Given the profound integration of the sharing economy and the energy system, energy storage sharing is promoted as a viable solution to address the underutilization of energy storage and the challenges associated with cost recovery. While energy stor...
Peptides, or short chains of amino-acid residues, are becoming increasingly important as active ingredients of drugs and as crucial probes and/or tools in medical, biotechnological, and pharmaceutical research. Situated at the interface between small...
In this paper, we presented a straightforward strategy to generate 15 combinations of three samples based on an experimental simplex lattice design using a single-layer microfluidic network. First, we investigated the performances of the plain struct...
While integrated circuit technologies keep scaling aggressively, analog, mixed-signal, and radio-frequency (RF) circuits encounter challenges by creating robust designs in advanced complementary metal–oxide–semiconductor (CMOS) processes...
This study proposes a productization framework to improve the design standardization of rural low-rise prefabricated residences (RLPR) in southern Jiangsu, China. The framework is built on three industrialized structural system prototypes: the prefab...
The influence of various Zr contents (0–45 wt.%) on the microstructure and mechanical properties of Ti6Al4V alloy was investigated through a combinatorial approach. The diffusion multiples of Ti6Al4V–Ti6Al4V20Fe–Ti6Al4V20Cr–Ti...
Smocking is a handicraft technique of sewing and making pleats to produce shapes over the surface of cloth, and has been widely used in clothing and fashion. However, it is not easy to combine several pieces of smocking without wrinkles on cloth, sin...
In the past few decades, metaheuristics have demonstrated their suitability in addressing complex problems over different domains. This success drives the scientific community towards the definition of new and better-performing heuristics and results...
Protein sequence space is vast; nature uses only an infinitesimal fraction of possible sequences to sustain life. Are there solutions to biological problems other than those provided by nature? Can we create artificial proteins that sustain life? To...
Many key pre-distribution (KPD) schemes based on combinatorial design were proposed for secure communication of wireless sensor networks (WSNs). Due to complexity of constructing the combinatorial design, it is infeasible to generate key rings using...
Combinatorial optimization problems are often considered NP-hard problems in the field of decision science and the industrial revolution. As a successful transformation to tackle complex dimensional problems, metaheuristic algorithms have been implem...
The preliminary task of a project consists of the definition of the scenarios that will guide further development work and validate the results. In this paper, we present an approach for the systematic generation of validation scenarios using a speci...
This paper presents a systematic review on reinforcement learning approaches for combinatorial optimization problems based on real-world industrial applications. While this topic is increasing in popularity, explicit implementation details are not al...
A point-cyclic resolution of a 2-
This paper revisits a combinatorial structure called the large set of ordered design (
Peptides are widely used in pharmaceutical industry as active pharmaceutical ingredients, versatile tools in drug discovery, and for drug delivery. They find themselves at the crossroads of small molecules and proteins, possessing favorable tissue pe...
Designing solid-state circuit breakers (SSCBs) involves a large discrete design space spanning MOSFET type, bypass configuration, and heatsink selection. This work formulates SSCB design as a multi-objective combinatorial optimisation problem that mi...
It is a well-known fact that a graph of diameter d has at least
A structure-based lead optimization procedure is an essential step to finding appropriate ligand molecules binding to a target protein structure in order to identify drug candidates. This procedure takes a known structure of a protein-ligand complex...
The optimal combinatorial parameters of antimicrobial photodynamic therapy (aPDT) mediated by methylene blue (MB) with the addition of potassium iodide (KI) against Candida species have never been defined. This study aimed to optimize the combinatori...
Synthetic DNA barcodes are double-stranded DNA molecules designed to carry recoverable information, information that can be used to represent and track objects and organisms. DNA barcodes offer robust, sensitive detection using standard amplification...
The increasing complexity of real-world engineering problems, ranging from manufacturing scheduling to resource optimization in smart grids, has driven demand for adaptive and high-performing heuristic methods. Automatic Heuristic Design (AHD) and ne...
Latin squares are an essential tool in the construction of combinatorial designs. Optimal solutions for problems such as scheduling problems and permutation arrays for powerline communication rely on the ability to construct sets of mutually orthogon...
The esterase EstSIT01 from Microbacterium can catalyze the asymmetric hydrolysis of meso-dimethyl ester to produce the crucial chiral intermediate (4S, 5R)-hemimethyl ester for d-biotin synthesis. Despite its high yields and stereoselectivity, the lo...
Security in wireless sensor networks is commonly based on symmetric encryption and requires key-management systems to establish and exchange secret keys. A constraint that is common to many key-management approaches is an upper bound to the total num...
Cost-effective therapy of neglected and tropical diseases such as malaria requires everlasting drug discovery efforts due to the rapidly emerging drug resistance of the plasmodium parasite. We have carried out computational design of new inhibitors o...
