You are currently on the new version of our website. Access the old version .

84 Results Found

  • Article
  • Open Access
3 Citations
3,827 Views
10 Pages

Chemical Imaging of Single Anisotropic Polystyrene/Poly (Methacrylate) Microspheres with Complex Hierarchical Architecture

  • Alexandra Wagner,
  • Stefanie Wagner,
  • Jan-Erik Bredfeldt,
  • Julia C. Steinbach,
  • Ashutosh Mukherjee,
  • Sandra Kronenberger,
  • Kai Braun,
  • Andreas Kandelbauer,
  • Hermann A. Mayer and
  • Marc Brecht

29 April 2021

Monodisperse polystyrene spheres are functional materials with interesting properties, such as high cohesion strength, strong adsorptivity, and surface reactivity. They have shown a high application value in biomedicine, information engineering, chro...

  • Article
  • Open Access
14 Citations
4,353 Views
13 Pages

The True Costs and Benefits of Miscanthus Cultivation

  • Moritz Wagner,
  • Bastian Winkler,
  • Jan Lask,
  • Jan Weik,
  • Andreas Kiesel,
  • Mirjam Koch,
  • John Clifton-Brown and
  • Moritz von Cossel

4 December 2022

Agroecosystems provide numerous ecosystem services (ESs) such as provisioning, regulating, habitat and cultural services. At the same time, the management of these agroecosystems can cause various negative impacts on the environment such as the gener...

  • Article
  • Open Access
77 Citations
9,439 Views
15 Pages

Recent Advances and Applications of External Cavity-QCLs towards Hyperspectral Imaging for Standoff Detection and Real-Time Spectroscopic Sensing of Chemicals

  • Ralf Ostendorf,
  • Lorenz Butschek,
  • Stefan Hugger,
  • Frank Fuchs,
  • Quankui Yang,
  • Jan Jarvis,
  • Christian Schilling,
  • Marcel Rattunde,
  • André Merten and
  • Joachim Wagner
  • + 3 authors

External-cavity quantum cascade lasers (EC-QCL) are now established as versatile wavelength-tunable light sources for analytical spectroscopy in the mid-infrared (MIR) spectral range. We report on the realization of rapid broadband spectral tuning wi...

  • Article
  • Open Access
59 Citations
6,218 Views
20 Pages

Evaluation of a TEM based Approach for Size Measurement of Particulate (Nano)materials

  • Eveline Verleysen,
  • Thorsten Wagner,
  • Hans-Gerd Lipinski,
  • Ralf Kägi,
  • Robert Koeber,
  • Ana Boix-Sanfeliu,
  • Pieter-Jan De Temmerman and
  • Jan Mast

15 July 2019

An approach for the size measurement of particulate (nano)materials by transmission electron microscopy was evaluated. The approach combines standard operating procedures for specimen preparation, imaging, and image analysis, and it was evaluated on...

  • Article
  • Open Access
10 Citations
5,832 Views
25 Pages

Individual- and Connectivity-Based Real-Time fMRI Neurofeedback to Modulate Emotion-Related Brain Responses in Patients with Depression: A Pilot Study

  • Maximilian Maywald,
  • Marco Paolini,
  • Boris Stephan Rauchmann,
  • Christian Gerz,
  • Jan Lars Heppe,
  • Annika Wolf,
  • Linda Lerchenberger,
  • Igor Tominschek,
  • Sophia Stöcklein and
  • Susanne Karch
  • + 4 authors

14 December 2022

Introduction: Individual real-time functional magnetic resonance imaging neurofeedback (rtfMRI NF) might be a promising adjuvant in treating depressive symptoms. Further studies showed functional variations and connectivity-related changes in the dor...

  • Article
  • Open Access
4 Citations
3,012 Views
27 Pages

Combating Drug Resistance by Exploiting miRNA-200c-Controlled Phase II Detoxification

  • Bianca Köhler,
  • Sviatlana Dubovik,
  • Elisa Hörterer,
  • Ulrich Wilk,
  • Jan Bernd Stöckl,
  • Hande Tekarslan-Sahin,
  • Bojan Ljepoja,
  • Philipp Paulitschke,
  • Thomas Fröhlich and
  • Andreas Roidl

11 November 2022

Acquired drug resistance constitutes a serious obstacle to the successful therapy of cancer. In the process of therapy resistance, microRNAs can play important roles. In order to combat resistance formation and to improve the efficacy of chemotherape...

