DNA Replication Controls

Dear Colleagues,

The conditions for DNA replication are not ideal, owing to endogenous and exogenous replication stresses that lead to arrest of the replication fork. Arrested forks are among the most serious threats to genomic integrity because they can break or rearrange, leading to genomic instability. Thus, it is important to understand the cellular programs that preserve genomic integrity during DNA replication. Indeed, the most common cancer therapies use agents that block DNA replication or cause DNA damage during replication. Thus, without a precise understanding of the DNA replication program, development of anticancer therapeutics is limited.

In this Special Issue, we welcome reviews, new methods, and original articles covering many aspects of DNA replication controls. These include, but not limited to, regulation of the replisome and its components, DNA replication checkpoints, S-phase stress responses, replication of difficult-to-replication sites, replication of specific genomic loci (such as telomeres and rDNA), translesion synthesis, DNA repair during DNA replication, and other cellular processes that are coordinated with DNA replication. We look forward to your contributions.

Dr. Eishi Noguchi
Guest Editor

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