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1,764 Results Found

  • Article
  • Open Access
10 Citations
2,394 Views
11 Pages

Characterizing Microstructural Evolution of TP304 Stainless Steel Using a Pulse-Echo Nonlinear Method

  • Yichen Liu,
  • Xiongbing Li,
  • Guangdong Zhang,
  • Shuzeng Zhang and
  • Hyunjo Jeong

19 March 2020

Tube/Pipe (TP) 304 stainless steel has been widely used in industry, but a change in its microstructures may endanger its service safety, and it is essential to evaluate its microstructural evolution. In this work, a pulse-echo nonlinear method is pr...

  • Feature Paper
  • Article
  • Open Access
1 Citations
4,244 Views
12 Pages

Temple Recommendation Engine for Route Planning Based on TPS Clustering CNN Method

  • Dasarada Rajagopalan Thirupurasundari,
  • Annadurai Hemlathadhevi,
  • Amit Kumar Gupta,
  • Ruchi Rani Garg and
  • Mangal Sain

22 August 2022

There are no restrictions on religious or cultural practices in India. India’s temples are becoming an ideal platform for Hindu groups to express their ideals in a global context. For the sake of devotees, temples now require widespread accessi...

  • Article
  • Open Access
1,704 Views
20 Pages

A Rapid RI-TP Model for Predicting Turbine Wake Interaction Broadband Noise

  • Kangshen Xiang,
  • Weijie Chen,
  • Siddiqui Aneeb and
  • Weiyang Qiao

Future UHBR (Ultra-High Bypass-Ratio) engines might cause serious ‘turbine noise storms’ but, at present, turbine noise prediction capability is lacking. The large turning angle of the turbine blade is the first major factor deserving spe...

  • Article
  • Open Access
11 Citations
4,958 Views
20 Pages

13 March 2020

Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is an ultra-rare disorder caused by mutations in TYMP, leading to a deficiency in thymidine phosphorylase and a subsequent systemic accumulation of thymidine and 2’-deoxyuridine. Erythrocy...

  • Article
  • Open Access
7 Citations
2,295 Views
35 Pages

24 January 2024

Process algebra can be considered one of the most practical formal methods for modeling Smart IoT Systems in Digital Twin, since each IoT device in the systems can be considered as a process. Further, some of the algebras are applied to predict the b...

  • Communication
  • Open Access
790 Views
12 Pages

Selected Properties of a TPS/PA12 Composite Material Produced in a Two-Stage Method

  • Ewa Tomaszewska-Ciosk,
  • Ewa Zdybel,
  • Małgorzata Kapelko-Żeberska and
  • Beata Anwajler

29 May 2025

The world economy is struggling with the increasing pollution of the natural environment with non-biodegradable synthetic polymers produced from petroleum products. This fact has prompted research on the use of natural renewable polymers. Starch is o...

  • Article
  • Open Access
1 Citations
1,834 Views
48 Pages

15 June 2024

Process algebra is one of the most suitable formal methods to model smart IoT systems for smart cities. Each IoT in the systems can be modeled as a process in algebra. In addition, the nondeterministic behavior of the systems can be predicted by defi...

  • Article
  • Open Access
5 Citations
3,127 Views
14 Pages

Simultaneous DC Railway Power System Analysis Method Using Model-Based TPS

  • Hwanhee Cho,
  • Jaewon Kim,
  • Hosung Jung and
  • Hyungchul Kim

8 July 2022

This paper focuses on the development of a model-based train performance simulation with the practical train operation data using MATLAB Simulink. The developed program uses input operation data of a DC 1500 V metro line. And the simultaneous and mul...

  • Article
  • Open Access
1,964 Views
12 Pages

Experimental Investigation of Thermal Properties of Frozen Tap, Demineralized, and Sea Water

  • Jelena Bošnjak,
  • Mišo Jurčević,
  • Natalia Bodrožić Ćoko and
  • Sandro Nižetić

24 November 2023

This paper reports an experimental investigation of the thermal properties of frozen tap, demineralized, and sea water. The presented research assists in a better understanding of the thermal properties of ice and the processes within it and contribu...

