cells by Modulating Mitotic Kinases

  • Carolina Girotto Pressete,
  • Flávia Pereira Dias Viegas,
  • Thâmara Gaspar Campos,
  • Ester Siqueira Caixeta,
  • João Adolfo Costa Hanemann,
  • Guilherme Álvaro Ferreira-Silva,
  • Bruno Zavan,
  • Alexandre Ferro Aissa,
  • Marta Miyazawa and
  • Marisa Ionta
  • + 1 author

19 January 2023

Melanoma is considered the most aggressive form of skin cancer, showing high metastatic potential and persistent high mortality rates despite the introduction of immunotherapy and targeted therapies. Thus, it is important to identify new drug candida...

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