Irregularly-shaped bridges are usually adopted to connect the main bridge and ramps in urban overpasses, which are under significant flexion-torsion coupling effects and in complicated stress states. In irregular-shaped bridge design, the parameters...
The rapid expansion of RNA therapeutics requires analytical methods that resolve molecular integrity, heterogeneity, and process-related impurities. Capillary electrophoresis (CE) provides direct RNA separation with low sample consumption and can be...
A key principle of developing a new medicine is that quality should be built in, with a thorough understanding of the product and the manufacturing process supported by appropriate process controls. Quality by design principles that have been establi...
This paper is devoted to the creation of an information and analytical system (IAS) which is under development to manage the data obtained in experiments and investigations to justify the safety of atomic energy, which the National Nuclear Center of...
Home healthcare has recently been promoted in response to the increase in vulnerable people, such as elderly patients who can have difficulty accessing clinics and hospitals in Japan. A characteristic specific to home healthcare is that laboratory te...
This study explores the implementation of the analytic hierarchy process in usability evaluations, specifically focusing on user interface assessment during software development phases. Addressing the challenge of diverse and unstandardized evaluatio...
Quality-by-Design (QbD) is demanded by regulatory authorities in biopharmaceutical production. Within the QbD frame advanced process control (APC), facilitated through process analytical technology (PAT) and digital twins (DT), plays an increasingly...
The Yonglian tunnel in China has experienced 15 instances of severe water and mud inrush disasters, resulting in a total volume of 53,000 m3 of gushing water and mud. These disasters have caused irreversible environmental damage, including hilltop co...
Autonomous vehicles (AVs) must fulfill adequate safety requirements before formal application, and performing an effective functional evaluation to verify vehicle safety requires extensive testing in different scenarios. However, it is crucial to rat...
The integration of real time release testing into an advanced process control (APC) concept in combination with digital twins accelerates the process towards autonomous operation. In order to implement this, on the one hand, measurement technology is...
Rockfalls from stratified unstable rock masses on cliffs present a significant geological hazard. This study investigates their seismic failure mechanisms and quantifies the influence of key controlling factors through an integrated approach of shaki...
Background and Objectives: Point of care test (POCT) is generally performed by non-laboratory staff who often lack an understanding on the quality control and quality assurance programs. The purpose of this study was to understand the current status...
It is popular to use software defect prediction (SDP) techniques to predict bugs in software in the past 20 years. Before conducting software testing (ST), the result of SDP assists on resource allocation for ST. However, DP usually works on fine-lev...
9 November 2022
The performance of job tasks is increasingly being viewed through the prism of time constraints. Stress, as a consequence of these constraints, can play a dual role: motivating or destructive. This paper addresses the role of time pressure during the...
Background: Order picking process is critical for accurate and efficient order fulfilment. Pick-by-vision is a promising technology that may support order picking process, however there is still a limited amount of research concerning the impact of t...
In view of the characteristics of small- and medium-sized manufacturing enterprises and the status quo of digitalization, it is necessary to develop a more applicable digital transformation maturity model. The decision testing and evaluation laborato...
In the Huainan and Huaibei mining areas, a layer of calcareous clay is buried deep in the surface soil layer (at approximately 400 m). This layer is in a high-stress state and is prone to freezing pipe fractures in the freezing method. To obtain the...
In order to ensure the safe and stable operation of a power system, the performance evaluation of transformer windings after a short-circuit test can predict whether the windings are deformed in order to provide a useful reference for the operation a...
Nowadays, with the green economy becoming mainstream in the world, an industrial revolution as the core of green development has emerged. Based on the empirical evidence from China’s 30 provinces, this study establishes an evaluation index system of...
To address the susceptibility of premium threaded connections in deepwater gas production strings to fretting wear and seal failure under long-term cyclic loading, a numerical simulation method for fretting wear was developed based on the Archard wea...
The intelligent vehicle infrastructure system (IVIS) requires systematic testing before being put into large-scale applications. IVIS testing under closed conditions includes stress tests for typical scenarios and extreme scenario strength testing. T...
Continuous manufacturing (CM) is defined as a process in which the input material(s) are continuously fed into and transformed, and the processed output materials are continuously removed from the system. CM can be considered as matching the FDA’s so...
This study addresses the critical issue of cardiovascular diseases (CVDs) as the leading cause of death globally, emphasizing the importance of stent delivery catheter manufacturing. Traditional manufacturing processes, reliant on destructive end-of-...
Photometric methods are essential in analytical chemistry for environmental, biological, and industrial monitoring. Conventional spectrometers rely on deuterium or tungsten lamps, which are bulky, energy-intensive, and costly to maintain. Advances in...
The 2-Minute Step Test (2MST) is commonly scored by step count, which overlooks how the task is performed. This study tested whether a smartphone held to the thigh can be used to quantify thigh kinematics to determine 2MST outcome parameters, and whe...