  • Article
  • Open Access
25 Citations
2,893 Views
12 Pages

Low-Energy X-Ray Intraoperative Radiation Therapy (Lex-IORT) for Resected Brain Metastases: A Single-Institution Experience

  • Christian D. Diehl,
  • Steffi U. Pigorsch,
  • Jens Gempt,
  • Sandro M. Krieg,
  • Silvia Reitz,
  • Maria Waltenberger,
  • Melanie Barz,
  • Hanno S. Meyer,
  • Arthur Wagner and
  • Stephanie E. Combs
  • + 3 authors

20 December 2022

Background: Resection followed by local radiation therapy (RT) is the standard of care for symptomatic brain metastases. However, the optimal technique, fractionation scheme and dose are still being debated. Lately, low-energy X-ray intraoperative RT...

  • Case Report
  • Open Access
3,146 Views
6 Pages

Schwannoma of the Hypoglossal Nerve Mimicking Carotid Body Paraganglioma

  • Maximilian Linxweiler,
  • Wolfgang Reith,
  • Mathias Wagner,
  • Jan Philipp Kühn and
  • Bernhard Schick

Carotid body paragangliomas (CBPs) clinically present as highly vascularized cervical masses with a pathognomonic localization at the carotid artery bifurcation. Following ultrasonography and MRI/CT imaging, surgical resection with optional preoperat...

  • Article
  • Open Access
6 Citations
4,064 Views
20 Pages

A Scenario-Based Model Comparison for Short-Term Day-Ahead Electricity Prices in Times of Economic and Political Tension

  • Denis E. Baskan,
  • Daniel Meyer,
  • Sebastian Mieck,
  • Leonhard Faubel,
  • Benjamin Klöpper,
  • Nika Strem,
  • Johannes A. Wagner and
  • Jan J. Koltermann

24 March 2023

In recent years, energy prices have become increasingly volatile, making it more challenging to predict them accurately. This uncertain market trend behavior makes it harder for market participants, e.g., power plant dispatchers, to make reliable dec...

  • Article
  • Open Access
26 Citations
7,983 Views
14 Pages

Solubility Enhanced Formulation Approaches to Overcome Oral Delivery Obstacles of PROTACs

  • Florian Pöstges,
  • Kevin Kayser,
  • Jan Appelhaus,
  • Marius Monschke,
  • Michael Gütschow,
  • Christian Steinebach and
  • Karl G. Wagner

PROteolysis TArgeting Chimaeras (PROTACs) offer new opportunities in modern medicine by targeting proteins that are undruggable to classic inhibitors. However, due to their hydrophobic structure, PROTACs typically suffer from low solubility, and oral...

  • Article
  • Open Access
10 Citations
3,134 Views
25 Pages

An Antiherpesviral Host-Directed Strategy Based on CDK7 Covalently Binding Drugs: Target-Selective, Picomolar-Dose, Cross-Virus Reactivity

  • DongHoon Yu,
  • Sabrina Wagner,
  • Martin Schütz,
  • Yeejin Jeon,
  • Mooyoung Seo,
  • Jaeseung Kim,
  • Nadine Brückner,
  • Jintawee Kicuntod,
  • Julia Tillmanns and
  • Manfred Marschall
  • + 6 authors

The repertoire of currently available antiviral drugs spans therapeutic applications against a number of important human pathogens distributed worldwide. These include cases of the pandemic severe acute respiratory coronavirus type 2 (SARS-CoV-2 or C...

