The main purpose of the article is to describe the methodology used for multi-criteria optimization of the geometric features of the orthopedic implant used for the reconstruction of the anterior cruciate ligament located in the knee joint. The metho...
Surgeries’ sterile conditions and perioperative antibiotic therapies decrease implant associated infections rates significantly. However, up to 10% of orthopedic devices still fail due to infections. An implant infection generates a high socio-econom...
Introduction: Orthopedic implant-associated infections caused by multidrug-resistant Enterobacteriaceae are a growing challenge for healthcare providers due to their increasing incidence and the difficulties of medical and surgical treatment. Materia...
Orthopedic implants have a critical role in modern medical practice, being useful in bone regeneration, joint arthroplasty, and healing fractures. The success of osseointegration depends on implant properties (composition, stability, geometry, biocom...
Implant-associated infections (IAIs) represent a major health burden due to the complex structural features of biofilms and their inherent tolerance to antimicrobial agents and the immune system. Thus, the viable options to eradicate biofilms embedde...
Orthopedic implant technology has historically seen difficulties in attaining long-term stability and biological integration, leading to complications such as implant loosening, wear debris production, and heightened infection risk. Nanotechnology pr...
Background/Objectives: Orthopedic implant infections are rare but represent a significant problem for patients, surgeons, and the healthcare systems. This is because these infections cause severe and persistent pain and, in some cases, may require re...
Bacterial biofilms on orthopedic implants are resistant to the host immune response and to traditional systemic antibiotics. Novel therapies are needed to improve patient outcomes. TRL1068 is a human monoclonal antibody (mAb) against a biofilm anchor...
Prevention of orthopedic implant-related infections is a major medical challenge, particularly due to the involvement of biofilm-encased and multidrug-resistant bacteria. Current therapies, based on antibiotic administration, have proven to be insuff...
The design of orthopedic implants is a complex challenge, requiring the careful balance of mechanical performance and biological integration to ensure long-term success. This study focuses on the development of a porous femoral stem implant aimed at...
The demand for orthopedic implants is increasing, driven by a rising number of young patients seeking an active lifestyle post-surgery. This has led to changes in manufacturing requirements. Joint arthroplasty operations are on the rise globally, and...
Background: Metallic orthopedic implants face persistent clinical challenges that have proved resistant to incremental conventional development. Machine learning and artificial intelligence offer a complementary paradigm for navigating the high-dimen...
Background/Objectives: In staphylococcal implant infections, there is often discussion about the optimal postoperative timing of the introduction of rifampicin in the postoperative period with open wounds. Methods: We reviewed all adult patients with...
The goal of the study was to compare the surface characteristics of typical implant materials used in orthopedic surgery and traumatology, as these determine their successful biointegration. The morphological and chemical structure of Vortex plate an...
Metals have been used for orthopedic implants for a long time due to their excellent mechanical properties. With the rapid development of additive manufacturing (AM) technology, studying customized implants with complex microstructures for patients h...
Orthopedic implant failure is the most common complication of orthopedic surgery, causing serious trauma and resulting in a tremendous economic burden for patients. There are many reasons for implant failure, among which peri-implant infection (or im...
Implant-associated infection is a major complication of orthopedic surgery. One of the most common organisms identified in periprosthetic joint infections is Staphylococcus aureus, a biofilm-forming pathogen. Orthopedic implants are composed of a var...
The High Speed High Pressure Torsion (HSHPT) is the severe plastic deformation method (SPD) designed for the grain refinement of hard-to-deform alloys, and it is able to produce large, rotationally complex shells. In this paper, the new bulk nanostru...
Titanium, stainless steel, and CoCrMo alloys are the most widely used biomaterials for orthopedic applications. The most common causes of orthopedic implant failure after implantation are infections, inflammatory response, least corrosion resistance,...
Postoperative implant infection is a severe complication in orthopedic surgery, often leading to implant failure. Current treatment strategies mainly rely on systemic antibiotic therapies, despite contributing to increasing bacterial resistance. In r...
A major advantage of additive manufacturing (AM) technologies is the ability to print customized products, which makes these technologies well suited for the orthopedic implants industry. Another advantage is the design freedom provided by AM technol...
In this paper, fracture behavior of four types of implants with different geometries (pure titanium locking plate, pure titanium femoral implant, Ti-6Al-4V titanium alloy pelvic implant, X2CrNiMo18 14-3 steel femoral implant) was studied in detail. E...
Implants and materials are indispensable in trauma and orthopedic surgery. The continuous improvements of implant design have resulted in an optimized mechanical function that supports tissue healing and restoration of function. One of the still unso...
Due to its excellent biocompatibility and mechanical properties, various different applications of polyvinyl alcohol-hydrogels (PVA-H) has been attempted in many fields. In the field of orthopedic surgery, we have been engaged for long time in resear...
The long-term success of orthopedic implants depends not only on their mechanical performance but also on their ability to establish a stable and biologically active interface with surrounding tissues. Despite the widespread clinical use of metallic,...
