The high conservation of nucleotides of the T-loop, including their chemical identity, are hallmarks of tRNAs from organisms belonging to the three Domains of Life. These structural characteristics allow the T-loop to adopt a peculiar intraloop confo...
Prominent in the L-shaped three-dimensional structure of tRNAs is the “elbow” where their two orthogonal helical stacks meet. It has a conserved structure arising from the interaction of the terminal loops of the D- and T-stem-loops, and presents to...
Productive transcription of the integrated HIV-1 provirus is restricted by cellular factors that inhibit RNA polymerase II elongation. The viral Tat protein overcomes this by recruiting a general elongation factor, P-TEFb, to the TAR RNA element that...
The neurobiology of schizophrenia is multifactorial, comprising the dysregulation of several biochemical pathways and molecules. This research proposes a peripheral biomarker for schizophrenia that involves the second extracellular loop of norepineph...
Given the high risk of Internet of Things (IoT) device compromise, it is crucial to discuss the attack detection aspect. However, due to the physical limitations of IoT, such as battery life and sensing and processing power, the widely used detection...
Sensors, actuators, and wireless communication technologies have developed significantly. Consequently, closed-loop systems that can be monitored and controlled by devices in IoT environments, such as farms and factories, have emerged. Such systems a...
Human T-cell leukemia virus type 1 (HTLV-1) is a human delta retrovirus that causes adult T-cell leukemia/lymphoma (ATL) in 3–5% of the infected population after decades of clinical latency. HTLV-1 Tax is a potent activator of IKK/NF-κB a...
Length determination is a fundamental problem in biology and chemistry. Numerous proteins measure distances on linear biopolymers to exert effects with remarkable spatial precision. Recently, ruler-like devices made of noncoding RNAs have been struct...
Transfer RNAs (tRNAs) are chemically matured decoding molecules that are central to protein synthesis. Their post-transcriptional modifications, especially those in the anticodon stem-loop (ASL), shape local RNA structure, codon recognition and trans...
Telomeres are complex nucleoprotein structures that protect the extremities of linear chromosomes. Telomere replication is a major challenge because many obstacles to the progression of the replication fork are concentrated at the ends of the chromos...
Degraded network conditions and intermittent disconnections can impair solar greenhouse Internet of Things (IoT) systems by delaying cloud-to-field control, generating burst traffic after reconnection, and disrupting alarm feedback loops. This paper...
Artificial intelligence (AI) and the Internet of Things (IoT) are converging to create densely sensed, connected, and increasingly automated urban environments. However, research on AI–IoT integration remains dominated by optimisation-centric p...
Ambient Internet-of-Things (IoT) deployments place large fleets of battery-less, energy-harvesting devices in environments where human operators cannot review every security event. Autonomous Artificial-Intelligence (AI) defenders can reduce this bur...
Previous studies have found a benefit of closed-loop transcranial alternating current stimulation (CL-tACS) matched to ongoing slow-wave oscillations (SWO) during sleep on memory consolidation for words in a paired associates task (PAT). Here, we exa...
The advent of chimeric antigen receptor (CAR) T cells expedited the field of cancer immunotherapy enabling durable remissions in patients with refractory hematological malignancies. T cells redirected for universal cytokine-mediated killing (TRUCKs),...
Because tRNA is the core biological intellectual property that was necessary to evolve translation systems, tRNAomes, ribosomes, aminoacyl-tRNA synthetases, and the genetic code, the evolution of tRNA is the core story in evolution of life on earth....
Combining proton and phosphorus magnetic resonance spectroscopy offers a unique opportunity to study the oxidative and glycolytic components of metabolism in working muscle. This paper presents a 7 T proton calf coil design that combines dipole and l...
CDK6 plays a key role in the regulation of the cell cycle and is considered a crucial target for cancer therapy. In this work, conformational transitions of CDK6 were identified by using Gaussian accelerated molecular dynamics (GaMD), deep learning (...
T-cell recognition of antigens is complex, leading to biochemical and cellular events that impart both specific and targeted immune responses. The end result is an array of cytokines that facilitate the direction and intensity of the immune reaction&...
Protein inhibition is a natural regulatory process to control cellular metabolic fluxes. PII-family signal-transducing effectors are in this matter key regulators of the nitrogen metabolism. Their interaction with their various targets is governed by...
The rapid development of electric vehicle ultra-fast battery chargers is increasingly demanding higher efficiency and power density. In particular, a proper control of the grid-connected active front–end can ensure minimum passive component size (i.e...
Glioblastoma, a highly aggressive brain tumor, poses significant treatment challenges. A deeper investigation into its molecular complexity is essential for the identification of novel prognostic biomarkers and therapeutic strategies, potentially imp...
The HIV-1 mature capsid (CA) assumes an amorphous, fullerene conical configuration due to its high flexibility. How native CA self-assembles is still unclear despite having well-defined structures of its pentamer and hexamer building blocks. Here we...
Transcranial electrical stimulation (tES) is a non-invasive neuromodulatory technique that alters ongoing neural dynamics by injecting an exogenous electrical current through the scalp. Although tES protocols are becoming more common in both clinical...
Aminoacyl tRNA synthetases (aaRSs) are a well-studied family of enzymes with a canonical role in charging tRNAs with a specific amino acid. These proteins appear to also have non-canonical roles, including post-transcriptional regulation of mRNA expr...