  • Article
  • Open Access
12 Citations
2,577 Views
19 Pages

Seasonal Monitoring Method for TN and TP Based on Airborne Hyperspectral Remote Sensing Images

  • Lei Dong,
  • Cailan Gong,
  • Xinhui Wang,
  • Yang Wang,
  • Daogang He,
  • Yong Hu,
  • Lan Li and
  • Zhe Yang

30 April 2024

Airborne sensing images harness the combined advantages of hyperspectral and high spatial resolution, offering precise monitoring methods for local-scale water quality parameters in small water bodies. This study employs airborne hyperspectral remote...

  • Protocol
  • Open Access
5 Citations
4,177 Views
12 Pages

A Method for Isolation Bacteriophage Particles-Free Genomic DNA, Exemplified by TP-84, Infecting Thermophilic Geobacillus

  • Ireneusz Sobolewski,
  • Katarzyna Adamowicz,
  • Anna Struck,
  • Agnieszka Zylicz-Stachula and
  • Piotr M. Skowron

DNA purification methods are indispensable tools of molecular biology, used for many decades. Nevertheless, for certain specialized applications, the currently employed techniques are not sufficiently effective. While examining a number of the existi...

  • Protocol
  • Open Access
2 Citations
3,522 Views
9 Pages

A Method for Rapid Polyethyleneimine-Based Purification of Bacteriophage-Expressed Proteins from Diluted Crude Lysates, Exemplified by Thermostable TP-84 Depolymerase

  • Beata Łubkowska,
  • Edyta Czajkowska,
  • Ireneusz Sobolewski,
  • Natalia Krawczun,
  • Agnieszka Żylicz-Stachula and
  • Piotr M. Skowron

Purification of bacteriophage-expressed proteins poses methodological difficulties associated with the need to process entire culture medium volume upon bacteriophage-induced bacterial cell lysis. We have used novel capsule glycosylase-depolymerase (...

  • Article
  • Open Access
1,473 Views
13 Pages

14 May 2025

Background/Aims: Circulating tumor DNA (ctDNA) is becoming a valuable cancer biomarker for clinical decision-making. Nevertheless, the lack of quality control materials to assess the reliability of test results remains a challenge. This study aimed t...

  • Article
  • Open Access
9 Citations
2,665 Views
30 Pages

15 September 2022

The coal gasifier is the core unit of the coal gasification system. Due to its exposure to high temperatures, high pressures, and aggressive media, it is highly susceptible to serious accidents in the event of failure. Therefore, it is important for...

  • Article
  • Open Access
8 Citations
3,588 Views
13 Pages

8 October 2022

Developing a simple and effective method for measuring carbaryl residues in food is urgent due to its widespread use and the associated health risks in agriculture, as well as various defects in existing detection techniques. The COF (TpPa-NH2)@Fe3O4...

  • Article
  • Open Access
20 Citations
4,551 Views
12 Pages

Diagnostic Performance of Immunohistochemistry Compared to Molecular Techniques for Microsatellite Instability and p53 Mutation Detection in Endometrial Cancer

  • Sylvie Streel,
  • Alixe Salmon,
  • Adriane Dheur,
  • Vincent Bours,
  • Natacha Leroi,
  • Lionel Habran,
  • Katty Delbecque,
  • Frédéric Goffin,
  • Clémence Pleyers and
  • Christine Gennigens
  • + 4 authors

Molecular algorithms may estimate the risk of recurrence and death for patients with endometrial cancer (EC) and may impact treatment decisions. To detect microsatellite instabilities (MSI) and p53 mutations, immunohistochemistry (IHC) and molecular...