  • Article
  • Open Access
2 Citations
4,493 Views
19 Pages

Co-Design Methods for Non-Standard Multi-Storey Timber Buildings

  • Luis Orozco,
  • Anna Krtschil,
  • Hans Jakob Wagner,
  • Simon Bechert,
  • Felix Amtsberg,
  • Jan Knippers and
  • Achim Menges

21 November 2023

To meet climate change goals and respond to increased global urbanisation, the building industry needs to improve both its building technology and its design methods. Constrained urban environments and building stock extensions are challenges for sta...

  • Article
  • Open Access
9 Citations
5,383 Views
37 Pages

Integrating Open-Source Datasets to Analyze the Transboundary Water–Food–Energy–Climate Nexus in Central Asia

  • Jan De Keyser,
  • Daniel S. Hayes,
  • Beatrice Marti,
  • Tobias Siegfried,
  • Carina Seliger,
  • Hannah Schwedhelm,
  • Oyture Anarbekov,
  • Zafar Gafurov,
  • Raquel M. López Fernández and
  • Helmut Habersack
  • + 5 authors

3 October 2023

In today’s intrinsically connected world, the Water–Food–Energy–Climate Nexus (WFEC Nexus) concept provides a starting point for informed and transparent decision-making based on the trade-offs and synergies between different...

  • Article
  • Open Access
3 Citations
1,598 Views
14 Pages

Expression of 3q Oncogene SEC62 Predicts Survival in Head and Neck Squamous Cell Carcinoma Patients Treated with Primary Chemoradiation

  • Maximilian Linxweiler,
  • Matthias Schneider,
  • Sandrina Körner,
  • Moritz Knebel,
  • Lukas Alexander Brust,
  • Felix Leon Braun,
  • Silke Wemmert,
  • Mathias Wagner,
  • Markus Hecht and
  • Jan Philipp Kühn

24 December 2023

Primary chemoradiotherapy (CRT) is an established treatment option for locally advanced head and neck squamous cell carcinomas (HNSCC) usually combining intensity modified radiotherapy with concurrent platinum-based chemotherapy. Though the majority...

  • Article
  • Open Access
1 Citations
2,532 Views
16 Pages

Elucidating the Role of Optical Activity of Polymers in Protein–Polymer Interactions

  • Samin Jahan,
  • Catherine Doyle,
  • Anupama Ghimire,
  • Diego Combita,
  • Jan K. Rainey,
  • Brian D. Wagner and
  • Marya Ahmed

24 December 2023

Proteins are biomolecules with potential applications in agriculture, food sciences, pharmaceutics, biotechnology, and drug delivery. Interactions of hydrophilic and biocompatible polymers with proteins may impart proteolytic stability, improving the...

  • Article
  • Open Access
1 Citations
1,596 Views
10 Pages

31 July 2024

Background/Objectives: Building upon the rising value of Confocal Laser Endomicroscopy (CLE) in squamous cell carcinoma of the head and neck, we present the first application of CLE during the resection of sinonasal malignant melanomas. This study ai...

  • Article
  • Open Access
28 Citations
4,014 Views
16 Pages

HPV Status as Prognostic Biomarker in Head and Neck Cancer—Which Method Fits the Best for Outcome Prediction?

  • Jan Philipp Kühn,
  • Wendelin Schmid,
  • Sandrina Körner,
  • Florian Bochen,
  • Silke Wemmert,
  • Hugo Rimbach,
  • Sigrun Smola,
  • Julia Caroline Radosa,
  • Mathias Wagner and
  • Maximilian Linxweiler
  • + 3 authors

21 September 2021

The incidence of human papillomavirus (HPV)-related head and neck cancer (HNSCC) is rising globally, presenting challenges for optimized clinical management. To date, it remains unclear which biomarker best reflects HPV-driven carcinogenesis, a proce...

  • Article
  • Open Access
8 Citations
2,293 Views
12 Pages

Upfront Surgery vs. Primary Chemoradiation in an Unselected, Bicentric Patient Cohort with Oropharyngeal Squamous Cell Carcinoma—A Matched-Pair Analysis

  • Philipp H. Zimmermann,
  • Marijn Stuut,
  • Nora Wuerdemann,
  • Kathrin Möllenhoff,
  • Malte Suchan,
  • Hans Eckel,
  • Philipp Wolber,
  • Shachi J. Sharma,
  • Fabian Kämmerer and
  • Jens P. Klussmann
  • + 4 authors

20 October 2021

The two pillars of therapy for oropharyngeal squamous cell carcinoma (OPSCC) are upfront surgery and primary chemoradiotherapy. Substantial regional preferences exist with regard to the selection of treatment. Despite new therapeutic approaches, pati...

