Botulinum toxin (BoTX) is the standard treatment for task-specific dystonias (TSDs) such as musician’s dystonia (MD). Our aim was to assess the long-term changes in BoTX treatment in a highly homogeneous and, to our knowledge, largest group of MD pat...
This paper proposes a modification to existing saliency-based, sensorless control strategy for interior permanent magnet synchronous motors. The proposed approach leverages a two-interval, six-segment high-frequency voltage signal injection technique...
Background/Objectives: Faricimab is a bispecific antibody targeting vascular endothelial growth factor A and angiopoietin-2, developed to extend treatment intervals in neovascular age-related macular degeneration (nAMD). Real-world evidence on farici...
Chronic rhinosinusitis with nasal polyps is a Type 2 inflammatory disease associated with a significant burden on quality of life. While biological therapies have shown efficacy in randomized controlled trials, data on long-term real-world outcomes r...
To study the influence of control parameters under cold-start and low-load conditions on the performance of a heavy-oil, two-stroke, direct-injection, ignition engine for use in aviation, the operation of a two-stroke, direct-injection engine was stu...
Supplier selection is one of the most important multi-criteria decision-making (MCDM) problems for decision-makers in the competitive market. Today’s organizations are seeking new ways to reduce the negative effects they have on the environment...
Background/Objectives: Dupilumab is an effective long-term treatment for chronic rhinosinusitis with nasal polyps (CRSwNP), but continuous biweekly (Q2W) treatment is associated with high costs, cumulative drug exposure, and treatment burden. Extendi...
Background: This prospective, multicenter, open-label, single-arm study (jRCT2031230690) evaluated the efficacy and safety of a tailored dosing strategy of incobotulinumtoxinA, including high doses (up to 500 U) and flexible injection intervals (as s...
The implementation of methanol-ammonia dual-fuel engines has the potential to contribute to a reduction in carbon emissions in the environment. The present study employs numerical simulations of the methanol-ammonia dual-fuel engine to investigate me...
Background/Objectives: We aimed to evaluate the efficacy of a flexible loading-phase treat-and-extend regimen using faricimab, in which the number of loading-phase intravitreal injections was tailored to individual disease activity. Methods: This obs...
The separate-layer gas injection technology is a key means to improve the effect of refined gas injection development. Currently, the measurement and adjustment of separate injection wells primarily rely on manual experience and automatic measurement...
In opposed-piston, opposed-cylinder (OPOC) two-stroke diesel engines, the relative movement rules of opposed-pistons, combustion chamber components and injector position are different from those of conventional diesel engines. In this study, the comb...
Treat and extend (T&E) is a standard treatment regimen for treating neovascular age-related macular degeneration (nAMD) with anti-vascular endothelial growth factors (anti-VEGFs), but the treatment intervals attained are not well documented. This...
Background and Objectives: Faricimab is the first intravitreal injection of vascular endothelial growth factor-A and angiopoietin-2 bispecific monoclonal antibody. Here, we evaluate the functional and anatomical outcomes of faricimab treatment in pat...
Botulinum toxin (BT) is an effective treatment for spasticity symptoms in multiple sclerosis (MS). Despite its wide use in clinical practices, only few studies have explored long-term persistence. We aim to evaluate the rate of discontinuation of BT...
The plasma concentration profile of bleomycin in the distribution phase of patients younger than 65 years is needed to determine the suitable time interval for efficient application of electric pulses during electrochemotherapy. Additionally, bleomyc...
Intravitreal anti-VEGF injections are the current gold standard for treating diabetic macular edema (DME). However, injection practice patterns of retina specialists have varied markedly based on physician discretion. This retrospective study analyze...
To evaluate the functional and anatomical effects of switching to faricimab for patients with neovascular age-related macular degeneration (nAMD) refractory to intravitreal aflibercept, this retrospective study evaluated patients with nAMD who receiv...
Net fluid balance in the Alberta Basin has been negative over the last 60 years because extensive fluid production has consistently exceeded injection during this period. However, future gigaton-scale carbon sequestration, among other activities, can...
Background: Anal fissures cause severe pain and can be difficult to treat. Medical therapy is initially used, followed by sigmoidoscopy-guided botox injections if the medical therapy is not successful. With this technique, however, it is not clear wh...
Objective: To purpose of this study was to retrospectively evaluate the 1-year outcomes and factors associated with the treatment responsiveness of switching to intravitreal brolucizumab (IVBR) for neovascular age-related macular degeneration (nAMD)...
Aim: To evaluate the real-world effectiveness, durability, and safety of faricimab 6 mg in eyes with treatment-refractory retinal vein occlusion (RVO)-associated macular oedema (MO) in the United Kingdom (UK). Methods: This was a retrospective, singl...
Background/Objectives: There is limited evidence of a combination of intraventricular injection and shunt soaking with a vancomycin–gentamicin technique as a prophylaxis for shunt infection. This study aimed to evaluate if a combination of this...
Ammonia can partially replace diesel in compression ignition engines, but the relative influences of the ammonia energy ratio (AER), pilot–main injection timing advance, and injection pressure on engine performance remain insufficiently quantif...
Background/Objectives: Rezum water vapor therapy for benign prostatic obstruction lacks standardized documentation, complicating data comparison. This study evaluates the completeness of non-standardized Rezum operative reports and validates a novel...