  • Article
  • Open Access
1 Citations
2,610 Views
16 Pages

Development and Validation of a Duplex RT-qPCR for Detection of Peach Latent Mosaic Viroid and Comparison of Different Nucleic-Acid-Extraction Protocols

  • Marta Luigi,
  • Anna Taglienti,
  • Carla Libia Corrado,
  • Marco Cardoni,
  • Simona Botti,
  • Rita Bissani,
  • Paola Casati,
  • Alessandro Passera,
  • Niccolò Miotti and
  • Francesco Faggioli
  • + 4 authors

27 April 2023

Peach latent mosaic viroid (PLMVd) is an important pathogen that causes disease in peaches. Control of this viroid remains problematic because most PLMVd variants are symptomless, and although there are many detection tests in use, the reliability of...

  • Article
  • Open Access
430 Views
24 Pages

This work presents a microstructure-informed pathway for assigning a material symmetry class to distinguish between tensor components and scalar effective thermal conductivity (ETC) values derived from directional measurements. The framework combines...

  • Article
  • Open Access
1 Citations
7,914 Views
28 Pages

7 September 2015

Light detection and ranging (LiDAR) technique is currently one of the most important tools for collecting elevation points with a high density in the context of digital elevation model (DEM) construction. However, the high density data always leads t...

  • Article
  • Open Access
1 Citations
1,570 Views
15 Pages

17 October 2024

In order to enhance the reliability and accuracy of the results from the transient plane source (TPS) method for measuring the thermal conductivity of wood, this paper investigates setting parameters and measurement methods to improve measurement acc...

  • Review
  • Open Access
31 Citations
5,668 Views
29 Pages

Advances in the Utilization of Tea Polysaccharides: Preparation, Physicochemical Properties, and Health Benefits

  • Qian Wang,
  • Xiaoyan Yang,
  • Changwei Zhu,
  • Guodong Liu,
  • Yujun Sun and
  • Lisheng Qian

6 July 2022

Tea polysaccharide (TPS) is the second most abundant ingredient in tea following tea polyphenols. As a complex polysaccharide, TPS has a complex chemical structure and a variety of bioactivities, such as anti-oxidation, hypoglycemia, hypolipidemic, i...

  • Article
  • Open Access
10 Citations
3,268 Views
13 Pages

20 October 2021

TP53 plays critical roles in maintaining genome stability. Deleterious genetic variants damage the function of TP53, causing genome instability and increased cancer risk. Of the large quantity of genetic variants identified in TP53, however, many rem...

  • Article
  • Open Access
4 Citations
3,879 Views
18 Pages

The study concerns the photodegradation of the antidepressant escitalopram (ESC), the S-enantiomer of the citalopram raceme, both in ultrapure and surface water, considering the contribution of indirect photolysis through the presence of nitrate and...

  • Article
  • Open Access
14 Citations
6,065 Views
18 Pages

Accessing a New Dimension in TP53 Biology: Multiplex Long Amplicon Digital PCR to Specifically Detect and Quantitate Individual TP53 Transcripts

  • Annette Lasham,
  • Peter Tsai,
  • Sandra J. Fitzgerald,
  • Sunali Y. Mehta,
  • Nicholas S. Knowlton,
  • Antony W. Braithwaite and
  • Cristin G. Print

24 March 2020

TP53, the most commonly-mutated gene in cancer, undergoes complex alternative splicing. Different TP53 transcripts play different biological roles, both in normal function and in the progression of diseases such as cancer. The study of TP53’s a...

  • Brief Report
  • Open Access
3 Citations
4,502 Views
9 Pages

Decitabine and Melphalan Fail to Reactivate p73 in p53 Deficient Myeloma Cells

  • Pierre-Samuel Gillardin,
  • Géraldine Descamps,
  • Sophie Maiga,
  • Benoit Tessoulin,
  • Hanane Djamai,
  • Benedetta Lucani,
  • David Chiron,
  • Philippe Moreau,
  • Steven Le Gouill and
  • Agnès Moreau-Aubry
  • + 2 authors

(1) Background: TP53 deficiency remains a major adverse event in Multiple Myeloma (MM) despite therapeutic progresses. As it is not possible to target TP53 deficiency with pharmacological agents, we explored the possibility of activating another p53...