  • Article
  • Open Access
5 Citations
4,617 Views
9 Pages

Yttria-Coated Tungsten Fibers for Use in Tungsten Fiber-Reinforced Composites: A Comparative Study on PVD vs. CVD Routes

  • Saravanan Palaniyappan,
  • Maik Trautmann,
  • Yiran Mao,
  • Johann Riesch,
  • Parikshith Gowda,
  • Nick Rudolph,
  • Jan Willem Coenen,
  • Rudolf Neu and
  • Guntram Wagner

16 September 2021

Tungsten fiber-reinforced tungsten (Wf/W) composites are being developed to improve the intrinsic brittleness of tungsten. In these composites, engineered fiber/matrix interfaces are crucial in order to realize toughening mechanisms. For such a purpo...

  • Article
  • Open Access
1 Citations
2,980 Views
13 Pages

Central Sleep Apnea Is Associated with an Abnormal P-Wave Terminal Force in Lead V1 in Patients with Acute Myocardial Infarction Independent from Ventricular Function

  • Jan Pec,
  • Michael Wester,
  • Christoph Fisser,
  • Kurt Debl,
  • Okka W. Hamer,
  • Florian Poschenrieder,
  • Stefan Buchner,
  • Lars S. Maier,
  • Michael Arzt and
  • Stefan Wagner

26 November 2021

Sleep-disordered breathing (SDB) is highly prevalent in patients with cardiovascular disease. We have recently shown that an elevation of the electrocardiographic (ECG) parameter P wave terminal force in lead V1 (PTFV1) is linked to atrial proarrhyth...

  • Perspective
  • Open Access
19 Citations
6,918 Views
11 Pages

Accelerated Development of COVID-19 Vaccines: Technology Platforms, Benefits, and Associated Risks

  • Ralf Wagner,
  • Eberhard Hildt,
  • Elena Grabski,
  • Yuansheng Sun,
  • Heidi Meyer,
  • Annette Lommel,
  • Brigitte Keller-Stanislawski,
  • Jan Müller-Berghaus and
  • Klaus Cichutek

Multiple preventive COVID-19 vaccines have been developed during the ongoing SARS coronavirus (CoV) 2 pandemic, utilizing a variety of technology platforms, which have different properties, advantages, and disadvantages. The acceleration in vaccine d...

  • Article
  • Open Access
3 Citations
4,203 Views
17 Pages

26 December 2021

We study the efficient computation of power indices for weighted voting games with precoalitions amongst subsets of players (reflecting, e.g., ideological proximity) using the paradigm of dynamic programming. Starting from the state-of-the-art algori...

  • Article
  • Open Access
3 Citations
5,437 Views
20 Pages

In Vitro and In Vivo Feasibility Study for a Portable VV-ECMO and ECCO2R System

  • Lasse J. Strudthoff,
  • Hannah Lüken,
  • Sebastian V. Jansen,
  • Jan Petran,
  • Peter C. Schlanstein,
  • Lotte Schraven,
  • Benjamin J. Schürmann,
  • Niklas B. Steuer,
  • Georg Wagner and
  • Rüdger Kopp
  • + 2 authors

22 January 2022

Extracorporeal membrane oxygenation (ECMO) is an established rescue therapy for patients with chronic respiratory failure waiting for lung transplantation (LTx). The therapy inherent immobilization may result in fatigue, consecutive deteriorated prog...

