Solid-liquid dissolution is a central step in many industrial applications such as pharmaceutical, process engineering, and pollution control. Accurate mathematical models are proposed to improve reactor design and process operations. Analytical meth...
During the solution heat treatment (SHT) process of aluminum alloys, precipitates dissolve into the matrix. To predict the dissolution time, modeling of isothermal dissolution of precipitates in 6061 aluminum alloy during SHT was conducted. A precipi...
Thermodynamic modeling helps to reveal insights into the basic chemical kinetics of dissolution and precipitation in cementitious materials, but relevant applications to cement-stabilized soils have seldom been reported. Based on the thermodynamic da...
Although vanadinite (Pb5(VO4)3Cl) occurs in abundance in various terrestrial geochemical systems of natural and anthropogenic origin and is seriously considered as a potential nuclear waste sequestering agent, its actual application is severely limit...
The goal of this work is to assess the application of ultrasonic power to the reactive dissolution of limestone particles in an acidic environment; this would represent a novel method for improving wet Flue Gas Desulfurization industrial systems. In...
Hydrometallurgical leaching processes contain complex and nonlinear parameter interactions that are difficult to capture with conventional empirical models. In this study, a multiple hybrid machine learning approach was developed to predict manganese...
Objectives: Tacrolimus, a Biopharmaceutics Classification System (BCS) class II drug, is widely used for transplant patients to prevent graft rejection. To enhance its bioavailability, amorphous solid dispersion (ASD) formulations were developed and...
Background/Objectives: In the past, many drug release models have been presented which attempt to describe the interaction of drugs and excipients in a formulation. Nevertheless, modeling the intrinsic dissolution behavior is essential for understand...
The dissolution kinetics of Portland cement is a critical factor in controlling the hydration reaction and improving the performance of concrete. Tricalcium silicate (C3S), the primary phase in Portland cement, is known to have complex dissolution me...
Coupling biorelevant in vitro dissolution with in silico physiological-based pharmacokinetic (PBPK) tools represents a promising method to describe and predict the in vivo performance of drug candidates in formulation development including non-passiv...
The in vitro release of theophylline from an extended-release dosage form was studied under different hydrodynamic conditions in a United States Pharmacopoeial (USP) dissolution system II and a bespoke in vitro tubular model of the human colon, the D...
Due to the invalidity of traditional models, pretreatment conditions dependent parameter of susceptible dissolution degree of xylan (dX) was introduced into the kinetic models. After the introduction of dX, the dissolution of xylan, and the formation...
Using iron and steel slags as feedstock for a mineral carbonation reaction using carbon dioxide gas is an excellent technique because they are easily accessible, contribute to land pollution, and have a reasonable quantity of lime and magnesia. The r...
The purpose of this study was to predict the in vivo bioequivalence (BE) outcome of valsartan (VALS, BCS class IV) from three oral-fixed combination products with hydrochlorothiazide (HCTZ, BCS class III) (Co-Diovan® Forte as reference and two ge...
The mineralization of benzene, toluene, ethylbenzene, and xylene (BTEX) into inorganic substances by microorganisms may affect the water–rock interaction. However, few studies have quantitatively analyzed the processes. To quantitatively reveal...
Physiologically based pharmacokinetic and absorption modeling are being used by industry and regulatory bodies to address various scientifically challenging questions. While there is high confidence in the prediction of exposure for the BCS class I d...
Biphasic dissolution systems achieved good predictability for the in vivo performance of several formulations of poorly water-soluble drugs by characterizing dissolution, precipitation, re-dissolution, and absorption. To achieve a high degree of pred...
Understanding the hydration behavior of cementitious materials is crucial as it governs the setting, strength development and long-term durability of concrete. This study provides fundamental insights into these processes by investigating the early h...
The Linz–Donawitz (LD) converter is still the dominant process for converting hot metal into crude steel with the help of technically pure oxygen. Beside hot metal, scrap is the most important charging material which acts as an additional iron...
Purpose: To review in vitro testing and simulation platforms that are in current use to predict in vivo performances of generic products as well as other situations to provide evidence for biowaiver and support drug formulations development. Methods:...
In this paper, a novel analytical modeling of the growth and dissolution of precipitates in substitutional alloys is presented. This model uses an existing solution for the shape-preserved growth of ellipsoidal precipitates in the mixed-mode regime,...
Utilizing spent refractory material (SRM), generated after the overhaul of aluminum electrolytic cells, as a raw material for producing Al-Si alloys presents an efficient approach towards achieving full resource utilization of SRM. However, a bottlen...
Solution mining for glauberite salt rock is a long-term process that takes several years to several decades. Therefore, deposit deformations and subsidence of ground surfaces are time-dependent deformation problems that should consider the effect of...
Sandstones and many carbonates (e.g., oolitic limestone and other grainstones), comprise solid particulates (grains) and pores, which have a given pore network architecture relationship, and associated porosity—permeability values. Over time, t...
In this article, a numerical study of a one-dimensional, volume-based batch crystallization model (PBM) is presented that is used in numerous industries and chemical engineering sciences. A numerical approximation of the underlying model is discussed...
Ultrasonic irradiation is known to enhance various physicochemical processes. In this work, the effect of ultrasound on the dissolution of sugarcane bagasse was studied, with the specific aims of quantifying the effect at low solids loading and mild...