  • Article
  • Open Access
6 Citations
4,162 Views
12 Pages

Morphological Analysis of the Tibial Slope in 720 Adult Knee Joints

  • Marc-Pascal Meier,
  • Yara Hochrein,
  • Dominik Saul,
  • Mark-Tilmann Seitz,
  • Friederike Sophie Klockner,
  • Wolfgang Lehmann and
  • Thelonius Hawellek

Background: The tibial slope (TS) defines the posterior inclination of the tibial plateau (TP). The “individual physiological” TS plays a crucial role in knee-joint stability and should be taken into account in knee-joint surgery. The aim...

  • Article
  • Open Access
24 Citations
3,423 Views
15 Pages

24 August 2020

The total phosphorus (TP) concentration is a key water quality parameter for water monitoring and a major indicator of the state of eutrophication in inland lakes. Using remote-sensing to estimate TP concentration is useful, as it provides a synoptic...

  • Feature Paper
  • Review
  • Open Access
32 Citations
6,875 Views
23 Pages

Transformation Products of Organic Contaminants and Residues—Overview of Current Simulation Methods

  • Lisa Kotthoff,
  • Julia Keller,
  • Dominique Lörchner,
  • Tessema F. Mekonnen and
  • Matthias Koch

19 February 2019

The formation of transformation products (TPs) from contaminants and residues is becoming an increasing focus of scientific community. All organic compounds can form different TPs, thus demonstrating the complexity and interdisciplinarity of this top...

  • Article
  • Open Access
13 Citations
3,247 Views
23 Pages

Cellular Uptake and Transport Mechanism Investigations of PEGylated Niosomes for Improving the Oral Delivery of Thymopentin

  • Mengyang Liu,
  • Darren Svirskis,
  • Thomas Proft,
  • Jacelyn Loh,
  • Yuan Huang and
  • Jingyuan Wen

Background: Although its immunomodulatory properties make thymopentin (TP5) appealing, its rapid metabolism and inactivation in the digestive system pose significant challenges for global scientists. PEGylated niosomal nanocarriers are hypothesized t...

  • Article
  • Open Access
4 Citations
3,023 Views
19 Pages

23 October 2022

Due to the inherent uncertainties in material properties, loads, geometric dimensions, et al., the uncertainty-based optimization design method has become increasingly important for the design of the thermal protection system (TPS) by carefully consi...

  • Article
  • Open Access
2 Citations
2,621 Views
16 Pages

Generally, only wind effect is considered in the collapse evaluation of transmission poles (TPs). However, during a typhoon landing, the rainfall is usually very heavy and the influence of the wind and rainfall should be considered simultaneously. To...

  • Article
  • Open Access
357 Views
13 Pages

Prognostic Impact of RAS and TP53 Mutation Profiles in Metastatic Colorectal Cancer

  • Mustafa Emre Duygulu,
  • Elanur Karaman,
  • Serdar Karakullukçu and
  • Sevdegül Aydın Mungan

9 January 2026

Background and Objectives: Our study aimed to investigate the effect of RAS and TP53 mutations, either alone or in combination, on survival in patients with metastatic colorectal carcinoma (mCRC). Materials and Methods: Patients diagnosed with mCRC a...

  • Article
  • Open Access
6 Citations
2,669 Views
16 Pages

Arginine-Containing Tripeptides as Analgesic Substances: The Possible Mechanism of Ligand-Receptor Binding to the Slow Sodium Channel

  • Ilya V. Rogachevskii,
  • Vera B. Plakhova,
  • Valentina A. Penniyaynen,
  • Arina D. Kalinina,
  • Svetlana A. Podzorova,
  • Dmitriy M. Samosvat,
  • Georgy G. Zegrya and
  • Boris V. Krylov

Two short arginine-containing tripeptides, H-Arg-Arg-Arg-OH (TP1) and Ac-Arg-Arg-Arg-NH2 (TP2), have been shown by the patch-clamp method to modulate the NaV1.8 channels of DRG primary sensory neurons, which are responsible for the generation of noci...