Current research applies an energy-based design model to improve performance in existing modern buildings, in Rio de Janeiro, from the 1940’s, improving these buildings’ shading systems. This article proposes a methodology tested through...
With the introduction of mechanization in agriculture, the area of terraced slopes has increased. However, in most cases, the planning of terracing in practice remains experience-based, which is no longer effective from an agricultural, geological, a...
EphB3 is a major key player in a variety of cellular activities, including cell migration, proliferation, and apoptosis. However, the exact role of EphB3 in cancer remains ambiguous. Accordingly, new EphB3 inhibitors can increase the understanding of...
Traditionally, drug development involved the individual synthesis and biological evaluation of hundreds to thousands of compounds with the intention of highlighting their biological activity, selectivity, and bioavailability, as well as their low tox...
A random matrix needs large storage space and is difficult to be implemented in hardware, and a deterministic matrix has large reconstruction error. Aiming at these shortcomings, the objective of this paper is to find an effective method to balance t...
Background: During the previous decade a new class of benzamide-based inhibitors of 2-trans enoyl-acyl carrier protein reductase (InhA) of Mycobacterium tuberculosis (Mt) with unusual binding mode have emerged. Here we report in silico design and eva...
A combinatorial material adhesion study was used to optimize the composition of an adhesion promoting layer for a nanocrystalline diamond (NCD) coating on silicon. Three different adhesion promoting metals, namely W, Cr, and Ta, were selected to fabr...
A combinatorial hydrothermal reaction has been used to prepare pure and additive (Sb, Cu, Nb, Pd, and Ni)-loaded In2O3 hollow spheres for gas sensor applications. The operation of Pd- and Cu-loaded In2O3 sensors at 371 °C leads to selective H2S detec...
Multi-principal element alloys (MPEAs) are at the forefront of materials science due to their large variety of compositions, which can yield unexplored properties. Mapping the structure and properties of a compositional MPEA library in a reasonable t...
This study explored the combined administration of docetaxel (DOC) and erlotinib (ERL) using nanostructured lipid carriers (NLCs), with folic acid (FA) conjugation to enhance their synergistic anticancer efficacy against triple-negative breast cancer...
Leveraging human insight and intuition has been identified as having the potential for the improvement of traditional algorithmic methods. For example, in a video game, a user may not only be entertained but may also be challenged to beat the score o...
The optimization of blank design is the key to the implementation of a green innovation strategy. The process of blank design determines more than 80% of resource consumption and environmental emissions during the blank processing. Unfortunately, the...
The freeway service patrol problem involves patrol routing design and fleet allocation on freeways that would help transportation agency decision-makers when developing a freeway service patrols program and/or altering existing route coverage and fle...
Industrial production facilities have been facing the requirement to optimise resource efficiency, while considering sustainable goals. This paper addresses the introduction of renewable energies in production by exploring the combined design and sch...
Background: The main purpose of this article is to introduce a universal mathematics-aided vaccine design method against malignant melanoma based on neoantigens. The universal method can be adapted to the mutanome of each patient so that a specific c...
This review summarises the state-of-the-art methodologies used for designing homogeneous catalysts and optimising reaction conditions (e.g. choosing the right solvent). We focus on computational techniques that can complement the current advances in...
Virtual screening (VS) methods have emerged as an adaptive response to massive throughput synthesis and screening technologies. Based on the structure-permeability paradigm, the Lipinski rule of five has become a standard property filtering protocol...
We present a self-organizing map (SOM) approach to predicting macromolecular targets for combinatorial compound libraries. The aim was to study the usefulness of the SOM in combination with a topological pharmacophore representation (CATS) for select...
We introduce a new strategy that extends the established diffusion couple approach for efficient mapping of microstructural and mechanical properties in bulk samples. The featured diffusion couples undergo an interdiffusion annealing followed by a th...
In recent years, reagentless aptamer biosensors, named aptasensors, have shown significant advancements. Particularly, electrochemical aptasensors could change the field of biosensors in this era, where digitalization seems to be a common goal of ma...
One-bead-one-compound peptide libraries, developed following the top-down experimental approach, have attracted great interest in the identification of potential ligands or active peptides. By exploiting a reverse experimental design approach based o...
The subject of the study was an application of nature-inspired metaheuristic algorithms to node configuration optimization in optical networks. The main objective of the optimization was to minimize capital expenditure, which includes the costs of op...
Determining an appropriate sequence of interrelated activities is one of the keys to developing a complex product. One of the approaches used to sequence activities consists of solving the feedback length minimization problem (FLMP). Several metaheur...
Wind power is one of the most important sources of renewable energy available today. A large part of the cost of wind energy is due to the cost of maintaining wind power equipment. When a wind turbine component fails to function, it might need to be...
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