Steel fibre-reinforced concrete (SFRC) consists of short, hooked steel fibres that are randomly distributed and oriented within the cementitious matrix. This paper presents a new analytical load-bounding approach that captures the tensile response of...
Insulation pull rods used in gas-insulated switchgear (GIS) inevitably contain the micro defects generated during production. The intelligent identification method, which requires large datasets with a balanced distribution of defect types, is regard...
In this paper, we consider techniques for establishing lower bounds on the number of arm pulls for best-arm identification in the multi-armed bandit problem. While a recent divergence-based approach was shown to provide improvements over an older gap...
Our understanding of pull-apart basins and their fault systems has been enhanced by analog experiments and simulations. However, there has been scarce interest to compare the faults that bound pull-apart basins with surface ruptures during earthquake...
B cells are central to the adaptive immune response and provide long-lasting immunity after infection. B cell activation is mediated by the surface membrane-bound B cell receptor (BCR) following recognition of a specific antigen. The BCR has been cha...
This paper attempts to qualitatively identify the static pull-in position, pull-in voltage, and fundamental frequency of one-electrode microresonators from a physical perspective. During theoretical derivation, a generalized one-degree-of-freedom (1-...
In transtensional regions, structures striking obliquely to the extension direction generally exhibit oblique or partitioned slips. However, their on-fault partitioning patterns and controlling factors are less known, hindering our understanding of t...
Beer flavor stability is greatly influenced by external temperature, vibrations, and longer delivery times. The present study assessed the impact of transport and storage conditions on staling aldehyde evolution in lager beers across five sample grou...
The PSGL-1-actin cytoskeleton linker proteins ezrin/radixin/moesin (ERM), an adaptor between P-selectin glycoprotein ligand-1 (PSGL-1) and spleen tyrosine kinase (Syk), is a key player in PSGL-1 signal, which mediates the adhesion and recruitment of...
In recent years, there has been an exponential increase in the number of devices developed to measure or estimate physical exercise. However, before these devices can be used in a practical and research environment, it is necessary to determine their...
In the mean-field approximation, the well-known effect of the critical quantum collapse in a 3D gas of particles pulled to the center by potential U(r)=−U0/2r2 is suppressed by repulsive inter-particle interactions, which create the otherwise n...
In Notch signaling, the Jagged1-Notch3 ligand-receptor pairing is implicated for regulating the phenotype maturity of vascular smooth muscle cells. However, less is known about the role of Jagged1 presentation strategy in this regulation. In this stu...
This study presents three-point bending fracture tests on glass fiber-reinforced polymer (GFRP) reinforced concrete notched beams. Few studies have been conducted to date to understand the fracture behavior of this type of specimens. The specimens ha...
Emerging evidence indicates that the TRPM8 channel plays an important role in prostate cancer (PCa) progression, by impairing the motility of these cancer cells. Here, we reveal a novel facet of PCa motility control via direct protein-protein interac...
The globalisation of the beer market forces brewers to have methodologies that rapidly evaluate the evolution of beer flavour stability. Commonly used forced ageing methods have limitations since temperature and transportation conditions (temperature...
Background/Objective: It has been established that HINTW plays a pivotal role in the female differentiation of chickens; nevertheless, the underlying molecular mechanism remains to be fully elucidated. Method: To investigate the role of HINTW in avia...
This paper presents a comprehensive analysis of Class-E series-tuned radio-frequency power amplifiers (RFPAs), focusing on their design and optimization for high efficiency and performance. However, achieving optimal performance involves navigating t...
An H-bond involves the sharing of a hydrogen atom between an electronegative atom to which it is covalently bound (the donor) and another electronegative atom serving as an acceptor. Such bonds represent a critically important geometrical force in bi...
Over the last few years, the study of the SARS-CoV-2 spike protein and its mutations has become essential in understanding how it interacts with human host receptors. Since the crystallized structure of the spike protein bound to the angiotensin-conv...
Steroidal sodium channel agonist batrachotoxin (BTX), one of the most potent animal toxins, dramatically increases calcium permeation and alters other channel characteristics. In a cryoEM structure of rat sodium channel Nav1.5 with two BTX-B molecule...
Undeniably, the Internet of Things (IoT) ecosystem continues to evolve at a breakneck pace, exceeding all growth expectations and ubiquity barriers. From sensor to cloud, this giant network keeps breaking technological bounds in several domains, and...
We investigate the quantum geometry of a 2d surface S bounding the Cauchy slices of a 4d gravitational system. We investigate in detail for the first time the boundary symplectic current that naturally arises in the first-order formulation of general...
In inventory management, storage capacity constraints complicate multi-item lot-sizing decisions. As the number of items increases, deciding how much of each item to order without exceeding capacity becomes more difficult. Dynamic programming works e...
Many transportation structures collapse or sustain severe damage as a result of natural disasters such as earthquakes, floods, wars, and similar attacks. These collapsed or severely damaged structures must be rebuilt and returned to service as quickl...
Calcium carbonate (CaCO3) is one of the most important inorganic powders and is widely used as filler in order to reduce costs in the rubber industry. Nanocalcium carbonate reduces costs and acts as a semireinforcing filler that improves the mechanic...
This paper proposes the preliminary results on a novel control architecture based on model predictive control (MPC) for cable-driven parallel robots (CDPRs) and applies them to a three degrees of freedom (3-DOF) robot with a suspended configuration,...
