Special Issue "Evolution of tRNA"
Deadline for manuscript submissions: closed (31 October 2015).
Interests: genetic code; genetic translation; codon usage; proteome control; tRNAs; ribosomes; proteome quality control in cell biology and disease; structure-function studies of protein-RNA interactions; biomedicine and biotechnology
Special Issues and Collections in MDPI journals
Interests: small non-coding RNA biology; nucleic acids-based therapeutics; post-transcriptional control of gene expression
Transfer RNAs (tRNAs) are the key adaptor molecules that translate information from codons in messenger RNAs (mRNAs) into a polypeptide chain that will ultimately form a newly synthesized protein. Because of the essential role of tRNAs in protein translation, these molecules are, from an evolutionary point of view, as old as life itself.
Despite being discovered more than 50 years ago, tRNAs continue to amaze us. New non-canonical functions of tRNAs are being described, physiological roles for post-transcriptional modifications on tRNA residues have started to emerge, and the overall biology of tRNAs, from their enzymatic processing to their cellular transport, is being revisited.
In this Special Issue, experts in the field will present their thoughts and views on the evolution of tRNAs and how this evolution has affected the decoding strategies that different species have chosen for efficient protein translation. The scope of this Special Issue encompasses not only analysis of the conservation and divergence of tRNA genes, but also of canonical and non-canonical tRNA functions (such as aminoacylation), post-transcriptional editing, the role of codon usage, cellular control of translation elongation, links to other cellular pathways, and the balance between translation fidelity and efficiency.
We hope to include multi-disciplinary articles. Molecular, cellular, biochemical, and bioinformatical approaches that focus on tRNA are all welcome. In this way, we hope to compile an up-to-date perspective on this exciting and ever-growing research “arena”.
Prof. Dr. Lluís Ribas de Pouplana
Dr. Adrian Gabriel Torres
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- protein translation
- transfer RNA
- messenger RNA
- post-transcriptional modifications
- tRNA synthetase
- codon usage
- translation fidelity
- translation efficiency
- translation machinery