External exhaust gas recirculation (EGR) stratification in diesel engines contributes to reduction of toxic emissions. Weak EGR stratification lies in that strong turbulence and mixing between EGR and intake air by current introduction strategies of...
Pharmacological studies have demonstrated antibody production and infection prevention with an intradermal coronavirus disease 2019 (COVID-19) DNA vaccine (AG0302-COVID-19). This clinical trial aimed to investigate the safety and immunogenicity of hi...
Background/Objectives: The visual acuity (VA) outcomes after the first and second years of anti-vascular endothelial growth factor (anti-VEGF) treatment in patients with diabetic macular oedema (DMO) were evaluated, and the factors associated with tr...
Botulinum toxin type A (BoNT-A) injection and micro-focused ultrasound with visualization (MFU-V) are becoming increasingly popular for various esthetic conditions. However, performing MFU-V subsequently to BoNT-A injection may diminish the efficacy...
This study aims to evaluate the real-world efficacy and safety of aflibercept 8 mg intravitreal injections (IVTs) in pretreated patients with neovascular age-related macular degeneration (nAMD) throughout the first three IVTs. Background: Established...
This article presents experimental evidence demonstrating the feasibility of implementing a quasi-dual-frequency microwave signal generator using a 1 kW commercial magnetron. The injection-pulled magnetron may generate quasi-dual-frequency output wit...
Low-speed two-stroke marine diesel engines dominate the modern global long-distance transportation market; with the increasingly stringent regulations, the combustion and emissions of these engines is gaining intense interest. The primary objective o...
Distributed fiber optic temperature sensing (DTS) monitoring technology is increasingly widely applied in oil reservoir water injection development. However, existing DTS interpretation methods for layered water injection processes have insufficientl...
Temporary plugging acidizing is a critical well stimulation technique for improving water absorption profiles and addressing low/zero water intake in individual intervals of heterogeneous reservoirs, serving as a core measure for production stabiliza...
We propose and experimentally demonstrate an approach for generating a wideband optical frequency comb (OFC) featuring multiple comb lines and wavelength tunability based on a gain-switched weak-resonant-cavity Fabry–Perot laser diode (WRC-FPLD...
The geological storage of CO2 in saline aquifers is a crucial method for achieving large-scale carbon storage in the future. The saline aquifers with low porosity and permeability in the Ordos Basin exhibit high irreducible water saturation and restr...
Long-standing facial palsy sequelae cause functional, aesthetic, and psychological problems in patients. Botulinum toxin is an effective way to manage them, but no standardized recommendations exist. Through this non-systematic review, we aimed to gu...
Purpose: This study aimed to assess the incidence of axillary lymphadenopathy on ultrasound after COVID-19 vaccination and to investigate the factors affecting lymphadenopathy. Methods: We evaluated patients who had received a COVID-19 vaccination wi...
CAR T-cell immunotherapy is a new development in the treatment of leukemia, promising a new era in oncology. Although so far, this procedure only helps 50–90% of patients and, like other cancer treatments, has serious side effects. In this work...
Background and objectives: The aim of this study was to evaluate the therapeutic results in patients with exudative AMD treated with ranibizumab and aflibercept intravitreal injections over a two-year observation period. Materials and methods: A retr...
Background/Objectives: Currently, treatments for age-related macular degeneration (AMD) consist of regular intravitreal injections that exert significant pressure on healthcare systems via their high labor costs and economic burden. To address this,...
Background: The aim of this study is the clinical observation of gingival tissue condition after atelocollagen injection. Methods: In 18 patients, 97 gingival class I Miller recessions were divided according to recession height, gingival papillae los...
Islanding detection methods, based on injecting high-/low-frequency currents or negative sequence fundamental frequency currents and observing the resultant responses, are collectively referred to as irregular current injection methods in this paper....
Ophidism is a public health problem in tropical countries, occurring predominantly in rural areas. In Colombia, among the species responsible for snakebite envenomation, inflicting high mortality, is the Chocoan bushmaster, Lachesis acrochorda, bette...
In this work, we experimentally demonstrate a scheme for generating a multi-band FMCW signal with a tunable sweep bandwidth and inter-band interval. For such a scheme, an original FMCW signal is first acquired by directly current-modulating a master...
Anti-vascular endothelial growth factor (VEGF) therapy for diabetic macular edema (DME) improves visual acuity. However, repeated injections during routine outpatient visits are required to maintain this effect. The recent sudden global outbreak of c...
To investigate the flow characteristics of movable water in coal under the influence of micro-nano pore fractures with multiple fractal structures, this study employed nuclear magnetic resonance (NMR) and multifractal theory to analyze gas–wate...
Background: Diabetic macular edema (DME) is the primary cause of visual impairment in individuals with diabetes. Anti-vascular endothelial growth factor (VEGF) is the current first-line treatment for DME owing to its effectiveness. However, frequent...
Background: Treatment cessation due to a dry retina has not been systematically addressed in diabetic macular edema (DME). In three out of four patients receiving 6 mg of brolucizumab in the KITE study, treatment was terminated after the study ended....
The piezoelectric injection-system provides a reliable approach for precise small-quantity fuel injection due to its fast, dynamic response. Considering the nonlinearity of a piezoelectric actuator, the complete electro-mechanical-hydraulic model of...
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