TSC-22 (TGF-β stimulated clone-22) has been reported to induce differentiation, growth inhibition, and apoptosis in various cells. TSC-22 is a member of a family in which many proteins are produced from four different family genes. TSC-22 (correspond...
Geometrically, the affine connection is the main ingredient that underlies the covariant derivative, the parallel transport, the auto-parallel curves, the torsion tensor field, and the curvature tensor field on a finite-dimensional differentiable man...
The homeodomain protein PDX-1 is a critical regulator of pancreatic development and insulin production in pancreatic β-cells. We have recently shown that PDX-1 is a substrate of protein kinase CK2; a multifunctional protein kinase which is implicated...
This paper presents a study on a quadrotor unmanned aerial vehicle (UAV) fault-tolerant control scheme. According to the attitude model and safety control of the aircraft under the uncertainty of inertial matrix, the attitude state constraint by rein...
(1) Background: The myristoylated pre-S1 peptide (Myr47) synthesized to mimic pre-S1 domain (2-48) in large (L) surface protein of hepatitis B virus (HBV) prevents HBV infection to hepatocytes by binding to sodium taurocholate cotransporting polypept...
Translocated in LipoSarcoma/Fused in Sarcoma (TLS/FUS) is a nuclear RNA binding protein whose mutations cause amyotrophic lateral sclerosis. TLS/FUS undergoes LLPS and forms membraneless particles with other proteins and nucleic acids. Interaction wi...
In eukaryotes three of the four ribosomal RNA (rRNA) molecules are transcribed as a long precursor that is processed into mature rRNAs concurrently with the assembly of ribosomal subunits. However, the relative timing of association of ribosomal prot...
The purpose of this research is to demystify literature on aerotropolis using systematic review. Literature on aerial life and aeronautical studies suggests that airports are frequently cited outside urban centres. However, recent events surrounding...
The P2Y12 receptor is an important member of the purinergic receptor family, known for its critical role in platelet activation and thrombosis. In our previously published study, the acridinone analogue NSC618159 was identified as a potent antagonist...
We designed a vector for the bacterial expression of recombinant antibodies fused to a double tag composed of 6xHis and the EPEA amino acid sequence. EPEA sequence (C tag) is tightly bound by a commercial antibody when expressed at the C-term end of...
Human genomic DNA contains a number of diverse repetitive sequence motifs, often identified as fragile sites leading to genetic instability. Among them, expansion events occurring at triplet repeats have been extensively studied due to their associat...
Classical swine fever (CSF) is caused by the classical swine fever virus (CSFV), which poses a threat to swine production. The activation of host innate immunity through linker proteins such as tumor necrosis factor receptor (TNF-R)-associated factor...
The nuclear envelope (NE) consists of the outer and inner nuclear membrane (INM), whereby the latter is bound to the nuclear lamina. Src1 is a Dictyostelium homologue of the helix-extension-helix family of proteins, which also includes the human lami...
Carrion’s disease, caused by infection with the bacterium Bartonella bacilliformis (B. bacilliformis), is effectively treated with antibiotics, but reaches fatality rates of ~90% if untreated. Current diagnostic methods are limited, insuff...
To overcome early cancer detection challenges, diagnostic tools enabling more sensitive, rapid, and noninvasive detection are necessary. An attractive cancer target for diagnostic blood tests is human Ecto-NOX disulfide–thiol exchanger 2 (ENOX2...
The P-loop fold nucleoside triphosphate (NTP) hydrolases (also known as Walker NTPases) function as ATPases, GTPases, and ATP synthases, are often of medical importance, and represent one of the largest and evolutionarily oldest families of enzymes....
Swarming regulation is complicated in flagellated bacteria, especially those possessing dual flagellar systems. It remains unclear whether and how the movement of the constitutive polar flagellum is regulated during swarming motility of these bacteri...
Structural analyses of protein filaments formed by self-assembly, such as actin, tubulin, or recombinase filaments, have suffered for decades from technical issues due to difficulties in crystallization, their large size, or the dynamic behavior inhe...
Circular RNAs (CircRNAs) are a type of non-coding RNAs, which contain a covalently closed loop structure without 5′ to 3′ free ends. CircRNAs play essential roles in the regeneration of secondary hair follicle (SHF) and cashmere growth in...
Salt stress inhibits normal plant growth and development by disrupting cellular water absorption and metabolism. Therefore, understanding plant salt tolerance mechanisms should provide a theoretical basis for developing salt-resistant varieties. Here...
Despite its high thermodynamic stability, the presence of a negative electric field is known to facilitate the activation of CO2 through electrostatic effects. To utilize electric fields for a reverse water gas shift reaction, it is critical to eluci...
Determining the network size is a critical process in numerous areas (e.g., computer science, logistic, epidemiology, social networking services, mathematical modeling, demography, etc.). However, many modern real-world systems are so extensive that...
The vast majority of transcribed RNAs are noncoding RNAs. Among noncoding RNAs, long noncoding RNAs (lncRNAs), which contain hundreds to thousands of bases, have received attention in many fields. The vast majority of the constituent cells in bone ti...
Retinoic acid receptor-related orphan receptor alpha (RORα), a candidate tumor suppressor, is prevalently downregulated or lost in malignant breast cancer cells. However, the mechanisms of how RORα expression is regulated in breast epithe...
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