Special Issue "Surfaces Modification and Analysis for Innovative Biomaterials"

A special issue of Coatings (ISSN 2079-6412).

Deadline for manuscript submissions: 30 November 2019

Special Issue Editor

Guest Editor
Prof. Elvira De Giglio

Department of Chemistry, Università degli Studi di Bari "Aldo Moro", Bari, Italy
Website | E-Mail
Interests: development and characterization of innovative polymeric biomaterials; surface modification methods; surface analysis techniques; surface composition and properties

Special Issue Information

Dear Colleagues,

The surface of a biomaterial defines its reactivity, driving biological responses. Therefore, the physico-chemical features of biomaterial surfaces require special attention. Indeed, they could be properly tuned in order to elicit specific bioreactions, leading to a safe and predictable biomaterial integration.

To reach this goal, several surface modification strategies are available, including chemical and electrochemical functionalizations, modifications of topography and/or morphology. Each of these treatments demands an accurate analysis of the modified surface. Hence, surface characterization techniques contribute to the biomaterial optimization, exploring and predicting in vivo and in vitro interactions, monitoring reproducibility, contaminations and stability, shedding light on biomaterials’ advantages and drawbacks.

Contributions to this Special Issue are welcomed on all topics of biomaterial surface modification and analysis. Especially appreciated are papers dealing with new strategies to direct and control surface-driven interactions or works that discuss the main progresses in surface modification and analyses from a critical perspective.

Prof. Elvira De Giglio
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Coatings is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Surface modification
  • surface analysis
  • surface characterization techniques
  • biomaterial surface
  • functionalization

Published Papers (4 papers)

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Research

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Open AccessArticle
Biomimetic Properties of Force-Spun PHBV Membranes Functionalised with Collagen as Substrates for Biomedical Application
Coatings 2019, 9(6), 350; https://doi.org/10.3390/coatings9060350
Received: 3 May 2019 / Revised: 22 May 2019 / Accepted: 24 May 2019 / Published: 28 May 2019
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Abstract
The force-spinning process parameters (i.e., spin speed, spinneret-collector distance, and polymer concentration), optimised and characterised in previous work by this group, allowed the rapid fabrication of large quantities of high surface area poly(3-hydroxybutyric acid-co-3-hydroxyvaleric acid) (PHBV) polymeric fibre membranes. This paper examined the [...] Read more.
The force-spinning process parameters (i.e., spin speed, spinneret-collector distance, and polymer concentration), optimised and characterised in previous work by this group, allowed the rapid fabrication of large quantities of high surface area poly(3-hydroxybutyric acid-co-3-hydroxyvaleric acid) (PHBV) polymeric fibre membranes. This paper examined the potential application for force-spun PHBV fibres functionalised with type I collagen for tissue regeneration applications. PHBV fibre scaffolds provide a biologically suitable substrate to guide the regeneration of dermal tissues, however, have poor cellular adhesion properties. The grafting of collagen type-I to PHBV fibres demonstrated improved cell adhesion and growth in Neo-NHDF (neonatal human dermal fibroblasts) fibroblasts. The examination of fibre morphology, thermal properties, collagen content, and degradability was used to contrast the physicochemical properties of the PHBV and PHBV-Collagen fibres. Biodegradation models using phosphate buffered saline determined there was no appreciable change in mass over the course of 6 weeks; a Sirius Red assay was performed on degraded samples, showing no change in the quantity of collagen. Cell metabolism studies showed an increase in cell metabolism on conjugated samples after three and 7 days. In addition, in vitro cytocompatibility studies demonstrated superior cell activity and adhesion on conjugated samples over 7 days. Full article
(This article belongs to the Special Issue Surfaces Modification and Analysis for Innovative Biomaterials)
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Open AccessArticle
Implant Coating Manufactured by Micro-Arc Oxidation and Dip Coating in Resorbable Polylactide for Antimicrobial Applications in Orthopedics
Coatings 2019, 9(5), 284; https://doi.org/10.3390/coatings9050284
Received: 26 March 2019 / Revised: 19 April 2019 / Accepted: 24 April 2019 / Published: 26 April 2019
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Abstract
Prophylaxis and the treatment of implant-related infections has become a key focus area for research into improving the outcome of orthopedic implants. Functional resorbable coatings have been developed to provide an antimicrobial surface on the implant and reduce the risk of infection. However, [...] Read more.
Prophylaxis and the treatment of implant-related infections has become a key focus area for research into improving the outcome of orthopedic implants. Functional resorbable coatings have been developed to provide an antimicrobial surface on the implant and reduce the risk of infection. However, resorbable coatings developed to date still suffer from low adhesive strength and an inadequate release rate of antibiotics. This study presents a novel double-coating of micro-arc oxidation and resorbable polylactide copolymer on a Ti-6Al-4V implant with the aim of reducing the risk of infection post-implantation. The adhesive strength, rate of coating degradation, and antibiotic release rate were investigated. A key finding was that the micro-arc oxidation coating with the addition of antibiotics increased the adhesive strength of the poly-l-lactide-co-ε-caprolactone (PLC) coatings. The adhesive strength was influenced by the concentration of the PLC solution, the surface structure of the titanium substrate, and the composition of the coatings. The antibiotics blended into the PLC coating had a release cycle of approximately 10 days, which would be long enough to reduce the risk of developing an infection after implantation. The double coatings presented in this study have an excellent potential for reducing the incidence and severity of implants-related early infections. Full article
(This article belongs to the Special Issue Surfaces Modification and Analysis for Innovative Biomaterials)
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Review