  • Article
  • Open Access
15 Citations
4,824 Views
23 Pages

Optimizing Training Population Size and Content to Improve Prediction Accuracy of FHB-Related Traits in Wheat

  • Emmanuel Adeyemo,
  • Prabin Bajgain,
  • Emily Conley,
  • Ahmad H. Sallam and
  • James A. Anderson

9 April 2020

Genomic selection combines phenotypic and molecular marker data from a training population to predict the genotypic values of untested lines. It can improve breeding efficiency as large pools of untested lines can be evaluated for selection. Training...

  • Article
  • Open Access
12 Citations
4,535 Views
24 Pages

15 December 2020

A thermal protection system (TPS) is designed and fabricated to protect a hypersonic vehicle from extreme conditions. Good condition of the TPS panels is necessary for the next flight mission. A loose bolted joint is a crucial defect in a metallic TP...

  • Article
  • Open Access
7 Citations
2,368 Views
22 Pages

30 March 2023

Tire polymers (TPs) are the most prevalent type of microplastics and are of great concern due to their potential environmental risks. This study aims to determine the toxicity of TPs with the help of molecular-dynamics simulations of their interactio...

  • Article
  • Open Access
52 Views
14 Pages

15 February 2026

Background: In advanced non-small cell lung cancer (NSCLC) with sensitizing EGFR mutations, EGFR tyrosine kinase inhibitors (EGFR-TKIs) improve progression-free survival (PFS). However, clinical outcomes vary according to EGFR mutation subtype and TP...

  • Article
  • Open Access
3 Citations
2,670 Views
13 Pages

The Mediating Role of Time Perspective in the Relationship between Chronotype and Suicide in Bipolar Disorder

  • Mahmut Onur Karaytuğ,
  • Lut Tamam,
  • Mehmet Emin Demirkol,
  • Zeynep Namlı,
  • Mahmut Gürbüz,
  • Caner Yeşiloğlu and
  • Özge Eriş Davut

2 December 2022

(1) Background: Suicide in patients with bipolar disorder (BD) is related to the chronotype of the person from a biological perspective. However, it is not known whether there is a relationship between suicide and psychological time in BD. The aim of...

  • Article
  • Open Access
8 Citations
4,270 Views
16 Pages

7 August 2019

To minimize conventional total-phosphorus (TP) analysis systems, TP pretreatment microfluidic chip is proposed and characterized in this paper. Phosphorus (P) is one of the most important elements in ecosystem but it causes the eutrophication due to...

  • Article
  • Open Access
30 Citations
6,850 Views
28 Pages

TP53 Mutation Is a Prognostic Factor in Lower Grade Glioma and May Influence Chemotherapy Efficacy

  • Humaira Noor,
  • Nancy E. Briggs,
  • Kerrie L. McDonald,
  • Jeff Holst and
  • Orazio Vittorio

26 October 2021

Background: Identification of prognostic biomarkers in cancers is a crucial step to improve overall survival (OS). Although mutations in tumour protein 53 (TP53) is prevalent in astrocytoma, the prognostic effects of TP53 mutation are unclear. Method...

  • Article
  • Open Access
6 Citations
2,612 Views
11 Pages

The TP53 Codon 72 Arginine Polymorphism Is Found with Increased TP53 Somatic Mutations in HPV(−) and in an Increased Percentage among HPV(+) Norwegian HNSCC Patients

  • Svein Erik Moe,
  • Fredrik A. Erland,
  • Siren Fromreide,
  • Stein Lybak,
  • Marianne Brydoy,
  • Harsh N. Dongre,
  • Sophia M. Dhayalan,
  • Daniela-Elena Costea,
  • Olav K. Vintermyr and
  • Hans Jørgen Aarstad

Background: Somatic TP53 mutations are frequent in head and neck squamous cell carcinoma (HNSCC) and are important pathogenic factors. Objective: To study TP53 mutations relative to the presence of human papillomavirus (HPV) in tumors in HNSCC patien...