  • Feature Paper
  • Article
  • Open Access
9 Citations
2,907 Views
34 Pages

Assessment of Covalently Binding Warhead Compounds in the Validation of the Cytomegalovirus Nuclear Egress Complex as an Antiviral Target

  • Julia Tillmanns,
  • Sigrun Häge,
  • Eva Maria Borst,
  • Julia Wardin,
  • Jan Eickhoff,
  • Bert Klebl,
  • Sabrina Wagner,
  • Christina Wangen,
  • Friedrich Hahn and
  • Manfred Marschall

14 April 2023

Herpesviral nuclear egress is a regulated process of viral capsid nucleocytoplasmic release. Due to the large capsid size, a regular transport via the nuclear pores is unfeasible, so that a multistage-regulated export pathway through the nuclear lami...

  • Article
  • Open Access
2,821 Views
14 Pages

Segregated by Wealth, Health, and Development: An Analysis of Pre-School Child Health in a Medium-Sized German City

  • Karoline Wagner,
  • Andreas Wienke,
  • Christine Gröger,
  • Jan-Henning Klusmann and
  • Amand Führer

The School Entry Examination (SEE) can be used to identify children with current health issues, developmental delays, and risk factors for later diseases. This study analyzes the health status of preschool children in a German city with considerable...

  • Systematic Review
  • Open Access
870 Views
25 Pages

KAVAI: A Systematic Review of the Building Blocks for Knowledge-Assisted Visual Analytics in Industrial Manufacturing

  • Adrian J. Böck,
  • Stefanie Größbacher,
  • Jan Vrablicz,
  • Christina Stoiber,
  • Alexander Rind,
  • Josef Suschnigg,
  • Tobias Schreck,
  • Wolfgang Aigner and
  • Markus Wagner

18 September 2025

Industry 4.0 produces large volumes of sensor and machine data, offering new possibilities for manufacturing analytics but also creating challenges in combining domain knowledge with visual analysis. We present a systematic review of 13 peer-reviewed...

  • Article
  • Open Access
1 Citations
1,791 Views
14 Pages

Background: The PACIFIC study showed that after radio-chemotherapy, patients with NSCLC derived a benefit in PFS and OS when treated with durvalumab. This effect was limited to patients with a PD-L1 expression of >1%, partly because the outcome in...

  • Article
  • Open Access
11 Citations
2,490 Views
19 Pages

Combined Treatment with Host-Directed and Anticytomegaloviral Kinase Inhibitors: Mechanisms, Synergisms and Drug Resistance Barriers

  • Markus Wild,
  • Dubravka Karner,
  • Jan Eickhoff,
  • Sabrina Wagner,
  • Jintawee Kicuntod,
  • William Chang,
  • Peter Barry,
  • Stipan Jonjić,
  • Tihana Lenac Roviš and
  • Manfred Marschall

Despite the availability of currently approved antiviral drugs, infections with human cytomegalovirus (HCMV) still cause clinically challenging, sometimes life-threatening situations. There is an urgent need for enhanced anti-HCMV drugs that offer im...

  • Article
  • Open Access
46 Citations
15,338 Views
10 Pages

A High Temperature Capacitive Humidity Sensor Based on Mesoporous Silica

  • Thorsten Wagner,
  • Sören Krotzky,
  • Alexander Weiß,
  • Tilman Sauerwald,
  • Claus-Dieter Kohl,
  • Jan Roggenbuck and
  • Michael Tiemann

14 March 2011

Capacitive sensors are the most commonly used devices for the detection of humidity because they are inexpensive and the detection mechanism is very specific for humidity. However, especially for industrial processes, there is a lack of dielectrics t...

  • Article
  • Open Access
33 Citations
10,999 Views
13 Pages

Study of Interdigitated Electrode Arrays Using Experiments and Finite Element Models for the Evaluation of Sterilization Processes

  • Jan Oberländer,
  • Zaid B. Jildeh,
  • Patrick Kirchner,
  • Luisa Wendeler,
  • Alexander Bromm,
  • Heiko Iken,
  • Patrick Wagner,
  • Michael Keusgen and
  • Michael J. Schöning

14 October 2015

In this work, a sensor to evaluate sterilization processes with hydrogen peroxide vapor has been characterized. Experimental, analytical and numerical methods were applied to evaluate and study the sensor behavior. The sensor set-up is based on plana...