Titanium alloys are useful for application in orthopedic implants. However, complications, such as prosthetic infections and aseptic loosening, often occur after orthopedic devices are implanted. Therefore, innovation in surface modification techniqu...
Using orthopedic devices or prosthetic joints to treat various conditions is expected in a Traumatology and Orthopedics Unit. Recently, the materials used to build these different devices have evolved; however, pathogens can still infect these materi...
Bacteria-associated late infection of the orthopedic devices would further lead to the failure of the implantation. However, present ordinary antimicrobial strategies usually deal with early infection but fail to combat the late infection of the impl...
The number for orthopedic implants and reconstructive joint replacements, including knee and hip implants, underwent a considerable increase, driven by the aging population and increasing prevalence of musculoskeletal disorders [...]
Multiscale interface engineering has influenced the engineering of orthopedic and dental implants through the integration of macroscale architecture, micro-textured surfaces and nanoscale bio-cues. These characteristics help to increase mechanical st...
Polyetheretherketone (PEEK) is widely employed in orthopedic applications due to its bone-mimetic mechanical properties and excellent biocompatibility, establishing it as a promising candidate for bone repair and regeneration. However, the investigat...
This research aims to optimize piezoelectric implants for orthopedic applications, enhancing energy harvesting efficiency and mechanical integrity. Our objectives include comparing piezoelectric materials (PZT, PVDF, and BaTiO3) and employing advance...
Background: Implant-related infections remain a major cause of failure in orthopedic surgery, partly because biofilm formation on implant surfaces limits conventional infection-control strategies. This prospective pilot study evaluated the short-term...
Atypical joint spaces, such as those encountered in complex segmental bone loss and large structural defects, remain challenging to manage with conventional implants within divisions across orthopedics, including arthroplasty, tumor reconstruction, t...
The present paper reports on the development of a biodegradable overmolded orthopedic implant: a metal bone fixing screw, which has been overmolded with a functionalized thin layer of biodegradable polymer to enhance cell adhesion during the healing...
Prophylaxis and the treatment of implant-related infections has become a key focus area for research into improving the outcome of orthopedic implants. Functional resorbable coatings have been developed to provide an antimicrobial surface on the impl...
Plasma surface modification has emerged as a powerful, versatile tool for tailoring the surface properties of biomedical devices and implants without altering the material characteristics in the bulk. This comprehensive review critically examines the...
The general improvement in life expectancy and standard of living makes it easier for patients to get access to routine medical exams and is anticipated to increase the prevalence of several degenerative joint illnesses. In addition, it is anticipate...
An experimental comparative study of the biomechanical behavior of commonly used orthopedic implants for tibial plateau fractures was carried out. An artificial bone model Synbone1110 was used and a Schatzker V type tibial plateau fracture was create...
Titanium alloys, particularly Ti6Al4V, are commonly used in biomedical applications. However, the inclusion of aluminum (Al) and vanadium (V) in this alloy can cause cytotoxic effects in the human body, resulting in Alzheimer’s disease and canc...
Periprosthetic joint infections (PJI) are difficult to treat due to biofilm formation on implant surfaces, often requiring removal or exchange of prostheses along with long-lasting antibiotic treatment. This in vitro study investigated the effect of...
The method of micro-arc oxidation has been utilized to synthesize a protective biocompatible coating for a bioresorbable orthopedic Mg implant. This paper presents the results of comprehensive research of micro-arc coatings based on diatomite—a...
In this work, composite coatings of chitosan and silver nanoparticles were presented as an antibacterial coating for orthopedic implants. Coatings were deposited on AISI 304L using the galvanic deposition method. In galvanic deposition, the differenc...
Background: Titanium-based orthopedic implants can release titanium in chloride, acidic and protein-containing biological environments. Conventional acid-digestion ICP-MS can be used to determine the total titanium content released from the implants,...
In recent decades, the risk of developing opportunistic infections has increased in parallel with the ever-increasing number of people suffering from chronic immunosuppressive diseases or undergoing prosthetic surgery. Staphylococcus warneri is a Gra...
Implant-associated osteomyelitis is one of the most feared complications following orthopedic surgery. Although the risk is low, sufficient antibiotic protection of the implant surface is important. The aim of this study was to assess steady-state pi...
The topology optimization (TO) process has the objective to structurally optimize products in various industries, such as in biomechanical engineering. Additive manufacturing facilitates this procedure and enables the utility of advanced structures i...
Objectives: For a better understanding of the mechanisms involved in biofilm formation, we performed a broad identification and characterization of the strains affecting implants by evaluating the morphology of biofilms formed in vitro in correlation...
Three-dimensional (3D) printing has gained substantial interest among scientists and surgeons over the past decade due to its broad potential in medical applications. Its clinical utility has been increasingly recognized, demonstrating promising outc...
Glucocorticoids may be given prior to major orthopedic surgery to decrease postoperative nausea, vomiting, and pain. Additionally, many orthopedic patients may be on chronic glucocorticoid therapy. The aim of our study was to investigate whether gluc...
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