Gene expression patterns are very sensitive to external influences and are reflected in phenotypic changes. It was previously described that transferring melanoma cells from a plastic surface to Matrigel led to formation of de novo vascular networks&...
The use of androgen receptor pathway inhibitors (ARPIs) has led to an increase in the proportion of AR-null prostate cancer, including neuroendocrine prostate cancer (NEPC) and double-negative prostate cancer (DNPC), but the mechanism underlying this...
Obesity is a risk factor for preeclampsia. We investigated how obesity influences preeclampsia in mice lacking ankyrin-repeat-and-SOCS-box-containing-protein 4 (ASB4), which promotes trophoblast differentiation via degrading the inhibitor of DNA-bind...
Reproductive efficiency is a key determinant of sheep productivity, yet Hetian sheep remain limited by relatively low fecundity despite their adaptability to harsh environments. The inhibitor of DNA binding 2 (ID2) gene is known to regulate cell prol...
In preeclampsia (PE), impaired trophoblast proliferation and differentiation are thought to cause abnormal placentation and subsequent clinical manifestations of the disease, i.e., hypertension, proteinuria, and end-organ damage. Insulin-like growth...
BioID is a well-established method for identifying protein–protein interactions and has been utilized within live cells and several animal models. However, the conventional labeling period requires 15–18 h for robust biotinylation which m...
The present study aims to validate a new research method called IDeS (industrial design structure) through the design of an electric bicycle for everyday city life. IDeS is the latest evolution of a combination of innovative and advanced systematic a...
Fc-mediated effector functions of antibodies, including antibody-dependent cytotoxicity (ADCC), have been shown to contribute to vaccine-induced protection from HIV-1 infection, especially those directed against non-neutralizing, CD4 inducible (CD4i)...
The evolution of innovative and systematic design methodologies over time has widened the design concept involvement from the product development phase, which also includes the production and start-up phases. Literature findings have presented to acc...
This study aims to gather a sustainable understanding of additive manufacturing and other Manufacturing 4.0 approaches like horizontal and vertical integration and cloud computing techniques with a focus on industrial applications. The DfAM will appl...
This case study aims to develop a new innovative SUV (Sport Utility Vehicle) model exploiting IDeS (Industrial Design Structure), which is an engineering approach conceived to optimize car design projects in the automotive industry like never before....
12 October 2025
Personal identification (ID) is a prerequisite to many financial and social services; however, many vulnerable residents do not have ID and lack the resources to acquire it. To assess the impact of ID inaccessibility in a local context, a study was c...
Inhibitor of differentiation (ID) proteins are a family of transcription factors that contribute to maintaining proliferation during embryogenesis as they avoid cell differentiation. Afterward, their expression is mainly silenced, but their reactivat...
The present study was set to validate two different suburban-type sportscar bodies with shared common underpinnings. The chosen method to develop this project was the Industrial Design Structure (IDeS), which characterizes the ability to use the diff...
In the contemporary automobile scene, environmental effect abatement is being increasingly sought; this demands a full rethinking of the entire system and entails more than just the reduction in exhaust pollutant emissions. Currently, the most popula...
Innovation-driven enterprises (IDEs) steer their businesses with ideas, technology, and innovation. However, many of them have limited resources, capabilities, and readiness to turn their valuable creativity into marketable products. For IDE startups...
In recent years, Radio Frequency Identification (RFID) has become very popular. The main feature of this technology is that RFID tags do not require close handling and no line of sight is required between the reader and the tags. RFID is a technology...
This study is on the conception of the DS700 HYBRID project by the application of the Industrial Design Structure method (IDeS), which applies different tools sourced from engineering and style departments, including QFD and SDE, used to create the c...
This study proposes a methodological approach to the redesign of a 1980s vehicle, the Lancia Beta HPE, integrating the TRIZ (Theory of Inventive Problem Solving) and the Industrial Design Structure (IDeS) frameworks within the design process. The red...
Computer network security is an important aspect of computer science. Many researchers are trying to increase security using different methods, technologies, or tools. One of the most common practices is the deployment of an Intrusion Detection Syste...
Building Information Modeling (BIM) has become a central paradigm in the architecture, engineering, and construction industry, enabling integrated management of design and construction data. Accessibility standards are essential to ensure inclusive a...
Aldosterone excess is a cardiovascular risk factor. Aldosterone can directly stimulate an electrical remodeling of cardiomyocytes leading to cardiac arrhythmia and hypertrophy. L-type and T-type voltage-gated calcium (Ca2+) channels expression are in...
Mucopolysaccharidosis type II (MPS II) is an X-linked disorder resulting from a deficiency in iduronate 2-sulfatase (IDS), which is reported to be caused by gene mutations in the iduronate 2-sulfatase (IDS) gene. Many IDS mutation sites have not yet...
Background: Migraine is often not diagnosed or treated properly, despite being a common condition. The ID-migraine is a brief, self-administered test developed as a valuable tool for screening and diagnosing migraine in primary care settings. The obj...
In order to improve stability of a peptide marine drug lead, α-conotoxin TxID, we synthesized and modified TxID at the N-terminal with DSPE-PEG-NHS by a nucleophilic substitution reaction to prepare the DSPE-PEG-TxID for the first time. The rea...