  • Article
  • Open Access
17 Citations
7,264 Views
11 Pages

A Cancer-Indicative microRNA Pattern in Normal Prostate Tissue

  • Olaf J. C. Hellwinkel,
  • Christina Sellier,
  • Yu-Mi Jessica Sylvester,
  • Jan C. Brase,
  • Hendrik Isbarn,
  • Andreas Erbersdobler,
  • Thomas Steuber,
  • Holger Sültmann,
  • Thorsten Schlomm and
  • Christina Wagner

4 March 2013

We analyzed the levels of selected micro-RNAs in normal prostate tissue to assess their potential to indicate tumor foci elsewhere in the prostate. Histologically normal prostate tissue samples from 31 prostate cancer patients and two cancer negative...

  • Article
  • Open Access
1 Citations
907 Views
12 Pages

Discordance Between p16-Expression and HPV-Status in Sinonasal Carcinoma: A Multicenter Retrospective Study

  • Nina Wenda,
  • Henrike Barbara Zech,
  • Marta Barde,
  • Leoni Ramke,
  • Anna Sophie Hoffmann,
  • Till Clauditz,
  • Sebastian Wagner,
  • Jan Gosepath and
  • Christian Stephan Betz

26 September 2025

Background/Objectives: Human papillomavirus (HPV) infection is a well-established risk factor for oropharyngeal squamous cell carcinoma (OPSCC), where p16 immunohistochemistry serves as a surrogate marker. However, the role of HPV in sinonasal squamo...

  • Case Report
  • Open Access
56 Citations
29,005 Views
20 Pages

Solid Waste Management in Ho Chi Minh City, Vietnam: Moving towards a Circular Economy?

  • Petra Schneider,
  • Le Hung Anh,
  • Jörg Wagner,
  • Jan Reichenbach and
  • Anja Hebner

17 February 2017

The paper presents the current situation of the waste management system of the megacity Ho Chi Minh in Vietnam, and the options for waste and land recycling in a low income country. Generally, there is a large potential for circular economy in the ci...

  • Article
  • Open Access
2 Citations
2,762 Views
10 Pages

Clavicle Shaft Non-Unions–Do We Even Need Bone Grafts?

  • Nils Mühlenfeld,
  • Ferdinand C. Wagner,
  • Andreas Hupperich,
  • Lukas Heykendorf,
  • Andreas Frodl,
  • Peter Obid,
  • Jan Kühle,
  • Hagen Schmal,
  • Benjamin Erdle and
  • Martin Jaeger

16 August 2024

Background: The surgical treatment of bony non-unions is traditionally performed with additional bone grafts when atrophic and/or stronger implants when hypertrophic. In the case of the clavicle shaft, however, in our experience, a more controversial...

  • Article
  • Open Access
3 Citations
3,570 Views
11 Pages

Inferior Frontal Sulcal Hyperintensities on Brain MRI Are Associated with Amyloid Positivity beyond Age—Results from the Multicentre Observational DELCODE Study

  • Marc Dörner,
  • Katharina Seebach,
  • Michael T. Heneka,
  • Inga Menze,
  • Roland von Känel,
  • Sebastian Euler,
  • Frank Schreiber,
  • Philipp Arndt,
  • Katja Neumann and
  • Jose Bernal
  • + 49 authors

Inferior frontal sulcal hyperintensities (IFSHs) on fluid-attenuated inversion recovery (FLAIR) sequences have been proposed to be indicative of glymphatic dysfunction. Replication studies in large and diverse samples are nonetheless needed to confir...

  • Article
  • Open Access
2 Citations
2,312 Views
17 Pages

XModNN: Explainable Modular Neural Network to Identify Clinical Parameters and Disease Biomarkers in Transcriptomic Datasets

  • Jan Oldenburg,
  • Jonas Wagner,
  • Sascha Troschke-Meurer,
  • Jessica Plietz,
  • Lars Kaderali,
  • Henry Völzke,
  • Matthias Nauck,
  • Georg Homuth,
  • Uwe Völker and
  • Stefan Simm

25 November 2024

The Explainable Modular Neural Network (XModNN) enables the identification of biomarkers, facilitating the classification of diseases and clinical parameters in transcriptomic datasets. The modules within XModNN represent specific pathways or genes o...