The development and adoption of digital twins (DT) for Quality-by-Design (QbD)-based processes with flexible operating points within a proven acceptable range (PAR) and automation through Advanced Process Control (APC) with Process Analytical Technol...
Despite intensive research over the last three decades, it has not yet been possible to bring an effective vaccine against human immunodeficiency virus (HIV) and the resulting acquired immunodeficiency syndrome (AIDS) to market. Virus-like particles...
Storage is still limiting the implementation of hydrogen as an energy carrier to integrate the intermittent operation of renewable energy sources. Among different solutions to the currently used compressed or liquified hydrogen systems, physical adso...
With the continuous development of assisted driving technology, the autonomous emergency braking (AEB) system has emerged as a critical innovation in preventing collisions and improving vehicular safety. In this paper, to test the performance of the...
This study proposes a reliable inline PAT concept for the simultaneous monitoring of different product components after chromatography. The feed for purification consisted of four main components, IgG monomer, dimer, and two lower molecular weight co...
Climate change poses a significant threat to agroecosystems, especially in the dry areas, characterized by abrupt precipitation pattern and frequent drought events. Ideal crops, tolerant to these events, such as cactus, can perform well under such ch...
To avoid any type of cross-contamination, residue-free production equipment is of utmost importance in the pharmaceutical industry. The equipment cleaning for continuous processes such as hot melt extrusion (HME), which has recently gained popularity...
Based on experiences about the planning of decentralized wastewater treatment systems for slums of two rural towns in India, the paper asks to what extent affordability for the future users may impede the realization of other sustainability goals. Th...
Continuous manufacturing opens up new operation windows with improved product quality in contrast to documented lot deviations in batch or fed-batch operations. A more sophisticated process control strategy is needed to adjust operation parameters an...
In this study, a methodology was developed for ranking manufacturing technologies of removable complete dentures (RCDs) according to the results of their full-scale mechanical tests. The actuality of the study is motivated by establishing the advanta...
Background/Objectives: Automated inspection is valuable when visual and process signals map to critical quality attributes (CQAs). This narrative review evaluates computer vision and complementary process analytical technology (PAT) for surface integ...
Objectives: In the era of precision oncology, the management of lung cancer depends fundamentally on the acquisition of sufficient neoplastic material for both definitive histological subtyping and comprehensive molecular profiling. This study aimed...
Hydrolysis of protein samples into amino acids facilitates the use of NMR spectroscopy for protein and peptide quantification. Different conditions have been tested for quantifying aromatic amino acids and proteins. The pH-dependent signal shifts in...
In precision agriculture, the estimation of soil parameters via sensors and the creation of nutrient maps are a prerequisite for farmers to take targeted measures such as spatially resolved fertilization. In this work, 68 soil samples uniformly distr...
Quality assurance in a clinical laboratory is essential to ensure reliable, accurate and precise laboratory test results all the time. A hemostasis laboratory is an important part of a clinical laboratory setting in a hospital or a healthcare center,...
Bathua (Chenopodium album) is a rich source of extensive-ranging nutrients, including bio-active carbohydrates, flavonoids and phenolics, minerals, and vitamins that translate to countless health benefits such as anticancer, antidiabetic, anti-inflam...
To answer the call for more evidence on the adoption and effectiveness of Big Data Analytics in auditing, this study investigates auditors’ use of data analytic tools in audit-process management, including audit planning, testing, and conclusio...
Scientific interest in the relationship between analytic processing and creativity has increased in recent years. However, there is conflicting evidence on whether analytic processing reduces or enhances creativity. We hypothesize that differences in...
In urban humanitarian-aid operations, safe treatment of fecal sludge is highly important. While currently field-deployable fecal-sludge treatment plants are being developed, field-ready analytical equipment for process-control and public health monit...
Torpedo anchors are a new type of anchoring system in deepwater that is much more economical than conventional anchoring methods. The dynamic penetration process is vitally important to the installation of torpedo anchors. Based on the spherical cavi...
A core component of energy storage systems like vanadium redox flow batteries (VRFB) is the polymer electrolyte membrane (PEM). In this work, the frequently used perfluorosulfonic-acid (PFSA) membrane Nafion™ 117 and a novel poly (vinylidene difluori...
D-dimer is a multifaceted biomarker of concomitant activation of coagulation and fibrinolysis, which is routinely used for ruling out pulmonary embolism (PE) and/or deep vein thrombosis (DVT) combined with a clinical pretest probability assessment. T...
The friction coefficient in the simulation of stamping processes should be defined. Modern simulation software allows its definition as constant or its dependence on pressure or temperature. It is also useful in stamping processes to define different...
In this work, a rapid process optimization framework for laser powder bed fusion (LPBF) based on a high-throughput mechanical testing platform and data analytical methods was proposed and validated. This framework enables the efficient building of a...
In a chemical analysis laboratory, sample detection via most analytical devices obtains raw data and processes it to validate data reports, including raw data filtering, editing, effectiveness evaluation, error correction, etc. This process is usuall...
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