Jump to: Research

Open AccessReview
Functionalization of Ceramic Coatings for Enhancing Integration in Osteoporotic Bone: A Systematic Review
Coatings 2019, 9(5), 312; https://doi.org/10.3390/coatings9050312
Received: 11 April 2019 / Revised: 3 May 2019 / Accepted: 6 May 2019 / Published: 9 May 2019
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Abstract
Background: The success of reconstructive orthopaedic surgery strongly depends on the mechanical and biological integration between the prosthesis and the host bone tissue. Progressive population ageing with increased frequency of altered bone metabolism conditions requires new strategies for ensuring an early implant fixation [...] Read more.
Background: The success of reconstructive orthopaedic surgery strongly depends on the mechanical and biological integration between the prosthesis and the host bone tissue. Progressive population ageing with increased frequency of altered bone metabolism conditions requires new strategies for ensuring an early implant fixation and long-term stability. Ceramic materials and ceramic-based coatings, owing to the release of calcium phosphate and to the precipitation of a biological apatite at the bone-implant interface, are able to promote a strong bonding between the host bone and the implant. Methods: The aim of the present systematic review is the analysis of the existing literature on the functionalization strategies for improving the implant osteointegration in osteoporotic bone and their relative translation into the clinical practice. The review process, conducted on two electronic databases, identified 47 eligible preclinical studies and 5 clinical trials. Results: Preclinical data analysis showed that functionalization with both organic and inorganic molecules usually improves osseointegration in the osteoporotic condition, assessed mainly in rodent models. Clinical studies, mainly retrospective, have tested no functionalization strategies. Registered trademarks materials have been investigated and there is lack of information about the micro- or nano- topography of ceramics. Conclusions: Ceramic materials/coatings functionalization obtained promising results in improving implant osseointegration even in osteoporotic conditions but preclinical evidence has not been fully translated to clinical applications. Full article
(This article belongs to the Special Issue Surfaces Modification and Analysis for Innovative Biomaterials)
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Open AccessFeature PaperReview
Electrochemical Strategies for Titanium Implant Polymeric Coatings: The Why and How
Coatings 2019, 9(4), 268; https://doi.org/10.3390/coatings9040268
Received: 1 April 2019 / Revised: 15 April 2019 / Accepted: 18 April 2019 / Published: 20 April 2019
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Abstract
Among the several strategies aimed at polymeric coatings deposition on titanium (Ti) and its alloys, metals commonly used in orthopaedic and orthodontic prosthesis, electrochemical approaches have gained growing interest, thanks to their high versatility. In this review, we will present two main electrochemical [...] Read more.
Among the several strategies aimed at polymeric coatings deposition on titanium (Ti) and its alloys, metals commonly used in orthopaedic and orthodontic prosthesis, electrochemical approaches have gained growing interest, thanks to their high versatility. In this review, we will present two main electrochemical procedures to obtain stable, low cost and reliable polymeric coatings: electrochemical polymerization and electrophoretic deposition. Distinction should be made between bioinert films—having mainly the purpose of hindering corrosive processes of the underlying metal—and bioactive films—capable of improving biological compatibility, avoiding inflammation or implant-associated infection processes, and so forth. However, very often, these two objectives have been pursued and achieved contemporaneously. Indeed, the ideal coating is a system in which anti-corrosion, anti-infection and osseointegration can be obtained simultaneously. The ultimate goal of all these coatings is the better control of properties and processes occurring at the titanium interface, with a special emphasis on the cell-coating interactions. Finally, advantages and drawbacks of these electrochemical strategies have been highlighted in the concluding remarks. Full article
(This article belongs to the Special Issue Surfaces Modification and Analysis for Innovative Biomaterials)
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Curcumin loaded in pH-responsive polymer coated liposomes:  evaluation of their antioxidant potential for oral colonic delivery

Authorship: V. De Leo (1), E. Mancini (1), F.Milano (2), S. Di Gioia  (3), M. Conese (3), A.Agostiano (1), L. Catucci* (1)

(1) Department of Chemistry, University of Bari, Via Orabona 4, 70126  
Bari, Italy
(2)CNR-IPCF Institute for Physical and Chemical Processes, Bari unit,  
Via Orabona 4, 70126 Bari, Italy
(3)Department of Medical and Surgical Sciences, University of Foggia  
Viale Luigi Pinto 1, 71122 FOGGIA, Italy

 

Title: Functionalization of silk fibers by PDGF and ceramic materials for bone tissue regeneration

Authorship:  Michael Wöltje1*, Ronny Brünler1, Melanie Böbel1, Dilbar Aibibu1, Sabine Neuss2,3, Chokri Cherif1


1 TU Dresden, Institute of Textile Machinery and High Performance Material Technology, Dresden, Germany

2 RWTH Aachen, Institute of Pathology, Aachen, Germany

3 RWTH Aachen, Helmholtz Institute for Biomedical Engineering – Biointerface Group, Aachen, Germany

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