Intrusion Detection Systems (IDS) still prevail as an important line of defense in modern computing environments. Cloud environment characteristics such as resource sharing, extensive connectivity, and agility in deploying new applications pose secur...
The basic helix-loop-helix (bHLH) transcription factors inhibitor of differentiation 1 (Id1) and inhibitor of differentiation 3 (Id3) (referred to as Id) have an important role in maintaining the cancer stem cell (CSC) phenotype in the triple-negativ...
Since its inception, proximity-dependent biotin identification (BioID), an in vivo biochemical screening method to identify proximal protein interactors, has seen extensive developments. Improvements and variants of the original BioID technique are b...
The decision tree algorithm is a core technology in data classification mining, and ID3 (Iterative Dichotomiser 3) algorithm is a famous one, which has achieved good results in the field of classification mining. Nevertheless, there exist some disadv...
Background/Objectives: Ovarian cancer (OC) remains the most lethal gynecologic malignancy, largely due to late-stage diagnosis and high rates of recurrence following platinum-based chemotherapy. Growing evidence implicates cancer stem-like cells (CSC...
The E2A and inhibitor of DNA binding (ID) proteins are transcription factors involved in cell cycle regulation and cellular differentiation. Imbalance of ID/E2A activity is associated with oncogenesis in various tumors, but their expression patterns...
The paper presents a new approach in the field of precise electrolytic conductivity measurements with planar thin- and thick-film electrodes. This novel measuring method was developed for measurement with comb-like electrodes called interdigitated el...
Person re-identification (ReID) has attracted the attention of a large number of researchers due to its wide range of applications. However, due to the difficulty of extracting robust features and the complexity of the feature extraction process, ReI...
Inhibitor of DNA binding (Id) genes comprise a family of four helix–loop–helix (HLH) transcriptional inhibitors. Our earlier studies revealed a role for ID2 within the circadian system, contributing to input, output, and core clock function through i...
Plant phenotyping experiments increasingly integrate diverse data types, including physical samples, image-derived traits, environmental measurements, and multi-omics datasets. As experimental complexity grows, maintaining traceability between indivi...
Background: Tumor-associated macrophages (TAMs) constitute a major portion of the leukocyte infiltrate found in breast cancer (BC). BC cells may reprogram TAMs in a pro-angiogenic and immunosuppressive sense. We previously showed that high expression...
A new type of actuator is presented in the paper that integrates the IDEs into a conventional piezoelectric sheet. The electrodes and polarization play a key role in the strain. Adopting constitutive equations of piezoelectric theory and variation pr...
Person Re-identification (Person Re-ID) is essential in surveillance and security. Traditional image processing methods often struggle to identify individuals accurately due to the sensitivity to occlusions and limited discriminative capability of th...
The design of healthcare facilities must comply with applicable regulatory requirements, which significantly influence functional, spatial, and performance aspects of healthcare buildings. However, compliance checking is still predominantly conducted...
α4/6-conotoxin TxID, which was identified from Conus textile, simultaneously blocks rat (r) α3β4 and rα6/α3β4 nicotinic acetylcholine receptors (nAChRs) with IC50 values of 3.6 nM and 33.9 nM, respectively. In order...
Hunter syndrome (mucopolysaccharidosis II; MPS II) is caused by a defect of the iduronate-2-sulfatase (IDS) gene. Few studies have reported integrated mutation data of Taiwanese MPS II phenotypes. In this study, we summarized genotype and phenotype c...
Multi-modal object re-identification (ReID) is a challenging task that seeks to identify objects across different image modalities by leveraging their complementary information. Traditional CNN-based methods are constrained by limited receptive field...
The paper describes a new tool called JupyTEP integrated development environment (IDE), which is an online integrated development environment for earth observation data processing available in the cloud. This work is a result of the project entitled...
An environmentally friendly chelating agent, tetrasodium iminodisuccinate (IDS), was investigated as an inhibitor in the simulated concrete pore solution on Q235 carbon steel by using Tafel polarization (TF), electrochemical impedance spectroscopy (E...
An intrusion detection system (IDS) is a crucial element in cyber security concerns. IDS is a safeguarding module that is designed to identify unauthorized activities in network environments. The importance of constructing IDSs has never been this si...
Building information modeling (BIM) relies on well-defined information requirements to ensure data availability, accurate data exchange, and model consistency. The information delivery specification (IDS) schema has emerged as a standard for structur...
The intrusion detection system (IDS) which is used widely in enterprises, has produced a large number of logs named alerts, from which the intrusion patterns can be mined. These patterns can be used to construct the intrusion scenarios or discover th...
The novel coronavirus SARS-CoV-2 is responsible for the ongoing COVID-19 pandemic and has caused a major health and economic burden worldwide. Understanding how SARS-CoV-2 viral proteins behave in host cells can reveal underlying mechanisms of pathog...
The main task for real-time vehicle tracking is establishing associations with objects in consecutive frames. After occlusion occurs between vehicles during the tracking process, the vehicle is given a new ID when it is tracked again. In this study,...
In the Fourth Industrial Revolution, artificial intelligence technology and big data science are emerging rapidly. To apply these informational technologies to the engineering industries, it is essential to digitize the data that are currently archiv...
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