Carbon dioxide density-driven dissolution in a water-filled laboratory flume of the dimensions 60 cm length, 40 cm height, 1 cm thickness, was visualized using a pH-sensitive color indicator. We focus on atmospheric pressure conditions, like in caves...
The study of mass transfer is essential in the food digestion process, especially when gastric acid interacts with food and nutrients dissolve in the gastric system. In this study, a computational fluid dynamics (CFD) model was built based on an in v...
Achieving optimal nutrient concentrations is essential to increasing the biomass productivity of algal raceway ponds. Nutrient mixing or distribution in raceway ponds is significantly affected by hydrodynamic and geometric properties. The nutrient mi...
Background/Objectives: Fixed-dose combinations (FDCs) hold significant clinical value for the management of hypertension, diabetes and other chronic diseases. However, since the complexity of formulations, generic compounds require both in vitro phar...
The purpose of this study was to predict in vivo performance of three oral products of Etoricoxib (Arcoxia® as reference and two generic formulations in development) by conducting in vivo predictive dissolution with GIS (Gastro Intestinal Simulator)...
To study the influence of water–rock interactions on the deterioration of rock, particularly the problems of the complex dissolution mechanism of dolomite and the difficulty in establishing chemical damage, dolomite obtained from a tunnel in Yu...
This work investigates the dissolution of CaO into three different compositions of SiO2-CaO-Al2O3 slag similar to those found in industrial Si furnaces. It was found that CaO dissolution into the slag is fast. During the dissolution process, a layer...
A small-scale biphasic dissolution setup and a small-scale dissolution-permeation (D-P) setup were evaluated for their usefulness in simulating the luminal precipitation of three lipophilic weak bases—dipyridamole, ketoconazole and itraconazole...
This study aimed to establish a physiologically relevant in vitro-in vivo correlation (IVIVC) model reflecting site-dependent dissolution kinetics for sildenafil based on population-pharmacokinetic (POP-PK) modeling. An immediate release (IR, 20 mg)...
Understanding the mechanisms of mineral dissolution at the atomic scale is crucial for interpreting geochemical processes in soils and sediments, particularly those involving clay minerals. This study addresses the dissolution of pyrophyllite, a mode...
The distribution and quality of the Lower Cretaceous reservoir sandstone units of the Mesozoic–Cenozoic Scotian Basin, offshore eastern Canada, is well known in producing fields but difficult to extrapolate to less-explored areas of the deep-ba...
Glass fibres slowly degrade due to dissolution when exposed to water. Such environmental aging results in the deterioration of the mechanical properties. In structural offshore and marine applications, as well as in the wind energy sector, R-glass fi...
The aim of this study was to further evaluate and optimize the Transwell® system for assessing the dissolution behavior of orally inhaled drug products (OIDPs), using fluticasone propionate as a model drug. Sample preparation involved the collection...
Hydrometallurgical extraction and treatment of bloedite waste is one necessity for the sustainable development of sodium sulfate subtype salt lake mining areas, but the industrial dissolution of bloedite is not stable. One of the reasons for this is...
Seismic wave attenuation is affected by wave-induced pore fluid dissolution. The mechanism of wave-induced pore fluid dissolution is the mutual dissolution between different fluids caused by pore fluid pressure. Compared with the traditional WIFF (wa...
Background/Objectives: The present work proposes a mathematical model able to describe the dissolution of poly-disperse drug spherical particles in a solution (Dissolution Rate Test—DRT). DRT is a pivotal test performed in the pharmaceutical fi...
Amending the neglect of finite dissolution in traditional release models, this study proposed a more generalized drug release model considering the simultaneous dissolution and diffusion procedure from a drug-loaded spherical matrix. How the shape fa...
Poor aqueous solubility and consequently low bioavailability of various NSAIDs (non-steroidal anti-inflammatory drugs) usually result in high and multiple dosing with potentially serious side effects. Therefore, systems for the effective transport of...
Seepage–dissolution in carbonate rock fractures serves as the core driver governing the evolution of key engineering projects, including reservoir dam stability, CO2 geological sequestration, and unstable rock collapse mitigation strategies. Wh...
In this paper, a novel numerical model for characterizing the seepage and dissolution coupling effect on the durability of anti-seepage walls of earth-rock dams is proposed. The model considers the influence of hydraulic gradient-driven seepage on th...
K-jarosite (KFe3(SO4)2(OH)6), the most common jarosite-type mineral in natural and industrial settings, has been widely studied to understand its dissolution behavior in both environmental and industrial contexts. However, reported kinetic data remai...
Background/Objectives: The integration of artificial intelligence (AI) into pharmaceutical development has the potential to accelerate early-stage formulation design. In this study, large language models (ChatGPT (GPT-4o, OpenAI) and DeepSeek (DeepSe...
Numerical simulations enable us to couple multiphase flow and geochemical processes to evaluate how sequestration impacts brine chemistry and reservoir properties. This study investigates these impacts during CO2 storage at the San Juan Basin CarbonS...
Particle size reduction is a simple means to enhance the dissolution rate of poorly water soluble BCS-class II and IV drugs. However, the major drawback of this process is the possible introduction of process induced disorder. Drugs with different mo...
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