The experimental data of core flow distribution are indispensable for obtaining licensing and facilitating the design of fluid systems of nuclear reactors. In this study, an Advanced power reactor Core flow and Pressure (ACOP) test facility was estab...
The core inlet flow distribution in the APR1000 reactor is critical for ensuring the reactors safety and efficient operation by maintaining uniform coolant flow across fuel assemblies. Previous studies, though insightful, faced challenges in fully re...
Automatic packet reporting system (APRS) is selected as a candidate for automatic dependent surveillance-broadcast (ADS-B) like solution for unmanned aircraft system traffic management (UTM). The APRS on-board unit (OBU) at 0.5 W radio power and a pr...
The destabilization of UHT milk during its shelf life can be promoted by the residual proteolytic activity attributed to the protease AprX from Pseudomonas. To better understand the hydrolysis patterns of AprX, and to evaluate the feasibility of usin...
Background: TP53 is the most commonly mutated gene in human cancer with loss of function mutations largely concentrated in “hotspots” affecting DNA binding. APR-246 and COTI-2 are small molecules under investigation in P53 mutated ca...
APR-246 (Eprenetapopt) is a small-molecule drug that restores the activity of dysfunctional p53 proteins caused by missense mutations that affect the DNA-binding domain. However, recent studies suggest that APR-246 can also induce cell death in cance...
We performed a hydrogen combustion analysis in the Advanced Power Reactor 1400 MWe (APR1400) containment during a severe accident initiated by a small break loss of coolant accident (SBLOCA) which occurred at a lower part of the cold leg using a mult...
Breast cancer is the most frequent cancer in women. Despite recent clinical advances, new therapeutic approaches are still required. The cystine-glutamate antiporter xCT, encoded by the SLC7A11 gene, which imports cystine in exchange with glutamate,...
Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer lacking targeted therapy. Here, we evaluated the anti-cancer activity of APR-246, a P53 activator, and CX-5461, a RNA polymerase I inhibitor, in the treatment of TNBC cell...
The use of lignocellulosic biomasses for the production of renewable hydrogen is surely among the hot-topic research tasks. In this review, we report on the recent advances in the catalytic conversion of cellulose and its derived C6-C5 sugars (glucos...
Korea Atomic Energy Research Institute (KAERI) established a multi-dimensional hydrogen analysis system to evaluate hydrogen release, distribution, and combustion in the containment of a Nuclear Power Plant (NPP), using MAAP, GASFLOW, and COM3D. In p...
Because of its role in the regulation of the cell cycle, DNA damage response, apoptosis, DNA repair, cell migration, autophagy, and cell metabolism, the TP53 tumor suppressor gene is a key player for cellular homeostasis. TP53 gene is mutated in more...
This paper describes benchmark calculations for the APR1400 nuclear reactor performed using the high-fidelity deterministic whole-core simulator MPACT compared to reference solutions generated by the Monte Carlo code McCARD. The methodology presented...
Human papillomavirus positive (HPV+) tonsillar and base of tongue cancer (TSCC/BOTSCC) is rising in incidence, but chemoradiotherapy is not curative for all. Therefore, targeted therapy with PI3K (BYL719), PARP (BMN-673), and WEE1 (MK-1775) inhibitor...
The aim of this paper is to present the isotopic changes in nuclear fuel during the first reactor cycle of the Korean Advanced Power Reactor 1400 (APR1400). The neutron transport and burnup calculations were performed using the Monte Carlo continuous...
This work studied the feasibility of digitalizing the analog Ex-Core Neutron Flux Monitoring System (ENFMS) being used for APR1400 nuclear power plants (NPPs) and as to which strategies and steps must be taken. A fission chamber neutron flux detectio...
The KEPCO Nuclear Fuel Company (KNF) has undertaken considerable efforts to improve the KARMA/ASTRA nuclear design code system to meet the increasing demand for high-fidelity core analyses. Through years of effort, the KARMA lattice transport code ba...
We developed two distinct automatic packet reporting system (APRS) payload designs to establish a reliable backup communication system for disaster risk reduction and management. The payloads are designed to perform a significant key operation, prima...
p53 protects cells from genetic assaults by triggering cell-cycle arrest and apoptosis. Inactivation of p53 pathway is found in the vast majority of human cancers often due to somatic missense mutations in TP53 or to an excessive degradation of the p...
17 December 2025
Associations between prenatal exposure to phthalates, bisphenols and their mixtures and early childhood allergic conditions and asthma were examined. Five hundred and fifty-six mother–child pairs from the Alberta Pregnancy Outcomes and Nutritio...
This study examined the associations between maternal pre-pregnancy BMI and gestational weight gain (GWG) and children’s neuropsychological outcomes at 3 to 5 years of age. A total of 379 women and their children from the Alberta Pregnancy Outc...
Chemorepulsion mechanisms for eukaryotic cells are poorly understood. We performed proteomics and phosphoproteomics to elucidate how Dictyostelium discoideum responds to its two endogenous chemorepellent signals, the protein AprA and inorganic polyph...
This review is intended to demonstrate that the local production of acute phase proteins (termed local acute phase response (lAPR)) and especially fibrin/fibrinogen (FN) is a defense mechanism of cancer cells to therapy, and inhibition of the lAPR ca...
Background: Abdominoperineal resection (APR) has been advocated for persistent or recurrent disease after failure of chemoradiation (CRT) for anal squamous cell cancer (SCC). Treatment with salvage APR can potentially achieve a cure. This study aimed...