Idiopathic pulmonary fibrosis (IPF) has been associated with mitochondrial dysfunction. We investigated whether mitochondrial DNA variants in peripheral blood leukocytes (PBLs), which affect proteins of the respiratory chain and mitochondrial functio...
This work presents a compact meandered loop slot-line 5G antenna for Internet of Things (IoT) applications. Recently, sub-gigahertz (sub-GHz) IoT technology is widely spreading. It enables long-range communications with low power consumption. The pro...
Chromosomal rearrangements have been shown to alter genome organization, consequently having an impact on gene expression. Studies on certain types of leukemia have shown that gene expression can be exacerbated by the altered nuclear positioning of f...
There are various techniques and designs for springs used in orthodontic treatment, including frictionless methods for closing spaces. However, there is limited explicit evidence to support the superiority of one method over another. This review aims...
Type 1 Diabetes Mellitus (T1DM) is an autoimmune disease in which the insulin-producing beta cells of the pancreas are destroyed and insulin must be injected daily to enable the body to metabolize glucose. Standard therapy for T1DM involves self-mo...
Modern Electric Vehicles (EVs) and their charging points (CPs) function as Internet of Things (IoT) nodes embedded in the distribution grid: they continuously sense local electrical conditions, exchange real-time data with the Charging Station Manage...
This systematic review examines the combined use of electroencephalography (EEG) and transcranial electrical stimulation (tES) in both clinical and healthy populations. The review focuses on EEG’s role in guiding, monitoring, and evaluating tES...
With the convergence of information technology (IT) and operational technology (OT) in Industry 4.0, edge computing is increasingly relevant in the context of the Industrial Internet of Things (IIoT). While the use of simulation is already the state...
Loop-mediated isothermal amplification is a promising candidate for the rapid detection of Mycobacterium tuberculosis. However, the high potential for carry-over contamination is the main obstacle to its routine use. Here, a closed tube LAMP was inte...
Zinc transporters take up/release zinc ions (Zn2+) across biological membranes and maintain intracellular and intra-organellar Zn2+ homeostasis. Since this process requires a series of conformational changes in the transporters, detailed information...
Telomeres (chromosome-end nucleoprotein complexes) are prone to replication fork stalling because of their G-rich repetitive sequences, G-quadruplexes, t-loops, oxidative lesions, and telomeric R-loops generated when telomeric repeat-containing RNA (...
A new controller based on a fractional-order synergetic controller (FOSC) is proposed for a three-level T-type inverter using a shunt active power filter (SAPF). The SAPF is designed to compensate for the reactive power and eliminate the current harm...
Background: Poor sleep quality is a common complaint, affecting over one third of people in the United States. While sleep quality is thought to be related to slow-wave sleep (SWS), there has been little investigation to address whether modulating sl...
Autonomous Networked Robot (ANR) systems feature multi-robot systems (MRSs) and wireless sensor networks (WSNs). These systems help to extend coverage, maximize efficiency in data routing, and provide practical and reliable task management, among oth...
The rapid development of Low Earth Orbit Position, Navigation, and Timing (LEO-PNT) constellations presents opportunities to augment Global Navigation Satellite Systems (GNSSs) with additional signals from Low Earth Orbit (LEO) satellites, thereby im...
This paper presents an integrated framework for aircraft engines, which consists of three phases: modeling, control, and experimental testing. The engine is formulated as an uncertain T–S fuzzy model. By a hierarchical dynamical parameter clust...
This paper describes our conceptual framework of closed-loop lifecycle information sharing for product-service in the Internet of Things (IoT). The framework is based on the ontology model of product-service and a type of IoT message standard, Open M...
This paper presents a universal point-of-care system for fully automated quantification of human T-cell lymphotropic virus type 1 (HTLV-1) proviral load, including genomic RNA, based on digital reverse RNA transcription and c-DNA amplification by MD...
Telomeres, the natural ends of chromosomes, hide the linear telomeric DNA from constitutive exposure to the DNA damage response with a lariat structure or t-loop. Progressive telomere shortening associated with DNA replication in the absence of a com...
This review addresses the complexities of type 1 diabetes (T1D) and its associated complications, with a particular focus on diabetic retinopathy (DR). This review outlines the progression from non-proliferative to proliferative diabetic retinopathy...
Modern microgrids face critical challenges in maintaining stability and efficiency due to renewable energy intermittency and dynamic load demands. This paper proposes a novel real-time energy management framework that synergizes a bio-inspired T-Cell...
Background/Objectives: Accurate blood glucose forecasting is critical for closed-loop insulin delivery systems to support effective disease management in people with type 1 diabetes (T1D). While long short-term memory (LSTM) neural networks have show...
Transfer RNAs (tRNAs) are central players in translation, functioning as adapter molecules between the informational level of nucleic acids and the functional level of proteins. They show a highly conserved secondary and tertiary structure and the hi...
The Internet of Things (IoT), robotics, and artificial intelligence have only recently converged in agriculture, driven by the need for sustainable, resilient food systems. Precision farming demands real-time physical action, not just data-driven ins...
At present, because of their advantages of simple structure, low cost, low power consumption and high efficiency, single winding bearingless permanent magnet synchronous motors (SBPMSMs) have become one of the research hotspots in the bearingless tec...
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