  • Article
  • Open Access
5 Citations
3,205 Views
14 Pages

1 October 2024

Background: Rheumatoid arthritis (RA) tends to occur in symmetrical joints and is always accompanied by synovial hyperplasia and cartilage damage. Triptolide (TP), an extract from Tripterygium, has anti-inflammatory and immunomodulatory properties an...

  • Article
  • Open Access
6 Citations
2,774 Views
10 Pages

14 August 2023

High-resolution nanotransfer printing (nTP) technologies have attracted a tremendous amount of attention due to their excellent patternability, high productivity, and cost-effectiveness. However, there is still a need to develop low-cost mold manufac...

  • Article
  • Open Access
24 Citations
11,580 Views
20 Pages

Smoking Cessation among Low-Socioeconomic Status and Disadvantaged Population Groups: A Systematic Review of Research Output

  • Ryan J. Courtney,
  • Sundresan Naicker,
  • Anthony Shakeshaft,
  • Philip Clare,
  • Kristy A. Martire and
  • Richard P. Mattick

Background: Smoking cessation research output should move beyond descriptive research of the health problem to testing interventions that can provide causal data and effective evidence-based solutions. This review examined the number and type of publ...

  • Article
  • Open Access
4 Citations
3,562 Views
12 Pages

The drug salinomycin (SAL) is a polyether antibiotic and used in veterinary medicine as coccidiostat and growth promoter. Recently, SAL was suggested as a potential anticancer drug. However, transformation products (TPs) resulting from metabolic and...

  • Article
  • Open Access
2 Citations
1,826 Views
16 Pages

As new pesticides continue to emerge in agricultural systems, understanding their environmental behavior is crucial for effective risk assessment. Tiafenacil (TFA), a promising novel pyrimidinedione herbicide, was the focus of this study. We develope...

  • Article
  • Open Access
18 Citations
11,542 Views
9 Pages

The aim of this study was to determine the effect of total dissolved solids (TDS), extraction yield (EY), and grinding on total polyphenols (TP), total flavonoids (TF), and total antioxidant capacity (TAC) in a fermented specialty coffee prepared usi...

  • Article
  • Open Access
10 Citations
2,805 Views
17 Pages

Protective Effects of Different Selenium Green Tea Polysaccharides on the Development of Type 2 Diabetes in Mice

  • Weilan Gao,
  • Zhan Zheng,
  • Xuehua Wang,
  • Li Wang,
  • Na Zhang,
  • Haiyuan Liu,
  • Xin Cong,
  • Shuyi Li and
  • Zhenzhou Zhu

21 November 2023

Selenium polysaccharides have attracted significant interest due to their superior function to that of individual polysaccharides. However, limited research has compared the protective effects of different selenium polysaccharides from different sele...

  • Article
  • Open Access
4 Citations
2,507 Views
11 Pages

27 July 2022

Background: Total pancreatectomy (TP) can be performed in cases with positive resection margin after partial pancreatectomy for pancreatic cancer. However, despite complete removal of the residual pancreatic parenchyme, it is questionable whether an...

  • Article
  • Open Access
3 Citations
3,827 Views
17 Pages

Targeting the MDM2-p53 Interaction with Siremadlin: A Promising Therapeutic Strategy for Treating TP53 Wild-Type Chronic Lymphocytic Leukemia

  • Erhan Aptullahoglu,
  • Mohammed Howladar,
  • Jonathan P. Wallis,
  • Helen Marr,
  • Scott Marshall,
  • Julie Irving,
  • Elaine Willmore and
  • John Lunec

16 January 2025

Background: Chronic lymphocytic leukemia (CLL) treatment has transitioned from traditional chemotherapy to more targeted therapies, but challenges such as resistance and suboptimal responses persist. This study aimed to evaluate HDM201, a second-gene...

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