In this work, aprepitant (APR) was loaded in a high-molecular-weight poly(ethylene oxide) (PEO) and PEO/clay nanocomposites via the melt-mixing process in order to investigate the combined effect of the PEO and PEO/clay phases on the dissolution prof...
Background/Objectives: IgA nephropathy (IgAN) is a highly heterogeneous glomerular disease with variable clinical presentation and response to therapy. Standard histopathology provides a static assessment and may not fully reflect dynamic podocyte in...
The main efforts in common wheat (Triticum aestivum L.) breeding focus on yield, grain quality, and resistance to biotic and abiotic stresses. One of the major threats affecting global wheat cultivation and causing significant crop production losses...
The development of financial markets and the low level of financial literacy does not facilitate consumer protection. A significant problem is the lack of information or unclear information regarding financial offers, including consumer credit. Finan...
This paper describes the evolution of the Assistant Personal Robot (APR) project developed at the Robotics Laboratory of the University of Lleida, Spain. This paper describes the first APR-01 prototype developed, the basic hardware improvement, the s...
Diffuse intrinsic pontine glioma (DIPG) is an aggressive pediatric brainstem tumor with a 5-year survival of <1%. Up to 80% of the DIPG tumors contain a specific K27M mutation in one of the two genes encoding histone H3 (H3K27M). Furthermore, p53...
Automated program repair (APR) plays a vital role in enhancing software quality and reducing developer maintenance efforts. Neural Machine Translation (NMT)-based methods demonstrate notable potential by learning translation patterns from bug-fix cod...
Recently, Automatic Program Repair (APR) has shown a high capability of repairing software bugs automatically. In general, most of the APR techniques require test suites to validate automatically generated patches. However, the test suites used for p...
The APR1400 Nuclear Heat Storage and Recovery (NHS&R) System described here represents the conceptual design and interface of a tertiary cycle with the secondary system of the Korean nuclear reactor plant APR1400. The system is intended to reliab...
Bacillus subtilis produces eight industrially important exo-proteases. For the detection of proteases, the activity- and antibody-based assays are normally used. Current activity-based assays require expensive multiplex chemical substrates which allo...
Pseudomonas fluorescens is the main spoilage bacterium in milk, and its proliferation is one of the factors leading to the deterioration of the quality of raw milk. In this study, a rapid detection system for P. fluorescens was developed based on rec...
Adult plant resistance (APR) is widely used in wheat breeding, but its behaviour across genetic backgrounds remains poorly understood. In this study, we analysed the expression of three APR loci (Lr34, Lr46, Lr67) following their introgression into e...
Stripe rust (Puccinia striiformis West. f.sp. tritici, Pst) is a destructive disease that seriously threatens wheat production globally. Exploring novel resistance genes for use in wheat breeding is an urgent need, as continuous Pst evolution frequen...
The cystine/glutamate antiporter xCT is a tumor-associated antigen that has been newly identified in many cancer types. By participating in glutathione biosynthesis, xCT protects cancer cells from oxidative stress conditions and ferroptosis, and cont...
APR-246 (Eprenetapopt/PRIMA-1Met) is a very potent anti-cancer drug in clinical trials and was initially developed as a p53 refolding agent. As an alternative mode of action, the elevation of reactive oxygen species (ROS) has been proposed. Through a...
This article examines motifs of falling, recoiling, and turning across Chester Himes’ oeuvre as figurations of Black susceptibility to racial violence. These images reference and reconstruct an event from Himes’ early adulthood: his catas...
In terrestrial hot springs, some members of the microbial mat community utilize sulfur chemical species for reduction and oxidization metabolism. In this study, the diversity and activity of sulfur-metabolizing bacteria were evaluated along a tempera...
Background: Maternal depressive symptoms have been associated with adverse child and family outcomes, including child behavioural problems, suboptimal parenting quality, and increased child screen time. However, the developmental pathways linking the...
The increasing threat posed by wheat rust diseases caused by Puccinia spp. necessitates the development of resistance strategies that extend beyond conventional race-specific mechanisms. Although recent reviews (2023–2025) have emphasized gene...
We develop a geometric approach to financial risk based on Crofton’s idea and the tools of the Radon transform. The trajectory of a financial instrument is defined with respect to a frame of reference (money, benchmark). A central role is playe...
Sulfur is an essential nutrient that can be converted into utilizable metabolic forms to produce sulfur-containing metabolites in plant. Adenosine 5′-phosphosulfate (APS) reductase (APR) plays a vital role in catalyzing the reduction of activat...
This review provides an overview of heterogeneous bimetallic Pd-Fe catalysts in the C–C and C–O cleavage of platform molecules such as C2–C6 polyols, furfural, phenol derivatives and aromatic ethers that are all easily obtainable from renewable cellu...
Biomass is an interesting candidate raw material for the production of renewable hydrogen. The conversion of biomass into hydrogen can be achieved by several processes. In particular, this short review focuses on the recent advances in glycerol refor...
The substantial value held by smart contracts (SCs) makes them an enticing target for malicious attacks. The process of fixing vulnerabilities in SCs is intricate, primarily due to the immutability of blockchain technology. This research paper introd...
Background: The COVID-19 pandemic had a widespread impact on families with dependent children. To better understand the impact of the pandemic on families’ health and relationships, we examined the association between mothers’ and childre...
Mutant p53 is one of the most attractive targets for new anti-cancer drugs. Although traditionally regarded as difficult to drug, several new strategies have recently become available for targeting the mutant protein. One of the most promising of the...
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