  • Article
  • Open Access
10 Citations
2,915 Views
38 Pages

Fiducial Reference Measurements for Air Quality Monitoring Using Ground-Based MAX-DOAS Instruments (FRM4DOAS)

  • Michel Van Roozendael,
  • Francois Hendrick,
  • Martina M. Friedrich,
  • Caroline Fayt,
  • Alkis Bais,
  • Steffen Beirle,
  • Tim Bösch,
  • Monica Navarro Comas,
  • Udo Friess and
  • Steffen Ziegler
  • + 11 authors

2 December 2024

The UV–Visible Working Group of the Network for the Detection of Atmospheric Composition Changes (NDACC) focuses on the monitoring of air-quality-related stratospheric and tropospheric trace gases in support of trend analysis, satellite validat...

  • Article
  • Open Access
1,551 Views
26 Pages

22 May 2025

Background/Objectives: The prediction of cancer types is primarily reliant on driver genes and their specific mutations. The advancement in novel omics technologies has led to the acquisition of additional genetic data. When integrated with artificia...

  • Article
  • Open Access
3 Citations
1,812 Views
15 Pages

Impact of T Cell Exhaustion and Stroma Senescence on Tumor Cell Biology and Clinical Outcome of Head and Neck Squamous Cell Carcinomas

  • Lukas A. Brust,
  • Meike Vorschel,
  • Sandrina Körner,
  • Moritz Knebel,
  • Jan Philipp Kühn,
  • Silke Wemmert,
  • Sigrun Smola,
  • Mathias Wagner,
  • Bernhard Schick and
  • Maximilian Linxweiler

17 December 2024

Head and neck squamous cell carcinomas (HNSCC) have an overall poor prognosis, especially in locally advanced and metastatic stages. In most cases, multimodal therapeutic approaches are required and show only limited cure rates with a high risk of tu...

  • Article
  • Open Access
1 Citations
1,176 Views
15 Pages

20 December 2024

Abstract: Background/Objectives: Sinonasal malignancies are rare and highly diverse cancers that pose significant diagnostic challenges due to their variable histological features and complex anatomical locations. Accurate diagnosis is critical for g...

  • Article
  • Open Access
1,742 Views
17 Pages

24 March 2025

Postpartum adaptation causes an increased formation of free radicals (FRs) in the organism, which can lead to development of various FR-mediated diseases (FRMDs) in the newborn. The present study investigates the kinetics of skin and blood carotenoid...

  • Article
  • Open Access
8 Citations
3,774 Views
18 Pages

Planar Proton Minibeam Irradiation Elicits Spatially Confined DNA Damage in a Human Epidermis Model

  • Harry Scherthan,
  • Stephanie-Quinta Wagner,
  • Jan Grundhöfer,
  • Nicole Matejka,
  • Jessica Müller,
  • Steffen Müller,
  • Sarah Rudigkeit,
  • Matthias Sammer,
  • Sarah Schoof and
  • Judith Reindl

17 March 2022

Purpose: High doses of ionizing radiation in radiotherapy can elicit undesirable side effects to the skin. Proton minibeam radiotherapy (pMBRT) may circumvent such limitations due to tissue-sparing effects observed at the macro scale. Here, we mapped...

  • Article
  • Open Access
7 Citations
5,738 Views
17 Pages

GMP Manufacturing and IND-Enabling Studies of a Recombinant Hyperimmune Globulin Targeting SARS-CoV-2

  • Rena A. Mizrahi,
  • Wendy Y. Lin,
  • Ashley Gras,
  • Ariel R. Niedecken,
  • Ellen K. Wagner,
  • Sheila M. Keating,
  • Nikita Ikon,
  • Vishal A. Manickam,
  • Michael A. Asensio and
  • Adam S. Adler
  • + 24 authors

Conventionally, hyperimmune globulin drugs manufactured from pooled immunoglobulins from vaccinated or convalescent donors have been used in treating infections where no treatment is available. This is especially important where multi-epitope neutral...

