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Implant Coating Manufactured by Micro-Arc Oxidation and Dip Coating in Resorbable Polylactide for Antimicrobial Applications in Orthopedics

1
School of Biological Science and Medical Engineering, Beihang University, Beijing 100083, China
2
Beijing Engineering Laboratory of Functional Medical Materials and Devices, Beijing Nation Technology Group Co. LTD, Beijing 100082, China
3
Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing 100083, China
*
Author to whom correspondence should be addressed.
Coatings 2019, 9(5), 284; https://doi.org/10.3390/coatings9050284
Received: 26 March 2019 / Revised: 19 April 2019 / Accepted: 24 April 2019 / Published: 26 April 2019
(This article belongs to the Special Issue Surfaces Modification and Analysis for Innovative Biomaterials)
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Abstract

Prophylaxis and the treatment of implant-related infections has become a key focus area for research into improving the outcome of orthopedic implants. Functional resorbable coatings have been developed to provide an antimicrobial surface on the implant and reduce the risk of infection. However, resorbable coatings developed to date still suffer from low adhesive strength and an inadequate release rate of antibiotics. This study presents a novel double-coating of micro-arc oxidation and resorbable polylactide copolymer on a Ti-6Al-4V implant with the aim of reducing the risk of infection post-implantation. The adhesive strength, rate of coating degradation, and antibiotic release rate were investigated. A key finding was that the micro-arc oxidation coating with the addition of antibiotics increased the adhesive strength of the poly-l-lactide-co-ε-caprolactone (PLC) coatings. The adhesive strength was influenced by the concentration of the PLC solution, the surface structure of the titanium substrate, and the composition of the coatings. The antibiotics blended into the PLC coating had a release cycle of approximately 10 days, which would be long enough to reduce the risk of developing an infection after implantation. The double coatings presented in this study have an excellent potential for reducing the incidence and severity of implants-related early infections. View Full-Text
Keywords: micro-arc oxidation coating; resorbable polylactide coating; adhesive strength; degradation rate; antibiotic release; orthopedic implants micro-arc oxidation coating; resorbable polylactide coating; adhesive strength; degradation rate; antibiotic release; orthopedic implants
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Cao, X.-Y.; Tian, N.; Dong, X.; Cheng, C.-K. Implant Coating Manufactured by Micro-Arc Oxidation and Dip Coating in Resorbable Polylactide for Antimicrobial Applications in Orthopedics. Coatings 2019, 9, 284.

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