  • Review
  • Open Access
18 Citations
5,290 Views
33 Pages

Software and Techniques for VLBI Data Processing and Analysis

  • Michael Janssen,
  • Jack F. Radcliffe and
  • Jan Wagner

10 October 2022

Very-long-baseline interferometry (VLBI) is a challenging observational technique, which requires in-depth knowledge about radio telescope instrumentation, interferometry, and the handling of noisy data. The reduction in raw data is mostly left to th...

  • Article
  • Open Access
27 Citations
4,333 Views
11 Pages

Learning Curve and Comparison of Dynamic Implant Placement Accuracy Using a Navigation System in Young Professionals

  • Johannes Spille,
  • Eva Helmstetter,
  • Paul Kübel,
  • Jan-Tobias Weitkamp,
  • Juliane Wagner,
  • Henning Wieker,
  • Hendrik Naujokat,
  • Christian Flörke,
  • Jörg Wiltfang and
  • Aydin Gülses

2 October 2022

The aim of the current study was to evaluate the learning curve and accuracy of implant placement by young professionals using a dynamic computer-assisted surgical system for dental implant placement. Ten students tried to place eight implants with a...

  • Article
  • Open Access
7 Citations
2,910 Views
13 Pages

Relation between Ga Vacancies, Photoluminescence, and Growth Conditions of MOVPE-Prepared GaN Layers

  • Alice Hospodková,
  • Jakub Čížek,
  • František Hájek,
  • Tomáš Hubáček,
  • Jiří Pangrác,
  • Filip Dominec,
  • Karla Kuldová,
  • Jan Batysta,
  • Maciej O. Liedke and
  • Andreas Wagner
  • + 1 author

5 October 2022

A set of GaN layers prepared by metalorganic vapor phase epitaxy under different technological conditions (growth temperature carrier gas type and Ga precursor) were investigated using variable energy positron annihilation spectroscopy (VEPAS) to fin...

  • Article
  • Open Access
26 Citations
6,979 Views
16 Pages

Saccharin Supplementation Inhibits Bacterial Growth and Reduces Experimental Colitis in Mice

  • Annika Sünderhauf,
  • René Pagel,
  • Axel Künstner,
  • Anika E. Wagner,
  • Jan Rupp,
  • Saleh M. Ibrahim,
  • Stefanie Derer and
  • Christian Sina

17 April 2020

Non-caloric artificial sweeteners are frequently discussed as components of the “Western diet”, negatively modulating intestinal homeostasis. Since the artificial sweetener saccharin is known to depict bacteriostatic and microbiome-modula...

  • Article
  • Open Access
22 Citations
4,395 Views
14 Pages

Determination of Dairy Cattle Euthanasia Criteria and Analysis of Barriers to Humane Euthanasia in the United States: Dairy Producer Surveys and Focus Groups

  • Brooklyn K. Wagner,
  • Mary Caitlin Cramer,
  • Heather N. Fowler,
  • Hannah L. Varnell,
  • Alia M. Dietsch,
  • Kathryn L. Proudfoot,
  • Jan Shearer,
  • Maria Correa and
  • Monique D. Pairis-Garcia

29 April 2020

There are currently no clear guidelines in the US and some other countries regarding euthanasia decision making timelines for dairy cattle that become injured or ill to the extent that recovery is unlikely or impossible. Our study aimed to identify d...

  • Feature Paper
  • Review
  • Open Access
27 Citations
8,913 Views
21 Pages

Application of Modern Multi-Sensor Holter in Diagnosis and Treatment

  • Erik Vavrinsky,
  • Jan Subjak,
  • Martin Donoval,
  • Alexandra Wagner,
  • Tomas Zavodnik and
  • Helena Svobodova

7 May 2020

Modern Holter devices are very trendy tools used in medicine, research, or sport. They monitor a variety of human physiological or pathophysiological signals. Nowadays, Holter devices have been developing very fast. New innovative products come to th...

of 2